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Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
The Role Of Nadph Oxidase 2 (Nox2) In High-Fat Diet-Induced Adiposopathy And Brain Dysfunction In A Mouse Model, Jennifer Kathleen Pepping
The Role Of Nadph Oxidase 2 (Nox2) In High-Fat Diet-Induced Adiposopathy And Brain Dysfunction In A Mouse Model, Jennifer Kathleen Pepping
LSU Master's Theses
Obesity can have numerous detrimental consequences, namely metabolic syndrome, type 2 diabetes, cardiovascular disease, cancer, and Alzheimer’s disease. The pathogenesis and physiologic consequences of obesity are unknown, but they are often associated with increased inflammation and oxidative stress in both the body and in the brain. One factor that has been implicated in causing inflammation associated with a high fat diet is the enzyme NADPH oxidase, or NOX, specifically the subunit NOX2. Two studies were performed in order to assess the effects of a high fat diet in combination with a universal NOX2 deficiency and a NOX2 deficiency targeted to …
Phonological Encoding Of Medial Vowels In Adults Who Stutter, Allison Elizabeth Jacobs
Phonological Encoding Of Medial Vowels In Adults Who Stutter, Allison Elizabeth Jacobs
LSU Master's Theses
Previous data suggest the metrical properties of a word may influence the time course of phonological encoding, particularly in adults who stutter. The purpose of the present study is to examine phonological and metrical encoding skills in fluent and non-fluent adults, in particular the medial stress-bearing vowel. Investigators used a silent phoneme monitoring paradigm to assess reaction times for all phonemes within nonword CVCCVC stimuli. This paradigm required participants to manually identify target phonemes within a nonword to further isolate the level of phonological encoding from other processes. Eight participants were exposed to stimuli with initial-stress, and eight participants were …
Role Of Histone H4 Mutations In Dna Repair Pathways, Sheikh Arafatur Rahman
Role Of Histone H4 Mutations In Dna Repair Pathways, Sheikh Arafatur Rahman
LSU Master's Theses
Histone H3K79 methylation has been shown to play roles in different DNA repair pathways. Histone H4 residues serine 64 to threonine 80 surround histone H3K79 residue. We have analyzed the effect of the mutations of the residues on UV sensitivity, H3K79 methylation, nucleotide excision repair, chromatin state and homologous recombination. We found that mutation of the residues 64 to 72 cause resistance to killing by UV whereas mutation of the residues 73 to 80 cause sensitivity to killing by UV compared to wild type. In general, we found that the mutations make nucleotide excision repair more proficient at the constitutively …
Treating Attention Deficits In Individuals With Parkinson's Disease, Mora Johanna Mahoney
Treating Attention Deficits In Individuals With Parkinson's Disease, Mora Johanna Mahoney
LSU Master's Theses
Purpose: The purpose of this study was to determine the presence and degree of treatment effects found for direct attention training on three individuals with idiopathic Parkinson’s disease (PD) using the Attention Process Training, Third Edition (APT-III; Sohlberg & Mateer, 2010). APT-III was designed for use with individuals who have sustained a traumatic brain injury (TBI), and was selected for this study because of the similarities in cognitive deficits between those with TBI and those with PD. Methods: This study was designed as a phase 2, randomized baseline, A1-B-A2-A3 (baseline, treatment, post-treatment, and follow-up assessment), single-subject experimental design. The study …
Convergence Of Excitatory And Inhibitory Projections In The Mouse Medial Geniculate Body, Blaise Andre Clarke
Convergence Of Excitatory And Inhibitory Projections In The Mouse Medial Geniculate Body, Blaise Andre Clarke
LSU Master's Theses
The medial geniculate body (MGB) is the target of excitatory and inhibitory inputs from several neural sources. Among these, the inferior colliculus (IC) is an important nucleus in the midbrain that acts as a nexus for many auditory pathways and projections, ascending and descending, throughout the rest of the central auditory system and provides both excitatory and inhibitory projections to the MGB. In addition, the thalamic reticular nucleus (TRN) is a major source of inhibition to the MGB, particularly in rodents. Finally, the auditory cortex (AC) is a major source of descending input to the MGB, providing direct excitation and …
Reliability Of Auditory-Perceptual Ratings Of Dysarthric Speech: Hypokinetic Dysarthria Secondary To Parkinson's Disease, Jessica Lynn Miller
Reliability Of Auditory-Perceptual Ratings Of Dysarthric Speech: Hypokinetic Dysarthria Secondary To Parkinson's Disease, Jessica Lynn Miller
LSU Master's Theses
Perceptual judgment has been the gold standard in clinical practice, especially regarding differential diagnosis and treatment of dysarthria. Thus, it is critical to establish the reliability of perceptual ratings of the speech characteristics associated with different types of dysarthria. Despite its importance, the reliability and sensitivity of perceptual ratings of speech disturbance have been somewhat questioned. The purpose of this study was to examine the interrater reliability of ratings of perceptual characteristics and the saliency of these characteristics as related to hypokinetic dysarthria. Due to the feasibility issue, the scope of the study was limited to hypokinetic dysarthria associated with …