Medicine and Health Sciences Commons^™

Estimates Of Mortality Benefit From Ideal Cardiovascular Health Metrics: A Dose Response Meta‐Analysis, Ehimen C. Aneni, Alessio Crippa, Chukwuemeka U. Osondu, Javier Valero‐Elizondo, Adnan Younus, Khurram Nasir, Emir Veledar

Department of Biostatistics Faculty Publications

Background Several studies have shown an inverse relationship between ideal cardiovascular health (CVH) and mortality. However, there are no studies that pool these data to show the shape of the relationship and quantify the mortality benefit from ideal CVH.

Methods and Results We conducted a systematic internet literature search of multiple databases including MEDLINE, Web of Science, Embase, CINAHL, and Scopus for longitudinal studies assessing the relationship between ideal CVH and mortality in adults, published between January 1, 2010, and May 31, 2017. We included studies that assessed the relationship between ideal CVH and mortality in populations that were initially …

Life's Simple 7 And Incident Heart Failure: The Multi‐Ethnic Study Of Atherosclerosis, Oluseye Ogunmoroti, Ebenezer Oni, Erin D. Michos, Erica S. Spatz, Norrina B. Allen, Kaiser Permanente Northern California; University Of California, Salim S. Virani, Ron Blankstein, Konstantinos N. Aronis, Roger S. Blumenthal, Emir Veledar, Moyses Szklo, Michael J. Blaha, Khurram Nasir

Department of Biostatistics Faculty Publications

Background The American Heart Association introduced the Life's Simple 7 (LS7) metrics to assess and promote cardiovascular health. We sought to examine the association between the LS7 metrics and incident heart failure (HF) in a multiethnic cohort.

Methods and Results We analyzed data from 6506 participants of the Multi‐Ethnic Study of Atherosclerosis free of cardiovascular disease at baseline. The LS7 metrics (smoking, physical activity, body mass index, diet, blood pressure, total cholesterol, and blood glucose) were graded on a scale of 0 to 2, with 2 indicating “ideal” status, 1 “intermediate” status, and 0 “poor” status. Points were summed, thus …

Association Between Modifiable Risk Factors And Pharmaceutical Expenditures Among Adults With Atherosclerotic Cardiovascular Disease In The United States: 2012–2013 Medical Expenditures Panel Survey, Joseph A. Salami, Javier Valero‐Elizondo, Oluseye Ogunmoroti, Erica S. Spatz, Jamal S. Rana, Salim S. Virani, Ron Blankenstein, Adnan Younus, Alejandro Arrieta, Michael J. Blaha, Emir Veledar, Khurram Nasir

Department of Biostatistics Faculty Publications

Background Atherosclerotic cardiovascular disease (ASCVD) causes most deaths in the United States and accounts for the highest healthcare spending. The association between the modifiable risk factors (MRFs) of ASCVD and pharmaceutical expenditures are largely unknown.

Methods and Results We examined the association between MRFs and pharmaceutical expenditures among adults with ASCVD using the 2012 and 2013 Medical Expenditure Panel Survey. A 2‐part model was used while accounting for the survey's complex design to obtain nationally representative results. All costs were adjusted to 2013 US dollars using the gross domestic product deflator. The annual total pharmaceutical expenditure among those with ASCVD …

Effect Of Thyroxin Treatment On Carotid Intima – Media Thickness (Cimt) Reduction In Patients With Subclinical Hypothyroidism (Sch): A Meta-Analysis Of Clinical Trials, Muhammad Aziz, Yugandhar Kandimalla, Archana Machavarapu, Anshul Saxena, Sankalp Das, Adnan Younus, Michelle Nguyen, Rehan Malik, Dixitha Anugula, Muhammad A. Latif, Choudhry Humayun, Idrees M. Khan, Ali Adus, Aisha Rasool, Emir Veledar, Khurram Nasir

Department of Biostatistics Faculty Publications

Aim: Research shows that subclinical hypothyroidism (SCH) is related to an increased carotid intima–media thickness (CIMT), a surrogate marker of subclinical cardiovascular disease (CVD). It is controversial whether or not SCH should be treated to reduce CVD morbidity and mortality. This meta-analysis aimed to determine whether SCH is associated with an increase in CIMT as compared to Euthyroidism (EU) and whether thyroxin (T4) treatment in SCH can reverse the change in CIMT.

Methods: Two independent reviewers conducted an extensive database research up to December 2016. A total of 12 clinical trials discussed the effect of Thyroxin on CIMT …

Economic Evaluation Of Pcsk9 Inhibitors In Reducing Cardiovascular Risk From Health System And Private Payer Perspectives, Alejandro Arrieta, Timothy Page, Emir Veledar, Khurram Nasir

Department of Biostatistics Faculty Publications

The introduction of Proprotein covertase subtilisin/kexin type 9 (PCSK9) inhibitors has been heralded as a major advancement in reducing low-density lipoprotein cholesterol levels by nearly 50%. However, concerns have been raised on the added value to the health care system in terms of their costs and benefits. We assess the cost-effectiveness of PCSK9 inhibitors based on a decision-analytic model with existing clinical evidence. The model compares a lipid-lowering therapy based on statin plus PCSK9 inhibitor treatment with statin treatment only (standard therapy). From health system perspective, incremental cost per quality adjusted life years (QALYs) gained are presented. From a private …

Association Of Subjective And Objective Sleep Duration As Well As Sleep Quality With Non-Invasive Markers Of Sub-Clinical Cardiovascular Disease (Cvd): A Systematic Review, Muhammad Aziz, Shozab S. Ali, Sankalp Das, Adnan Younus, Rehan Malik, Muhammad A. Latif, Choudhry Humayun, Dixitha Anugula, Ghulam Abbas, Joseph Salami, Javier Valero Elizondo, Emir Veledar, Khurram Nasir

Department of Biostatistics Faculty Publications

Aim: Abnormal daily sleep duration and quality have been linked to hypertension, diabetes, stroke, and overall cardiovascular disease (CVD) morbidity& mortality. However, the relationship between daily sleep duration and quality with subclinical measures of CVD remains less well studied. This systematic review evaluated how daily sleep duration and quality affect burden of subclinical CVD in subjects free of symptomatic CVD.

Methods: Literature search was done via MEDLINE, EMBASE, Web of Science until June 2016 and 32 studies met the inclusion criteria. Sleep duration and quality were measured either via subjective methods, as self-reported questionnaires or Pittsburg Sleep Quality …