Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Dominican University of California

Series

Discipline
Keyword
Publication Year
Publication

Articles 1 - 30 of 196

Full-Text Articles in Medicine and Health Sciences

Assessment Of Salivary Cadmium Levels And Breast Density In The Marin Women's Study, Michaela F. George, Shayne Paff, Jenyse Rojo, Mark Powell, Christopher Benz, Karl Pope, Karla Kerlikowske, John Shepard, Matthew Willis, Rochelle Ereman, Leeann Prebil Feb 2024

Assessment Of Salivary Cadmium Levels And Breast Density In The Marin Women's Study, Michaela F. George, Shayne Paff, Jenyse Rojo, Mark Powell, Christopher Benz, Karl Pope, Karla Kerlikowske, John Shepard, Matthew Willis, Rochelle Ereman, Leeann Prebil

Global Public Health | Faculty Scholarship

Background: We aimed to determine if salivary cadmium (Cd) levels had any association with breast density, hoping to establish a less invasive cost-effective method of stratifying Cd burden as an environmental breast cancer risk factor.

Methods: Salivary Cd levels were quantified from the Marin Women's Study, a Marin County, California population composite. Volumetric compositional breast density (BDsxa) data were measured by single x-ray absorptiometry techniques. Digital screening mammography was performed by the San Francisco Mammography Registry. Radiologists reviewed mammograms and assigned a Breast Imaging-Reporting and Data System score. Early morning salivary Cd samples were assayed. Association analyses were then …


Covid-19 Pandemic’S Effect On Occupational Therapy Students’ Time-Use And Occupational Engagement On Returning To In-Person Learning, Jhannell Hannah D. Ocampo, Susan Macdermott, Karen Mccarthy Jan 2024

Covid-19 Pandemic’S Effect On Occupational Therapy Students’ Time-Use And Occupational Engagement On Returning To In-Person Learning, Jhannell Hannah D. Ocampo, Susan Macdermott, Karen Mccarthy

Occupational Therapy | Faculty Scholarship

The COVID-19 pandemic emotionally and physically impacted students in occupational therapy and occupational therapy assistant programs. College students lost autonomy and access to meaningful occupations and environments. As students returned to campus, they struggled to navigate and adapt to in-person occupations and how they use their time. This study uses a mixed method descriptive research design to understand how the pandemic affected occupational therapy students' time-use and occupational engagement during the transition to in-person learning. Seventy-three students completed an online survey, while 12 of those students additionally participated in a follow-up time-use diary and interview. Eighty-three percent of the participants …


Ensuring A Knowledgeable Geriatric Workforce: Interdisciplinary Education In Long-Term Services And Supports, Gina Tucker-Roghi Dec 2022

Ensuring A Knowledgeable Geriatric Workforce: Interdisciplinary Education In Long-Term Services And Supports, Gina Tucker-Roghi

Occupational Therapy | Faculty Scholarship

In this symposium, we describe five interdisciplinary educational programs to enhance the geriatric workforce in long-term services and supports (LTSS): Skilled nursing facilities (SNFs), assisted living, and home health and hospice. The interdisciplinary teams that came together to offer the programs leveraged technology to maximize access to experts in both the curriculum development process and the delivery of the educational programs for a wide range of target learners. The first program, an interdisciplinary telementoring series on dementia care for therapists in SNFs, was developed by a team of experts from occupational, physical and speech therapy. The program included asynchronous online …


Interdisciplinary Telementoring For Therapists In Snfs To Improve Dementia Care Knowledge And Skills, Gina Tucker-Roghi Dec 2022

Interdisciplinary Telementoring For Therapists In Snfs To Improve Dementia Care Knowledge And Skills, Gina Tucker-Roghi

Occupational Therapy | Faculty Scholarship

Occupational, physical, and speech therapists possess knowledge and skills that have the potential to reduce the burden of care and improve the quality of life of skilled nursing facility (SNF) residents living with dementia. Despite this opportunity to impact the well-being of residents with dementia, many therapy practitioners lack specialized training on the management of dementia. Therapy practitioners (n=31) from 22 SNFs participated in eight weekly interdisciplinary educational sessions using the Project ECHO (Extension for Community Health Outcomes) tele-mentoring model. An interdisciplinary team of therapy experts collaborated on the development of the curriculum, which included didactic content on dementia-care best …


Education Research: Neurologic Education In Physician Assistant Programs, Carl Garubba Dec 2022

Education Research: Neurologic Education In Physician Assistant Programs, Carl Garubba

Physician Assistant Studies | Faculty Scholarship

Background and Objectives A growing number of advanced practice providers (APPs) are entering neurologic practice, and educational initiatives focused on postgraduate training in neurology for these providers are growing in turn. Neurologic education in APP degree programs is not well defined, which limits the ability to tailor these initiatives to the specific needs of APPs. We aim to describe neurologic education in physician assistant (PA) degree programs to better inform these efforts.

Methods The 2018 American Academy of Neurology clerkship director survey was adapted for directors of PA programs via an iterative approach. The survey was distributed to program directors …


Systematic Review Brief: Virtual Interventions That Address Motor And Balance Impairments And Skills For Adults With Traumatic Brain Injury (Tbi) (12-21), Kitsum Li, Beth Fields, Adam Kinney, Olivia Condon, Emilio Villavicencio Sep 2022

Systematic Review Brief: Virtual Interventions That Address Motor And Balance Impairments And Skills For Adults With Traumatic Brain Injury (Tbi) (12-21), Kitsum Li, Beth Fields, Adam Kinney, Olivia Condon, Emilio Villavicencio

Occupational Therapy | Faculty Scholarship

Systematic Review Briefs provide a summary of the findings from systematic reviews developed in conjunction with the American Occupational Therapy Association’s (AOTA’s) Evidence-Based Practice Program. Each Systematic Review Brief summarizes the evidence on a theme related to a systematic review topic. This Systematic Review Brief presents findings from the theme of virtual interventions that address motor and balance impairments and skills for adults with traumatic brain injury (TBI).


Physical Activity Interventions That Address Motor And Balance Impairments And Skills For Adults With Traumatic Brain Injury (Tbi) (2012-2021), Beth Fields, Kitsum Li, Adam Kinney, Olivia Condon, Emilio Villavicencio Sep 2022

Physical Activity Interventions That Address Motor And Balance Impairments And Skills For Adults With Traumatic Brain Injury (Tbi) (2012-2021), Beth Fields, Kitsum Li, Adam Kinney, Olivia Condon, Emilio Villavicencio

Occupational Therapy | Faculty Scholarship

Systematic Review Briefs provide a summary of the findings from systematic reviews developed in conjunction with the American Occupational Therapy Association’s (AOTA’s) Evidence-Based Practice Program. Each Systematic Review Brief summarizes the evidence on a theme related to a systematic review topic. The systematic review is on interventions to address motor and balance impairments to improve occupational performance for adults with TBI, the theme reported in this Systematic Review Brief is physical activity interventions.


Batok: The Exploration Of Indigenous Filipino Tattooing As A Resistive Collective Occupation, Chelsea Ramirez, Karen Mccarthy, Ana Cabalquinto, Carmela Dizon, Mai Santiago Aug 2022

Batok: The Exploration Of Indigenous Filipino Tattooing As A Resistive Collective Occupation, Chelsea Ramirez, Karen Mccarthy, Ana Cabalquinto, Carmela Dizon, Mai Santiago

Occupational Therapy | Faculty Scholarship

Batok (also known as Fatek/Burik/Tatak/Batek/Patik) is an Indigenous Filipino tattooing practice where the practitioner marks the skin by hand-tapping the ink using bone/wood implements. Previous research on tattooing from an occupational science perspective has considered European tattooing and its engagement and implication on the individual. This qualitative research explores how batok is experienced by the person and their identified community. Three Filipino participants with batok, and four family or community members were interviewed. Thematic analysis highlighted three themes recognized as Kapwa, Revealing One’s Batok, and Decolonization and Reclamation as a Cultural Practice. These themes are situated in the lens of …


Exploring The Meaningful Qualities Of Transactions In Virtual Environments For Massively Multiplayer Online Role-Playing Gamers, Karen Mccarthy, Shasta Rice, Amanda Flores, John Miklos, Alex Nold Aug 2022

Exploring The Meaningful Qualities Of Transactions In Virtual Environments For Massively Multiplayer Online Role-Playing Gamers, Karen Mccarthy, Shasta Rice, Amanda Flores, John Miklos, Alex Nold

Occupational Therapy | Faculty Scholarship

To date, most research on massively multiplayer online role-playing games (MMORPGs) has focused on the effects playing MMORPGs have on players’ health and wellness. The virtual environment of MMORPGs has yet to be explored as a space where meaningful occupations occur. This qualitative descriptive study examined the virtual environment using a transactional perspective to describe the qualities of gaming to which MMORPG players ascribe meaning. Participants included six MMORPG players with experience playing World of Warcraft, Runescape, or Guild Wars 2. Data were gathered using interviews, participant observation, and a focus group, and analyzed using thematic analysis. Three themes were …


Exploring Dating As An Occupation For Young Heterosexual Women In Ireland, Karen Mccarthy, Jeanne Jackson Jul 2022

Exploring Dating As An Occupation For Young Heterosexual Women In Ireland, Karen Mccarthy, Jeanne Jackson

Occupational Therapy | Faculty Scholarship

Purpose – Dating is a meaningful occupation for many single people. The occupation of dating has transformed considerably in Ireland due to recent changes in Irish culture and the advent of online dating technology. The purpose of this study was to explore the complexities and intricacies of dating in an Irish context.

Design/methodology/approach – A qualitative research approach was used and data were collected using semi-structured interviews with ten heterosexual women (age 24-34) living in urban areas of Ireland. Data were analysed using inductive thematic analysis (Braun and Clarke, 2006).

Findings – Dating did not fully resonate with their experience, …


Global Developments In Social Prescribing, Daniel F. Morse, Sahil Sandhu, Kate Mulligan, Stephanie Tierney, Marie Polley, Bogdan Chiva Giurca, Siân Slade, Sónia Dias, Kamal R. Mahtani, Leanne Wells, Huali Wang, Bo Zhao, Cristiano Emanuel Marta De Figueiredo, Jan Joost Meijs, Hae Kweun Nam, Kheng Hock Lee, Carolyn Wallace, Megan Eliott, Juan Manuel Mendive, David Robinson, Miia Palo, Wolfram Hermann, Rasmus Østergaard Nielsen, Kerryn Husk May 2022

Global Developments In Social Prescribing, Daniel F. Morse, Sahil Sandhu, Kate Mulligan, Stephanie Tierney, Marie Polley, Bogdan Chiva Giurca, Siân Slade, Sónia Dias, Kamal R. Mahtani, Leanne Wells, Huali Wang, Bo Zhao, Cristiano Emanuel Marta De Figueiredo, Jan Joost Meijs, Hae Kweun Nam, Kheng Hock Lee, Carolyn Wallace, Megan Eliott, Juan Manuel Mendive, David Robinson, Miia Palo, Wolfram Hermann, Rasmus Østergaard Nielsen, Kerryn Husk

Applied Computer Science | Faculty Scholarship

Social prescribing is an approach that aims to improve health and well-being. It connects individuals to non-clinical services and supports that address social needs, such as those related to loneliness, housing instability and mental health. At the person level, social prescribing can give individuals the knowledge, skills, motivation and confidence to manage their own health and well-being. At the society level, it can facilitate greater collaboration across health, social, and community sectors to promote integrated care and move beyond the traditional biomedical model of health. While the term social prescribing was first popularised in the UK, this practice has become …


Preclinical Characterization And Target Validation Of The Antimalarial Pantothenamide Mmv693183., Laura E. De Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M J Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering Apr 2022

Preclinical Characterization And Target Validation Of The Antimalarial Pantothenamide Mmv693183., Laura E. De Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M J Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering

Natural Sciences and Mathematics | Faculty Scholarship

Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibitor to enter preclinical development. Our studies demonstrate attractive drug-like properties and in vivo efficacy in a humanized mouse model of Plasmodium falciparum infection. The compound shows single digit nanomolar in vitro activity against P. falciparum and P. vivax clinical isolates, and potently blocks P. falciparum transmission to Anopheles mosquitoes. Genetic and biochemical studies identify AcAS as the target of the MMV693183-derived antimetabolite, CoA-MMV693183. Pharmacokinetic-pharmacodynamic modelling predict that a single 30 mg oral dose is sufficient …


Discovery And Preclinical Pharmacology Of Ine963, A Potent And Fast-Acting Blood-Stage Antimalarial With A High Barrier To Resistance And Potential For Single-Dose Cures In Uncomplicated Malaria., Benjamin R. Taft, Fumiaki Yokokawa, Tom Kirrane, Anne-Catherine Mata, Richard Huang, Nicole Blaquiere, Grace Waldron, Bin Zou, Oliver Simon, Subramanyam Vankadara, Wai Ling Chan, Mei Ding, Sandra Sim, Judith Straimer, Armand Guiguemde, Suresh B Lakshminarayana, Jay Prakash Jain, Christopher Bodenreider, Christopher Thompson, Christian Lanshoeft, Wei Shu, Eric Fang, Jafri Qumber, Katherine Chan, Luying Pei, Yen-Liang Chen, Hanna Schulz, Jessie Lim, Siti Nurdiana Abas, Xiaoman Ang, Yugang Liu, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Glaxosmithkline Gamo, Benigno Crespo-Fernandez, Philip J. Rosenthal, Roland A. Cooper, Patrick Tumwebaze, Anna Caroline Campos Aguiar, Brice Campo, Simon Campbell, Jürgen Wagner, Thierry T Diagana, Christopher Sarko Mar 2022

Discovery And Preclinical Pharmacology Of Ine963, A Potent And Fast-Acting Blood-Stage Antimalarial With A High Barrier To Resistance And Potential For Single-Dose Cures In Uncomplicated Malaria., Benjamin R. Taft, Fumiaki Yokokawa, Tom Kirrane, Anne-Catherine Mata, Richard Huang, Nicole Blaquiere, Grace Waldron, Bin Zou, Oliver Simon, Subramanyam Vankadara, Wai Ling Chan, Mei Ding, Sandra Sim, Judith Straimer, Armand Guiguemde, Suresh B Lakshminarayana, Jay Prakash Jain, Christopher Bodenreider, Christopher Thompson, Christian Lanshoeft, Wei Shu, Eric Fang, Jafri Qumber, Katherine Chan, Luying Pei, Yen-Liang Chen, Hanna Schulz, Jessie Lim, Siti Nurdiana Abas, Xiaoman Ang, Yugang Liu, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Glaxosmithkline Gamo, Benigno Crespo-Fernandez, Philip J. Rosenthal, Roland A. Cooper, Patrick Tumwebaze, Anna Caroline Campos Aguiar, Brice Campo, Simon Campbell, Jürgen Wagner, Thierry T Diagana, Christopher Sarko

Natural Sciences and Mathematics | Faculty Scholarship

A series of 5-aryl-2-amino-imidazothiadiazole (ITD) derivatives were identified by a phenotype-based high-throughput screening using a blood stage Plasmodium falciparum (Pf) growth inhibition assay. A lead optimization program focused on improving antiplasmodium potency, selectivity against human kinases, and absorption, distribution, metabolism, excretion, and toxicity properties and extended pharmacological profiles culminated in the identification of INE963 (1), which demonstrates potent cellular activity against Pf 3D7 (EC50 = 0.006 μM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of/kg is fully curative in the Pf-humanized severe combined immunodeficient mouse model. INE963 (1) also exhibits a high barrier to resistance …


Bits & Pieces: Project Review, Erin Partridge, Sadie Harmon, Katie Wade, Casey O'Neill Jan 2022

Bits & Pieces: Project Review, Erin Partridge, Sadie Harmon, Katie Wade, Casey O'Neill

Art Therapy | Project Reports

This project explores the impact of creative collaboration on social connections between participants and volunteers in a friendly visiting program to answer the following questions:

  1. What is the significance of a participatory based research process where older adults, staff, and volunteers are all primary contributors?

  2. How can we co-design programming to elevate a sense of meaning and connection for staff, participants, and volunteers?


Interprofessional Collaboration In High Performing Healthcare Teams, Zilola Khashimova Jan 2022

Interprofessional Collaboration In High Performing Healthcare Teams, Zilola Khashimova

Physician Assistant Studies | Faculty Scholarship

As healthcare becomes more complicated, it is important for healthcare workers to collaborate and work together as a team to provide high quality healthcare to patients. Interprofessional teams have been widely introduced into healthcare organizations across the nation aimed at achieving patient centered care and increasing the quality of patient care. The introduction of technology like electronic medical records, escribing, telehealth, and telemedicine gave interprofessional collaborators alternative mediums for communication to achieve patient centered care rather than traditional communication mediums. Technology has evolved the way interprofessional collaboration is done in the healthcare field and has created barriers and solutions for …


Providing Healthcare Workers In Medically Underserved Areas: A Case Study, Zilola Khashimova Jan 2022

Providing Healthcare Workers In Medically Underserved Areas: A Case Study, Zilola Khashimova

Physician Assistant Studies | Faculty Scholarship

Introduction: Demographic trends forecast an increasing population of aging, chronically ill patents in rural areas of the Southeastern United States. Most healthcare professionals opt to practice in or near urban areas because of higher incomes and nearness to desirable facilities. This leaves a chronic shortage of healthcare providers in rural areas where they are critically needed. A university located in one of the critically underserved areas started a program to train physician assistants with the idea that most of the students would be residents of the area and tend to stay in the area to practice after graduation.
Purpose of …


Can Repurposing Drugs Play A Role In Malaria Control?, Roland A. Cooper, Laura Kirkman Dec 2021

Can Repurposing Drugs Play A Role In Malaria Control?, Roland A. Cooper, Laura Kirkman

Natural Sciences and Mathematics | Faculty Scholarship

Innovative drug treatments for malaria, optimally with novel targets, are needed to combat the threat of parasite drug resistance. As drug development efforts continue, there may be a role for a host-targeting, repurposed cancer drug administered together with an artemisinin combination therapy that was shown to improve the speed of recovery from a malaria infection.


Systematic Review Comparing All-Cause Mortality Rates Between Tavr And Savr To Treat High Risk Surgical Patients With Severe Aortic Stenosis, Emily Belz Nov 2021

Systematic Review Comparing All-Cause Mortality Rates Between Tavr And Savr To Treat High Risk Surgical Patients With Severe Aortic Stenosis, Emily Belz

Physician Assistant Studies | Student Articles

Background: Our goal was to conduct a systematic review of available randomized controlled trials to compare the safety and efficacy of TAVR to SAVR by looking at absolute risk reduction in all-cause mortality for high risk surgical patients with severe aortic stenosis at 1, 2 and 5 years post-intervention.

Methods/Results: The PubMed database was searched according to the PRISMA guidelines from inception until September 2020. 6 high quality randomized controlled trials analyzing all-cause mortality for TAVR versus SAVR in the CoreValve US High-Risk Clinical Study and Placement of Aortic Transcatheter Valves (PARTNER) Trial populations at 1, 2 and 5 years …


Using A Health Promotion Approach To Frame Parent Experiences Of Family Routines And Their Significance For Health And Well-Being, Jennifer S. Pitonyak, Kelly Souza, Caroline Umeda, Tracy Jirikowic Oct 2021

Using A Health Promotion Approach To Frame Parent Experiences Of Family Routines And Their Significance For Health And Well-Being, Jennifer S. Pitonyak, Kelly Souza, Caroline Umeda, Tracy Jirikowic

Occupational Therapy | Faculty Scholarship

Occupational therapy providers working with young children and their families in early intervention settings frequently provide interventions to support family routines related to social participation, health management, and related occupations at home and in the community. Family routines are inextricably tied to individual and family health and well-being, yet contextual influences can impact satisfaction with and performance of routines resulting in disparities in health and occupational outcomes. A health promotion approach to intervention is intended to address contextual aspects of occupational performance in natural settings, and therefore, may be a useful approach for providing family-centered, routines-based intervention in early intervention …


Associations Between Varied Susceptibilities To Pfatp4 Inhibitors And Genotypes In Ugandan Plasmodium Falciparum Isolates., Oriana Kreutzfeld, Stephanie A. Rasmussen, Aarti A. Ramanathan, Patrick K. Tumwebaze, Oswald Byaruhanga, Thomas Katairo, Victor Asua, Martin Okitwi, Stephen Orena, Jennifer Legac, Melissa D. Conrad, Samuel L. Nsobya, Ozkan Aydemir, Jeffrey Bailey, Maelle Duffey, Brett R. Bayles, Akhil B. Vaidya, Roland A. Cooper, Philip J. Rosenthal Sep 2021

Associations Between Varied Susceptibilities To Pfatp4 Inhibitors And Genotypes In Ugandan Plasmodium Falciparum Isolates., Oriana Kreutzfeld, Stephanie A. Rasmussen, Aarti A. Ramanathan, Patrick K. Tumwebaze, Oswald Byaruhanga, Thomas Katairo, Victor Asua, Martin Okitwi, Stephen Orena, Jennifer Legac, Melissa D. Conrad, Samuel L. Nsobya, Ozkan Aydemir, Jeffrey Bailey, Maelle Duffey, Brett R. Bayles, Akhil B. Vaidya, Roland A. Cooper, Philip J. Rosenthal

Natural Sciences and Mathematics | Faculty Scholarship

Among novel compounds under recent investigation as potential new antimalarial drugs are three independently developed inhibitors of the Plasmodium falciparum P-type ATPase (PfATP4): KAE609 (cipargamin), PA92, and SJ733. We assessed ex vivo susceptibilities to these compounds of 374 fresh P. falciparum isolates collected in Tororo and Busia districts, Uganda, from 2016 to 2019. Median IC50s were 65 nM for SJ733, 9.1 nM for PA92, and 0.5 nM for KAE609. Sequencing of pfatp4 for 218 of these isolates demonstrated many nonsynonymous single nucleotide polymorphisms; the most frequent mutations were G1128R (69% of isolates mixed or mutant), Q1081K/R (68%), G223S (25%), N1045K …


Drug Susceptibility Of Plasmodium Falciparum In Eastern Uganda: A Longitudinal Phenotypic And Genotypic Study, Patrick K. Tumwebaze, Thomas Katairo, Martin Okitwi, Oswald Byaruhanga, Stephen Orena, Victor Asua, Marvin Duvalsaint, Jennifer Legac, Sevil Chelebieva, Frida G. Ceja, Stephanie A. Rasmussen, Melissa D. Conrad, Samuel L. Nsobya, Ozkan Aydemir, Jeffrey A. Bailey, Brett R. Bayles, Philip J. Rosenthal, Roland A. Cooper Sep 2021

Drug Susceptibility Of Plasmodium Falciparum In Eastern Uganda: A Longitudinal Phenotypic And Genotypic Study, Patrick K. Tumwebaze, Thomas Katairo, Martin Okitwi, Oswald Byaruhanga, Stephen Orena, Victor Asua, Marvin Duvalsaint, Jennifer Legac, Sevil Chelebieva, Frida G. Ceja, Stephanie A. Rasmussen, Melissa D. Conrad, Samuel L. Nsobya, Ozkan Aydemir, Jeffrey A. Bailey, Brett R. Bayles, Philip J. Rosenthal, Roland A. Cooper

Natural Sciences and Mathematics | Faculty Scholarship

Background: Treatment and control of malaria depends on artemisinin-based combination therapies (ACTs) and is challenged by drug resistance, but thus far resistance to artemisinins and partner drugs has primarily occurred in southeast Asia. The aim of this study was to characterise antimalarial drug susceptibility of Plasmodium falciparum isolates from Tororo and Busia districts in Uganda.

Methods: In this prospective longitudinal study, P falciparum isolates were collected from patients aged 6 months or older presenting at the Tororo District Hospital (Tororo district, a site with relatively low malaria incidence) or Masafu General Hospital (Busia district, a high-incidence site) in eastern Uganda …


The Antimalarial Mmv688533 Provides Potential For Single-Dose Cures With A High Barrier To, James M. Murithi, Cécile Pascal, Jade Bath, Xavier Boulenc, Nina F. Gnädig, Charisse Flerida A. Pasaje, Kelly Rubiano, Tomas Yeo, Sachel Mok, Sylvie Klieber, Paul Desert, María Belén Jiménez-Díaz, Jutta Marfurt, Mélanie Rouillier, Mohammed H. Cherkaoui-Rbati, Nathalie Gobeau, Sergio Wittlin, Anne-Catrin Uhlemann, Ric N. Price, Grennady Wirjanata, Rintis Noviyanti, Patrick Tumwebaze, Roland A. Cooper, Philip J. Rosenthal, Laura M. Sanz, Francisco-Javier Gamo, Jayan Joseph, Shivendra Singh, Sridevi Bashyam, Jean Michel Augereau, Elie Giraud, Tanguy Bozec, Thierry Vermat, Gilles Tuffal, Jean-Michel Guillon, Jérôme Menegotto, Laurent Sallé, Guillaume Louit, Marie-José Cabanis, Marie Françoise Nicolas, Michel Doubovetzky, Rita Merino, Nadir Bessila, Iñigo Angulo-Barturen, Delphine Baud, Lidiya Bebrevska, Fanny Escudié, Jacquin C. Niles, Benjamin Blasco, Simon Campbell, Gilles Courtemanche, Laurent Fraisse, Alain Pellet, David A. Fidock, Didier Leroy Jul 2021

The Antimalarial Mmv688533 Provides Potential For Single-Dose Cures With A High Barrier To, James M. Murithi, Cécile Pascal, Jade Bath, Xavier Boulenc, Nina F. Gnädig, Charisse Flerida A. Pasaje, Kelly Rubiano, Tomas Yeo, Sachel Mok, Sylvie Klieber, Paul Desert, María Belén Jiménez-Díaz, Jutta Marfurt, Mélanie Rouillier, Mohammed H. Cherkaoui-Rbati, Nathalie Gobeau, Sergio Wittlin, Anne-Catrin Uhlemann, Ric N. Price, Grennady Wirjanata, Rintis Noviyanti, Patrick Tumwebaze, Roland A. Cooper, Philip J. Rosenthal, Laura M. Sanz, Francisco-Javier Gamo, Jayan Joseph, Shivendra Singh, Sridevi Bashyam, Jean Michel Augereau, Elie Giraud, Tanguy Bozec, Thierry Vermat, Gilles Tuffal, Jean-Michel Guillon, Jérôme Menegotto, Laurent Sallé, Guillaume Louit, Marie-José Cabanis, Marie Françoise Nicolas, Michel Doubovetzky, Rita Merino, Nadir Bessila, Iñigo Angulo-Barturen, Delphine Baud, Lidiya Bebrevska, Fanny Escudié, Jacquin C. Niles, Benjamin Blasco, Simon Campbell, Gilles Courtemanche, Laurent Fraisse, Alain Pellet, David A. Fidock, Didier Leroy

Natural Sciences and Mathematics | Faculty Scholarship

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of MMV688533, an acylguanidine that was developed following a whole-cell screen with compounds known to hit high-value targets in human cells. MMV688533 displays fast parasite clearance in vitro and is not cross-resistant with known antimalarials. In a P. falciparum NSG mouse model, MMV688533 displays a long-lasting pharmacokinetic profile and excellent safety. Selection studies reveal a low propensity for resistance, with modest loss of potency mediated by point mutations in …


The Antimalarial Mmv688533 Provides Potential For Single-Dose Cures With A High Barrier To, James M. Murithi, Cécile Pascal, Jade Bath, Xavier Boulenc, Nina F. Gnädig, Charisse Flerida A. Pasaje, Kelly Rubiano, Tomas Yeo, Sachel Mok, Sylvie Klieber, Paul Desert, María Belén Jiménez-Díaz, Jutta Marfurt, Mélanie Rouillier, Mohammed H. Cherkaoui-Rbati, Nathalie Gobeau, Sergio Wittlin, Anne-Catrin Uhlemann, Ric N. Price, Grennady Wirjanata, Rintis Noviyanti, Patrick K. Tumwebaze, Roland A. Cooper, Philip J. Rosenthal, Laura M. Sanz, Francisco-Javier Gamo, Jayan Joseph, Shivendra Singh, Sridevi Bashyam, Jean Michel Augereau, Elie Giraud, Tanguy Bozec, Thierry Vermat, Gilles Tuffal, Jean-Michel Guillon, Jérôme Menegotto, Laurent Sallé, Guillaume Louit, Marie-José Cabanis, Marie Françoise Nicolas, Michel Doubovetzky, Rita Merino, Nadir Bessila, Iñigo Angulo-Barturen, Delphine Baud, Lidiya Bebrevska, Fanny Escudié, Jacquin C. Niles, Benjamin Blasco, Simon Campbell, Gilles Courtemanche, Laurent Fraisse, Alain Pellet, David A. Fidock, Didier Leroy Jul 2021

The Antimalarial Mmv688533 Provides Potential For Single-Dose Cures With A High Barrier To, James M. Murithi, Cécile Pascal, Jade Bath, Xavier Boulenc, Nina F. Gnädig, Charisse Flerida A. Pasaje, Kelly Rubiano, Tomas Yeo, Sachel Mok, Sylvie Klieber, Paul Desert, María Belén Jiménez-Díaz, Jutta Marfurt, Mélanie Rouillier, Mohammed H. Cherkaoui-Rbati, Nathalie Gobeau, Sergio Wittlin, Anne-Catrin Uhlemann, Ric N. Price, Grennady Wirjanata, Rintis Noviyanti, Patrick K. Tumwebaze, Roland A. Cooper, Philip J. Rosenthal, Laura M. Sanz, Francisco-Javier Gamo, Jayan Joseph, Shivendra Singh, Sridevi Bashyam, Jean Michel Augereau, Elie Giraud, Tanguy Bozec, Thierry Vermat, Gilles Tuffal, Jean-Michel Guillon, Jérôme Menegotto, Laurent Sallé, Guillaume Louit, Marie-José Cabanis, Marie Françoise Nicolas, Michel Doubovetzky, Rita Merino, Nadir Bessila, Iñigo Angulo-Barturen, Delphine Baud, Lidiya Bebrevska, Fanny Escudié, Jacquin C. Niles, Benjamin Blasco, Simon Campbell, Gilles Courtemanche, Laurent Fraisse, Alain Pellet, David A. Fidock, Didier Leroy

Natural Sciences and Mathematics | Faculty Scholarship

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of MMV688533, an acylguanidine that was developed following a whole-cell screen with compounds known to hit high-value targets in human cells. MMV688533 displays fast parasite clearance in vitro and is not cross-resistant with known antimalarials. In a P. falciparum NSG mouse model, MMV688533 displays a long-lasting pharmacokinetic profile and excellent safety. Selection studies reveal a low propensity for resistance, with modest loss of potency mediated by point mutations in …


Balanced Impacts Of Fitness And Drug Pressure On The Evolution Of Pfmdr1 Polymorphisms In Plasmodium Falciparum., Marvin Duvalsaint, Melissa D. Conrad, Stephen Tukwasibwe, Patrick K. Tumwebaze, Jennifer Legac, Roland A. Cooper, Philip J. Rosenthal Jun 2021

Balanced Impacts Of Fitness And Drug Pressure On The Evolution Of Pfmdr1 Polymorphisms In Plasmodium Falciparum., Marvin Duvalsaint, Melissa D. Conrad, Stephen Tukwasibwe, Patrick K. Tumwebaze, Jennifer Legac, Roland A. Cooper, Philip J. Rosenthal

Natural Sciences and Mathematics | Faculty Scholarship

BACKGROUND: Anti-malarial drug resistance may be limited by decreased fitness in resistant parasites. Important contributors to resistance are mutations in the Plasmodium falciparum putative drug transporter PfMDR1.

METHODS: Impacts on in vitro fitness of two common PfMDR1 polymorphisms, N86Y, which is associated with sensitivity to multiple drugs, and Y184F, which has no clear impact on drug sensitivity, were evaluated to study associations between resistance mediators and parasite fitness, measured as relative growth in competitive culture experiments. NF10 P. falciparum lines engineered to represent all PfMDR1 N86Y and Y184F haplotypes were co-cultured for 40 days, and the genetic make-up of the …


A Framework To Guide Planetary Health Education., Carlos A. Faerron Guzmán, A. Alonso Aguirre, Barbara Astle, Enrique Barros, Brett R. Bayles, Moses Chimbari, Naglaa El-Abbadi, Jessica Evert, Finola Hackett, Courtney Howard, Jonathan Jennings, Amy Krzyzek, Jessica Leclair, Filip Maric, Olwenn Martin, Odipo Osano, Jonathan Patz, Teddie Potter, Nicole Redvers, Noortje Trienekens, Sarah Walpole, Lynda Wilson, Chenchen Xu, Matthew Zylstra May 2021

A Framework To Guide Planetary Health Education., Carlos A. Faerron Guzmán, A. Alonso Aguirre, Barbara Astle, Enrique Barros, Brett R. Bayles, Moses Chimbari, Naglaa El-Abbadi, Jessica Evert, Finola Hackett, Courtney Howard, Jonathan Jennings, Amy Krzyzek, Jessica Leclair, Filip Maric, Olwenn Martin, Odipo Osano, Jonathan Patz, Teddie Potter, Nicole Redvers, Noortje Trienekens, Sarah Walpole, Lynda Wilson, Chenchen Xu, Matthew Zylstra

Global Public Health | Faculty Scholarship

People around the world are increasingly facing the pressing challenges of today’s interconnected environmental, social, and health crises. The COVID-19 pandemic has been an important wake-up call reminding us that we need a healthy planet to ensure the health of all people.1 The emerging field of planetary health is a framework for understanding these interconnections and identifying solutions to the complex challenges confronting our civilization. Building on the unique role and responsibility of education institutions in shaping our futures, embedding planetary health education in curricula is an essential step to achieving the transformative change needed. Planetary health education across …


Right Under Our Noses: Nursing Homes And Covid-19., Debbie Daunt Mar 2021

Right Under Our Noses: Nursing Homes And Covid-19., Debbie Daunt

Nursing | Faculty Scholarship

A medical mission volunteer bears witness to nightmarish inequalities.


Utilizing On-Line Interactive, Adaptive Technology In Healthcare Education – Interactive Skill-Building Workshop, Zilola Khashimova Feb 2021

Utilizing On-Line Interactive, Adaptive Technology In Healthcare Education – Interactive Skill-Building Workshop, Zilola Khashimova

Physician Assistant Studies | Faculty Conference Presentations

This workshop will show how interactive online resources can be used by healthcare educators to enhance a classroom course or for distance learning, including self-directed modules and learning activities that could be converted to virtual interactions. It will showcase the technology that is available and how to incorporate it into existing courses to utilize what research has shown increases student acceptance and learning outcomes.


Social Participation In College Students With Chronic Pain, Karen Mccarthy, Megan Chamberlain, Megan Chinn, Jennifer Pineda, Camille Santiago, Jamie Spitzer, Patricia Tran Jan 2021

Social Participation In College Students With Chronic Pain, Karen Mccarthy, Megan Chamberlain, Megan Chinn, Jennifer Pineda, Camille Santiago, Jamie Spitzer, Patricia Tran

Occupational Therapy | Faculty Scholarship

Background: College students with invisible disabilities, including chronic pain, often experience difficulty engaging in social occupations, both on and off campus, because of stigma, misconceptions, or social exclusion. Previous research has examined the use of academic accommodations to address these concerns or focused on the physical barriers to participation, failing to address the psychosocial and holistic impact of pain. Chronic pain can affect a variety of occupations, including social participation, which is a significant occupation for college students. This research explores the lived experience of chronic pain for college students and the impact of pain on social participation from …


Exploring Voice Hearers' Occupational Experience Of Romantic And Sexual Relationships, Karen Mccarthy, Kristen Gottheil, Emilio Villavicencio, Huilim Jeong Jan 2021

Exploring Voice Hearers' Occupational Experience Of Romantic And Sexual Relationships, Karen Mccarthy, Kristen Gottheil, Emilio Villavicencio, Huilim Jeong

Occupational Therapy | Faculty Scholarship

Background: Limited research has been conducted that explores the occupational experience of hearing voices, including the impact it has on romantic and/or sexual relationships. This study aims to address this gap by capturing the experience of romantic and sexual relationships for those who hear voices.

Method: A phenomenological approach was used to gather data from a survey, electronic diaries, and interviews of three voice hearers who were interested or actively in a casual or serious relationship.

Results: All of the participants reported that the voices in some way impacted their past or current romantic and sexual relationships. …


Interdisciplinary Community-Based Support For Caregivers Of Individuals Living With Dementia, Gina Tucker-Roghi, Jamie Escoubas, Renee Tolliver, Sarah Tucker Jan 2021

Interdisciplinary Community-Based Support For Caregivers Of Individuals Living With Dementia, Gina Tucker-Roghi, Jamie Escoubas, Renee Tolliver, Sarah Tucker

Occupational Therapy | Faculty Scholarship

Evidence indicates family caregivers of individuals living with dementia (ILwD) are at risk for diminished physical and mental health; which may decrease their quality of life and directly impact their ability to provide care. An interdisciplinary approach to self-care and skill-building for caregivers is provided in a virtual support group offered by Council on Aging in Sonoma County, CA. As part of the nonprofit’s Adult Day Program, the group is offered to client caregivers and has two goals: First, creating a communitybased, long-term support system for ILwD who are agingin-place; second, fostering a safe and supportive community for family caregivers, …