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Articles 31 - 60 of 142
Full-Text Articles in Medicine and Health Sciences
What Is The Risk For Metabolic Syndrome In Police Officers?, Warren D. Franke
What Is The Risk For Metabolic Syndrome In Police Officers?, Warren D. Franke
Warren D Franke
The report by Jayakrishnan and colleagues in this Journal is noteworthy since it provides an assessment of the presence of the metabolic syndrome and related cardiovascular risk factors in one of the largest, if not the largest, cohort of police officers to date. Two aspects of this research especially warrant comment.
Quantitative Normative Gait Data In A Large Cohort Of Ambulatory Persons With Parkinson’S Disease, Chris J. Hass, Paul Malczak, Joe Nocera, Elizabeth L. Stegemoller, Aparna Wagle Shukala, Irene Malaty, Charles E. Jacobson Iv, Michael S. Okun, Nick Mcfarland
Quantitative Normative Gait Data In A Large Cohort Of Ambulatory Persons With Parkinson’S Disease, Chris J. Hass, Paul Malczak, Joe Nocera, Elizabeth L. Stegemoller, Aparna Wagle Shukala, Irene Malaty, Charles E. Jacobson Iv, Michael S. Okun, Nick Mcfarland
Elizabeth L. Stegemoller
Background: Gait performance is widely evaluated to assess health status in older adult populations. While several investigators have presented normative values for spatiotemporal gait parameters drawn from older adult populations, the literature has been void of large-scale cohort studies, which are needed in order to provide quantitative, normative gait data in persons with Parkinson’s disease. The aim of this investigation was to provide reference values for clinically important gait characteristics in a large sample of ambulatory persons with Parkinson’s disease to aid both clinicians and researchers in their evaluations and treatments of gait impairment. Methodology/Principal Findings: Gait performance was collected …
Does Immunocontraception In Feral Horses (Equus Caballus) Extend Reproductive Cycling Beyond The Normal Breeding Season?, Cassandra M.V. Nuñez, James S. Adelman, Daniel I. Rubenstein
Does Immunocontraception In Feral Horses (Equus Caballus) Extend Reproductive Cycling Beyond The Normal Breeding Season?, Cassandra M.V. Nuñez, James S. Adelman, Daniel I. Rubenstein
Cassandra M.V. Nuñez
Although the physiological effects of immunocontraceptive treatment with porcine zona pellucida (PZP) have been well studied, little is known about PZP’s effects on the scheduling of reproductive cycling. Recent behavioral research has suggested that recipients of PZP extend the receptive breeding period into what is normally the non-breeding season. To determine if this is the case, we compiled foaling data from wild horses (Equus caballus) living on Shackleford Banks, North Carolina for 4 years pre- and 8 years post-contraception management with PZP (pre-contraception, n = 65 births from 45 mares; post-contraception, n = 97 births from 46 mares). Gestation lasts …
The Use Of A Ditopic Gd(Iii) Paramagnetic Probe For Investigating Α-Bungarotoxin Surface Accessibility, Andrea Bernini, Ottavia Spiga, Vincenzo Venditti, Filippo Prischi, Mauro Botta, Gianluca Croce, Angela Pui-Ling Tong, Wing-Talk Wong, Neri Niccolai
The Use Of A Ditopic Gd(Iii) Paramagnetic Probe For Investigating Α-Bungarotoxin Surface Accessibility, Andrea Bernini, Ottavia Spiga, Vincenzo Venditti, Filippo Prischi, Mauro Botta, Gianluca Croce, Angela Pui-Ling Tong, Wing-Talk Wong, Neri Niccolai
Vincenzo Venditti
Protein surface accessibility is a critical parameter which drives all intermolecular interaction processes. In this respect a big deal of information has been derived by analyzing paramagnetic perturbation profiles obtained from NMR protein spectra, particularly in the case that the effects due to different soluble paramagnets can be compared. Here Gd2L7, a neutral ditopic paramagnetic NMR probe, has been characterized in terms of structure and relaxivity and its paramagnetic perturbations on α-bungarotoxin CαH signals in 1H–13C HSQC (heteronuclear single quantum coherence) spectra have been analyzed. Then, these signal attenuations have been compared with the ones previously obtained in the presence …
An Efficient Protocol For Incorporation Of An Unnatural Amino Acid In Perdeuterated Recombinant Proteins Using Glucose-Based Media, Vincenzo Venditti, Nicolas L. Fawzi, G. Marius Clore
An Efficient Protocol For Incorporation Of An Unnatural Amino Acid In Perdeuterated Recombinant Proteins Using Glucose-Based Media, Vincenzo Venditti, Nicolas L. Fawzi, G. Marius Clore
Vincenzo Venditti
The in vivo incorporation of unnatural amino acids into proteins is a well-established technique requiring an orthogonal tRNA/aminoacyl-tRNA synthetase pair specific for the unnatural amino acid that is incorporated at a position encoded by a TAG amber codon. Although this technology provides unique opportunities to engineer protein structures, poor protein yields are usually obtained in deuterated media, hampering its application in the protein NMR field. Here, we describe a novel protocol for incorporating unnatural amino acids into fully deuterated proteins using glucose-based media (which are relevant to the production, for example, of amino acid-specific methyl-labeled proteins used in the study …
Conformational Selection And Substrate Binding Regulate The Monomer/Dimer Equilibrium Of The C-Terminal Domain Of Escherichia Coli Enzyme I, Vincenzo Venditti, G. Marius Clore
Conformational Selection And Substrate Binding Regulate The Monomer/Dimer Equilibrium Of The C-Terminal Domain Of Escherichia Coli Enzyme I, Vincenzo Venditti, G. Marius Clore
Vincenzo Venditti
The bacterial phosphotransferase system (PTS) is a signal transduction pathway that couples phosphoryl transfer to active sugar transport across the cell membrane. The PTS is initiated by the binding of phosphoenolpyruvate (PEP) to the C-terminal domain (EIC) of enzyme I (EI), a highly conserved protein that is common to all sugar branches of the PTS. EIC exists in a dynamic monomer/dimer equilibrium that is modulated by ligand binding and is thought to regulate the overall PTS. Isolation of EIC has proven challenging, and conformational dynamics within the EIC domain during the catalytic cycle are still largely unknown. Here, we present …
Phaseolus Beans: Impact On Glycaemic Response And Chronic Disease Risk In Human Subjects, Andrea M. Hutchins, Donna M. Winham, Sharon V. Thompson
Phaseolus Beans: Impact On Glycaemic Response And Chronic Disease Risk In Human Subjects, Andrea M. Hutchins, Donna M. Winham, Sharon V. Thompson
Donna Winham
Consumption of Phaseolus vulgaris bean species such as pinto, black, navy or kidney may be beneficial in the prevention and treatment of chronic diseases. In particular, conditions that are promoted by increased glycaemic stress (hyperglycaemia and hyperinsulinaemia) including diabetes, CVD and cancer seem to be reduced in individuals who eat more of these beans. The present paper discusses the influence of P. vulgaris species on glycaemic response and the impact that relationship may have on the risk of developing diabetes, CVD and cancer.
Perceptions Of Flatulence From Bean Consumption Among Adults In 3 Feeding Studies, Donna M. Winham, Andrea M. Hutchins
Perceptions Of Flatulence From Bean Consumption Among Adults In 3 Feeding Studies, Donna M. Winham, Andrea M. Hutchins
Donna Winham
Background: Many consumers avoid eating beans because they believe legume consumption will cause excessive intestinal gas or flatulence. An increasing body of research and the 2010 Dietary Guidelines for Americans supports the benefits of a plant-based diet, and legumes specifically, in the reduction of chronic disease risks. The purpose of the current research was to investigate the perception of increased flatulence and gastrointestinal discomfort among participants who consumed a ½ cup of beans daily for 8 or 12 weeks. Methods: Participants in three studies to test the effects of beans on heart disease biomarkers completed the same weekly questionnaire to …
Spatiotemporal Effects Of A Controlled-Release Anti-Inflammatory Drug On The Cellular Dynamics Of Host Response, Tram T. Dang, Kaitlin M. Bratlie, Said R. Bogatyrev, Xiao Chen, Robert Langer, Daniel G. Anderson
Spatiotemporal Effects Of A Controlled-Release Anti-Inflammatory Drug On The Cellular Dynamics Of Host Response, Tram T. Dang, Kaitlin M. Bratlie, Said R. Bogatyrev, Xiao Chen, Robert Langer, Daniel G. Anderson
Kaitlin M. Bratlie
In general, biomaterials induce a non-specific host response when implanted in the body. This reaction has the potential to interfere with the function of the implanted materials. One method for controlling the host response is through local, controlled-release of anti-inflammatory agents. Herein, we investigate the spatial and temporal effects of an anti-inflammatory drug on the cellular dynamics of the innate immune response to subcutaneously implanted poly(lactic-co-glycolic) microparticles. Noninvasive fluorescence imaging was used to investigate the influence of dexamethasone drug loading and release kinetics on the local and systemic inhibition of inflammatory cellular activities. Temporal monitoring of host response showed that …
Automated Sequence- And Stereo-Specific Assignment Of Methyl-Labeled Proteins By Paramagnetic Relaxation And Methyl–Methyl Nuclear Overhauser Enhancement Spectroscopy, Vincenzo Venditti, Nicolas L. Fawzi, G. Marius Clore
Automated Sequence- And Stereo-Specific Assignment Of Methyl-Labeled Proteins By Paramagnetic Relaxation And Methyl–Methyl Nuclear Overhauser Enhancement Spectroscopy, Vincenzo Venditti, Nicolas L. Fawzi, G. Marius Clore
Vincenzo Venditti
Methyl-transverse relaxation optimized spectroscopy is rapidly becoming the preferred NMR technique for probing structure and dynamics of very large proteins up to ~1 MDa in molecular size. Data interpretation, however, necessitates assignment of methyl groups which still presents a very challenging and time-consuming process. Here we demonstrate that, in combination with a known 3D structure, paramagnetic relaxation enhancement (PRE), induced by nitroxide spin-labels incorporated at only a few surface-exposed engineered cysteines, provides fast, straightforward and robust access to methyl group resonance assignments, including stereoassignments for the methyl groups of leucine and valine. Neither prior assignments, including backbone assignments, for the …
A Structurally Driven Analysis Of Thiol Reactivity In Mammalian Albumins, Ottavia Spiga, Domenico Summa, Simone Cirri, Andrea Bernini, Vincenzo Venditti, Matteo De Chiara, Raffaella Priora, Simona Frosail, Antonios Margaritis, Danila Di Giuseppe, Paolo Di Simplicio, Neri Niccolai
A Structurally Driven Analysis Of Thiol Reactivity In Mammalian Albumins, Ottavia Spiga, Domenico Summa, Simone Cirri, Andrea Bernini, Vincenzo Venditti, Matteo De Chiara, Raffaella Priora, Simona Frosail, Antonios Margaritis, Danila Di Giuseppe, Paolo Di Simplicio, Neri Niccolai
Vincenzo Venditti
Understanding the structural basis of protein redox activity is still an open question. Hence, by using a structural genomics approach, different albumins have been chosen to correlate protein structural features with the corresponding reaction rates of thiol exchange between albumin and disulfide DTNB. Predicted structures of rat, porcine, and bovine albumins have been compared with the experimentally derived human albumin. High structural similarity among these four albumins can be observed, in spite of their markedly different reactivity with DTNB. Sequence alignments offered preliminary hints on the contributions of sequence-specific local environments modulating albumin reactivity. Molecular dynamics simulations performed on experimental …
Real-Time In Vivo Detection Of Biomaterial-Induced Reactive Oxygen Species, Minglin Ma, Wendy F. Liu, Kaitlin M. Bratlie, Tram Dang, Robert Langer, Daniel G. Anderson
Real-Time In Vivo Detection Of Biomaterial-Induced Reactive Oxygen Species, Minglin Ma, Wendy F. Liu, Kaitlin M. Bratlie, Tram Dang, Robert Langer, Daniel G. Anderson
Kaitlin M. Bratlie
The non-specific host response to implanted biomaterials is often a key challenge of medical device design. To evaluate biocompatibility, measuring the release of reactive oxygen species (ROS) produced by inflammatory cells in response to biomaterial surfaces is a well-established method. However, the detection of ROS in response to materials implanted in vivo has not yet been demonstrated. Here, we develop a bioluminescence whole animal imaging approach to observe ROS released in response to subcutaneously-implanted materials in live animals. We compared the real-time generation of ROS in response to two representative materials, polystyrene and alginate, over the course of 28 days. …
Immunocontraception In Wild Horses (Equus Caballus) Extends Reproductive Cycling Beyond The Normal Breeding Season, Cassandra M.V. Nuñez, James S. Adelman, Daniel I. Rubenstein
Immunocontraception In Wild Horses (Equus Caballus) Extends Reproductive Cycling Beyond The Normal Breeding Season, Cassandra M.V. Nuñez, James S. Adelman, Daniel I. Rubenstein
Cassandra M.V. Nuñez
Although the physiological effects of immunocontraceptive treatment with porcine zona pellucida (PZP) have been well studied, little is known about PZP's effects on the scheduling of reproductive cycling. Recent behavioral research has suggested that recipients of PZP extend the receptive breeding period into what is normally the non-breeding season. To determine if this is the case, we compiled foaling data from wild horses (Equus caballus) living on Shackleford Banks, North Carolina for 4 years pre- and 8 years post-contraception management with PZP (pre-contraception, n = 65 births from 45 mares; post-contraception, n = 97 births from 46 mares). Gestation lasts …
Tbioptions Postcard, Debra M. Sellers
Tbioptions Postcard, Debra M. Sellers
Debra M. Sellers
TBIoptions helps people with traumatic brain injury (TBI), their families and caregivers. It links people to services and resources in their local communities to promote successful living.
Tbioptions Brochure, Debra M. Sellers
Tbioptions Brochure, Debra M. Sellers
Debra M. Sellers
TBIoptions helps survivors of traumatic brain injury and their families contact organizations in Kansas to promote successful living. Examples include therapy, personal care attendants, housing, transportation, legal, mental health, and vocational services.
Computational Vascular Fluid–Structure Interaction: Methodology And Application To Cerebral Aneurysms, Y. Bazilevs, Ming-Chen Hsu, Y. Zhang, Z. Wang, T. Kvamsdal, S. Hentschel, J. G. Isaksen
Computational Vascular Fluid–Structure Interaction: Methodology And Application To Cerebral Aneurysms, Y. Bazilevs, Ming-Chen Hsu, Y. Zhang, Z. Wang, T. Kvamsdal, S. Hentschel, J. G. Isaksen
Ming-Chen Hsu
A computational vascular fluid–structure interaction framework for the simulation of patient-specific cerebral aneurysm configurations is presented. A new approach for the computation of the blood vessel tissue prestress is also described. Simulations of four patient-specific models are carried out, and quantities of hemodynamic interest such as wall shear stress and wall tension are studied to examine the relevance of fluid–structure interaction modeling when compared to the rigid arterial wall assumption. We demonstrate that flexible wall modeling plays an important role in accurate prediction of patient-specific hemodynamics. Discussion of the clinical relevance of our methods and results is provided.
Kansans Optimizing Health Handout, Debra M. Sellers
Kansans Optimizing Health Handout, Debra M. Sellers
Debra M. Sellers
You will attend six classes with other people with ongoing health issues, family members and caregivers. Manage health and control chronic disease symptoms with medication, communication, exercise and diet.
A Survey Of Lymphoedema Practitioners Across The Us., Jane M. Armer, Electra D. Paskett, Mei R. Fu, Joseph L. Feldman, Robin Shook, Melanie K. Schneider, Bob R. Stewart, Janice N. Cormier
A Survey Of Lymphoedema Practitioners Across The Us., Jane M. Armer, Electra D. Paskett, Mei R. Fu, Joseph L. Feldman, Robin Shook, Melanie K. Schneider, Bob R. Stewart, Janice N. Cormier
Robin Shook
An online survey was developed by the American Lymphedema Framework Project (ALFP) executive and research committees to assess the current scope of practice in lymphoedema treatment in the US. The analysis included responses from 415 therapists from 46 states. Respondents typically had a background in physical or occupational therapy. Nearly all reported having completed a 135-hour training course on lymphoedema treatment and management. Treatment options most often reported were comprehensive decongestive therapy (CDT), exercise/movement, risk-reduction education, and skin care.
Optimal Dynamic Policies For Influenza Management, Michael Ludkovski, Jarad Niemi
Optimal Dynamic Policies For Influenza Management, Michael Ludkovski, Jarad Niemi
Jarad Niemi
Management policies for influenza outbreaks balance the expected morbidity and mortality costs versus the cost of intervention policies. We present a methodology for dynamic determination of optimal policies in a completely observed stochastic compartmental model with parameter uncertainty. Our approach is simulation-based and searches the full set of sequential control strategies. For each time point, it generates a policy map describing the optimal intervention to implement as a function of outbreak state and Bayesian parameter posteriors. As a running example, we study a stochastic SIR model with isolation and vaccination as two possible interventions. Numerical simulations based on a classic …
Kansans Optimizing Health Postcard, Debra M. Sellers
Kansans Optimizing Health Postcard, Debra M. Sellers
Debra M. Sellers
For people with ongoing health issues, their family members and caregivers. Deal with problems, using communication, medication, exercise, and diet.
30-Month Post-Breast Cancer Treatment Lymphoedema, Jane M. Armer, Bob R. Stewart, Robin Shook
30-Month Post-Breast Cancer Treatment Lymphoedema, Jane M. Armer, Bob R. Stewart, Robin Shook
Robin Shook
Background—Quantification of lymphoedema (LE) has been problematic, and the reported incidence of LE varies greatly among women treated with surgery and radiation for breast cancer. Aims—This study aims to describe LE occurrence over time among breast cancer survivors using four diagnostic criteria based on three measurement techniques. Methods—Limb volume and symptom assessment data were followed after surgery every three months for 12 months, then every six months for 30 months. Limb volume changes (LVC) were measured by circumferences and by perometry, and by symptom experience via interview. Standard survival analysis methods identified when the criteria indicating LE were met. Results—Trends …
Alfp: Identifying Issues In Lymphoedema In Hte Us, Jane Armer, Joseph Feldman, Mei Fu, Nicole Stout, Bonnie Lasinski, Catherine Tuppo, Marcia Beck, Julie Rodrick, Robin Shook, Pierre Gonon, Constance Brooks, Christine Moffatt, Bob Stewart, Janice Cormier
Alfp: Identifying Issues In Lymphoedema In Hte Us, Jane Armer, Joseph Feldman, Mei Fu, Nicole Stout, Bonnie Lasinski, Catherine Tuppo, Marcia Beck, Julie Rodrick, Robin Shook, Pierre Gonon, Constance Brooks, Christine Moffatt, Bob Stewart, Janice Cormier
Robin Shook
The American Lymphedema Framework Project (ALFP) is a national initiative introduced in 2008 to improve the management of lymphoedema (LE) and related disorders in the United States. A National Stakeholders Conference was held in March 2009 to share perspectives on the current state of LE, establish priority issues, and recommend actions to move the field forward.
Protection Of Retinal Cells From Ischemia By A Novel Gap Junction Inhibitor, Satyabrata Das, Dingo Lin, Snehalata Jena, Aibin Shi, Srinivas Battina, Duy H. Hua, Rachel A. Allbaugh, Dolores J. Takemoto
Protection Of Retinal Cells From Ischemia By A Novel Gap Junction Inhibitor, Satyabrata Das, Dingo Lin, Snehalata Jena, Aibin Shi, Srinivas Battina, Duy H. Hua, Rachel A. Allbaugh, Dolores J. Takemoto
Rachel A. Allbaugh
Retinal cells which become ischemic will pass apoptotic signal to adjacent cells, resulting in the spread of damage. This occurs through open gap junctions. A class of novel drugs, based on primaquine (PQ), was tested for binding to connexin 43 using simulated docking studies. A novel drug has been synthesized and tested for inhibition of gap junction activity using R28 neuro-retinal cells in culture. Four drugs were initially compared to mefloquine, a known gap junction inhibitor. The drug with optimal inhibitory activity, PQ1, was tested for inhibition and was found to inhibit dye transfer by 70% at 10 μM. Retinal …
Plan Your Future With Advance Directives Poster, Debra M. Sellers
Plan Your Future With Advance Directives Poster, Debra M. Sellers
Debra M. Sellers
Poster, three pages that define Living Will, Durable Power of Attorney for Health Care.
Assistive Technology Postcard, Debra M. Sellers, Erin J. Dittman
Assistive Technology Postcard, Debra M. Sellers, Erin J. Dittman
Debra M. Sellers
Postcard on assistive technology, tools to help make life easier, for people with arthritis, disabilities, etc.
Fashion An Easier Lifestyle With Assistive Technology: Leader's Guide, Debra M. Sellers, Erin J. Dittman
Fashion An Easier Lifestyle With Assistive Technology: Leader's Guide, Debra M. Sellers, Erin J. Dittman
Debra M. Sellers
Assistive technology is about tools to help make life easier, for people with arthritis, disabilities, etc. It helps with meals, housework, personal care, and other activities.
Fashion An Easier Lifestyle With Assistive Technology: Fact Sheet, Debra M. Sellers, Erin J. Dittman
Fashion An Easier Lifestyle With Assistive Technology: Fact Sheet, Debra M. Sellers, Erin J. Dittman
Debra M. Sellers
Assistive technology is about tools to help make life easier, for people with arthritis, disabilities, etc. It helps with meals, housework, personal care, and other activities.
In Vivo Ultrasonic Attenuation Slope Estimates For Detecting Cervical Ripening In Rats: Preliminary Results, Timothy A. Bigelow, Barbara L. Mcfarlin, William D. O'Brien Jr., Michael L. Oelze
In Vivo Ultrasonic Attenuation Slope Estimates For Detecting Cervical Ripening In Rats: Preliminary Results, Timothy A. Bigelow, Barbara L. Mcfarlin, William D. O'Brien Jr., Michael L. Oelze
Timothy A. Bigelow
To effectively postpone preterm birth, cervical ripening needs to be detected and delayed. As the cervix ripens, the spacing between the collagen fibers increases and fills with water, hyaluronan, decorin, and enzymes suggesting that the ultrasonic attenuation of the cervix should decrease. The decrease in ultrasonic attenuation may be detectable, leading to an effective means of detecting cervical ripening. Herein, the traditional attenuation slope-estimation algorithm based on measuring the downshift in center frequency of the ultrasonic backscattered signal with propagation depth was modified and applied to the cervix of rats. The modified algorithm was verified using computer simulations and an …
Behavioral Effects Of Contraception Management: The Use Of Porcine Zona Pellucida On Wild Horses, Cassandra M.V. Nuñez
Behavioral Effects Of Contraception Management: The Use Of Porcine Zona Pellucida On Wild Horses, Cassandra M.V. Nuñez
Cassandra M.V. Nuñez
The advent of immunocontraception with porcine zona pellucida (PZP) has all but revolutionized wild horse management, providing a more humane method of population control than earlier strategies. Early studies on Assateague Island National Seashore have described it as an ideal form of fertility control in that it reduces the chance of conception to below 10%, can be delivered remotely, is reversible (after short-term use), lacks debilitating physiological side effects, cannot pass through the food chain, and shows minimal effects on social behaviors. However, recent research in other populations has revealed behavioral and physiological side effects of long-term PZP use. These …
Measuring The Dynamic Surface Accessibility Of Rna With The Small Paramagnetic Molecule Tempol, Vincenzo Venditti, Neri Niccolai, Samuel E. Butcher
Measuring The Dynamic Surface Accessibility Of Rna With The Small Paramagnetic Molecule Tempol, Vincenzo Venditti, Neri Niccolai, Samuel E. Butcher
Vincenzo Venditti
The surface accessibility of macromolecules plays a key role in modulating molecular recognition events. RNA is a complex and dynamic molecule involved in many aspects of gene expression. However, there are few experimental methods available to measure the accessible surface of RNA. Here, we investigate the accessible surface of RNA using NMR and the small paramagnetic molecule TEMPOL. We investigated two RNAs with known structures, one that is extremely stable and one that is dynamic. For helical regions, the TEMPOL probing data correlate well with the predicted RNA surface, and the method is able to distinguish subtle variations in atom …