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Dose-Response Association Between Physical Activity And Sedentary Time Categories On Ageing Biomarkers, Asier Mañas, Borja Del Pozo-Cruz, Irene Rodríguez-Gómez, Javier Leal-Martín, José Losa-Reyna, Leocadio Rodriguez Mañas, Francisco J. García-García, Ignacio Ara Jan 2019

Dose-Response Association Between Physical Activity And Sedentary Time Categories On Ageing Biomarkers, Asier Mañas, Borja Del Pozo-Cruz, Irene Rodríguez-Gómez, Javier Leal-Martín, José Losa-Reyna, Leocadio Rodriguez Mañas, Francisco J. García-García, Ignacio Ara

Faculty of Health Sciences Publications

Background: Physical activity and sedentary behaviour have been suggested to independently affect a number of health outcomes. To what extent different combinations of physical activity and sedentary behaviour may influence physical function and frailty outcomes in older adults is unknown. The aim of this study was to examine the combination of mutually exclusive categories of accelerometer-measured physical activity and sedentary time on physical function and frailty in older adults. Methods: 771 older adults (54% women; 76.8 ± 4.9 years) from the Toledo Study for Healthy Aging participated in this cross-sectional study. Physical activity and sedentary time were measured by ...


Ingesting A Bitter Solution: The Sweet Touch To Increasing Short-Term Cycling Performance [Accepted Manuscript], Naroa Etxebarria, Megan L. Ross, Brad Clark, Louise M. Burke Jan 2019

Ingesting A Bitter Solution: The Sweet Touch To Increasing Short-Term Cycling Performance [Accepted Manuscript], Naroa Etxebarria, Megan L. Ross, Brad Clark, Louise M. Burke

Faculty of Health Sciences Publications

Purpose: The authors investigated the potential benefit of ingesting 2 mM of quinine (bitter tastant) on a 3000-m cycling time-trial (TT) performance. Methods: Nine well-trained male cyclists (maximal aerobic power: 386 [38] W) performed a maximal incremental cycling ergometer test, three 3000-m familiarization TTs, and four 3000-m intervention TTs (∼4 min) on consecutive days. The 4 interventions were (1) 25 mL of placebo, (2) a 25-mL sweet solution, and (3) and (4) repeat 25 mL of 2-mM quinine solutions (Bitter1 and Bitter2), 30 s before each trial. Participants self-selected their gears and were only aware of distance covered. Results: Overall ...


Single-Dose Prednisolone Alters Endocrine And Haematologic Responses And Exercise Performance In Men, Alexander Tacey, Lewan Parker, Bu B. Yeap, John Joseph, Ee Mun Lim, Andrew Garnham, David L. Hare, Tara C. Brennan-Speranza, Itamar Levinger Jan 2019

Single-Dose Prednisolone Alters Endocrine And Haematologic Responses And Exercise Performance In Men, Alexander Tacey, Lewan Parker, Bu B. Yeap, John Joseph, Ee Mun Lim, Andrew Garnham, David L. Hare, Tara C. Brennan-Speranza, Itamar Levinger

Faculty of Health Sciences Publications

The aim of this study was to investigate the effect of a single dose of prednisolone on (A) high-intensity interval cycling performance and (B) post-exercise metabolic, hormonal and haematological responses. Nine young men participated in this double-blind, randomised, cross-over study. The participants completed exercise sessions (4 × 4 min cycling bouts at 90–95% of peak heart rate), 12 h after ingesting prednisolone (20 mg) or placebo. Work load was adjusted to maintain the same relative heart rate between the sessions. Exercise performance was measured as total work performed. Blood samples were taken at rest, immediately post exercise and up to ...


High Dietary Fat Intake Increases Fat Oxidation And Reduces Skeletal Muscle Mitochondrial Respiration In Trained Humans [Accepted Manuscript], Jill J. Leckey, Nolan J. Hoffman, Evelyn B. Parr, Brooke L. Devlin, Adam J. Trewin, Nigel K. Stepto, James P. Morton, Louise M. Burke, John A. Hawley Jun 2018

High Dietary Fat Intake Increases Fat Oxidation And Reduces Skeletal Muscle Mitochondrial Respiration In Trained Humans [Accepted Manuscript], Jill J. Leckey, Nolan J. Hoffman, Evelyn B. Parr, Brooke L. Devlin, Adam J. Trewin, Nigel K. Stepto, James P. Morton, Louise M. Burke, John A. Hawley

Faculty of Health Sciences Publications

High-fat, low-carbohydrate (CHO) diets increase whole-body rates of fat oxidation and down-regulate CHO metabolism. We measured substrate utilization and skeletal muscle mitochondrial respiration to determine whether these adaptations are driven by high fat or low CHO availability. In a randomized crossover design, 8male cyclists consumed5dof a high-CHO diet [>70%energy intake (EI)], followed by 5dof either an isoenergetic high-fat (HFAT; >65% EI) or high-protein diet (HPRO; >65% EI) with CHO intake clamped at


Clinical Oncology Society Of Australia Position Statement On Exercise In Cancer Care [Accepted Manuscript], Prue Cormie, Morgan Atkinson, Lucy Bucci, Anne Cust, Elizabeth Eakin, Sandra Hayes, Alexandra Mccarthy, Andrew Murnane, Sharni Patchell, Diana Adams May 2018

Clinical Oncology Society Of Australia Position Statement On Exercise In Cancer Care [Accepted Manuscript], Prue Cormie, Morgan Atkinson, Lucy Bucci, Anne Cust, Elizabeth Eakin, Sandra Hayes, Alexandra Mccarthy, Andrew Murnane, Sharni Patchell, Diana Adams

Faculty of Health Sciences Publications

Introduction: Clinical research has established exercise as a safe and effective intervention to counteract the adverse physical and psychological effects of cancer and its treatment. This article summarises the position of the Clinical Oncology Society of Australia (COSA) on the role of exercise in cancer care, taking into account the strengths and limitations of the evidence base. It provides guidance for all health professionals involved in the care of people with cancer about integrating exercise into routine cancer care.

Main recommendations: COSA calls for:

  • exercise to be embedded as part of standard practice in cancer care and to be viewed ...


Effects Of Leisure-Time And Transport-Related Physical Activities On The Risk Of Incident And Recurrent Myocardial Infarction And Interaction With Traffic-Related Air Pollution: A Cohort Study, Nadine Kubesch, Jeanette Therming Jørgensen, Barbara Hoffmann, Steffen Loft, Mark Nieuwenhuijsen, Ole Raaschou-Nielsen, Marie Pedersen, Ole Hertel, Kim Overvad, Anne Tjønneland, Eva Prescot, Zorana Jovanovic Andersen Jan 2018

Effects Of Leisure-Time And Transport-Related Physical Activities On The Risk Of Incident And Recurrent Myocardial Infarction And Interaction With Traffic-Related Air Pollution: A Cohort Study, Nadine Kubesch, Jeanette Therming Jørgensen, Barbara Hoffmann, Steffen Loft, Mark Nieuwenhuijsen, Ole Raaschou-Nielsen, Marie Pedersen, Ole Hertel, Kim Overvad, Anne Tjønneland, Eva Prescot, Zorana Jovanovic Andersen

Faculty of Health Sciences Publications

Background
Physical activity enhances the uptake of air pollutants, possibly reducing its beneficial effects. We examined the effects of leisure‐time and transport‐related physical activities on the risk of myocardial infarction (MI), and whether potential benefits on MI are reduced by exposure to traffic‐related air pollution.
Methods and Results
A group of 57 053 participants (50–65 years of age) from the Danish Diet, Cancer, and Health cohort reported physical activity at baseline (1993–1997) and were linked to registry data on hospital contacts and out‐of‐hospital deaths caused by MI, until December 2015. Nitrogen dioxide levels ...


Objectively Measured Neighborhood Walkability And Changed In Physical Activity In Older Japanese Adults: A Five-Year Cohort Study, Hiroyuki Kikuchi, Tomoki Nakaya, Tomoya Hanibuchi, Noritoshi Fukushima, Shiho Amagasa, Koichiro Oka, Jim Sallis, Shigeru Inoue Jan 2018

Objectively Measured Neighborhood Walkability And Changed In Physical Activity In Older Japanese Adults: A Five-Year Cohort Study, Hiroyuki Kikuchi, Tomoki Nakaya, Tomoya Hanibuchi, Noritoshi Fukushima, Shiho Amagasa, Koichiro Oka, Jim Sallis, Shigeru Inoue

Faculty of Health Sciences Publications

Objectives:
This study investigated the longitudinal association between changes in older adults’ physical activity and neighborhood walkability measured by geographic information systems (GISs, (ArcGIS, ESRI Inc., Redlands, CA, USA)). Methods: A mail survey was conducted for Japanese older adults who were randomly selected from three different settlement types. Data on walking, total moderate to vigorous physical activity (MVPA), and sociodemographic characteristics were collected at baseline (in 2010) and follow-up (in 2015). Multiple linear regression analyses were employed to assess the association between MVPA change and neighborhood walkability, adjusted for potential confounders. Effect sizes for independent variables on MVPA change were ...


Repeated-Sprint Performance And Plasma Responses Following Beetroot Juice Supplementation Do Not Differ Between Recreational, Competitive And Elite Sprint Athletes, Kristin L. Jonvik, Jean Nyakayiru, Jan Willem Van Dijk, K. Maase, S. B. Ballak, Joan M. Senden, Luc Van Loon, Lex B. Verdijk Jan 2018

Repeated-Sprint Performance And Plasma Responses Following Beetroot Juice Supplementation Do Not Differ Between Recreational, Competitive And Elite Sprint Athletes, Kristin L. Jonvik, Jean Nyakayiru, Jan Willem Van Dijk, K. Maase, S. B. Ballak, Joan M. Senden, Luc Van Loon, Lex B. Verdijk

Faculty of Health Sciences Publications

Purpose:
There is an ongoing debate whether highly trained athletes are less responsive to the ergogenic properties of nitrate. We assessed the effects of nitrate supplementation on plasma nitrate and nitrite concentrations and repeated-sprint performance in recreational, competitive and elite sprint athletes.
Methods:
In a randomized double-blinded cross-over design, recreational cyclists (n = 20), national talent speed-skaters (n = 22) and Olympic-level track cyclists (n = 10) underwent two 6-day supplementation periods; 140 mL/d nitrate-rich (BR; ∼800 mg/d) and nitrate-depleted (PLA; ∼0.5 mg/d) beetroot juice. Blood samples were collected and three 30-s Wingate tests were performed.
Results:
Plasma nitrate ...


Age-Associated Impairments In Mitochondrial Adp Sensitivity Contribute To Redox Stress In Senescent Human Skeletal Muscle, Graham P. Holloway, Andrew M. Holwerda, Paula M. Miotto, Marlou L. Dirks, Lex B. Verdijk, Luc Van Loon Jan 2018

Age-Associated Impairments In Mitochondrial Adp Sensitivity Contribute To Redox Stress In Senescent Human Skeletal Muscle, Graham P. Holloway, Andrew M. Holwerda, Paula M. Miotto, Marlou L. Dirks, Lex B. Verdijk, Luc Van Loon

Faculty of Health Sciences Publications

It remains unknown if mitochondrial bioenergetics are altered with aging in humans. We established an in vitro method to simultaneously determine mitochondrial respiration and H2O2emission in skeletal muscle tissue across a range of biologically relevant ADP concentrations. Using this approach, we provide evidence that, although the capacity for mitochondrial H2O2emission is not increased with aging, mitochondrial ADP sensitivity is impaired. This resulted in an increase in mitochondrial H2O2and the fraction of electron leak to H2O2, in the presence of virtually all ADP concentrations examined. Moreover, although prolonged resistance training inolder individuals increased muscle mass, strength, and maximal mitochondrial respiration, exercise ...


The Effect Of Targeted Exercise On Knee-Muscle Function In Patients With Persistent Hamstring Deficiency Following Acl Reconstruction - Study Protocol For A Randomized Controlled Trial, Bo Bregenhof, Uffe Jørgensen, Per Aagaard, N. Nissen, Mark Creaby, Jonas Thorlund, Carsten Jensen, Trine Torfing, Anders Holsgaard-Larsen Jan 2018

The Effect Of Targeted Exercise On Knee-Muscle Function In Patients With Persistent Hamstring Deficiency Following Acl Reconstruction - Study Protocol For A Randomized Controlled Trial, Bo Bregenhof, Uffe Jørgensen, Per Aagaard, N. Nissen, Mark Creaby, Jonas Thorlund, Carsten Jensen, Trine Torfing, Anders Holsgaard-Larsen

Faculty of Health Sciences Publications

Background
Anterior cruciate ligament (ACL) reconstruction, using hamstring auto-graft is a common surgical procedure, which often leads to persistent hamstring muscle-strength deficiency and reduced function. The purpose of this randomized controlled trial (RCT) is to investigate the effect of a combined, progressive, strength and neuromuscular exercise intervention on knee muscle strength, functional capacity and hamstring muscle-tendon morphology in ACL-reconstructed patients with persistent hamstring muscle-strength deficiency compared with controls.
Methods/design
The study is designed as a multicenter, parallel-group RCT with balanced randomization (1:1) and blinded outcome assessments (level of evidence: II) and will be reported in accordance with the ...


Web-Based Physical Activity Intervention For Latina Adolescents: Feasibility, Acceptability, And Potential Efficacy Of The Niñas Saludables Study, Britta Larsen, Tanya Benitez, Mayra Cano, Shira S. Dunsiger, Bess Marcus, Andrea Mendoza-Vasconez, Jim Sallis, Michelle Zive Jan 2018

Web-Based Physical Activity Intervention For Latina Adolescents: Feasibility, Acceptability, And Potential Efficacy Of The Niñas Saludables Study, Britta Larsen, Tanya Benitez, Mayra Cano, Shira S. Dunsiger, Bess Marcus, Andrea Mendoza-Vasconez, Jim Sallis, Michelle Zive

Faculty of Health Sciences Publications

Background:
Physical activity is markedly low in Latina adolescents, yet few physical activity interventions have been attempted in this population. Web-based interventions can incorporate theory-based components, be appealing to adolescents, and have potential for low-cost dissemination.
Objective:
This study aimed to assess the feasibility, acceptability, and potential efficacy of a Web-based physical activity intervention for Latina adolescents in a single-arm pilot trial.
Methods:
A total of 21 Latina adolescents (aged 12-18 years) who could read and write in English and were underactive (<90 min/week) participated in a 12-week, theory-informed Web-based physical activity intervention. The intervention website was modified from a previous Web-based intervention for Latina adults. Web content was individually tailored based on the responses to monthly questionnaires. Feasibility was measured by recruitment, retention, and adherence/engagement, and acceptability was measured by satisfaction surveys. Physical activity was measured at baseline and follow-up (12 weeks) using the 7-day physical activity recall (PAR) interview and accelerometers.
Results:
Baseline activity as measured by the 7-day PAR and accelerometers was 24.7 (SD 26.11) and ...


Exercise And Glut4 In Human Subcutaneous Adipose Tissue, Marcelo Flores-Opazo, Eva Boland, Andrew Garnham, Robyn M. Murphy, Sean L. Mcgee, Mark Hargreaves Jan 2018

Exercise And Glut4 In Human Subcutaneous Adipose Tissue, Marcelo Flores-Opazo, Eva Boland, Andrew Garnham, Robyn M. Murphy, Sean L. Mcgee, Mark Hargreaves

Faculty of Health Sciences Publications

To examine the effect of acute and chronic exercise on adipose tissue GLUT4 expression, a total of 20 healthy, male subjects performed one of two studies. Ten subjects performed cycle ergometer exercise for 60 min at 73 ± 2% VO2 peak and abdominal adipose tissue samples were obtained immediately before and after exercise and after 3 h of recovery. Another 10 subjects completed 10 days of exercise training, comprising a combination of six sessions of 60 min at 75% VO2 peak and four sessions of 6 × 5 min at 90% VO2 peak, separated by 3 min at 40% VO2 peak. Abdominal ...


Trunk Exercises Improve Gait Symmetry In Parkinson Disease: A Blind Phase Ii Randomised-Controlled Trial [Accepted Manuscript], Ryan P. Hubble, Geraldine Naughton, Peter A. Silburn, Michael H. Cole Jan 2018

Trunk Exercises Improve Gait Symmetry In Parkinson Disease: A Blind Phase Ii Randomised-Controlled Trial [Accepted Manuscript], Ryan P. Hubble, Geraldine Naughton, Peter A. Silburn, Michael H. Cole

Faculty of Health Sciences Publications

Objective: Deficits in step-to-step symmetry and trunk muscle activations have been linked to falls in Parkinson disease. Given such symptoms are poorly managed with anti-parkinsonian medications, alternate therapies are needed. This blind phase II randomized controlled trial sought to establish whether exercise can improve step-to-step symmetry in Parkinson disease. Design: Twenty-four Parkinson disease patients with a falls history completed baseline assessments of symptom severity, balance confidence, mobility, and quality of life. Step-to-step symmetry was assessed by deriving harmonic ratios from three-dimensional accelerations collected for the head and trunk. Patients were randomly assigned to either 12 wks of exercise and falls ...


Feasibility And Preliminary Efficacy Of A 10-Week Resistance And Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment In Rectal Cancer Patients, Favil Singh, Daniel A. Galvão, Robert U. Newton, Nigel A. Spry, Michael K. Baker, Dennis R. Taaffe Jan 2018

Feasibility And Preliminary Efficacy Of A 10-Week Resistance And Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment In Rectal Cancer Patients, Favil Singh, Daniel A. Galvão, Robert U. Newton, Nigel A. Spry, Michael K. Baker, Dennis R. Taaffe

Faculty of Health Sciences Publications

Background: Neoadjuvant chemoradiation treatment (CRT) in rectal cancer patients is associated with a reduction in physical capacity, lean mass and increased fatigue. As a countermeasure to these treatment-related adverse effects, we examined the feasibility and preliminary efficacy of a 10-week exercise program during CRT. Methods: Ten rectal cancer patients (7 men, aged 27-70 years, body mass index = 26.4 ± 3.8 kg/m2) receiving CRT undertook supervised resistance and aerobic exercise twice weekly. Assessments were undertaken pre- and post-intervention for upper and lower body muscle strength by 1-RM, muscle endurance, physical performance tests, body composition by dual X-ray absorptiometry, quality ...


Targeting Reductions In Sitting Time To Increase Physical Activity And Improve Health [Accepted Manuscript], Sarah K. Keadle, David E. Conroy, Matthew P. Buman, David Wayne Dunstan, Charles E. Matthews Aug 2017

Targeting Reductions In Sitting Time To Increase Physical Activity And Improve Health [Accepted Manuscript], Sarah K. Keadle, David E. Conroy, Matthew P. Buman, David Wayne Dunstan, Charles E. Matthews

Faculty of Health Sciences Publications

New evidence suggests that reductions in sedentary behavior may increase physical activity and improve health. These findings point to new behavioral targets for intervention and new ways to think about intervening to increase overall physical activity in the population. This report provides a knowledge update reflecting the rapid accumulation of new evidence related to sedentary behavior and health among adults. Recent observational studies suggest that leveraging the time-inverse relationship between sedentary and active behaviors by replacing sitting with standing, light- or moderate-intensity activity can have important health benefits, particularly among less active adults. Clinical studies are providing evidence of the ...


Autophagy And Protein Turnover Responses To Exercise-Nutrient Interactions In Human Skeletal Muscle, William J. Smiles Jun 2017

Autophagy And Protein Turnover Responses To Exercise-Nutrient Interactions In Human Skeletal Muscle, William J. Smiles

Theses

Skeletal muscle is a dynamic tissue comprising the largest protein reservoir of the human body with a rate of turnover of ~1-2% per day. Protein turnover is regulated by the coordination of intracellular systems regulating protein synthesis and breakdown that converge in a spatiotemporal manner on lysosomal organelles responsible for integrating a variety of contractile and nutritional stimuli. One such system, autophagy, which literally means to ‘self-eat,’ involves capturing of cellular material for deliver to, and disintegration by, the lysosome. The autophagic ‘cargo’ is subsequently recycled for use in synthetic reactions and thus maintenance of protein balance. As a dynamic ...


Implementing Exercise In Cancer Care: Study Protocol To Evaluate A Community-Based Exercise Program For People With Cancer, Prue Cormie, Stephanie Lamb, Robert U. Newton, Lani Valentine, Sandy Mckiernan, Nigel Spry, David Joseph, Dennis R. Taaffe, Christopher M. Doran, Daniel A. Galvão Jan 2017

Implementing Exercise In Cancer Care: Study Protocol To Evaluate A Community-Based Exercise Program For People With Cancer, Prue Cormie, Stephanie Lamb, Robert U. Newton, Lani Valentine, Sandy Mckiernan, Nigel Spry, David Joseph, Dennis R. Taaffe, Christopher M. Doran, Daniel A. Galvão

Faculty of Health Sciences Publications

Background: Clinical research has established the efficacy of exercise in reducing treatment-related side-effects and increasing wellbeing in people with cancer. Major oncology organisations have identified the importance of incorporating exercise in comprehensive cancer care but information regarding effective approaches to translating evidence into practice is lacking. This paper describes the implementation of a community-based exercise program for people with cancer and the protocol for program evaluation. Methods/Design: The Life Now Exercise program is a community-based exercise intervention designed to mitigate and rehabilitate the adverse effects of cancer and its treatment and improve physical and psychosocial wellbeing in people with ...


Striated Muscle Activator Of Rho Signalling (Stars) Is Reduced In Ageing Human Skeletal Muscle And Targeted By Mir-628-5p, Andrew Russell, M. A. Wallace, M. Kalanon, Evelyn Zacharewicz, P. A.D. Gatta, Andrew Garnham, Séverine Lamon Jan 2017

Striated Muscle Activator Of Rho Signalling (Stars) Is Reduced In Ageing Human Skeletal Muscle And Targeted By Mir-628-5p, Andrew Russell, M. A. Wallace, M. Kalanon, Evelyn Zacharewicz, P. A.D. Gatta, Andrew Garnham, Séverine Lamon

Faculty of Health Sciences Publications

Aim: The striated muscle activator of Rho signalling (STARS) is a muscle-specific actin-binding protein. The STARS signalling pathway is activated by resistance exercise and is anticipated to play a role in signal mechan-otransduction. Animal studies have reported a negative regulation of STARS signalling with age, but such regulation has not been investigated in humans. Methods: Ten young (18–30 years) and 10 older (60–75 years) subjects completed an acute bout of resistance exercise. Gene and protein expres-sion of members of the STARS signalling pathway and miRNA expression of a subset of miRNAs, predicted or known to target members of ...


Changes In Physical Activity And Sedentary Behavior Associated With An Exercise Intervention In Depressed Adults, Björg Helgadottir, Neville Owen, David Dunstan, Örjan Ekblom, Mats A. Hallgren, Yvonne Forsell Jan 2017

Changes In Physical Activity And Sedentary Behavior Associated With An Exercise Intervention In Depressed Adults, Björg Helgadottir, Neville Owen, David Dunstan, Örjan Ekblom, Mats A. Hallgren, Yvonne Forsell

Faculty of Health Sciences Publications

Background: Exercise is beneficial for depression, but less is known about its impact on post-intervention physical activity and sedentary behavior. The aim of this paper was to determine the extent to which participation in light-, moderate- and vigorous-intensity exercise intervention influenced habitual physical activity and sedentary behavior patterns in depressed adults. Methods: Accelerometer data was collected pre- and post-intervention from depressed participants randomized to one of three 12-week intervention groups: light (n ¼ 21), moderate (n ¼ 25) and vigorous (n ¼ 22) exercise. Mixed models examined changes in time spent sedentary and in light and moderateto- vigorous physical activity ...


Effects Of Different Exercise Modalities On Fatigue In Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Year-Long Randomised Controlled Trial, Dennis R. Taaffe, Robert U. Newton, Nigel A. Spry, David Joseph, Suzanne K. Chambers, Robert Alexander Gardiner, Bradley Alan Wall, Prue Cormie, Kate Bolam, Daniel A. Galvao Jan 2017

Effects Of Different Exercise Modalities On Fatigue In Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Year-Long Randomised Controlled Trial, Dennis R. Taaffe, Robert U. Newton, Nigel A. Spry, David Joseph, Suzanne K. Chambers, Robert Alexander Gardiner, Bradley Alan Wall, Prue Cormie, Kate Bolam, Daniel A. Galvao

Faculty of Health Sciences Publications

Background: Physical exercise mitigates fatigue during androgen deprivation therapy (ADT); however, the effects of different exercise prescriptions are unknown. Objectives: To determine the long-term effects of different exercise modes on fatigue in prostate cancer patients undergoing ADT. Design, setting, and participants: Between 2009 and 2012, 163 prostate cancer patients aged 43–90 y on ADT were randomised to exercise targeting the musculoskeletal system (impact loading + resistance training; ILRT; n = 58), the cardiovascular and muscular systems (aerobic + resistance training; ART; n = 54), or to usual care/delayed exercise (DEL; n = 51) for 12 mo across university-affiliated exercise clinics in Australia. Intervention ...


Feasibility Of Presurgical Exercise In Men With Prostate Cancer Undergoing Prostatectomy, Favil Singh, Robert U. Newton, Michael K. Baker, Nigel A. Spry, Dennis R. Taaffe, Jeffery Thavaseelan, Daniel A. Galvão Jan 2017

Feasibility Of Presurgical Exercise In Men With Prostate Cancer Undergoing Prostatectomy, Favil Singh, Robert U. Newton, Michael K. Baker, Nigel A. Spry, Dennis R. Taaffe, Jeffery Thavaseelan, Daniel A. Galvão

Faculty of Health Sciences Publications

Background: Prostatectomy is associated with short- and long-term morbidity, which includes attenuation of muscle function and deterioration of lean body mass. Physical function is a known predictor of morbidity and mortality, with initial evidence indicating that presurgical exercise is associated with fewer postsurgical complications and shorter hospitalization. The aim was to determine the feasibility of a supervised presurgical exercise program for prostate cancer (PCa) patients scheduled for prostatectomy. Methods: Ten men (68+6.4 years old) with localized PCa undertook a 6-week resistance and aerobic exercise program prior surgery. Training was undertaken twice weekly and patients were assessed at baseline ...


A Single Dose Of Prednisolone As A Modulator Of Undercarboxylated Osteocalcin And Insulin Sensitivity Post-Exercise In Healthy Young Men: A Study Protocol, Itamar Levinger, Tara C. Brennan-Speranza, Nigel K. Stepto, George Jerums, Lewan Parker, Glenn K. Mcconell, Mitchell Anderson, Andrew Garnham, David L. Hare, Peter R. Ebeling, Ego Seeman Jan 2016

A Single Dose Of Prednisolone As A Modulator Of Undercarboxylated Osteocalcin And Insulin Sensitivity Post-Exercise In Healthy Young Men: A Study Protocol, Itamar Levinger, Tara C. Brennan-Speranza, Nigel K. Stepto, George Jerums, Lewan Parker, Glenn K. Mcconell, Mitchell Anderson, Andrew Garnham, David L. Hare, Peter R. Ebeling, Ego Seeman

Faculty of Health Sciences Publications

Background: Undercarboxylated osteocalcin (ucOC) increases insulin sensitivity in mice. In humans, data are supportive, but the studies are mostly cross-sectional. Exercise increases whole-body insulin sensitivity, in part via ucOC, while acute glucocorticoid treatment suppresses ucOC in humans and mice. Objectives: A single dose of prednisolone reduces the rise in ucOC produced by exercise, which partly accounts for the failed increase in insulin sensitivity following exercise. Methods: Healthy young men (n=12) aged 18 to 40 years will be recruited. Initial assessments will include analysis of fasting blood, body composition, aerobic power (VO2peak), and peak heart rate. Participants will then be ...


Effect Of Motor Control Training On Hip Muscles In Elite Football Players With And Without Low Back Pain [Accepted Manuscript], Marianne Dilani Mendis, Julie Anne Hides Jan 2016

Effect Of Motor Control Training On Hip Muscles In Elite Football Players With And Without Low Back Pain [Accepted Manuscript], Marianne Dilani Mendis, Julie Anne Hides

Faculty of Health Sciences Publications

Objectives: Previous research has shown that motor control training improved size and function of trunk muscles in elite football players with and without low back pain (LBP). Imbalances in hip muscles have been found in athletes with LBP and it is not known if motor control training can change these muscles. This study investigated if a motor control intervention program affected hip muscle size in elite football players with and without LBP. Design: Panel-randomised intervention design. Methods: Forty-six players from one club in the Australian Football League (AFL) participated in a motor control training program delivered across the season as ...


Recruitment Of Older Adults With Type 2 Diabetes Into A Community-Based Exercise And Nutrition Randomised Controlled Trial, Eliza G. Miller, Caryl A. Nowson, David Wayne Dunstan, Deborah A. Kerr, Vicky Solah, David Menzies, Robin M. Daly Jan 2016

Recruitment Of Older Adults With Type 2 Diabetes Into A Community-Based Exercise And Nutrition Randomised Controlled Trial, Eliza G. Miller, Caryl A. Nowson, David Wayne Dunstan, Deborah A. Kerr, Vicky Solah, David Menzies, Robin M. Daly

Faculty of Health Sciences Publications

Background Recruitment of participants into long-term community-based lifestyle intervention trials, particularly adults with a chronic disease, is often slow and challenging. Currently there is limited data on successful recruitment strategies suitable for older adults with type 2 diabetes into community-based exercise and nutrition programs, and no information on cost estimates associated with such recruitment. The aim of this report is to describe the recruitment strategies used and the success of each approach in recruiting older adults with type 2 diabetes into a 6-month community-based exercise and nutritional supplementation randomised controlled trial (RCT). A secondary aim is to assess the costs ...


Physiotherapy For Cystic Fibrosis In Australia And New Zealand: A Clinical Practice Guideline, Brenda M. Button, Christine Wilson, Ruth Dentice, Narelle S. Cox, Anna Middleton, Esta Tannenbaum, Jennifer Bishop, Robyn Cobb, Kate Burton, Michelle Wood, Fiona Moran, Ryan Black, Summar Bowen, Rosemary Day, Julie Depiazzi, Katherine Doiron, Michael Doumit, Tiffany Dwyer, Alison Elliot, Louise Fuller, Kathleen Hall, Matthew Hutchins, Melinda Kerr, Annemarie L. Lee, Christina Mans, Lauren O'Connor, Ranjana Steward, Angela Potter, Tshepo Rasekaba, Rebecca Scoones, Ben Tarrant, Nathan Ward, Samantha West, Dianne White, Lisa Wilson, Jamie Wood, Anne E. Holland Jan 2016

Physiotherapy For Cystic Fibrosis In Australia And New Zealand: A Clinical Practice Guideline, Brenda M. Button, Christine Wilson, Ruth Dentice, Narelle S. Cox, Anna Middleton, Esta Tannenbaum, Jennifer Bishop, Robyn Cobb, Kate Burton, Michelle Wood, Fiona Moran, Ryan Black, Summar Bowen, Rosemary Day, Julie Depiazzi, Katherine Doiron, Michael Doumit, Tiffany Dwyer, Alison Elliot, Louise Fuller, Kathleen Hall, Matthew Hutchins, Melinda Kerr, Annemarie L. Lee, Christina Mans, Lauren O'Connor, Ranjana Steward, Angela Potter, Tshepo Rasekaba, Rebecca Scoones, Ben Tarrant, Nathan Ward, Samantha West, Dianne White, Lisa Wilson, Jamie Wood, Anne E. Holland

Faculty of Health Sciences Publications

Physiotherapy management is a key element of care for people with cystic fibrosis (CF) throughout the lifespan. Although considerable evidence exists to support physiotherapy management of CF, there is documented variation in practice. The aim of this guideline is to optimize the physiotherapy management of people with CF in Australia and New Zealand. A systematic review of the literature in key areas of physiotherapy practice for CF was undertaken. Recommendations were formulated based on National Health and Medical Research Council (Australia) guidelines and considered the quality, quantity and level of the evidence; the consistency of the body of evidence; the ...


Proposal For A Candidate Core Set Of Fitness And Strength Tests For Patients With Childhood Or Adult Idiopathic Inflammatory Myopathies [Accepted Manuscript], Djamilla K. D. Van Der Stap, Lisa G. Rider, Helene Alexanderson, Adam M. Huber, Bruno Gualano, Patrick Gordon, Janjaap Van Der Net, Pernille Mathiesen, Liam G. Johnson, Floranne C. Ernste, Brian M. Feldman, Kristin M. Houghton, Davinder Singh-Grewal, Abraham Garcia Kutzbach, Li Alemo Munters, Tim Takken Jan 2016

Proposal For A Candidate Core Set Of Fitness And Strength Tests For Patients With Childhood Or Adult Idiopathic Inflammatory Myopathies [Accepted Manuscript], Djamilla K. D. Van Der Stap, Lisa G. Rider, Helene Alexanderson, Adam M. Huber, Bruno Gualano, Patrick Gordon, Janjaap Van Der Net, Pernille Mathiesen, Liam G. Johnson, Floranne C. Ernste, Brian M. Feldman, Kristin M. Houghton, Davinder Singh-Grewal, Abraham Garcia Kutzbach, Li Alemo Munters, Tim Takken

Faculty of Health Sciences Publications

Objective. Currently there are no evidence-based recommendations regarding fitness and strength tests for patients with childhood or adult idiopathic inflammatory myopathies (IIM). This hinders clinicians and researchers in choosing the appropriate fitness- or muscle strength-related outcome measures for these patients. Through a Delphi survey, we aimed to identify a candidate core set of fitness and strength tests for children and adults with IIM. Methods. Fifteen experts participated in a Delphi survey that consisted of 5 stages to achieve a consensus. Using an extensive search of published literature and through the work of experts, a candidate core set based on expert ...


Exercise, Physical Activity, And Sedentary Behavior In The Treatment Of Depression: Broadening The Scientific Perspectives And Clinical Opportunities, Mats A. Hallgren, Matthew P. Herring, Neville Owen, David Wayne Dunstan, Örjan Ekblom, Björg Helgadottir, Olivia Aya Nakitanda, Yvonne Forsell Jan 2016

Exercise, Physical Activity, And Sedentary Behavior In The Treatment Of Depression: Broadening The Scientific Perspectives And Clinical Opportunities, Mats A. Hallgren, Matthew P. Herring, Neville Owen, David Wayne Dunstan, Örjan Ekblom, Björg Helgadottir, Olivia Aya Nakitanda, Yvonne Forsell

Faculty of Health Sciences Publications

Research exploring links between exercise and depression now span several decades, yet several clinically relevant research questions remain unanswered. This opinion article briefly describes the status of selected research issues from the exercise depression literature and offer insights into research areas that are currently lacking. We draw particular attention to the potential of research exploring links between sedentary behavior and depression.


Physical Activity, Television Viewing Time And 12-Year Changes In Waist Circumference, Ai Shibata, Koichiro Oka, Takemi Sugiyama, Jo Salmon, David Dunstan, Neville Owen Jan 2016

Physical Activity, Television Viewing Time And 12-Year Changes In Waist Circumference, Ai Shibata, Koichiro Oka, Takemi Sugiyama, Jo Salmon, David Dunstan, Neville Owen

Faculty of Health Sciences Publications

Purpose: Both moderate-to-vigorous physical activity (MVPA) and sedentary behavior can be associated with adult adiposity. Much of the relevant evidence is from cross-sectional studies or from prospective studies with relevant exposure measures at a single time point prior to weight gain or incident obesity. This study examined whether changes in MVPA and television (TV) viewing time are associated with subsequent changes in waist circumference, using data from three separate observation points in a large population-based prospective study of Australian adults.

Methods: Data were obtained from the Australian Diabetes, Obesity and Lifestyle study collected in 1999-2000 (baseline), 2004–05 (Wave 2 ...


Resistance Exercise Augments Postprandial Overnight Muscle Protein Synthesis Rates [Accepted Manuscript], Jorn Trommelen, Andrew M. Holwerda, Imre W. K. Kouw, Henning Langer, Shona L. Halson, Lex B. Verdijk, Luc J. C. Van Loon Jan 2016

Resistance Exercise Augments Postprandial Overnight Muscle Protein Synthesis Rates [Accepted Manuscript], Jorn Trommelen, Andrew M. Holwerda, Imre W. K. Kouw, Henning Langer, Shona L. Halson, Lex B. Verdijk, Luc J. C. Van Loon

Faculty of Health Sciences Publications

Introduction: We have previously shown that protein ingestion before sleep increases overnight muscle protein synthesis rates. Whether prior exercise further augments the muscle protein synthetic response to presleep protein ingestion remains to be established.

Objective: This study aimed to assess whether resistance-type exercise performed in the evening increases the overnight muscle protein synthetic response to presleep protein ingestion.

Methods: Twenty-four healthy young men were randomly assigned to ingest 30 g intrinsically L-[1-13C]-phenylalanine and L-[1-13C]-leucine-labeled casein protein before going to sleep with (PRO + EX, n = 12) or without (PRO, n = 12) prior resistance-type exercise performed in the ...


High Intensity Interval Training Improves Liver And Adipose Tissue Insulin Sensitivity, Katarina Marcinko, Sarah R. Sikkema, M. Constantine Samaan, Bruce Ernest Kemp, Morgan D. Fullerton, Gregory R. Steinberg Jan 2015

High Intensity Interval Training Improves Liver And Adipose Tissue Insulin Sensitivity, Katarina Marcinko, Sarah R. Sikkema, M. Constantine Samaan, Bruce Ernest Kemp, Morgan D. Fullerton, Gregory R. Steinberg

Faculty of Health Sciences Publications

Objective: Endurance exercise training reduces insulin resistance, adipose tissue inflammation and non-alcoholic fatty liver disease (NAFLD), an effect often associated with modest weight loss. Recent studies have indicated that high-intensity interval training (HIIT) lowers blood glucose in individuals with type 2 diabetes independently of weight loss; however, the organs affected and mechanisms mediating the glucose lowering effects are not known. Intense exercise increases phosphorylation and inhibition of acetyl-CoA carboxylase (ACC) by AMP-activated protein kinase (AMPK) in muscle, adipose tissue and liver. AMPK and ACC are key enzymes regulating fatty acid metabolism, liver fat content, adipose tissue inflammation and insulin sensitivity ...