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Articles 1 - 16 of 16
Full-Text Articles in Medicine and Health Sciences
Can Parasitized Lambs Self-Medicate Through Preferred Consumption Of Sericea Lespedeza Pellets?, Mallory Alicia Garcia
Can Parasitized Lambs Self-Medicate Through Preferred Consumption Of Sericea Lespedeza Pellets?, Mallory Alicia Garcia
Honors Theses
No abstract provided.
Density Functional Theory Calculations On The Doping Sequence Of Mnxfen(1-X)Ge, Jordan C. Ball
Density Functional Theory Calculations On The Doping Sequence Of Mnxfen(1-X)Ge, Jordan C. Ball
Honors Theses
No abstract provided.
Convergence Of Excitatory And Inhibitory Projections In The Mouse Medial Geniculate Body, Blaise Andre Clarke
Convergence Of Excitatory And Inhibitory Projections In The Mouse Medial Geniculate Body, Blaise Andre Clarke
LSU Master's Theses
The medial geniculate body (MGB) is the target of excitatory and inhibitory inputs from several neural sources. Among these, the inferior colliculus (IC) is an important nucleus in the midbrain that acts as a nexus for many auditory pathways and projections, ascending and descending, throughout the rest of the central auditory system and provides both excitatory and inhibitory projections to the MGB. In addition, the thalamic reticular nucleus (TRN) is a major source of inhibition to the MGB, particularly in rodents. Finally, the auditory cortex (AC) is a major source of descending input to the MGB, providing direct excitation and …
The Ability Of Bull And Stallion Thawed Spermatozoa Refrozen Without Cryoprotectants To Activate Intra- And Interspecies Oocytes, Jose Len Yin
LSU Doctoral Dissertations
Semen cryopreservation has allowed the establishment of genome banks and the large scale propagation of species. The development of simple techniques to cryopreserve semen or alternatives to efficiently use cryopreserved semen from males of valuable genetics that have become infertile will permit continuous propagation of the genetics from these males and may serve as a model for preservation and propagation of endangered species. Sperm cryopreservation without cryoprotectants is a simple process, and offspring have been produced following intracytoplasmic sperm injection (ICSI); however the ability of frozen-thawed sperm refrozen without the addition of cryoprotectants to activate oocytes following ICSI was unknown. …
Role Of An Adenylyl Cyclase Isoform In Alcohol's Effect On Cyclic Amp Regulated Gene Expression In Mammalian Cells, Rebecca Ann Hill
Role Of An Adenylyl Cyclase Isoform In Alcohol's Effect On Cyclic Amp Regulated Gene Expression In Mammalian Cells, Rebecca Ann Hill
LSU Doctoral Dissertations
Research suggests that the cyclic AMP (cAMP) signaling pathway including CREB-CRE regulated expression of various genes is implicated in the predisposition to and development of alcoholism in humans. Alcohol also induces changes in inflammatory and immune responses; these changes increase the incidence of pneumonias and other infections, which can negatively affect recovery from infections. Cyclic AMP (cAMP) is known for its immunosuppressive effects and is also required for proper development of the immune system. Previous work in our laboratory has demonstrated that ethanol enhances the activity of adenylyl cyclase (AC) in an isoform-specific manner; type 7 AC (AC7) is most …
Amblyomma Maculatum Immunomodulation In Mammalian Models Of Rickettsia Parkeri Rickettsiosis, Kaikhushroo Hormazd Banajee
Amblyomma Maculatum Immunomodulation In Mammalian Models Of Rickettsia Parkeri Rickettsiosis, Kaikhushroo Hormazd Banajee
LSU Doctoral Dissertations
Rickettsia parkeri is an emerging human pathogen and spotted fever group Rickettsia that is transmitted via Amblyomma maculatum (the Gulf Coast tick) in the United States. Since these ticks must feed for several days in order to molt to the next life cycle, they must be able to counteract the host immune response. Despite this fact, there have been few studies that evaluate the immunomodulatory effect of this vector and the resultant influence on rickettsial disease. The hypothesis of this research is that, if A. maculatum feeding modifies the host immune response, this immunomodulation will enhance disease caused by R. …
Rickettsia Felis, Transmission Mechanisms Of An Emerging Flea-Borne Rickettsiosis, Lisa Diane Brown
Rickettsia Felis, Transmission Mechanisms Of An Emerging Flea-Borne Rickettsiosis, Lisa Diane Brown
LSU Doctoral Dissertations
Rickettsia felis is an emerging insect-borne rickettsial pathogen and the causative agent of flea-borne spotted fever. First described as a human pathogen from the United States in 1991, R. felis is now identified throughout the world and considered a common cause of fever in Africa. The cosmopolitan distribution of this pathogen is credited to the equally widespread occurrence of cat fleas (Ctenocephalides felis), the primary vector and reservoir of R. felis. Additionally, R. felis has been identified in other hematophagous arthropods (including numerous species of fleas, ticks, mosquitoes, and mites). Most transmission cycles of pathogenic Rickettsia include transovarial and transstadial …
Characterization Of Rickettsial Infection Dynamics Within Dermacentor Variabilis And Amblyomma Maculatum, Emma Kate Harris
Characterization Of Rickettsial Infection Dynamics Within Dermacentor Variabilis And Amblyomma Maculatum, Emma Kate Harris
LSU Doctoral Dissertations
Spotted fever group (SFG) Rickettsia are primarily associated with their reservoir host and vector, the tick. Rickettsial colonization and maintenance within the arthropod is a key component of vector competence and pathogen transmission to the mammalian host. Contemporary detection of novel tick hosts for rickettsial species, combined with an unprecedented rise in human cases of SFG rickettsiosis, necessitates a deeper understanding of tick/Rickettsia interactions. The hypothesis for this work is that if primary tick/Rickettsia pairings do not exist then rickettsial determinants account for primary vector/pathogen relationships. To this end, Dermacentor variabilis and Amblyomma maculatum ticks were exposed to R. rickettsii, …
Phonological Encoding Of Medial Vowels In Adults Who Stutter, Allison Elizabeth Jacobs
Phonological Encoding Of Medial Vowels In Adults Who Stutter, Allison Elizabeth Jacobs
LSU Master's Theses
Previous data suggest the metrical properties of a word may influence the time course of phonological encoding, particularly in adults who stutter. The purpose of the present study is to examine phonological and metrical encoding skills in fluent and non-fluent adults, in particular the medial stress-bearing vowel. Investigators used a silent phoneme monitoring paradigm to assess reaction times for all phonemes within nonword CVCCVC stimuli. This paradigm required participants to manually identify target phonemes within a nonword to further isolate the level of phonological encoding from other processes. Eight participants were exposed to stimuli with initial-stress, and eight participants were …
Reliability Of Auditory-Perceptual Ratings Of Dysarthric Speech: Hypokinetic Dysarthria Secondary To Parkinson's Disease, Jessica Lynn Miller
Reliability Of Auditory-Perceptual Ratings Of Dysarthric Speech: Hypokinetic Dysarthria Secondary To Parkinson's Disease, Jessica Lynn Miller
LSU Master's Theses
Perceptual judgment has been the gold standard in clinical practice, especially regarding differential diagnosis and treatment of dysarthria. Thus, it is critical to establish the reliability of perceptual ratings of the speech characteristics associated with different types of dysarthria. Despite its importance, the reliability and sensitivity of perceptual ratings of speech disturbance have been somewhat questioned. The purpose of this study was to examine the interrater reliability of ratings of perceptual characteristics and the saliency of these characteristics as related to hypokinetic dysarthria. Due to the feasibility issue, the scope of the study was limited to hypokinetic dysarthria associated with …
The Role Of Nadph Oxidase 2 (Nox2) In High-Fat Diet-Induced Adiposopathy And Brain Dysfunction In A Mouse Model, Jennifer Kathleen Pepping
The Role Of Nadph Oxidase 2 (Nox2) In High-Fat Diet-Induced Adiposopathy And Brain Dysfunction In A Mouse Model, Jennifer Kathleen Pepping
LSU Master's Theses
Obesity can have numerous detrimental consequences, namely metabolic syndrome, type 2 diabetes, cardiovascular disease, cancer, and Alzheimer’s disease. The pathogenesis and physiologic consequences of obesity are unknown, but they are often associated with increased inflammation and oxidative stress in both the body and in the brain. One factor that has been implicated in causing inflammation associated with a high fat diet is the enzyme NADPH oxidase, or NOX, specifically the subunit NOX2. Two studies were performed in order to assess the effects of a high fat diet in combination with a universal NOX2 deficiency and a NOX2 deficiency targeted to …
Role Of Histone H4 Mutations In Dna Repair Pathways, Sheikh Arafatur Rahman
Role Of Histone H4 Mutations In Dna Repair Pathways, Sheikh Arafatur Rahman
LSU Master's Theses
Histone H3K79 methylation has been shown to play roles in different DNA repair pathways. Histone H4 residues serine 64 to threonine 80 surround histone H3K79 residue. We have analyzed the effect of the mutations of the residues on UV sensitivity, H3K79 methylation, nucleotide excision repair, chromatin state and homologous recombination. We found that mutation of the residues 64 to 72 cause resistance to killing by UV whereas mutation of the residues 73 to 80 cause sensitivity to killing by UV compared to wild type. In general, we found that the mutations make nucleotide excision repair more proficient at the constitutively …
The Contribution Of Self-Regulation To Reading Comprehension In Adolescent Learners, Rebecca Lynn Parker
The Contribution Of Self-Regulation To Reading Comprehension In Adolescent Learners, Rebecca Lynn Parker
LSU Doctoral Dissertations
The purpose of this study was to examine the dually implicated processes of language and self-regulation in reading comprehension and to determine if self-regulation contributes unique variance to reading comprehension beyond word recognition/decoding and oral language comprehension. The study also sought to determine if the unique contribution of self-regulation to reading comprehension differs for students with language/learning difficulties and students with typical language/learning histories. Thirty-two 6th, 7th, and 8th graders participated in this study. Of these participants, 17 students had language/learning difficulties and 15 students had typical language/learning histories. All participants attended a low performing public middle school located in …
Chikungunya Virus Infection-Associated Bone And Joint Disease, Brad A. Goupil
Chikungunya Virus Infection-Associated Bone And Joint Disease, Brad A. Goupil
LSU Doctoral Dissertations
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that circulates predominantly in tropical and subtropical regions. Infection results in severe debilitating polyarthralgia during the acute phase of disease, and reports suggest that chronic arthralgia lasting months to years after the initial infection can occur. More severe and prolonged disease has been associated with pre-existing joint disease, though this has not been experimentally examined. In the research presented herein, two established mouse models (adult IRF 3/7 -/- -/- and wild-type C57BL/6J mice) were utilized to characterize CHIKV-associated bone and joint disease and evaluate its impact on the progression of pre-existing osteoarthritis (OA) …
Treating Attention Deficits In Individuals With Parkinson's Disease, Mora Johanna Mahoney
Treating Attention Deficits In Individuals With Parkinson's Disease, Mora Johanna Mahoney
LSU Master's Theses
Purpose: The purpose of this study was to determine the presence and degree of treatment effects found for direct attention training on three individuals with idiopathic Parkinson’s disease (PD) using the Attention Process Training, Third Edition (APT-III; Sohlberg & Mateer, 2010). APT-III was designed for use with individuals who have sustained a traumatic brain injury (TBI), and was selected for this study because of the similarities in cognitive deficits between those with TBI and those with PD. Methods: This study was designed as a phase 2, randomized baseline, A1-B-A2-A3 (baseline, treatment, post-treatment, and follow-up assessment), single-subject experimental design. The study …
Identification And Characterization Of A Relish-Type Nf-Kb, Dvrelish In Dermacentor Variabilis, The American Dog Tick, Victoria Irene Verhoeve
Identification And Characterization Of A Relish-Type Nf-Kb, Dvrelish In Dermacentor Variabilis, The American Dog Tick, Victoria Irene Verhoeve
LSU Doctoral Dissertations
Ticks are important worldwide as vectors of bacteria, viruses, and parasites. Pathogenic and non-pathogenic Spotted fever group (SFG) Rickettsia are maintained and transmitted by ticks with specific hard tick-Rickettsia pairings evident in nature. The pathogenic SFG Rickettsia rickettsii is transmitted by the hard tick Dermacentor variabilis. In response to infection, D. variabilis is known differentially respond to SFG Rickettsia infection. The mechanisms of differential immune induction are currently unknown, and are likely involved in the establishment of specific tick-SFG Rickettsia pairings. It was hypothesized that the level of response by D. variabilis to SFG Rickettsia occurs in a species-specific manner, …