Medicine and Health Sciences Commons^™

Therapeutic Electromagnetic Field Effects On Angiogenesis And Tumor Growth, C. Douglas Williams, Marko S. Markov, W. Elaine Hardman, Ivan L. Cameron

Biochemistry and Microbiology

Background: A new approach to cancer therapy based on the application of therapeutic electromagnetic fields (TEMF) has been developed by EMF Therapeutics, Inc., Chattanooga, TN, USA. This study was designed to assess the effect of TEMF on tumor vascularization and growth of murine 16/C mammmary adenocarcinoma cells in C3H/HeJ mice.

Materials and Methods: Implanted tumors were allowed to grow for seven days until the tumor volume reached 100 mm3 before treatment was started. Mice (20 per control, 10 per EMF exposed group) received treatment (10 minutes per day with 0, 10 mT, 15 mT or 20 mT) with a 120 …

Chronic Pain: A Study Of Low Back Pain Patients From Southern West Virginia And Eastern Kentucky, Nickandrea M. Cooke

Theses, Dissertations and Capstones

The Minnesota Multiphasic Personality Inventory-2 (MMPI-2) was administered to 60 males ranging from 22 to 65 years of age. Subjects were seeking treatment at Mountain Comprehensive Care Center, an outpatient mental health center, for depression/anxiety with a secondary diagnosis of chronic pain stemming from low back pain related to an injury. This study considered T-scores of a K-corrected profile using Scales F (Faking, 1 (Hypochondriasis), 2 (Depression), and 3 (Hysteria). Statistical interpretation of data was obtained through use of the General Linear Model at the p < .05 level of significance to determine variance among the groups. Subjects were assigned to three of six groups based on the criteria of age (less than 35 years vs. 35 years or older); duration of pain (less than one year's duration vs. one year or more duration); and medical evidence available (with clinical evidence to support an orthopedic diagnosis vs. those with no clinical evidence available). The results of this study showed that there was no significant difference between groups on the age variable and the only significant differences on the medical evidence variable were for Scales 2 (D) and 3 (Hy). On the duration of pain variable, significant differences among groups for all scales were noted. Also, chronic low back pain patients from this geographic area presented with extreme elevations on Scale F and high elevations on Scales 1 (Hs), 2 (D), and 3 (Hy), with a higher elevation on Scale 2 (D).

The Effects Of A Low-Intensity Exercise Program On The Fitness Level Of A 22 Year-Old Female With Congenital Univentricular Heart Repair, Alice A. Elkins

Theses, Dissertations and Capstones

This case study examined the effects of exercise on a 22 year-old female with a repaired univentricular heart through early, modified Fontan technique. Improvements in oxygen consumption, blood pressure, heart rate and body composition were observed after a 12-week supervised fitness program. This program considers reversing hypoactivity and the subsequent deconditioning and obesity associated with this patient.

Examination Of Iv Antibiotic Use And Length Of Stay In Community-Acquired Pneumonia Patients, Shane Hammock

Theses, Dissertations and Capstones

The purpose of this study was to examine the relationship between IV antibiotic administration and the length of stay for patients with community-acquired pneumonia. Research demonstrates that pneumonia is a large economic burden to acute care facilities across the United States. An ex post facto design was used to examine the difference in lengths of stay (LOS) for two groups of patients diagnosed with community-acquired pneumonia in the Appalachian region. The first group received IV antibiotic therapy at or within 8 hours of arrival to the hospital. The second group received IV antibiotic therapy after 8 hours of arrival to …

Genomic Diversity Of Pseudomonas Aeruginosa In Cystic Fibrosis, Nathaniel Edwards Head

Theses, Dissertations and Capstones

Pseudomonas aeruginosa is a common environmental microorganism. However, it has the genetic capacity to cause diseases in patients with compromised host defense systems. Cystic fibrosis (CF) is one of the major hereditary diseases among Caucasian populations. CF patients are born with a defective chloride channel that is responsible for maintaining fluid and electrolyte balance across the lumen of the lung. This imbalance leads to the production of an abnormal dehydrated viscous mucous, prohibiting the patient from normally clearing the respiratory airway. Chronic pulmonary infections with P. aeruginosa are the major causes of high morbidity and mortality in CF. Two of …

An Investigation Of The Prevalence Of Disordered Eating Behaviors In Dietetic Students, Brandi Elizabeth Hicks

Theses, Dissertations and Capstones

Eating disorders are a debilitating mental illness that affects young people including those in the field of dietetics. Literature suggests that dietetic students have a higher prevalence of eating disorders than other students. Seventy-seven college student in Southern West Virginia enrolled in either dietetics or another major were included in a sample to determine if dietetic students have higher prevalence of disordered eating attitudes and behaviors. The participants completed a survey that included a general information section, a 26-item questionnaire concerning eating attitudes, and a behavioral information section. Upon completion of data collection, the survey was coded, and data was …

Isokinetic Dynamometer Versus A Multi-Axial Stability Platform In The Proprioception And Strength Training Of The Peroneal Muscle Group, Eric Johnson

Theses, Dissertations and Capstones

Ankle injuries are the most common and frequent occurring injuries in sports today (Feuerbach, Grabiner & Koh, 1994). Ankle sprains usually occur in athletes that are participating in running or jumping activities. Injuries to the ankle joint represent about 20% of all sports related injuries, and 15% of all time lost injuries (Payne, Berg, & Latin, 1997). The majority of the sprains to the ankle occur to the lateral ligamentous structures due to the forcefully plantar flexion and inversion of the talocrural joint. This inversion mechanism accounts for 85% of all ankle sprains (Kinzey, Ingersoll, & Knight, 1997). Often after …

Methods Development For The Identification Of Unknown Proteins, Laura Brumfield Neal

Theses, Dissertations and Capstones

The chemistry of transport, storage, energy production, and reproduction in physiological systems is controlled by the actions and interactions of proteins. A species full complement of these amazing machines is often referred to as its proteome. The new science of proteomics utilizes a set of powerful and evolving tools to characterize the nature of the proteome, and further to fully elucidate the functional attributes of the proteins and their associations.

A methodology was developed by combining several proteomic techniques, such as electrophoresis, RP-HPLC, and mass spectrometry, to correctly identity proteins. Three known proteins (myoglobin, albumin, and actin) were employed for …

The Regulation Of Manganese Superoxide Dismutase And Inducible Nitric Oxide Synthase By Nuclear Factor-Kappa B And Activator Protein 1 In Rat Aortic Endothelial Cells, Scott L. Cobbs

Theses, Dissertations and Capstones

Inducible nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) are two enzymes that influence reactive oxygen species within the cell. The promoter regions for the genes encoding these enzymes have two specific transcription factor elements in common, activator protein 1 (AP-1) and nuclear factor kappa b (NF-KB). This study was initiated to determine if either NF-KB or AP-1 regulates the transcription of both genes in endothelial cells. To test whether NF-KB or AP-1 binding sites in the MnSOD and iNOS promoter region were important for transcriptional regulation, we performed induction analysis using various deletion constructs of MnSOD and iNOS …

Effect Of Forskolin On Actin Polymerization In Cultured Vascular Smooth Muscle, Mary Janay Bailey

Theses, Dissertations and Capstones

Increases in intracellular cyclic AMP levels have been shown to affect vascular smooth muscle morphology. In the present study, effects of elevated cyclic AMP levels on actin polymerization were assessed to determine whether cyclic AMP induces specific changes in cytoskeletal proteins of vascular smooth muscle cells. Forskolin was used to increase intracellular cyclic AMP levels through direct activation of adenylate cyclase. Light and Electron microscopy was employed to appraise changes in the shape of vascular smooth muscle cells. Confocal microscopy was used to reveal cytoskeletal changes after exposure to M forskolin for increasing intervals of time. Differences in the expression …

The Ability Of Cryotherapy To Effect Vertical Jump And Single-Legged Hop Test, Douglas W. Branch

Theses, Dissertations and Capstones

Cryotherapy is an important component in the management and rehabilitation of musculoskeletal injuries that occur due to sports participation. Cryotherapy is described as the "therapeutic application of any substance to the body which results in the withdrawal of heat from the body" (Tsang, 1997). This cold modality is used initially when caring for injuries that are acute or chronic. The main reason for using cryotherapy in acute injury management is to lower the temperature of the injured tissue, which reduces the metabolic rate and helps the tissue to survive the period of hypoxia following an injury (Merrick, 1993). The effects …

Latino Access To Health Care: The Role Of Insurance, Managed Care, And Institutional Barriers, J. Emilio Carrillo, Fernando M. Trevino, Joseph R. Betancourt, Alberto Coustasse

Management Faculty Research

The health care system in the United States is the most expensive and yet arguably among the least cost effective in the developed world (Anderson, 1998). Despite the highest per person health care spending among the Organization for Economic Cooperation and Development (OECD) nations, the United States still ranks below many along a variety of health indicators (Woolhandler & Himmelstein, 1991). In a complicated health care system where the rules are many and economic forces drive both structure and function, the needs of vulnerable populations inevitably suffer. This chapter explores the consequences of these market forces on a vulnerable population--Latinos …