Medicine and Health Sciences Commons^™

The Wild West Of Edible Insects, Kyle Ligman

Capstones

After the UN came out with a report in 2013 recommending insects for human consumption, businesses and restaurants in the U.S. have been racing to grow a new industry. This project explores the psychological, regulatory and production challenges they face.

Well-Born: Black Women And The Infertility Crisis No One Is Talking About, Kaara Baptiste

Capstones

Black women are twice as likely to experience infertility than white women, but are less likely to seek treatment or to have successful fertility results once treated. Despite this alarming number, this topic is not often discussed, even among the black community. My narrative piece t tells the story of a black woman confronting her infertility diagnosis and the role her race played in her fertility treatment, while exploring the role racism and sexuality have had in keeping this issue in the shadows.

Lady Luck: The Rise Of Women Problem Gamblers, Antonia Massa

Capstones

Gambling addiction, once considered a nearly exclusively male affliction, is becoming more common among women. This story looks at the lives and addictions of two women problem gamblers. The project includes text, audio, images and a web app for smartphones, designed to help women who think they may have a gambling problem.

Sending Drugs Into The Fast Lane, Ross Keith

Capstones

Speedy drug approvals have become increasingly the norm at the FDA, a trend that began in 1992 with the passage of the Prescription Drug User Fee Act. Over the past 20 years, the approval process has shrunk, on average, from three years to ten months. As speed has risen, the number of safety issues has as well. Some notoriously harmful drugs, such as Vioxx and Avandia, that were pulled from the market because of dangerous side effects, were fast-tracked. Some doctors and industry analysts question whether the agency’s laissez faire approach is essentially moving the testing phase of drugs from …

Overcoming Obstacles, Melisa Stumpf

Capstones

the contributing factors that lead to the purported low life expectancy for transgenders (suicide, high risks of HIV, lack of healthcare access, refusal of care, etc.) which some experts, advocates and transgender individuals themselves think it's of about 35 years-old.

Mcdonald's Or Mesquite: Struggles On The Salt River Pima Reservation, Stefani Kim

Capstones

The Salt River Pima Indians, prior to colonization, had a strong tradition of harvesting and food sovereignity. As the tribe adapted to a more Westernized diet which consisted mainly of processed food rations, the rate of diabetes began to skyrocket on the reservation and, at one point, the tribe had one of the highest per capita diabetes rates in the world. This year, the tribe's cultural resources department will resurrect a 16-year-old community garden program originally funded by a USDA/Habitat for Humanity grant as a way to help combat health problems related to a poor diet such as diabetes and …

Turning Waste Into Resources In Haiti, Alexis Barnes

Capstones

Sanitation infrastructure in Haiti is an ongoing problem- one that only exacerbated a massive cholera epidemic brought to the country by Nepalese United Nations peacekeeping troops. SOIL is an NGO that works in alternative sanitation- using "urine-diverting dry toilets" to turn waste into a fertile resource. In my capstone, I explore the potential for alternative sanitation in Haiti, how it works and what internal and external political and economic factors lead to the current state of water and sanitation infrastructure in the country.

Urgent Cares Outpace Health Policy In The U.S., Ashley Rodriguez

Capstones

More and more medical practices across the country are rebranding themselves as urgent care centers to meet the growing demand for fast, affordable health care. In many states, they are regulated like physicians groups. However, there is a debate brewing among health care policy experts and government officials over whether these centers should have their own regulations. Such oversight could help patients expecting acute care avoid confusion to such a degree that they receive poor treatment from professionals who aren’t prepared to offer emergency services, or delayed treatment because they are bounced around from facility to facility.

Mapping A City's Invisible Residents, Kelly Dickerson

Capstones

A scientist is mapping the microbes of New York City in hopes of eventually creating a real-time map that could help prevent the spread of diseases.

When You Can't Watch What You Eat: Examining The Fda’S Recall Process For Food Allergies, Jacob Passy

Capstones

Over a third of all recalls for food products in the United States occur due to an undeclared allergen. In these situations, a food product is often mislabeled or contaminated in some way, resulting in the unknown presence of allergen. For food-allergic consumers, a company's mistake can become life-threatening. By investigating data from the Food and Drug Administration, I found that supermarket chains are responsible for about a fifth of all recalls, and that many recalls occur past the product's expiration date. These factors point to the need to improve the FDA's handling of food allergies in food manufacturing.

Sensory Abnormalities In Focal Hand Dystonia And Non-Invasive Brain Stimulation, Angelo Quartarone, Vincenzo Rizzo, Carmen Terranova, Demetrio Milardi, Daniele Bruschetta, Maria Felice Ghilardi, Paolo Girlanda

Publications and Research

It has been proposed that synchronous and convergent afferent input arising from repetitive motor tasks may play an important role in driving the maladaptive cortical plasticity seen in focal hand dystonia (FHD).This hypothesis receives support from several sources. First, it has been reported that in subjects with FHD, paired associative stimulation produces an abnormal increase in corticospinal excitability, which was not confined to stimulated muscles. These findings provide support for the role of excessive plasticity in FHD. Second, the genetic contribution to the dystonias is increasingly recognized indicating that repetitive, stereotyped afferent inputs may lead to late-onset dystonia, such as …

Activity-Based Therapies For Repair Of The Corticospinal System Injured During Development, Kathleen M. Friel, Preston T. J. A. Williams, Najet Serradj, Samit Chakrabarty, John H. Martin

Publications and Research

This review presents the mechanistic underpinnings of corticospinal tract (CST) development, derived from animal models, and applies what has been learned to inform neural activity-based strategies for CST repair.We first discuss that, in normal development, early bilateral CST projections are later refined into a dense crossed CST projection, with maintenance of sparse ipsilateral projections. Using a novel mouse genetic model, we show that promoting the ipsilateral CST projection produces mirror movements, common in hemiplegic cerebral palsy (CP), suggesting that ipsilateral CST projections become maladaptive when they become abnormally dense and strong.We next discuss howanimal studies support a developmental “competition rule” …

Rationale, Design, And Method Of The Diabetes & Women’S Health Study – A Study Of Long-Term Health Implications Of Glucose Intolerance In Pregnancy And Their Determinants, Cuilin Zhang, Frank B. Hu, Sjurdur F. Olsen, Allan Vaag, Robert Gore-Langton, Jorge E. Chavarro, Wei Bao, Edwina Yeung, Katherine Bowers, Louise Groth Grunnet, Seth Sherman, Michele Kiely, Marin Strøm, Susanne Hansen, Aiyi Liu, James Mills, Ruzong Fan

Publications and Research

Women who develop gestational diabetes mellitus or impaired glucose tolerance during pregnancy are at substantially increased risk for type 2 diabetes and comorbidities after pregnancy. Little is known about the role of genetic factors and their interactions with environmental factors in determining the transition from gestational diabetes mellitus to overt type 2 diabetes mellitus. These critical data gaps served as the impetus for this Diabetes & Women’s Health study with the overall goal of investigating genetic factors and their interactions with risk factors amenable to clinical or public health interventions in relation to the transition of gestational diabetes mellitus to …

Design And Development Of A Linked Open Data-Based Health Information Representation And Visualization System: Potentials And Preliminary Evaluation, Binyam Tilahun, Tomi Kauppinen, Carsten Keßler, Fleur Fritz

Publications and Research

Background: Healthcare organizations around the world are challenged by pressures to reduce cost, improve coordination and outcome, and provide more with less. This requires effective planning and evidence-based practice by generating important information from available data. Thus, flexible and user-friendly ways to represent, query, and visualize health data becomes increasingly important. International organizations such as the World Health Organization (WHO) regularly publish vital data on priority health topics that can be utilized for public health policy and health service development. However, the data in most portals is displayed in either Excel or PDF formats, which makes information discovery and reuse …

Explaining Racial/Ethnic Disparities In Use Of High-Volume Hospitals: Decision-Making Complexity And Local Hospital Environments, Karl Kronebusch, Bradford H. Gray, Mark Schlesinger

Publications and Research

Racial/ethnic minorities are less likely to use higher-quality hospitals than whites. We propose that a higher level of informationrelated complexity in their local hospital environments compounds the effects of discrimination and more limited access to services, contributing to racial/ethnic disparities in hospital use. While minorities live closer than whites to high-volume hospitals, minorities also face greater choice complexity and live in neighborhoods with lower levels of medical experience. Our empirical results reveal that it is generally the overall context associated with proximity, choice complexity, and local experience, rather than differential sensitivity to these factors, that provides a partial explanation of …

Breast Cancer Incidence And Mortality In A Transitioning Chinese Population: Current And Future Trends, O. L. Wong, Mary Schooling, Benjamin J. Cowling, Gabriel M. Leung

Publications and Research

Background Projections of future trends in cancer incidence and mortality are important for public health planning. Methods By using 1976–2010 data in Hong Kong, we fitted Poisson age-period-cohort models and made projections for future breast cancer incidence and mortality to 2025. Results Age-standardised breast cancer incidence (/mortality) is projected to increase (/decline) from 56.7 (/9.3) in 2011–2015 to 62.5 (/8.6) per 100 000 women in 2021–2025. Conclusions The incidence pattern may relate to Hong Kong’s socio-economic developmental history, while falling mortality trends are, most likely, due to improvements in survival from treatment advancement and improved health service delivery.

Effects Of Extreme Climate Events On Tea (Camellia Sinensis) Functional Quality Validate Indigenous Farmer Knowledge And Sensory Preferences In Tropical China, Selena Ahmed, John Richard Stepp, Colin M. Orians, Timothy S. Griffin, Corene Matyas, Albert Robbat, Sean Cash, Dayuan Xue, Chunlin Long, Uchenna Unachukwu, Sarabeth Buckley, Edward J. Kennelly

Publications and Research

Climate change is impacting agro-ecosystems, crops, and farmer livelihoods in communities worldwide. While it is well understood that more frequent and intense climate events in many areas are resulting in a decline in crop yields, the impact on crop quality is less acknowledged, yet it is critical for food systems that benefit both farmers and consumers through high-quality products. This study examines tea (Camellia sinensis; Theaceae), the world’s most widely consumed beverage after water, as a study system to measure effects of seasonal precipitation variability on crop functional quality and associated farmer knowledge, preferences, and livelihoods. Sampling was conducted in …

Dynamics Of Alpha Control: Preparatory Suppression Of Posterior Alpha Oscillations By Frontal Modulators Revealed With Combined Eeg And Event-Related Optical Signal, Kyle E. Mathewson, Diane M. Beck, Tony Ro, Edward L. Maclin, Kathy A. Low, Monica Fabiani, Gabriele Gratton

Publications and Research

We investigated the dynamics of brain processes facilitating conscious experience of external stimuli. Previously, we proposed that alpha (8–12 Hz) oscillations, which fluctuate with both sustained and directed attention, represent a pulsed inhibition of ongoing sensory brain activity. Here we tested the prediction that inhibitory alpha oscillations in visual cortex are modulated by top–down signals from frontoparietal attention networks. We measured modulations in phase-coherent alpha oscillations from superficial frontal, parietal, and occipital cortices using the event-related optical signal (EROS), a measure of neuronal activity affording high spatiotemporal resolution, along with concurrently recorded EEG, while participants performed a visual target detection …

A Meta-Analysis Of The Prediction Of Violence Among Adults With Mental Disorders, Hing Po Lam

Dissertations, Theses, and Capstone Projects

The study of the risk for violence among persons with mental disorders has received substantial scientific attention over the past few decades; however, many uncertainties and controversies remain due to the wide disparities in the reported results. Using the state-of-the-art perspective of public health, a meta-analysis was conducted to clarify the ambiguities by synthesizing quantitative findings from 85 research reports (completed between January 1970 and May 2010) on violence risk assessment among mentally disordered adults. Results of this meta-analytic study revealed that the estimates of the prevalence of violence among the psychiatric population varied considerably from 1.1% to 78.4% with …

Characterization Of Somatosensory Processing In Relation To Schizotypal Traits In A Sample Of Nonclinical Young Adults, Maureen Patricia Daly

Dissertations, Theses, and Capstone Projects

A core feature of schizophrenia spectrum disorders (SSDs) is a basic sensory (e.g., visual, auditory) processing disruption, yet few studies have examined somatosensation. The current dissertation project examined somatosensory processes among individuals at varying degrees of psychometric risk for psychosis using tactile texture and spatial discrimination and letter recognition tasks. Differential patterns of associations of somatosensory abilities with schizotypal trait dimensions (positive, negative, disorganized), independent of anxiety and depressive symptoms, and the relative contributions of bottom-up (peripheral and morphologic features) versus top-down (error types) processing were examined. It was hypothesized that: 1) performance on somatosensory tasks would account for significant …

Birthing, Blackness, And The Body: Black Midwives And Experiential Continuities Of Institutional Racism, Keisha La'nesha Goode

Dissertations, Theses, and Capstone Projects

Within the last decade, historical and contemporary accounts of midwives, along with the efficacy of the Midwives Model of Care for pregnancy, childbirth and general women's health, have become increasing popular in mainstream publications and documentaries. Yet, very few of these accounts represent historical or contemporary black midwives (and midwives of color, more generally). Despite a long history of midwifery in the black community, black women currently represent less than 2% of the nation's reported 15,000 midwives. Relatedly, black women and infants experience the worst birth outcomes of any racial-ethnic cohort in the United States.

In the early 20th century, …

Intra- And Intergenerational Effects Of Migration And The Role Of The Psychosocial Environment In The Development Of Perinatal Depression, Hannah R. Simons

Dissertations, Theses, and Capstone Projects

Background: Perinatal depression is a significant public health issue that affects women and their families. Studies conducted outside of the United States (US) have found a higher prevalence of perinatal depression in immigrant compared to native-born women. US studies have been less consistent but have relied on convenience samples and lacked appropriate comparison groups.

Objectives: To characterize the relationship between migration to the US and risk for perinatal depressive symptomatology and to examine the role of the post-migration psychosocial environment on the occurrence of perinatal depressive symptoms.

Methods: The dissertation used two data sources, the NYC Pregnancy Risk Assessment Monitoring …

Identification And Characterization Of Protein Kinase C Substrates In Human Breast Cells, Xin Zhao

Dissertations, Theses, and Capstone Projects

Aberrations in PKC signaling can lead to the development of multiple human diseases and the most prominent association of PKC with disease has been in tumor growth and metastasis. PKC and its related pathways have been recognized as promising targets for blocking the malignancy of breast cancer cells. To better understand PKC-mediated pathway in breast cancer cells, it is important to identify the cellular substrates of PKC. The main focus of this work is to identify physiologically relevant cellular substrates of PKC in human breast cells and to characterize their roles in cancer-related phenotypes. The work to be described consists …

When Less Can Be More: Dual Task Effects In Stuttering And Fluent Adults, Naomi Nechama Eichorn

Dissertations, Theses, and Capstone Projects

The present study tested the counterintuitive hypothesis that engaging cognitive resources in a secondary task while speaking could benefit aspects of speech production. Effects of dual task conditions on speech fluency, rate, and error patterns were examined in stuttering and fluent speakers based on specific predictions derived from three related theoretical frameworks. Twenty fluent adults and 19 adults with confirmed diagnoses of stuttering participated in the study. All participants completed two baseline tasks: (1) a continuous speaking task in which spontaneous speech was produced in response to given prompts; and (2) a working memory (WM) task involving manipulations of WM …

Clinical Implications Of Binaural Interference: A Systematic Review Of The Literature, Michael Bergen

Dissertations, Theses, and Capstone Projects

A binaural advantage has been described in many studies over the past fifty years, although research also has demonstrated examples of a disadvantage known as binaural interference. The literature varies greatly in suggesting the incidence of binaural interference across all populations. It also raises questions about the underlying causes of this phenomenon, as well as whether age-related changes have an impact.

A systematic review was engaged to summarize the literature associated with binaural interference, to identify clinical implications of this body of literature, and to answer two research questions:

1) Does the literature describe changes in susceptibility to binaural interference …

Underprivileged Children In Port-Au-Prince, Haiti: Hearing And Academic Performance Of Children In Public Schools In Port Au Prince, Talia Meisel

Dissertations, Theses, and Capstone Projects

Hearing loss is estimated to affect more than 360 million people worldwide, 32% of whom are children. Children with hearing loss tend to develop compromised communicative abilities and also have been found to perform more poorly academically than their normal hearing peers. Because of the lack of medical care, children in third world countries are expected to have more difficulty hearing and learning in a classroom setting than children in first world countries due to higher incidences of conductive pathology. The purpose of this study is to assess the hearing ability of underprivileged children in kindergarten and primary schools in …

The Status Of Neonatal Hearing Screening In Sub-Saharan Africa: A Systematic Review, David Engelman

Dissertations, Theses, and Capstone Projects

Late identification of hearing loss can lead to speech and language delays, as well as social and academic difficulties. Neonatal hearing screening has reduced the age of identification of hearing loss in many developed countries. However, the practice is limited or non-existent in much of the developing world, such as sub-Saharan Africa. This systematic review used currently available literature to determine the status of neonatal hearing screening programs in sub-Saharan Africa and to develop a model program for the region. Results suggested a lack of neonatal hearing screening services in sub-Saharan Africa, stressing the need for more pilot hearing screening …

Atypical Multisensory Integration In Niemann-Pick Type C Disease – Towards Potential Biomarkers, Gizely N. Andrade, Sophie Molholm, John S. Butler, Alice Brown Brandwein, Steven U. Walkley, John J. Foxe

Publications and Research

Background: Niemann-Pick type C (NPC) is an autosomal recessive disease in which cholesterol and glycosphingolipids accumulate in lysosomes due to aberrant cell-transport mechanisms. It is characterized by progressive and ultimately terminal neurological disease, but both pre-clinical studies and direct human trials are underway to test the safety and efficacy of cholesterol clearing compounds, with good success already observed in animal models. Key to assessing the effectiveness of interventions in patients, however, is the development of objective neurobiological outcome measures. Multisensory integration mechanisms present as an excellent candidate since they necessarily rely on the fidelity of long-range neural connections between the …

Low Risk Of Attrition Among Adults On Antiretroviral Therapy In The Rwandan National Program: A Retrospective Cohort Analysis Of 6, 12, And 18 Month Outcomes, Harriet Nuwagaba-Biribonwoha, Aleksandra Jakubowski, Veronicah Mudisha, Paulin Basinga, Anita Asiimwe, Denis Nash, Batya Elul

Publications and Research

Background
We report levels and determinants of attrition in Rwanda, one of the few African countries with universal ART access.

Methods
We analyzed data abstracted from health facility records of a nationally representative sample of adults [≥18 years] who initiated ART 6, 12, and 18 months prior to data collection; and collected facility characteristics with a health facility assessment questionnaire. Weighted proportions and rates of attrition [loss to follow-up or death] were calculated, and patient- and health facility-level factors associated with attrition examined using Cox proportional hazard models.

Results
1678 adults initiated ART 6, 12 and 18 months prior to …

Synthesis And Characterization Of Nanostructured Nickel Diselenide Nise2 From The Decomposition Of Nickel Acetate, (Ch3co2)2ni, Ming Yin, Stephen O'Brien

Publications and Research

Solution processed NiSe2 nanorods were synthesized by a modified colloidal synthesis technique, by chemical reaction of TOPSe and nickel acetate at 150 ∘C. The rods exist as an oleic acid ligand stabilized solution, with oleic acid acting as a capping group. Structural characterization by X-ray diffraction and transmission electron microscopy indicates that the particles are rod-like shaped crystals with a high and relatively constant aspect ratio (30 : 1). TEM shows that the width and the length of the nanorods are in the range 10–20nm and 300–350 nm, respectively. XRD indicates that the nanorods are pure and well crystallized. The …