Medicine and Health Sciences Commons^™

Estimates Of Mortality Benefit From Ideal Cardiovascular Health Metrics: A Dose Response Meta‐Analysis, Ehimen C. Aneni, Alessio Crippa, Chukwuemeka U. Osondu, Javier Valero‐Elizondo, Adnan Younus, Khurram Nasir, Emir Veledar

Department of Biostatistics Faculty Publications

Background Several studies have shown an inverse relationship between ideal cardiovascular health (CVH) and mortality. However, there are no studies that pool these data to show the shape of the relationship and quantify the mortality benefit from ideal CVH.

Methods and Results We conducted a systematic internet literature search of multiple databases including MEDLINE, Web of Science, Embase, CINAHL, and Scopus for longitudinal studies assessing the relationship between ideal CVH and mortality in adults, published between January 1, 2010, and May 31, 2017. We included studies that assessed the relationship between ideal CVH and mortality in populations that were initially …

Mitochondria: A Common Target For Genetic Mutations And Environmental Toxicants In Parkinson’S Disease, Martin P. Helley, Jennifer Pinnell, Carolina Sportelli, Kim Tieu

Environmental Health Sciences

Parkinson’s disease (PD) is a devastating neurological movement disorder. Since its first discovery 200 years ago, genetic and environmental factors have been identified to play a role in PD development and progression. Although genetic studies have been the predominant driving force in PD research over the last few decades, currently only a small fraction of PD cases can be directly linked to monogenic mutations. The remaining cases have been attributed to other risk associated genes, environmental exposures and gene–environment interactions, making PD a multifactorial disorder with a complex etiology. However, enormous efforts from global research have yielded significant insights into …

Associations Of Hiv Risk Behaviors Among Older Latinas And Their Adult Daughters, Gira J. Ravelo

FIU Electronic Theses and Dissertations

This dissertation examines the associations between adult Latina daughters’ HIV risk behaviors and that of their older Latina mothers’ HIV risk behaviors. The central hypothesis of the study is that adult Latina daughters’ influence their older mothers’ behaviors and that such behaviors interact with the level of their attachment.

Older Latinas are a vulnerable population that face cultural risk factors, health care provider bias, and engage in low rates of HIV testing. The primary mode of HIV infection for Latinas is through heterosexual contact. Yet, traditional gender norms such as marianismo belief place pressure on Latina women to be submissive …

Health Outcomes Of Hispanic Parents Caring For Children With Disabilities, Nelson Sanchez

FIU Electronic Theses and Dissertations

The purpose of this correlational study is to investigate the impact of the child’s functional status, family context, parent acculturation, and social support on parenting stress and, ultimately, on parents physical and mental health. A convenience sample of 50 Hispanic parents was recruited through a Facebook page and from agencies in South Florida providing services to children with disabilities and their families. The parents ages range from 21 to 62 years and the majority were mothers (n= 45). The majority of parents in this study live in low income households, have no college education, showed little participation in the workforce, …

Risk Associated With E-Cigarette Use And Marketing Messages On Other Tobacco Products Use And Dependence Symptoms Among Adolescents, Rehab Auf

FIU Electronic Theses and Dissertations

E-cigarettes became available in the United States during 2007. Studies using national data have found an increase in e- cigarette use among adolescents as early as 2011. In 2014, e-cigarettes became the most commonly used tobacco product among adolescents; however, little is known about its association with other tobacco products use. Therefore, the present study aimed to: 1) Examine the association between initiating tobacco use via e-cigarettes and subsequent use of other tobacco products; 2) Examine the association between the exposure to e-cigarettes marketing messages and tobacco use; 3) Describe symptoms of nicotine dependence associated with e-cigarette use, compared with …

Comparing Mothers' Postpartum Concerns In 2 Clinical Trials 18 Years Apart, Jean Hannan, Dorothy Brooten, Joanne M. Youngblut, Ali Marie Galindo

Nicole Wertheim College of Nursing and Health Sciences

Background/purpose

To determine if US women's postpartum concerns have changed overtime.

Methods

Mothers' postpartum concerns were compared in 2 clinical trials: 1997 (High Risk Pregnancy); 2015 (First Time Mothers). Advanced Practice Nurses (APNs) provided care through 8 weeks postpartum and recorded interactions in clinical logs. Content analysis of logs was used to identify concerns.

Results

95% of 58 1997 mothers were African American; 64% of 62 2015 mothers were Hispanic. Number of infant concerns (129 vs 144) was similar as were 4 of top 5; infant feeding was the top concern for both. 1997 mothers were concerned with body changes, …

Id3, Estrogenic Chemicals, And The Pathogenesis Of Tumor-Like Proliferative Vascular Lesions, Vincent E. Avecilla

FIU Electronic Theses and Dissertations

Tumor-like proliferative vascular lesions manifest in several diseases such as peripheral arterial disease (PAD) and atherosclerosis (AS) after arterial injury. The cause of the vascular cell dysfunction in PAD patients is not known. Our recent novel discovery shows that inhibitor of differentiation 3 (ID3) is highly expressed in intimal lesions of clinical vascular disease samples. The central hypothesis of our study is: estrogenic chemical induced dysregulation of ID3 target genes is involved in the development of vascular disease. NHANES data analysis demonstrated higher geometric levels of all 6 PCB congeners in both PAD diagnosed participants and participants at risk of …

An Introduction And High Yield Summary Of Female Contraceptive Methods, Dharam Persaud, J. Burns, J. Trangle, J. Agudelo, Ja Gonzalez, D. Nunez, K. Perez, D. Rasch, S. Valencia, C. V. Rao

HWCOM Faculty Publications

Globally, contraceptive studies and their use are major challenges in the realm of public health. The ideal goal is to obtain a contraceptive method that is highly effective at minimizing unplanned pregnancies and nullifying the chance of contracting a sexually transmitted disease. Abstinence is currently the only way to attain such a dualistic goal, and while effective, it may not be suitable for sexually active individuals. While there is an abundance of methodspecific information regarding the use of any one female contraceptive device, there is a paucity of resources that compare and contrast the advantages and disadvantages of such methods …

Health Indicators Of Us Older Adults Who Received Or Did Not Receive Meals Funded By The Older Americans Act, Edgar Vieira, Joan A. Vaccaro, Gustavo G. Zarini, Fatma Huffman

Department of Dietetics and Nutrition

Background. The Older Americans Act (OAA) requires that nutrition programs provide meals and related nutrition services that promote health and help manage chronic diseases. The purpose of this study was to compare health status, food security, functional limitations, and chronic diseases of older adults who received or did not receive OAA meals using data from a representative sample of US adults. Methods. Data were from the National Health and Nutrition Surveys 2011–2014 for 2,392 older adults ≥ 65 years of age, including 187 Mexican Americans, 212 other Hispanics, 521 non-Hispanic Blacks, 219 non-Hispanic Asians, and 1253 non-Hispanic Whites. Results. Those …

Male Contraceptives: A New Frontier In Contraception Medicine, Dharam Persaud, J. Burns, J. Trangle, A. Gilbert, M. Govea, M. Lorenzo, C. V. Rao

HWCOM Faculty Publications

In the field of contraceptive studies, discussions primarily focus on the practice of women’s health and contraception. While it is true that unintended pregnancies and sexually transmitted diseases/infections (STI) pose major challenges in global public health, historically the burden of preventing these has largely fallen on women. Assuming that sexual intercourse requires an equal contribution between two partners, we hold that contraception and STI prevention should be a shared responsibility. Additionally, the ideal contraceptive method should prevent both unplanned pregnancies and STIs simultaneously. While abstinence remains the only 100% proven method of achieving such goals, it is not always practical …

Epigenetic Instability Induced By Dna Base Lesion Via Dna Base Excision Repair, Zhongliang Jiang

FIU Electronic Theses and Dissertations

DNA damage can cause genome instability, which may lead to human cancer. The most common form of DNA damage is DNA base damage, which is efficiently repaired by DNA base excision repair (BER). Thus BER is the major DNA repair pathway that maintains the stability of the genome. On the other hand, BER mediates DNA demethylation that can occur on the promoter region of important tumor suppressor genes such as Breast Cancer 1 (BRCA1) gene that is also involved in prevention and development of cancer. In this study, employing cell-based and in vitro biochemical approaches along with bisulfite DNA sequencing, …

Molecular Risk Factors Of Pulmonary Arterial Hypertension, Hamza M. Assaggaf

FIU Electronic Theses and Dissertations

The overall objective of the research presented in this dissertation was to investigate molecular risk factors of susceptibility to estrogenic chemicals, polychlorinated biphenyls (PCBs), hormone replacement therapy, and oral contraceptives and how that leads to the development of pulmonary arterial hypertension (PAH). Environmental and molecular risk factors for PAH are not clearly understood. This is a major hurdle for the development of new therapy against PAH as well as understanding individual susceptibility to this disease. Gender has been shown to impact the prevalence of PAH. Although controversial, estrogens have been implicated to be a risk factor for PAH. Thus, we …

Quantitative Yttrium-90 Bremsstrahlung Spect/Ct And Pet/Ct Study For 3d Dosimetry In Radiomicrosphere Therapy, Senait Aknaw Debebe

FIU Electronic Theses and Dissertations

Liver cancer ranks the third most common cause of cancer related mortality worldwide. Radiomicrosphere therapy (RMT), a form of radiation therapy, involves administration of Yttrium-90 (90Y) microspheres to the liver via the hepatic artery. 90Y microspheres bremsstrahlung SPECT/CT or PET/CT imaging could potentially identify an extrahepatic uptake. An early detection of such an uptake, thus, could initiate preventative measures early on. However, the quantitative accuracy of bremsstrahlung SPECT/CT images is limited by the wide and continuous energy spectrum of 90Y bremsstrahlung photons. 90Y PET/CT imaging is also possible but limited by the extremely small internal pair production decay. These limitation …

Examining The Influence Of Contextual Factors On Risky Sexual Behavior Among Young Women In Zomba District, Malawi: A Multilevel Analysis, Melissa K. Ward-Peterson

FIU Electronic Theses and Dissertations

The objective of this study was to examine the association between risky sexual behavior and contextual factors related to economic resources, woman’s empowerment, and health facility characteristics among young women in Zomba district, Malawi. Secondary analyses of the Schooling, Income, and Health Risk (SIHR) study were undertaken. Four outcomes related to risky sexual behavior were examined: if participants had ever had sex, consistent condom use, and two scores measuring risk related to partner history and age during sexual activity. Regression models with cluster-robust standard errors and multilevel regression models were used to estimate associations; analyses were stratified by school enrolment …

Predictors Of Women's Postpartum Health Status In The First 3 Months After Childbirth, Sukhee Ahn, Joanne M. Youngblut

Nicole Wertheim College of Nursing and Health Sciences

Purpose

The purpose of this study was to examine the significant predictors of postpartum health indicated by physical health, mental health, and role performance during the first 3 months postpartum.

Methods

This study used a correlational survey design. The study subjects were 152 mothers at 6 weeks postpartum (T1) and 131 mothers at 3 months postpartum (T2). At 6 weeks and 3 months postpartum, subjects completed a packet of instruments–measuring physical and mental health, role performance, sense of mastery, social support, and infant temperament.

Results

Findings indicated that lower family income, more difficult infant temperament, and lower sense of mastery …

Racial Disparities In Cancer-Related Survival In Patients With Squamous Cell Carcinoma Of The Esophagus In The Us Between 1973 And 2013, Alice Kim, Peter Ashman, Melissa Ward-Peterson, Juan Manuel Lozano, Noel C. Barengo

HWCOM Faculty Publications

Background

Esophageal cancer makes up approximately 1% of all diagnosed cancers in the US. There is a persistent disparity in incidence and cancer-related mortality rates among different races for esophageal squamous cell carcinoma (SCC). Most previous studies investigated racial disparities between black and white patients, occasionally examining disparities for Hispanic patients. Studies including Asians/Pacific Islanders (API) as a subgroup are rare. Our objective was to determine whether there is an association between race and cancer-related survival in patients with esophageal SCC.

Methods and findings

This was a retrospective cohort study using the National Cancer Institute’s Surveillance, Epidemiology, and End Result …

Mitochondrial Division Inhibitor-1 Is Neuroprotective In The A53t-Α-Synuclein Rat Model Of Parkinson’S Disease, Simone Bido, Federico N. Soria, Rebecca Z. Fan, Erwan Bezard, Kim Tieu

Environmental Health Sciences

Alpha-synuclein (α-syn) is involved in both familial and sporadic Parkinson’s disease (PD). One of the proposed pathogenic mechanisms of α-syn mutations is mitochondrial dysfunction. However, it is not entirely clear the impact of impaired mitochondrial dynamics induced by α-syn on neurodegeneration and whether targeting this pathway has therapeutic potential. In this study we evaluated whether inhibition of mitochondrial fission is neuroprotective against α-syn overexpression in vivo. To accomplish this goal, we overexpressed human A53T-α- synuclein (hA53T-α-syn) in the rat nigrostriatal pathway, with or without treatment using the small molecule Mitochondrial Division Inhibitor-1 (mdivi-1), a putative inhibitor of the mitochondrial …

Disparities In Brain Cancer In The United States: A Literature Review Of Gliomas, Dharam Persaud, Joseph Burns, Jeran Trangle, Sabyasachi Moulik

HWCOM Faculty Publications

In the human body, the central regulatory system of homeostasis is maintained by the brain. Its complexity is mesmerizing and many of its functions are largely uncharted. Unfortunately, its functionality is often impaired through neoplastic growths, like gliomas, which are devastating to patients and their families. Annually, gliomas are the most common primary brain tumours affecting over 20,000 people in the United States. However, despite their status as the third most common cause of cancer related death for individuals between ages 20 and 39, the aetiology of gliomas remains unknown. This paper aims to review the latest information regarding the …

Health-Related Characteristics Of Older Adults Who Attend Congregate Meal Sites In The United States, Fatma Huffman, Joan A. Vaccaro, Edgar Vieira, Gustavo G. Zarini

Department of Dietetics and Nutrition

The purpose of this study was to determine health-related characteristics of a representative sample of older adults who attend congregate meal sites in the United States, and compare races/ethnicities and sexes. Participants were adults, aged 60 years and older, (N = 901) of the 2015 Tenth Annual National Survey of Older American Act Participants (NSOAAP). Difficulties with mobility and Activities of Daily Living were common among older adults who attended congregate meals. Health-related characteristics differed by race/ethnicity and sex. Higher percentages of men reported eating more than half their calories from the site: 61.0% (53, 68), compared to women: 41.2% …

Contribution Of Inhibitor Of Dna Binding/Differentiation-3 And Endocrine Disrupting Chemicals To Pathophysiological Aspects Of Chronic Disease, Vincent Avecilla, Mayur Doke, Quentin Felty

Environmental Health Sciences

The overwhelming increase in the global incidence of obesity and its associated complications such as insulin resistance, atherosclerosis, pulmonary disease, and degenerative disorders including dementia constitutes a serious public health problem. The Inhibitor of DNA Binding/Differentiation-3 (ID3), a member of the ID family of transcriptional regulators, has been shown to play a role in adipogenesis and therefore ID3 may influence obesity andmetabolic health in response to environmental factors.This reviewwill highlight the current understanding of howID3may contribute to complex chronic diseases viametabolic perturbations. Based on the increasing number of reports that suggest chronic exposure to and accumulation of endocrine disrupting chemicals …

Effect Of Charted Mental Illness On Reperfusion Therapy In Hospitalized Patients With An Acute Myocardial Infarction In Florida, Thomas R. Campri, Sharon George, Diego Villacis, Melissa Ward-Peterson, Noel C. Barengo, Juan C. Zevallos

HWCOM Faculty Publications

Patients with mental illness carry risk factors that predispose them to excess cardiovascular mortality from an acute myocardial infarction (AMI) compared to the general population. The aim of this study was to determine if patients with AMI and charted mental illness (CMI) received less reperfusion therapy following an AMI, compared to AMI patients without CMI in a recent sample population from Florida.

A secondary analysis of data was conducted using the Florida Agency for Health Care Administration (FL-AHCA) hospital discharge registry. Adults hospitalized with an AMI from 01/01/2010 to 12/31/2015 were included for the analysis. The dependent variable was administration …

Sex And Race/Ethnic Disparities In Food Security And Chronic Diseases In U.S. Older Adults, Joan A. Vaccaro, Fatma Huffman

Department of Dietetics and Nutrition

Objective: The purpose of this study was to determine the relationships among sex, race/ethnicity, and food security with the likelihood of cancer, diabetes, cardiovascular disease, and lung disease for older adults. Method: Complex sample analysis by logistic regression models for chronic diseases were conducted from National Health and Nutrition Examination Surveys, 2011 to 2012 and 2013 to 2014, for N = 3,871 adults aged ≥55 years. Results: Being female with low food security was associated with lung disease and diabetes. Poverty, rather than low food security, was associated with cardiovascular diseases. Minority status was independently associated with low food security …

Processing Of The English Verb Particle Construction In Persons With Aphasia, David Lopez

FIU Electronic Theses and Dissertations

This study examined comprehension of verb particle constructions in persons with aphasia (PWA) and young and older typical adults according to the semantic classes by Jackendoff (2002). The experimental task focused on the following three classes of verb particle constructions: idiomatic, directional, and aspectual verb particles. Movement of the object NP also was examined. The study involved a picture-matching task counterbalanced for each participant. The results revealed that PWAs showed slower than normal overall processing, slower processing of aspectual verb forms, and slower processing of syntactic form regardless of movement. Error analysis revealed a bias toward the meaning of the …

The Effect Of Target-Specific Biomolecules In Breast Cancer, Mohannad Garoub

FIU Electronic Theses and Dissertations

Cancer is the second leading cause of mortality in the United States and the World, therefore, early effective prevention, diagnosis, and therapy is needed. Estrogens play a major role in the initiation and progression of breast cancer. Elevated lifetime exposure to estrogens is associated with an increased risk of developing breast cancer. Estrogens through influencing mitochondria contribute to estrogen induced breast carcinogenesis; however, the exact mitochondrial mechanisms underlying the estrogen carcinogenic effect in breast tissue are not clearly understood. For this dissertation, the mitotoxic and cytotoxic effects of triphenylphosphonium cation (TPP) and Origanum majorana organic extract (OME) as well as …

Life's Simple 7 And Incident Heart Failure: The Multi‐Ethnic Study Of Atherosclerosis, Oluseye Ogunmoroti, Ebenezer Oni, Erin D. Michos, Erica S. Spatz, Norrina B. Allen, Kaiser Permanente Northern California; University Of California, Salim S. Virani, Ron Blankstein, Konstantinos N. Aronis, Roger S. Blumenthal, Emir Veledar, Moyses Szklo, Michael J. Blaha, Khurram Nasir

Department of Biostatistics Faculty Publications

Background The American Heart Association introduced the Life's Simple 7 (LS7) metrics to assess and promote cardiovascular health. We sought to examine the association between the LS7 metrics and incident heart failure (HF) in a multiethnic cohort.

Methods and Results We analyzed data from 6506 participants of the Multi‐Ethnic Study of Atherosclerosis free of cardiovascular disease at baseline. The LS7 metrics (smoking, physical activity, body mass index, diet, blood pressure, total cholesterol, and blood glucose) were graded on a scale of 0 to 2, with 2 indicating “ideal” status, 1 “intermediate” status, and 0 “poor” status. Points were summed, thus …

The Effect Of Vitamin D3 Supplementation On Kidney Function And Cardiovascular Disease Markers Among Hispanics And African Americans With Type 2 Diabetes, Gustavo G. Zarini

FIU Electronic Theses and Dissertations

Serum vitamin D deficiency/insufficiency, Chronic Kidney Disease (CKD) and elevated blood pressure are important health concerns especially among minorities with type 2 diabetes. The effect of vitamin D₃ supplementation (cholecalciferol) at 6,000 IU/day (d) vs. 4,000 IU/d on kidney function and cardiovascular disease markers among Hispanics and African Americans with type 2 diabetes and hypovitaminosis D (/ml) was evaluated. Subjects (n=63) were recruited from two clinics in Miami-Dade County, FL. Fasting venous blood and fresh, single-voided first morning urine samples were collected from each participant by a certified phlebotomist and analyzed by Solstas Lab Partners, Davie, FL. Linear mixed …

The Effects Of Children's Spiritual Coping After Parent, Grandparent Or Sibling Death On Children's Grief, Personal Growth, And Mental Health, Ivette M. Hidalgo

FIU Electronic Theses and Dissertations

Parental death can have a negative impact on children’s lives with changes in economic resources, and lead to change in residence, loss of contact with friends and neighbors, change in caretakers, and loss of time with the surviving parent. Research on the effects of a grandparent’s death on children is limited. Death of a sibling signifies the loss of a role model, friend, confidante, and playmate. The purpose of this correlational study was to identify: 1) differences in the spiritual coping strategies used by children across age groups, gender, race/ethnicity, participation in religious rituals and practices, and the relationship of …

Factors Related To Good Asthma Control Using Different Medical Adherence Scales In Latvian Asthma Patients: An Observational Study, Dins Smits, Girts Brigis, Jana Pavare, Baiba Maurina, Noel C. Barengo

HWCOM Faculty Publications

One of the main challenges in asthma control is adherence to pharmaceutical treatment. The aim of this study was to test the association between adherence to asthma medication, control and medical beliefs, cognitive and emotional perceptions using three different validated questionnaires. Beliefs about asthma medicine, cognitive and emotional factors were determined in a cross-sectional survey of patients attending outpatient pulmonologist practices in Latvia (n = 352). The validated Beliefs about Medicines Questionnaire and the Brief Illness Perception Questionnaire were used. Adherence to asthma medication was assessed using the Morisky Medication Adherence Scale and two different versions of the Medication …

Identification And Phenotypic Plasticity Of Metastatic Cells In A Mouse Model Of Melanoma, Xiaoshuang Li

FIU Electronic Theses and Dissertations

Melanoma is the deadliest form of skin cancer due to its high propensity to metastasize and resistance to current therapies. We have created a spontaneous mouse model of metastatic melanoma (Dct-Grm1/K5-Edn3) where metastasis to the lungs is 80% penetrant. The primary tumors of these mice present cellular heterogeneity with cells at varying levels of differentiation. The main goal of this study was to determine the metastatic potential of the primary tumor resident Tyrosinase positive cells and evaluate the dynamic phenotypic changes as those cells move from the primary tumors to the sites of metastasis. To accomplish this aim …

Association Between Modifiable Risk Factors And Pharmaceutical Expenditures Among Adults With Atherosclerotic Cardiovascular Disease In The United States: 2012–2013 Medical Expenditures Panel Survey, Joseph A. Salami, Javier Valero‐Elizondo, Oluseye Ogunmoroti, Erica S. Spatz, Jamal S. Rana, Salim S. Virani, Ron Blankenstein, Adnan Younus, Alejandro Arrieta, Michael J. Blaha, Emir Veledar, Khurram Nasir

Department of Biostatistics Faculty Publications

Background Atherosclerotic cardiovascular disease (ASCVD) causes most deaths in the United States and accounts for the highest healthcare spending. The association between the modifiable risk factors (MRFs) of ASCVD and pharmaceutical expenditures are largely unknown.

Methods and Results We examined the association between MRFs and pharmaceutical expenditures among adults with ASCVD using the 2012 and 2013 Medical Expenditure Panel Survey. A 2‐part model was used while accounting for the survey's complex design to obtain nationally representative results. All costs were adjusted to 2013 US dollars using the gross domestic product deflator. The annual total pharmaceutical expenditure among those with ASCVD …