Medicine and Health Sciences Commons^™

Levo-Tetrahydropalmatine Attenuates Cocaine Self-Administration Under A Progressive-Ratio Schedule And Cocaine Discrimination In Rats, John R. Mantsch, Samantha Wisniewski, Oliver Vranjkovic, Corey Peters, Amanda Becker, Abbey Valentine, Shi-Jiang Li, David A. Baker, Zheng Yang

Biomedical Sciences Faculty Research and Publications

Levo-tetrahydropalmatine (l-THP) is an alkaloid found in many traditional Chinese herbal preparations and has a unique pharmacological profile that includes dopamine receptor antagonism. Previously we demonstrated that l-THP attenuates fixed-ratio (FR) cocaine self-administration (SA) and cocaine-induced reinstatement in rats at doses that do not alter food-reinforced responding. This study examined the effects of l-THP on cocaine and food SA under progressive-ratio (PR) schedules of reinforcement and the discriminative stimulus effects of cocaine. In adult male Sprague–Dawley rats self-administering cocaine (0.5 or 1.0 mg/kg/inf), l-THP significantly reduced breaking points at the 1.875, 3.75 and 7.5 mg/kg …

The Association Of Religiosity, Sexual Education, And Parental Factors With Risky Sexual Behaviors Among Adolescents And Young Adults, Kristin Haglund, Richard Fehring

College of Nursing Faculty Research and Publications

This study examined the association of religiosity, sexual education and family structure with risky sexual behaviors among adolescents and young adults. The nationally representative sample, from the 2002 National Survey of Family Growth, included 3,168 women and men ages 15–21 years. Those who viewed religion as very important, had frequent church attendance, and held religious sexual attitudes were 27–54% less likely to have had sex and had significantly fewer sex partners than peers. Participants whose formal and parental sexual education included abstinence and those from two-parent families were 15% less likely to have had sex and had fewer partners.

Psychometric Properties Of The Arabic Version Of The Depressive Cognition Scale In First-Year Adolescent Egyptian Nursing Students, Abir K. Bekhet, Jaclene Zauszniewski

College of Nursing Faculty Research and Publications

Background: Identifying depressive cognitions in adolescent nursing students can be an important step to prevent the development of clinical depression, which is positively associated with suicide. Purpose: This study focused on the psychometric testing of the Arabic version of the Depressive Cognition Scale (A-DCS) among 170 first-year adolescent Egyptian nursing students. Methods: The questionnaire was assessed for internal consistency, homogeneity, and construct validity using factor analysis and convergent validity. Results: Cronbach's alpha for (A-DCS) was .86. The homogeneity of the instrument was supported by item-to-total correlations between .30 and .70. Factor extraction generated only one factor with eigenvalues greater than …

Resilience In Family Members Of Persons With Serious Mental Illness, Jaclene Zauszniewski, Abir K. Bekhet, M. Jane Suresky

College of Nursing Faculty Research and Publications

This integrative review summarizes current research on resilience in adult family members who have a relative with a diagnosed mental disorder that is considered serious. Within the context of resilience theory, studies identifying risk/vulnerability and positive/protective factors in family members are summarized, and studies examining seven indicators of resilience, including acceptance, hardiness, hope, mastery, self-efficacy, sense of coherence, and resourcefulness, are described. Implications for clinical practice and recommendations for future research are presented.

Technology-Enhanced Practice For Patients With Chronic Cardiac Disease: Home Implementation And Evaluation, Patricia Flatley Brennan, Gail Casper, Laura Burke, Kathy Johnson, Roger L. Brown, Rupa Valdez, Margaret Sebern, Oscar Perez, Billie Sturgeon

College of Nursing Faculty Research and Publications

Objective: This 3-year field experiment engaged 60 nurses and 282 patients in the design and evaluation of an innovative home-care nursing model, referred to as technology-enhanced practice (TEP).

Methods: Nurses using TEP augmented the usual care with a web-based resource (HeartCareII) that provided patients with self-management information, self-monitoring tools, and messaging services.

Results: Patients exposed to TEP demonstrated better quality of life and self-management of chronic heart disease during the first 4 weeks, and were no more likely than patients in usual care to make unplanned visits to a clinician or hospital. Both groups demonstrated the same long-term symptom management …

Book Review Of Soul Searching: The Religious And Spiritual Lives Of American Teenagers By Smith, Christian & Lundquist-Denton, Dora L. Clayton-Jones

College of Nursing Faculty Research and Publications

No abstract provided.

Nurse Researchers In Children's Hospitals, Kathleen Sawin, Karen Gralton, Tondi Harrison, Shelly Malin, Mary Kay Balchunas, Lisa Brock, Brandi Cavegn, Lorna Cisler-Cahill, Sharon Graves, Kathleen Mussatto, Maureen O'Brien, Eileen Sherburne, Rachel Schiffman

College of Nursing Faculty Research and Publications

Little is known about the role of nurse researchers (NRs) and the structure of nursing research programs in children's hospitals in the United States. This descriptive study obtained survey data from 33 NRs. Data suggest that the NR role is emerging and has both commonalities and unique components when compared with the previous studies of NRs in adult hospitals. Most participants have been in their position for less than 4 years. Conducting research, having staff development related to research, and facilitating evidence-based practice or research were common responsibilities. The structure of nursing research programs impacts both the NRs and the …

Trail, Dr5 And Caspase 3-Dependent Apoptosis In Vessels Of Diseased Human Temporomandibular Joint Disc. An Immunohistochemical Study, Carla Loreto, Luis Eduardo Almeida, M. R. Migliore, M. Caltabiano, Rosalia Leonardi

School of Dentistry Faculty Research and Publications

To evaluate the apoptosis involvement in the angiogenesis as a self-limiting process in patients with temporomandibular joint (TMJ) degenerated disc vessels, we assessed, by immunohistochemistry, the detection of TRAIL, its death receptor DR5 and caspase 3. TRAIL, its death receptor DR5 and caspase 3 expression were studied by immunohistochemistry in 15 TMJ discs displaced without reduction and in 4 unaffected discs. These apoptosis molecules were detected in the intima and media layers of newly formed vessels affected discs. In conclusion, vessels apoptosis activation in TMJ disc with ID could be regarded as a self-limiting process that try to leads to …

The Relationship Of Two Types Of Trauma Exposure To Current Physical And Psychological Symptom Distress In A Community Sample Of Colombian Women: Why Interpersonal Violence Deserves More Attention, Ruth Belknap, Ashley Marie Schumacher, Bernal De Pheils, Janice Carrol Humphreys, Diva Jaramillo, Agnes Tiwari, Gladys Eugenia Canaval

College of Nursing Faculty Research and Publications

Our purpose in this study was to examine the relationship between interpersonal violence and background traumas and symptom distress in a community sample of Colombian women (N = 217). We utilized the Life Stressor Checklist-Revised (LSC-R) to measure lifetime interpersonal violence (IPV) and background trauma exposure and the Brief Symptom Inventory (BSI) to measure current symptom distress. Although both exposures were common in this sample, IPV was strongly correlated with current symptom distress; background traumas made no unique contribution to the variance in current symptom distress. Based on our findings, it is suggested that interpersonal events may be particularly …

Soft Tissue Grafting To Improve Implant Esthetics, Moawi M. Kassab

School of Dentistry Faculty Research and Publications

Dental implants are becoming the treatment of choice to replace missing teeth, especially if the adjacent teeth are free of restorations. When minimal bone width is present, implant placement becomes a challenge and often resulting in recession and dehiscence around the implant that leads to subsequent gingival recession. To correct such defect, the author turned to soft tissue autografting and allografting to correct a buccal dehiscence around tooth #24 after a malpositioned implant placed by a different surgeon. A 25-year-old woman presented with the chief complaint of gingival recession and exposure of implant threads around tooth #24. The patient received …

Effects Of Hypothyroidism On Cell Proliferation And Neuroblasts In The Hippocampal Dentate Gyrus In A Rat Model Of Type 2 Diabetes, Sun Shin Yi, In Koo Hwang, Ji Won Choi, Moo-Ho Won, Je Kyung Seong, Yeo Sung Yoon

Biomedical Sciences Faculty Research and Publications

We observed how the hypothyroid state affects diabetic states and modifies cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus (DG). For this, 0.03% methimazole, an anti-thyroid drug, was administered to 7-week-old, pre-diabetic Zucker diabetic fatty (ZDF) rats by drinking water for 5 weeks, and the animals were sacrificed at 12 weeks of age. At this age, corticosterone levels were significantly increased in the ZDF rats compared to those in the control (Zucker lean control, ZLC) rats. Methimazole (methi) treatment in the ZDF rats (ZDF-methi rats) significantly decreased corticosterone levels and diabetes-induced hypertrophy of adrenal glands. In the DG, …

Molecular Requirements For Ethanol Differential Allosteric Modulation Of Ligand-Gated Ion Channels Based On Selective G Beta Gamma Modulation, Gonzalo E. Yevenes, Gustavo Moraga-Cid, Ariel Avila, Leonardo Guzman, Maximiliano Figueroa, Robert W. Peoples, Luis G. Aguayo

Biomedical Sciences Faculty Research and Publications

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol sensitivity of diverse GlyR isoforms and mutants was explained by the presence of specific residues in putative alcohol pockets. Here, we demonstrate that ethanol sensitivity in two LGIC members, the GlyR adult alpha1 and embryonic alpha2 subunits, can be modified through selective mutations that rescued or impaired Gbetagamma modulation. Even though that both isoforms were able to physically interact with Gbetagamma, only the alpha1 GlyR was functionally modulated by Gbetagamma …

Clinical–Pathological Conference: Case 2, Nasser Said-Al-Naief, Molly S. Rosebush, Denis P. Lynch

School of Dentistry Faculty Research and Publications

No abstract provided.

Transcriptional Profiles For Glutamate Transporters Reveal Differences Between Organophosphates But Similarities With Unrelated Neurotoxicants, Theodore A. Slotkin, Doug Lobner, Frederic J. Seidler

Biomedical Sciences Faculty Research and Publications

The developmental neurotoxicity of organophosphates involves mechanisms other than their shared property as cholinesterase inhibitors, among which are excitotoxicity and oxidative stress. We used PC12 cells as a neurodevelopmental model to compare the effects of chlorpyrifos and diazinon on the expression of genes encoding glutamate transporters. Chlorpyrifos had a greater effect in cells undergoing nerve growth factor-induced neurodifferentiation as compared to undifferentiated PC12 cells, with peak sensitivity at the initiation of differentiation, reflecting a global upregulation of all the glutamate transporter genes expressed in this cell line. In differentiating cells, chlorpyrifos had a significantly greater effect than did diazinon and …

The P Wave: Indicator Of Atrial Enlargement, Patrick Loftis

Physician Assistant Studies Faculty Research and Publications

No abstract provided.

Web-Based Training Method For Interpretation Of Dental Images, Min Wu, Xiao Zhang, Lisa J. Koenig, John Lynch, Thomas S. Wirtz, En Mao, Lei Ying

School of Dentistry Faculty Research and Publications

No abstract provided.

A Systematic Review Of Dental Disease In Patients Undergoing Cancer Therapy, Catherine H.L. Hong, Joel J. Napeñas, Brian D. Hodgson, Monique A. Stokman, Vickie Mathers-Stauffer, Linda S. Elting, Fred K.L. Spijkervet, Michael T. Brennan

School of Dentistry Faculty Research and Publications

Introduction: The purpose of this systematic review was to evaluate the literature and update our current understanding of the impact of present cancer therapies on the dental apparatus (teeth and periodontium) since the 1989 NIH Development Consensus Conference on the Oral Compli­cations of Cancer Therapies.

Review Method: A systematic literature search was con­ducted with assistance from a research librarian in the databases MEDLINE/PubMed and EMBASE for articles published between 1 January 1990 and 31 December 2008. Each study was independently assessed by two reviewers. Taking into account predetermined quality measures, a weighted prevalence was calculated for the prevalence of dental …

Structural Empowerment: The Magnet Model Applied To Perioperative Nursing, Kathryn Schroeter

College of Nursing Faculty Research and Publications

No abstract provided.

Determining Axis And Axis Deviation On An Ecg, Patrick Loftis

Physician Assistant Studies Faculty Research and Publications

No abstract provided.

Site-Specific Effects On Respiratory Rhythm And Pattern Of Ibotenic Acid Injections In The Pontine Respiratory Group Of Goats, Joshua M. Bonis, Suzanne Neumueller, Katie L. Krause, T. Kiner, A. Smith, B. D. Marshall, B. Qian, Lawrence Pan, Hubert Forster

Physical Therapy Faculty Research and Publications

To probe further the contributions of the rostral pons to eupneic respiratory rhythm and pattern, we tested the hypothesis that ibotenic acid (IA) injections in the pontine respiratory group (PRG) would disrupt eupneic respiratory rhythm and pattern in a site- and state-specific manner. In 15 goats, cannulas were bilaterally implanted into the rostral pontine tegmental nuclei (RPTN; n = 3), the lateral (LPBN; n = 4) or medial parabrachial nuclei (MPBN; n = 4), or the Kölliker-Fuse nucleus (KFN; n = 4). After recovery from surgery, 1- and 10-μl injections (1 wk apart) of IA were made bilaterally through the …

Toxicity Of Flow Line, Durafill Vs, And Dycal To Dental Pulp Cells: Effects Of Growth Factors, Alyssa Furey, Julie Hjelmhaug, Doug Lobner

Biomedical Sciences Faculty Research and Publications

Introduction

The objective was to determine the effects of growth factor treatment on dental pulp cell sensitivity to toxicity of 2 composite restoration materials, Flow Line and Durafill VS, and a calcium hydroxide pulp capping material, Dycal.

Methods

Toxicity of the dental materials to cultures of primary dental pulp cells was determined by the MTT metabolism assay. The ability of 6 different growth factors to influence the toxicity was tested.

Results

A 24-hour exposure to either Flow Line or Durafill VS caused approximately 40% cell death, whereas Dycal exposure caused approximately 80% cell death. The toxicity of Flow Line and …

Involvement Of Noradrenergic Neurotransmission In The Stress- But Not Cocaine-Induced Reinstatement Of Extinguished Cocaine-Induced Conditioned Place Preference In Mice: Role For Β-2 Adrenergic Receptors, John R. Mantsch, Andy Meyer, Oliver Vranjkovic, Chad E. Beyer, David A. Baker, Holly Caretta

Biomedical Sciences Faculty Research and Publications

The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse. This study investigated the role of noradrenergic systems in the reinstatement of extinguished cocaine-induced conditioned place preference by cocaine and stress in male C57BL/6 mice. Cocaine- (15 mg/kg, i.p.) induced conditioned place preference was extinguished by repeated exposure to the apparatus in the absence of drug and reestablished by a cocaine challenge (15 mg/kg), exposure to a stressor (6-min forced swim (FS); 20–25°C water), or administration of the α-2 adrenergic receptor (AR) antagonists yohimbine …

Provision Of Fluoride Varnish Treatment By Medical And Dental Care Providers: Variation By Race/Ethnicity And Levels Of Urban Influence, Christopher Okunseri, Aniko Szabo, Raul I. Garcia, Scott Jackson, Nicholas M. Pajewski

School of Dentistry Faculty Research and Publications

Objective: In 2004, Wisconsin Medicaid policy changed to allow medical care providers to be reimbursed for fluoride varnish treatment (FVT) to children's teeth to improve access and utilization. To date, no study has been published on whether geographic and racial/ethnic variation in the provision of FVT in response to this policy change exists. This study's objective is to examine the association of rates of FVT for children enrolled in Wisconsin Medicaid with race/ethnicity, urban influence codes (UIC), and dental health professional shortage area (DHPSA) designation based on county of residence.

Methods: A retrospective, pre–post design was used based on FVT …

Listening Sessions With Latinas: Documenting Life Contexts And Creating Connections, Ruth Belknap, Leona Vandevusse

College of Nursing Faculty Research and Publications

Objective: To use listening sessions with groups of Latinas to develop a contextual understanding of the lives of immigrant women to inform program development and ultimately better serve the community's needs for domestic violence services.

Design and Sample: This study was exploratory and descriptive, mixing qualitative listening sessions with quantitative methods. Seven listening group sessions were facilitated with 63 women participating.

Measures: Data included information from a short demographic questionnaire, texts of narrative from the sessions, and tallies of thematic comments made during the listening sessions.

Results: Themes derived from aggregated data from the listening sessions …

Synaptotoxicity Of Alzheimer Beta Amyloid Can Be Explained By Its Membrane Perforating Property, Fernando Sepulveda, Jorge Parodi, Robert W. Peoples, Carlos Opazo, Luis G. Aguayo

Biomedical Sciences Faculty Research and Publications

The mechanisms that induce Alzheimer’s disease (AD) are largely unknown thereby deterring the development of disease-modifying therapies. One working hypothesis of AD is that Aβ excess disrupts membranes causing pore formation leading to alterations in ionic homeostasis. However, it is largely unknown if this also occurs in native brain neuronal membranes. Here we show that similar to other pore forming toxins, Aβ induces perforation of neuronal membranes causing an increase in membrane conductance, intracellular calcium and ethidium bromide influx. These data reveal that the target of Aβ is not another membrane protein, but that Aβ itself is the cellular target …

Cultural Comparison Of Chronic Conditions, Functional Status, And Acceptance In Older African-American And White Adults, Patricia Mcdonald, Jaclene Zauszniewski, Abir K. Bekhet

College of Nursing Faculty Research and Publications

Acceptance of functional decline accompanying chronic illness is challenging for all elders, and even more so for African-American elders. This study examined functional status and the number, types, and acceptance of chronic conditions in 16 African-American and 46 White elders. African-American elders reported better functioning but resembled Whites in number of chronic conditions and acceptance. All African-Americans reported hypertension; 76% of Whites reported arthritis. Greater acceptance was correlated with fewer chronic conditions (r = -.23, p < .05) and better functioning (r = -.59, p < .01). Poorer functioning (i.e., functional disability) was correlated with more chronic conditions (r = .27, p < .05). Culturally sensitive interventions are needed to enhance elders' acceptance of chronic conditions and to improve their functioning.

Probiotics Are Food; Herbs Are Plants; What’S The Risk? Informed Consent For Complementary And Integrative Therapies, Lisa Hanson, Leona Vandevusse

College of Nursing Faculty Research and Publications

No abstract provided.

Pathologically Activated Neuroprotection Via Uncompetitive Blockade Of N-Methyl-D-Aspartate Receptors With Fast Off-Rate By Novel Multifunctional Dimer Bis(Propyl)-Cognitin, Jialie Luo, Wenming Li, Yuming Zhao, Hongjun Fu, Dik-Lung Ma, Jing Tang, Chaoying Li, Robert W. Peoples, Fushun Li, Qinwen Wang, Pingbo Huang, Jun Xia, Yuanping Pang, Yifan Han

Biomedical Sciences Faculty Research and Publications

Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists with fast off-rate (UFO) may represent promising drug candidates for various neurodegenerative disorders. In this study, we report that bis(propyl)-cognitin, a novel dimeric acetylcholinesterase inhibitor and γ-aminobutyric acid subtype A receptor antagonist, is such an antagonist of NMDA receptors. In cultured rat hippocampal neurons, we demonstrated that bis(propyl)-cognitin voltage-dependently, selectively, and moderately inhibited NMDA-activated currents. The inhibitory effects of bis(propyl)-cognitin increased with the rise in NMDA and glycine concentrations. Kinetics analysis showed that the inhibition was of fast onset and offset with an off-rate time constant of 1.9 s. Molecular docking simulations showed moderate …

Effect Of Low-Magnitude, High-Frequency Vibration On Osteocytes In The Regulation Of Osteoclasts, Esther Lau, Saja Al-Dujaili, Axel Guenther, Dawei Liu, Liyun Wang, Lidan You

School of Dentistry Faculty Research and Publications

Osteocytes are well evidenced to be the major mechanosensor in bone, responsible for sending signals to the effector cells (osteoblasts and osteoclasts) that carry out bone formation and resorption. Consistent with this hypothesis, it has been shown that osteocytes release various soluble factors (e.g. transforming growth factor-β, nitric oxide, and prostaglandins) that influence osteoblastic and osteoclastic activities when subjected to a variety of mechanical stimuli, including fluid flow, hydrostatic pressure, and mechanical stretching. Recently, low-magnitude, high-frequency (LMHF) vibration (e.g., acceleration less than < 1 × g, where g = 9.81 m/s², at 20–90 Hz) has gained much interest as studies …

Age-Related Differences In Perception Of Quality Of Discharge Teaching And Readiness For Hospital Discharge, Kathleen Bobay, Teresa A. Jerofke, Marianne E. Weiss, Olga Yakusheva

College of Nursing Faculty Research and Publications

No abstract provided.