Medicine and Health Sciences Commons^™

Physical Activity And Amyloid Beta In Middle-Aged And Older Adults: A Systematic Review And Meta-Analysis, María Rodriguez-Ayllon, Patricio Solis-Urra, Cristina Arroyo-Ávila, Miriam Álvarez-Ortega, Pablo Molina-García, Cristina Molina-Hidalgo, Manuel Gómez-Río, Belinda Brown, Kirk I. Erickson, Irene Esteban-Cornejo

Research outputs 2022 to 2026

Background: One of the pathological hallmarks distinguishing Alzheimer's disease from other dementias is the accumulation of amyloid beta (A ). Higher physical activity is associated with decreased dementia risk, and one potential path could be through A levels modulation. We aimed to explore the relationship between physical activity and A in middle-aged and older adults. Methods: A systematic search of PubMed, Web of Science, PsycINFO, Cochrane Central Register of Controlled Trials, and SPORTDiscus was performed from inception to April 28, 2022. Studies were eligible if they included physical activity and A data in adults aged 45 years or older. Multi-level …

Supra-Additive Effect Of Chronic Inflammation And Atherogenic Dyslipidemia On Developing Type 2 Diabetes Among Young Adults: A Prospective Cohort Study, Yulong Lan, Dan Wu, Zhiwei Cai, Yuancheng Xu, Xiong Ding, Weiqiang Wu, Shaocong Lan, Lan Chen, Zheng Guo, Lois Balmer, Xingang Li, Manshu Song, Shouling Wu, Jingli Gao, Wei Wang, Youren Chen

Research outputs 2022 to 2026

Background: Both elevated inflammation and atherogenic dyslipidemia are prominent in young-onset diabetes and are increasingly identified as biologically intertwined processes that contribute to diabetogenesis. We aimed to investigate the age-specific risks of type 2 diabetes (T2D) upon concomitant chronic inflammation and atherogenic dyslipidemia. Methods: Age-stratified Cox regression analysis of the risk of incident diabetes upon co-exposure to time-averaged cumulative high-sensitivity C-reactive protein (CumCRP) and atherogenic index of plasma (CumAIP) among 42,925 nondiabetic participants from a real-world, prospective cohort (Kailuan Study). Results: During a median 6.41 years of follow-up, 3987 T2D developed. Isolated CumAIP and CumCRP were significantly associated with incident …

Effects Of Exercise Training On Muscle Quality In Older Individuals: A Systematic Scoping Review With Meta-Analyses, Tibor Hortobágyi, Tomas Vetrovsky, Jennifer S. Brach, Martijn Van Haren, Krystof Volesky, Regis Radaelli, Pedro Lopez, Urs Granacher

Research outputs 2022 to 2026

Background: The quantity and quality of skeletal muscle are important determinants of daily function and metabolic health. Various forms of physical exercise can improve muscle function, but this effect can be inconsistent and has not been systematically examined across the health-neurological disease continuum. The purpose of this systematic scoping review with meta-analyses was to determine the effects and potential moderators of exercise training on morphological and neuromuscular muscle quality (MMQ, NMQ) in healthy older individuals. In addition and in the form of a scoping review, we examined the effects of exercise training on NMQ and MMQ in individuals with neurological …

Drivesafe Driveaware: A Systematic Review, Erin Vito, Anna Barkla, Linda Coventry

Research outputs 2022 to 2026

Objectives: Driving is an activity of daily living that significantly affects independence, and driving cessation is associated with poor health, lower quality of life, cognitive decline and early entry into care facilities. There is no consensus regarding the best off-road tool to assess driving safety. Therefore, this review explored the diagnostic accuracy, reliability and clinical utility of DriveSafe DriveAware (DSDA) compared with an on-road driving assessment. Methods: This review adhered to the PRISMA guidelines. Electronic databases for all English language articles published prior to December 2021 were searched. Studies were assessed for methodological quality and results were synthesised using a …

Circulating Lipocalin-2 And Features Of Metabolic Syndrome In Community-Dwelling Older Women: A Cross-Sectional Study, Carlie Bauer, Marc Sim, Richard L. Prince, Kun Zhu, Ee M. Lim, Elizabeth Byrnes, Nathan Pavlos, Wai H. Lim, Germaine Wong, Joshua R. Lewis, Itamar Levinger

Research outputs 2022 to 2026

Lipocalin-2 (LCN2) is released by several cell types including osteoblasts and adipocytes and has been suggested as a marker of renal dysfunction, metabolic syndrome (MetS) and type 2 diabetes (T2D). Whether LCN2 is linked to these diseases in older women remains unknown. This study investigated whether LCN2 is related to features of MetS and T2D in older women. This cross-sectional study included 705 non-diabetic women (mean age 75.1 ± 2.6 years) for MetS analysis and 76 women (mean age 75.4 ± 2.8 years) with T2D. Total circulating LCN2 levels were analysed using a two-step chemiluminescent microparticle monoclonal immunoassay. MetS was …

Machine-Learning Assessed Abdominal Aortic Calcification Is Associated With Long-Term Fall And Fracture Risk In Community-Dwelling Older Australian Women, Jack Dalla Via, Abadi Gebre, Cassandra Smith, Zulqarnain Gilani, David Suter, Naeha Sharif, Pawel Szulc, John T. Schousboe, Douglas P. Kiel, Kun Zhu, William D. Leslie, Richard L. Prince, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Abdominal aortic calcification (AAC), a recognized measure of advanced vascular disease, is associated with higher cardiovascular risk and poorer long-term prognosis. AAC can be assessed on dual-energy X-ray absorptiometry (DXA)-derived lateral spine images used for vertebral fracture assessment at the time of bone density screening using a validated 24-point scoring method (AAC-24). Previous studies have identified robust associations between AAC-24 score, incident falls, and fractures. However, a major limitation of manual AAC assessment is that it requires a trained expert. Hence, we have developed an automated machine-learning algorithm for assessing AAC-24 scores (ML-AAC24). In this prospective study, we evaluated the …

Utility Of Dna Methylation As A Biomarker In Ageing And Alzheimer’S Disease, Lidija Milicic, Tenielle Porter, Michael Vacher, Simon M. Laws

Research outputs 2022 to 2026

Epigenetic mechanisms such as DNA methylation have been implicated in a number of diseases including cancer, heart disease, autoimmune disorders, and neurodegenerative diseases. While it is recognized that DNA methylation is tissue-specific, a limitation for many studies is the ability to sample the tissue of interest, which is why there is a need for a proxy tissue such as blood, that is reflective of the methylation state of the target tissue. In the last decade, DNA methylation has been utilized in the design of epigenetic clocks, which aim to predict an individual’s biological age based on an algorithmically defined set …

Epigenomic And Other Evidence For Cannabis-Induced Aging Contextualized In A Synthetic Epidemiologic Overview Of Cannabinoid-Related Teratogenesis And Cannabinoid-Related Carcinogenesis, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

Background: Twelve separate streams of empirical data make a strong case for cannabis-induced accelerated aging including hormonal, mitochondriopathic, cardiovascular, hepatotoxic, immunological, genotoxic, epigenotoxic, disruption of chromosomal physiology, congenital anomalies, cancers including inheritable tumorigenesis, telomerase inhibition and elevated mortality. Methods: Results from a recently published longitudinal epigenomic screen were analyzed with regard to the results of recent large epidemiological studies of the causal impacts of cannabis. We also integrate theoretical syntheses with prior studies into these combined epigenomic and epidemiological results. Results: Cannabis dependence not only recapitulates many of the key features of aging, but is characterized by both age-defining and …

Impact Of Sociodemographic Features And Lifestyle On Cognitive Performance Of Peruvian Adults, Brenda Chino, Jonathan Zegarra-Valdivia, Jaisalmer De Frutos-Lucas, Carmen Paredes-Manrique, Nilton Custodio

Research outputs 2022 to 2026

Background:

Cognitive impairment and dementia may result from a combination of modifiable and nonmodifiable risk and protective factors, such as the environment, educational attainment, time devoted to cognitively stimulating activities, and physical activity.

Objective:

This study aimed to investigate the mediating role of sociodemographic characteristics and lifestyle factors in the years of education and cognitive performance in Peruvian adults.

Methods:

This cross-sectional study included 1,478 subjects assessed by Addenbrooke’s Cognitive Examination Revised (ACE-R). Using mediation models, we evaluated the mediation role of parents’ educational level, reading time (RT), and physical activity time (PAT) in the years of education (IYE) and …

The Effects Of Acute High-Intensity Interval Exercise And Hyperinsulinemic-Euglycemic Clamp On Osteoglycin Levels In Young And Middle-Aged Men, Carlie Bauer, Alexander Tacey, Andrew Garnham, Cassandra Smith, Mary N. Woessner, Xuzhu Lin, Navabeh Zarekookandeh, David L. Hare, Joshua R. Lewis, Lewan Parker, Itamar Levinger

Research outputs 2022 to 2026

Osteoglycin (OGN) is a leucine-rich proteoglycan that has been implicated in the regulation of glucose in animal models. However, its relationship with glucose control in humans is unclear. We examined the effect of high-intensity interval exercise (HIIE) and hyperinsulinemic-euglycemic clamp on circulating levels of OGN as well as whether circulating OGN levels are associated with markers of glycemic control and cardio-metabolic health. Serum was analyzed for OGN (ELISA) levels from 9 middle-aged obese men (58.1 ± 2.2 years, body mass index [BMI] = 33.1 ± 1.4 kg∙m ^{− 2}, mean ± SEM) and 9 young men (27.8 ± 1.6 …

Abdominal Aortic Calcification On Lateral Spine Images Captured During Bone Density Testing And Late-Life Dementia Risk In Older Women: A Prospective Cohort Study, Tenielle Porter, Marc Sim, Richard L. Prince, John T. Schousboe, Catherine Bondonno, Wai H. Lim, Kun Zhu, Douglas P. Kiel, Jonathan M. Hodgson, Simon M. Laws, Joshua R. Lewis

Research outputs 2022 to 2026

Background: Dementia after the age of 80 years (late-life) is increasingly common due to vascular and non-vascular risk factors. Identifying individuals at higher risk of late-life dementia remains a global priority. Methods: In prospective study of 958 ambulant community-dwelling older women ( ≥ 70 years), lateral spine images (LSI) captured in 1998 (baseline) from a bone density machine were used to assess abdominal aortic calcification (AAC). AAC was classified into established categories (low, moderate and extensive). Cardiovascular risk factors and apolipoprotein E (APOE) genotyping were evaluated. Incident 14.5-year late-life dementia was identified from linked hospital and mortality records. Findings: At …

Effects Of An 8-Week Resistance Training Intervention On Plantar Flexor Muscle Quality And Functional Capacity In Older Women: A Randomised Controlled Trial, Pedro Lopez, Brendan James Crosby, Bruna Patrícia Robetti, Douglas Jean Preussler Turella, Thaís Andréia Schepa Weber, Morgana Lima De Oliveira, Anderson Rech

Research outputs 2014 to 2021

© 2020 The present study examined 8 weeks of resistance training and its effects on muscle quality measures, plantar flexor muscle strength, muscle thickness and functional capacity in older women. Moreover, we tested if changes in muscle quality were associated with functional capacity. Twenty-four older women (66.3 ± 5.8 years; 69.0 ± 3.0 kg; 25.3 ± 1.4 kg·m−2) were recruited to the study. After completion of the baseline assessment, participants were randomly assigned to either the resistance training (RET, n = 12) or an active control group (CTR, n = 12). Muscle quality was evaluated through muscle echo intensity (MQEI) …

Associations Between Social And Intellectual Activities With Cognitive Trajectories In Chinese Middle-Aged And Older Adults: A Nationally Representative Cohort Study, Haibin Li, Changwei Li, Anxin Wang, Yanling Qi, Wei Feng, Chengbei Hou, Lixin Tao, Xiangtong Liu, Xia Li, Wei Wang, Deqiang Zheng, Xiuhua Guo

Research outputs 2014 to 2021

BACKGROUND: Associations between the frequency of social and intellectual activities and cognitive trajectories are understudied in Chinese middle-aged and older adults. We aimed to examine this association in a nationally representative longitudinal study. METHODS: The China Health and Retirement Longitudinal Study (CHARLS) is a nationally representative sample of Chinese middle-aged and older participants. The frequency of social and intellectual activities was measured at baseline. Interview-based cognitive assessments of orientation and attention, episodic memory, and visuospatial skills and the calculation of combined global scores were assessed every 2 years from 2011 to 2016. Cognitive aging trajectories over time were analyzed using …

Relationships Between Plasma Lipids Species, Gender, Risk Factors And Alzheimer’S Disease, Wei Ling Florence Lim, Kevin Huynh, Pratishtha Chatterjee, Ian Martins, Kaushala S. Jayawardana, Corey Giles, Natalie A. Mellett, Simon M. Laws, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Brian G. Drew, Colin L. Masters, Peter J. Meikle, Ralph Martins, Australian Imaging, Biomarker & Lifestyle Research Group

Research outputs 2014 to 2021

Background:

Lipid metabolism is altered in Alzheimer’s disease (AD); however, the relationship between AD risk factors (age, APOE ɛ4, and gender) and lipid metabolism is not well defined.

Objective:

We investigated whether altered lipid metabolism associated with increased age, gender, and APOE status may contribute to the development of AD by examining these risk factors in healthy controls and also clinically diagnosed AD individuals.

Methods:

We performed plasma lipidomic profiling (582 lipid species) of the Australian Imaging, Biomarkers and Lifestyle flagship study of aging cohort (AIBL) using liquid chromatography-mass spectrometry. Linear regression and interaction analysis were used to explore …

Elecsys Csf Biomarker Immunoassays Demonstrate Concordance With Amyloid-Pet Imaging, James A. Doecke, Larry Ward, Samantha C. Burnham, Victor L. Villemagne, Qiao-Xin Li, Steven Collins, Christopher J. Fowler, Ekaterina Manuilova, Monika Widmann, Stephanie R. Rainey-Smith, Ralph N. Martins, Colin L. Masters, Aibl Research Group

Research outputs 2014 to 2021

Background: β-amyloid (Aβ) positron emission tomography (PET) imaging is currently the only Food and Drug Administration-approved method to support clinical diagnosis of Alzheimer's disease (AD). However, numerous research studies support the use of cerebrospinal fluid (CSF) biomarkers, as a cost-efficient, quick and equally valid method to define AD pathology. Methods: Using automated Elecsys® assays (Roche Diagnostics) for Aβ (1-42) (Aβ42), Aβ (1-40) (Aβ40), total tau (tTau) and phosphorylated tau (181P) (pTau), we examined CSF samples from 202 participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing cohort, to demonstrate the concordance with pathological AD via PET imaging. …

Global Variability Of The Human Igg Glycome, Jerko Stambuk, Natali Nakic, Frano Vuckovic, Maja Pucic-Bakovic, Genadij Razdorov, Irena Trbojevic-Akmacic, Mislav Novokmet, Toma Keser, Marija Vilaj, Tamara Stambuk, Ivan Gudelj, Mirna Simurina, Manshu Song, Hao Wang, Marijana Pericic Salihovic, Harry Campbell, Igor Rudan, Ivana Kolcic, Leigh Anne Eller, Paul Mckeigue, Merlin L. Robb, Jonas Halfvarson, Metin Kurtoglu, Vito Annese, Tatjana Skaric-Juric, Mariam Molokhia, Ozren Polasek, Caroline Hayward, Hannah Kibuuka, Kujtim Thaqi, Dragan Primorac, Christian Geieger, Sorachai Nitayaphan, Tim Spector, Youxin Wang, Therese Tillin, Nish Chaturvedi, James F. Wilson, Moses Schanfield, Maxim Filipenko, Wei Wang, Gordan Lauc

Research outputs 2014 to 2021

Immunoglobulin G (IgG) is the most abundant serum antibody which structural characteristics and effector functions are modulated through the attachment of various sugar moieties called glycans. Composition of the IgG N-glycome changes with age of an individual and in different diseases. Variability of IgG glycosylation within a population is well studied and is known to be affected by both genetic and environmental factors. However, global inter-population differences in IgG glycosylation have never been properly addressed. Here we present population-specific N-glycosylation patterns of IgG, analyzed in 5 different populations totaling 10,482 IgG glycomes, and of IgG’s fragment crystallizable region (Fc), analyzed …

Rates Of Age- And Amyloid Β-Associated Cortical Atrophy In Older Adults With Superior Memory Performance, Christa Dang, Nawaf Yassi, Karra D. Harrington, Ying Xia, Yen Ying Lim, David Ames, Simon M. Laws, Martha Hickey, Stephanie Rainey-Smith, Hamid R. Sohrabi, James D. Doecke, Jurgen Fripp, Olivier Salvado, Peter J. Snyder, Michael Weinborn, Victor L. Villemagne, Christopher C. Rowe, Colin L. Masters, Paul Maruff

Research outputs 2014 to 2021

Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid b (Ab) deposition (Ab1) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Ab-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n 5 172) and cognitively normal for age (n 5 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Ab status. Results: Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Ab1. …

Mediterranean Diet Adherence And Rate Of Cerebral Aβ-Amyloid Accumulation: Data From The Australian Imaging, Biomarkers And Lifestyle Study Of Ageing, Stephanie Rainey-Smith, Yian Gu, Samantha Gardener, James D Doecke, Victor L Villemagne, Belinda M Brown, Kevin Taddei, Simon M Laws, Hamid R. Sohrabi, Michael Weinborn, David Ames, Christopher Fowler, S Lance Macaulay, Paul Maruff, Colin L Masters, Olivier Salvado, Christopher C Rowe, Nikolaos Scarmeas, Ralph N. Martins

Research outputs 2014 to 2021

Accumulating research has linked Mediterranean diet (MeDi) adherence with slower cognitive decline and reduced Alzheimer's disease (AD) risk. However, no study to-date has examined the relationship between MeDi adherence and accumulation of cerebral Aβ-amyloid (Aβ; a pathological hallmark of AD) in older adults. Cognitively normal healthy control participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing completed the Cancer Council of Victoria Food Frequency Questionnaire at baseline, which was used to construct a MeDi score for each participant (score range 0-9; higher score indicating higher adherence). Cerebral Aβ load was quantified by Pittsburgh Compound B positron emission …

The Constituent Year Effect: Relative Age Disparities In Australian Masters Track And Field Athletic Participation, Nikola Medic, Jasmine Lares, Bradley W. Young

Research outputs 2014 to 2021

The constituent year effect, a source of relative age disparities, in masters sport has been demonstrated mainly amongst North American samples. Thus, the purpose of this study was to examine whether a participation-related constituent year effect exists among athletes (n = 6492) competing in Australian Masters Athletics competitions between 2000 and 2014. The results indicated that a participation-related constituent year effect was observed as the likelihood of participating was significantly higher for masters athletes in their first and second constituent year of any five-year age category (p < 0.0001) and was lower when they were in the fourth or fifth constituent year. The results also indicated this effect is influenced by gender and age. Specifically, the effect was significant for both male (p < 0.0001) and female (p < 0.001) masters athletes; as well during the third, sixth, seventh, and eighth + decades of life (all ps < 0.001). These data demonstrate that despite masters sport being an avenue for promotion of participation and overall health, there is potential for improving how competitive organizational strategies are implemented given the recurring intermittent patterns of participation associated with five-year age brackets which are likely to compromise benefits.

Barriers To Promoting Mobility In Hospitalized Older Adults, Gordana Dermody, Christine R. Kovach

Research outputs 2014 to 2021

Hospitalized older adults who do not receive sufficient mobility are more likely to sustain negative health outcomes, including higher rates of mortality and institutionalization. Accordingly, the purpose of the current secondary data analysis was to examine the nurse-promoted mobility of hospitalized older adults and the association between nurses’ barriers and nurse-promoted mobility. In addition, the relationship among patient severity of illness, proxy levels for function, and nurse-promoted mobility was examined. The final study sample included 61 nurses working in medical units caring for a total of 77 older adults. Findings suggest nurse knowledge gaps and attitude barriers could potentially influence …

Impact Of Aging On The Auditory System And Related Cognitive Functions: A Narrative Review, Dona M.P. Jayakody, Pete L. Friedland, Ralph Martins, Hamid R. Sohrabi

Research outputs 2014 to 2021

Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects approximately one-third of the world's population. The peripheral and central hearing alterations associated with age-related hearing loss have a profound impact on perception of verbal and non-verbal auditory stimuli. The high prevalence of hearing loss in the older adults corresponds to the increased frequency of dementia in this population. Therefore, researchers have focused their attention on age-related central effects that occur independent of the peripheral hearing loss as well as central effects of peripheral hearing loss and its association with cognitive decline and dementia. Here we review the …

Age-Related Neurodegenerative Disease Associated Pathways Identified In Retinal And Vitreous Proteome From Human Glaucoma Eyes, M. Mirzaei, Veer Bala Gupta, J. M. Chick, T. M. Greco, Y. Wu, N. Chitranshi, R. V. Wall, Eugene Hone, L. Deng, Y. Dheer, M. Abbasi, M. Rezaeian, N. Braidy, Y. You, G. H. Salekdeh, P. A. Haynes, M. P. Molloy, Ralph Martins, I. M. Cristea, S. P. Gygi, S. L. Graham, V. K. Gupta

Research outputs 2014 to 2021

Glaucoma is a chronic disease that shares many similarities with other neurodegenerative disorders of the central nervous system. This study was designed to evaluate the association between glaucoma and other neurodegenerative disorders by investigating glaucoma-associated protein changes in the retina and vitreous humour. The multiplexed Tandem Mass Tag based proteomics (TMT-MS3) was carried out on retinal tissue and vitreous humour fluid collected from glaucoma patients and age-matched controls followed by functional pathway and protein network interaction analysis. About 5000 proteins were quantified from retinal tissue and vitreous fluid of glaucoma and control eyes. Of the differentially regulated proteins, 122 were …

Bone Mineral Density, Adiposity, And Cognitive Functions, Hamid R. Sohrabi, Kristyn A. Bates, Michael Weinborn, Romola S. Bucks, Stephanie R. Rainey-Smith, Mark A. Rodrigues, Sabine M. Bird, Belinda M. Brown, John Beilby, Matthew Howard, Arthur Criddle, Megan Wraith, Kevin Taddei, Georgia Martins, Athena Paton, Tejal Shah, Satvinder S. Dhaliwal, Pankaj D. Mehta, Jonathan K. Foster, Ian J. Martins, Nicola T. Lautenschlager, Francis Mastaglia, Simon Laws, Ralph Martins

Research outputs 2014 to 2021

Cognitive decline and dementia due to Alzheimer's disease (AD) have been associated with genetic, lifestyle, and environmental factors. A number of potentially modifiable risk factors should be taken into account when preventive or ameliorative interventions targeting dementia and its preclinical stages are investigated. Bone mineral density (BMD) and body composition are two such potentially modifiable risk factors, and their association with cognitive decline was investigated in this study. 164 participants, aged 34–87 years old (62.78 ± 9.27), were recruited for this longitudinal study and underwent cognitive and clinical examinations at baseline and after 3 years. Blood samples were collected for …

Follow-Up Plasma Apolipoprotein E Levels In The Australian Imaging, Biomarkers And Lifestyle Flagship Study Of Ageing (Aibl) Cohort, Veer B. Gupta, V.B, Andrea C. Wilson, Samantha Burnham, Eugene Hone, Steve Pedrini, Simon M. Laws, Wei L.F. Lim, Alan Rembach, Stephanie Rainey-Smith, David Ames, Lynne Cobiac, S L. Macaulay, Colin L. Masters, Christopher C. Rowe, Ashley I. Bush, Ralph Martins, Aibl Research Group

Research outputs 2014 to 2021

Introduction: Alzheimer's disease (AD) is a growing socioeconomic problem worldwide. Early diagnosis and prevention of this devastating disease have become a research priority. Consequently, the identification of clinically significant and sensitive blood biomarkers for its early detection is very important. Apolipoprotein E (APOE) is a well-known and established genetic risk factor for late-onset AD; however, the impact of the protein level on AD risk is unclear. We assessed the utility of plasma ApoE protein as a potential biomarker of AD in the large, well-characterised Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) cohort. Methods: Total plasma ApoE levels were …

Risk Factors For Cerebrovascular Disease Mortality Among The Elderly In Beijing: A Competing Risk Analysis, Zhe Tang, Tao Zhou, Yanxia Luo, Changchun Xie, Da Huo, Lixin Tao, Lei Pan, Fei Sun, Huiping Zhu, Xinghua Yang, Wei Wang, Aoshuang Yan, Xia Li, Xiuhua Guo

Research outputs 2014 to 2021

Objective: To examine the associations of combined lifestyle factors and physical conditions with cerebrovascular diseases (CBVD) mortality, after accounting for competing risk events, including death from cardiovascular diseases, cancers and other diseases. Methods: Data on 2010 subjects aged over 55 years were finally analyzed using competing risk models. All the subjects were interviewed by the Beijing Longitudinal Study of Aging (BLSA), in China, between 1 January 1992 and 30 August 2009. Results: Elderly females were at a lower risk of death from CBVD than elderly males (HR = 0.639, 95% CI = 0.457-0.895). Increasing age (HR = 1.543, 95% CI …

Perceptions Of Five-Year Competitive Categories: Model Of How Relative Age Influences Competitiveness In Masters Sport, Nikola Medic, Bradley Young, J. Robert Grove

Research outputs 2013

The purpose of this study was to examine the contrasting perceptions of masters swimmers related to the first and fifth constituent years of a 5-year age category. Swimmers aged between 35 and 93 years (154 male, 184 female) were surveyed at the 2008 FINA World Masters Championships. Exploratory factor analysis indicated the existence of the following five factors considered important for preparation, attendance, and success at masters competitions: awareness of advantages, expectancy, motivation, training, and physiological capacity. One sample ttests showed that masters swimmers are conscious of advantages that 5-year age categories afford to relatively-younger cohorts (i.e., those who are …

Retinal Vascular Biomarkers For Early Detection And Monitoring Of Alzheimer's Disease, Shawn Frost, Yogi Kanagasingam, Hamid Sohrabi, J Vignarajan, P Bourgeat, Olivier Salvado, Victor Villemagne, Christopher Rowe, S Lance Macaulay, Cassandra Szoeke, Kathryn A. Ellis, David Ames, Colin L. Masters, Stephanie Rainey-Smith, Ralph N. Martins

Research outputs 2013

The earliest detectable change in Alzheimer's disease (AD) is the buildup of amyloid plaque in the brain. Early detection of AD, prior to irreversible neurological damage, is important for the efficacy of current interventions as well as for the development of new treatments. Although PiB-PET imaging and CSF amyloid are the gold standards for early AD diagnosis, there are practical limitations for population screening. AD-related pathology occurs primarily in the brain, but some of the hallmarks of the disease have also been shown to occur in other tissues, including the retina, which is more accessible for imaging. Retinal vascular changes …

Protocol For A Randomized Controlled Trial Evaluating The Effect Of Physical Activity On Delaying The Progression Of White Matter Changes On Mri In Older Adults With Memory Complaints And Mild Cognitive Impairment: The Aibl Active Trial, E V Cyarto, N T Lautenschlager, P M Desmond, D Ames, C Szoeke, O Salvado, Matthew Sharman, Kathryn A Ellis, P M Phal, C L Masters, C C Rowe, Ralph Martins, Kay L Cox

Research outputs 2012

Background: Older adults free of dementia but with subjective memory complaints (SMC) or mild cognitive impairment (MCI) are considered at increased risk of cognitive decline. Vascular risk factors (VRF), including hypertension, heart disease, smoking, hypercholesterolemia and lack of physical activity (PA) have been identified as modifiable risk factors contributing to cognitive decline, and white matter hyperintensities (WMH) are associated with VRF, SMC and cognitive impairment. Findings from a growing number of clinical trials with older adults are providing strong evidence for the benefits of physical activity for maintaining cognitive function, but few studies are investigating these benefits in high-risk populations. …

The Trajectories And Correlation Between Physical Limitation And Depression In Elderly Residents Of Beijing, 1992-2009, Xia Li, Wei Wang, Qi Gao, Lijuan Wu, Yanxia Luo, Zhe Tang, Xiuhua Guo

Research outputs 2012

Background Physical limitation and psychological distress have been reported to be related, but studies describing the change of instrumental activities of daily living (IADLs) and depression syndrome over time or exploring the link pattern for their development are limited. The study was to assess distinctive patterns for the development of physical limitation and depression and to explore their correlation to form a proper prevention strategy. Methods Dual trajectory analysis was conducted using data from the Beijing Longitudinal Study of Aging (BLSA) 1992–2009 hosted by Xuanwu hospital for subjects with full information on depression and physical limitation for all available visits. …

Predictors Of Rapid Cognitive Decline In Alzheimer's Disease: Results From The Australian Imaging, Biomarkers And Lifestyle (Aibl) Study Of Ageing, A Sona, P Zhang, D Ames, A I Bush, N T Lautenschlager, Ralph Martins, C L Masters, C C Rowe, C Szoeke, Kevin Taddei, Kathryn A Ellis

Research outputs 2012

Background: The AIBL study, which commenced in November 2006, is a two-center prospective study of a cohort of 1112 volunteers aged 60+. The cohort includes 211 patients meeting NINCDS-ADRDA criteria for Alzheimer's disease (AD) (180 probable and 31 possible). We aimed to identify factors associated with rapid cognitive decline over 18 months in this cohort of AD patients. Methods: We defined rapid cognitive decline as a drop of 6 points or more on the Mini-Mental State Examination (MMSE) between baseline and 18-month follow-up. Analyses were also conducted with a threshold of 4, 5, 7 and 8 points, as well as …