Medicine and Health Sciences Commons^™

Trail, Dr5 And Caspase 3-Dependent Apoptosis In Vessels Of Diseased Human Temporomandibular Joint Disc. An Immunohistochemical Study, Carla Loreto, Luis Eduardo Almeida, M. R. Migliore, M. Caltabiano, Rosalia Leonardi

School of Dentistry Faculty Research and Publications

To evaluate the apoptosis involvement in the angiogenesis as a self-limiting process in patients with temporomandibular joint (TMJ) degenerated disc vessels, we assessed, by immunohistochemistry, the detection of TRAIL, its death receptor DR5 and caspase 3. TRAIL, its death receptor DR5 and caspase 3 expression were studied by immunohistochemistry in 15 TMJ discs displaced without reduction and in 4 unaffected discs. These apoptosis molecules were detected in the intima and media layers of newly formed vessels affected discs. In conclusion, vessels apoptosis activation in TMJ disc with ID could be regarded as a self-limiting process that try to leads to …

Soft Tissue Grafting To Improve Implant Esthetics, Moawi M. Kassab

School of Dentistry Faculty Research and Publications

Dental implants are becoming the treatment of choice to replace missing teeth, especially if the adjacent teeth are free of restorations. When minimal bone width is present, implant placement becomes a challenge and often resulting in recession and dehiscence around the implant that leads to subsequent gingival recession. To correct such defect, the author turned to soft tissue autografting and allografting to correct a buccal dehiscence around tooth #24 after a malpositioned implant placed by a different surgeon. A 25-year-old woman presented with the chief complaint of gingival recession and exposure of implant threads around tooth #24. The patient received …

Clinical–Pathological Conference: Case 2, Nasser Said-Al-Naief, Molly S. Rosebush, Denis P. Lynch

School of Dentistry Faculty Research and Publications

No abstract provided.

Web-Based Training Method For Interpretation Of Dental Images, Min Wu, Xiao Zhang, Lisa J. Koenig, John Lynch, Thomas S. Wirtz, En Mao, Lei Ying

School of Dentistry Faculty Research and Publications

No abstract provided.

A Systematic Review Of Dental Disease In Patients Undergoing Cancer Therapy, Catherine H.L. Hong, Joel J. Napeñas, Brian D. Hodgson, Monique A. Stokman, Vickie Mathers-Stauffer, Linda S. Elting, Fred K.L. Spijkervet, Michael T. Brennan

School of Dentistry Faculty Research and Publications

Introduction: The purpose of this systematic review was to evaluate the literature and update our current understanding of the impact of present cancer therapies on the dental apparatus (teeth and periodontium) since the 1989 NIH Development Consensus Conference on the Oral Compli­cations of Cancer Therapies.

Review Method: A systematic literature search was con­ducted with assistance from a research librarian in the databases MEDLINE/PubMed and EMBASE for articles published between 1 January 1990 and 31 December 2008. Each study was independently assessed by two reviewers. Taking into account predetermined quality measures, a weighted prevalence was calculated for the prevalence of dental …

Provision Of Fluoride Varnish Treatment By Medical And Dental Care Providers: Variation By Race/Ethnicity And Levels Of Urban Influence, Christopher Okunseri, Aniko Szabo, Raul I. Garcia, Scott Jackson, Nicholas M. Pajewski

School of Dentistry Faculty Research and Publications

Objective: In 2004, Wisconsin Medicaid policy changed to allow medical care providers to be reimbursed for fluoride varnish treatment (FVT) to children's teeth to improve access and utilization. To date, no study has been published on whether geographic and racial/ethnic variation in the provision of FVT in response to this policy change exists. This study's objective is to examine the association of rates of FVT for children enrolled in Wisconsin Medicaid with race/ethnicity, urban influence codes (UIC), and dental health professional shortage area (DHPSA) designation based on county of residence.

Methods: A retrospective, pre–post design was used based on FVT …

Effect Of Low-Magnitude, High-Frequency Vibration On Osteocytes In The Regulation Of Osteoclasts, Esther Lau, Saja Al-Dujaili, Axel Guenther, Dawei Liu, Liyun Wang, Lidan You

School of Dentistry Faculty Research and Publications

Osteocytes are well evidenced to be the major mechanosensor in bone, responsible for sending signals to the effector cells (osteoblasts and osteoclasts) that carry out bone formation and resorption. Consistent with this hypothesis, it has been shown that osteocytes release various soluble factors (e.g. transforming growth factor-β, nitric oxide, and prostaglandins) that influence osteoblastic and osteoclastic activities when subjected to a variety of mechanical stimuli, including fluid flow, hydrostatic pressure, and mechanical stretching. Recently, low-magnitude, high-frequency (LMHF) vibration (e.g., acceleration less than < 1 × g, where g = 9.81 m/s², at 20–90 Hz) has gained much interest as studies …

Amelioration Of Oral Mucositis Pain By Nasa Near Infra Red Light Emitting Diodes In Bone Marrow Transplant Patients (Poster), Brian Hodgson, David Margolis, L D. Williams, D E. Salzman, J E. Sande, W P. Vaughan, Harry T. Whelan

School of Dentistry Faculty Research and Publications

No abstract provided.

Tooth Loss, Apolipoprotein E, And Decline In Delayed Word Recall, P. S. Stein, R. J. Kryscio, M. Desrosiers, Sara J. Donegan, M. B. Gibbs

School of Dentistry Faculty Research and Publications

Our previous research suggests an association between a low number of teeth and increased risk of dementia. The aim of the present study was to determine if a low number of teeth is specifically related to memory decline as evidenced by low Delayed Word Recall scores. In addition, we examined the combined effect of a low number of teeth and the apolipoprotein E ϵ4 allele on Delayed Word Recall scores. We hypothesized that the scores of those who had the allele and a low number of teeth (0-9) would decline more rapidly over time than those participants with a greater …

Quantifying Fluid Shear Stress In A Rocking Culture Dish, Xiaozhou Zhou, Dawei Liu, Lidan You, Liyun Wang

School of Dentistry Faculty Research and Publications

Fluid shear stress (FSS) is an important stimulus for cell functions. Compared with the well established parallel-plate and cone-and-plate systems, a rocking “see-saw” system offers some advantages such as easy operation, low cost, and high throughput. However, the FSS spatiotemporal pattern in the system has not been quantified. In the present study, we developed a lubrication-based model to analyze the FSS distributions in a rocking rectangular culture dish. We identified an important parameter (the critical flip angle) that dictates the overall FSS behaviors and suggested the right conditions to achieving temporally oscillating and spatially relatively uniform FSS. If the maximal …

Gender Trends In Dental Leadership And Academics: A Twenty-Two-Year Observation, Judy Chia-Chun Yuan, Damian J. Lee, Suchada Kongkiatkamon, Sasha Ross, Soni Prasad, Anne Koerber, Cortino Sukotjo

School of Dentistry Faculty Research and Publications

The purpose of this study was to examine gender disparities in dental leadership and academics in the United States. Nine journals that represent the dental specialties and high published impact factors were selected to analyze the percentage of female dentists’ first and senior authorship for the years 1986, 1990, 1995, 2000, 2005, and 2008. Data on appointment status and female deanship were collected from the American Dental Association (ADA) survey, and the trends were studied. The proportion of female presidents in ADA-recognized specialty organizations was also calculated. Overall, the increase in first female authorship was not statistically significant, but the …

Occurrence And Regional Distribution Of Trail And Dr5 On Temporomandibular Joint Discs: Comparison Of Disc Derangement With And Without Reduction, Rosalia Leonardi, Luis Eduardo Almeida, Paula C. Trevilatto, Carla Loreto

School of Dentistry Faculty Research and Publications

Background

Tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL) is an apoptosis-inducing member of the TNF gene family which triggers apoptotic signals by interaction with its receptors. It has been suggested to be a major contributing factor to tissue degeneration.

Objective

The present study investigated, through immunohistochemistry, the regional expression of TRAIL and in temporomandibular joint (TMJ) disc of anterior disc displacement with reduction (ADDwR) and without reduction (ADDwoR) patients, to help determine the relationship between TMJ disc displacement and apoptosis.

Study design

We studied 18 TMJ diseased discs affected by disc displacement without or with reduction and 4 normal TMJ …

Senior Dental Students’ Experience With Cariogram In A Pediatric Dentistry Clinic, Cesar Gonzalez, Christopher Okunseri

School of Dentistry Faculty Research and Publications

The study objective was to assess predoctoral dental students’ experience with a caries risk assessment computer program in the pediatric dentistry clinic at Marquette University School of Dentistry. In 2005, spring semester sophomore dental students (class of 2008) were introduced to the caries risk assessment computer program “Cariogram.” The students received a fifty-minute lecture on caries risk assessment and a demonstration on how to use Cariogram in the clinic. After two years of clinical exposure to Cariogram, sixty-six out of eighty senior dental students completed an anonymous eleven-item questionnaire on their experience with the tool. Each item on the questionnaire …

Designing Dental Student Portfolios To Assess Performance, Frederick J Sutkiewicz, Gary L. Stafford, Moawi M. Kassab, Sheila E. Stover, Thomas Wirtz

School of Dentistry Faculty Research and Publications

The purpose of this poster is to share a project developed by Marquette University’s liaisons to the American Dental Education Association’s Commission on Change and Innovation in Dental Education with others interested in learning about the use of portfolios to assess the quality of student performance in dental school. Sample components from the pilot portfolios will be integrated into the poster to provide participants with a view from portfolio design to completion. Portfolios are becoming a more common method of assessing the quality of student performance in health professions education. Portfolios can assist in documenting evidence of specific competencies at …

Maximizing Beneficence And Autonomy: Ethical Support For The Use Of Non-Pharmacological Methods For Managing Dental Anxiety, Evelyn Donate-Bartfield, Ryan Spellecy, Nicolas J. Shane

School of Dentistry Faculty Research and Publications

This article examines advantages associated with nonpharmacological behavioral management techniques and suggests that there are benefits to their use (such as achieving a more lasting solution to the problem of dental anxiety) that are not realized with medication-based interventions. Analyses that use Kantian and existential viewpoints for exploring the use of medication versus behavioral interventions for managing life problems yield parallel conclusions: there are advantages gained by using behavioral interventions that are not always associated with medication-based interventions. These analyses, taken together with an understanding of the psychology of dental anxiety management, suggest that using nonpharmacological techniques for the management …

The Quantification Of Tooth Displacement, Thomas W. Radmer, L Thomas Johnson, Mingan Yang, Thomas Wirtz

School of Dentistry Faculty Research and Publications

By using reference points from a single pixel marker placed at the center point of the cuspid teeth and the center point on each of the incisor teeth, a polynomial curve was generated as a native curve for each dental arch studied. The polynomial curve generated from actual tooth position in each arch provides the forensic odontologist with another reference point that is quantifiable. The study represents that individual characteristics, such as tooth displacement, can be quantified in a simple, reliable, and repeatable format.

Survival Rates Of Short-Span Implant-Supported Cantilever Fixed Dental Prostheses, Gary L. Stafford

School of Dentistry Faculty Research and Publications

Data sources

Publications were sought using Medline, and searches were made by hand of the journals Clinical Oral Implants Research, International Journal of Periodontics and Restorative Dentistry, Journal of Periodontology, Journal of Clinical Periodontology and the International Journal of Oral and Maxillofacial Implants, along with reference lists of identified articles.

Study selection

Titles and abstracts were initially screened by two independent reviewers to identify prospective or retrospective longitudinal cohort studies or controlled studies reporting on implant supported cantilever fixed dental prostheses (ICFDP) with a mean followup period of at least 5 years. A clinical examination had to be performed …

Effect Of Photobiomodulation On Vinblastine-Poisoned Murine Hers Cells, Brian D. Hodgson, B. Pyszka, Michele M. Henry, E. Buchmann, Harry T. Whelan

School of Dentistry Faculty Research and Publications

Objective: The aim of this study was to investigate the effect of near-infrared (NIR) photobiomodulation on the proliferation and glutathione levels in murine Hertwig's epithelial root sheath (HERS) cells after poisoning with vinblastine. Background: Photobiomodulation has been shown to improve wound healing in a number of animal models. There have been no studies on the effect of photobiomodulation on cancer-related chemotherapy injury to the cells that initiate tooth root growth. Materials and Methods: Control groups consisted of murine HERS cells without vinblastine (VB−) and cells with vinblastine at 10, 20, and 30 ng/mL (VB10, VB20, and VB30). Experimental groups consisted …

Moving Teeth Faster, Better And Painless. Is It Possible?, Jose A. Bosio, Dawei Liu

School of Dentistry Faculty Research and Publications

No abstract provided.

Treatment Of Gingival Recession, Moawia M. Kassab, Hala Badawi, Andrew R. Dentino

School of Dentistry Faculty Research and Publications

Gingival recession is an intriguing and complex phenomenon. Recession frequently disturbs patients because of sensitivity and esthetics. Many surgical techniques have been introduced to treat gingival recession, including those involving autogenous tissue grafting, various flap designs, orthodontics, and guided tissue regeneration (GTR). This article describes different clinical approaches to treat gingival recession with emphasis on techniques that show promising results and root coverage.