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Full-Text Articles in Medicine and Health Sciences

White Matter Organization In Developmental Coordination Disorder: A Pilot Study Exploring The Added Value Of Constrained Spherical Deconvolution, Christian Hyde, Ian Fuelscher, Peter G. Enticott, Derek K. Jones, Shawna Farquharson, Tim J. Silk, Jacqueline Williams, Karen Caeyenberghs Jan 2019

White Matter Organization In Developmental Coordination Disorder: A Pilot Study Exploring The Added Value Of Constrained Spherical Deconvolution, Christian Hyde, Ian Fuelscher, Peter G. Enticott, Derek K. Jones, Shawna Farquharson, Tim J. Silk, Jacqueline Williams, Karen Caeyenberghs

Faculty of Health Sciences Publications

Previous studies of white matter organization in sensorimotor tracts in developmental coordination disorder (DCD) have adopted diffusion tensor imaging (DTI), a method unable to reconcile pathways with ‘crossing fibres’. In response to limitations of the commonly adopted DTI approach, the present study employed a framework that can reconcile the ‘crossing fibre’ problem (i.e., constrained spherical deconvolution- CSD) to characterize white matter tissue organization of sensorimotor tracts in young adults with DCD. Participants were 19 healthy adults aged 18–46: 7 met diagnostic criteria for DCD (4 females) and 12 were controls (3 females). All underwent high angular diffusion MRI ...


Effects Of Sacubitril/Valsartan Versus Irbesartan In Patients With Chronic Kidney Disease: A Randomised Double-Blind Trial [Accepted Manuscript], Richard Hayes, Parminder K. Judge, Natalie Staplin, William G. Herrington, Benjamin C. Storey, Angelyn M. Bethel, Louise Bowman, Nigel Brunskill, Paul Cockwell, Michael Hill, Philip A. Kalra, John J. V. Mcmurray, Maarten Taal, David C. Wheeler, Martin J. Landray, Colin Baigent Oct 2018

Effects Of Sacubitril/Valsartan Versus Irbesartan In Patients With Chronic Kidney Disease: A Randomised Double-Blind Trial [Accepted Manuscript], Richard Hayes, Parminder K. Judge, Natalie Staplin, William G. Herrington, Benjamin C. Storey, Angelyn M. Bethel, Louise Bowman, Nigel Brunskill, Paul Cockwell, Michael Hill, Philip A. Kalra, John J. V. Mcmurray, Maarten Taal, David C. Wheeler, Martin J. Landray, Colin Baigent

Faculty of Health Sciences Publications

BACKGROUND: Sacubitril/valsartan reduces the risk of cardiovascular mortality among patients with heart failure with reduced ejection fraction, but its effects on kidney function and cardiac biomarkers in people with moderate to severe chronic kidney disease are unknown. METHODS: The UK HARP-III trial (United Kingdom Heart and Renal Protection-III), a randomized double-blind trial, included 414 participants with an estimated glomerular filtration rate (GFR) 20 to 60 mL/min/1.73 m2 who were randomly assigned to sacubitril/valsartan 97/103 mg twice daily versus irbesartan 300 mg once daily. The primary outcome was measured GFR at 12 months using ANCOVA ...


Exploring Health Education Delivered To Patients With Acute Coronary Syndrome And Type 2 Diabetes Mellitus Admitted To A Shanghai Hospital, Xian-Liang Liu Oct 2018

Exploring Health Education Delivered To Patients With Acute Coronary Syndrome And Type 2 Diabetes Mellitus Admitted To A Shanghai Hospital, Xian-Liang Liu

Theses

Introduction

Patients with both acute coronary syndrome (ACS) and type 2 diabetes mellitus (T2DM) are the focus of this thesis. Together these conditions represent a substantial burden of illness within Western and now Eastern countries. Patients presenting with multiple conditions are frequently encountered within clinical practice, with often poorer clinical outcomes than those with a single condition. The challenge of delivering health education is substantial when patients experience two or more health conditions. Within China, health education is provided principally during the acute admission period, often for ACS. In this unique cultural setting, there has been little research about the ...


Improving Analogical Reasoning Skills In Adolescence Through Figurative Music Lyric Exposure: Towards Better Decision-Making Skills, Shannon S. Clark Jul 2018

Improving Analogical Reasoning Skills In Adolescence Through Figurative Music Lyric Exposure: Towards Better Decision-Making Skills, Shannon S. Clark

Theses

Adolescents are known through both anecdotal and empirical research to be poor descision-makers; especially when risk is involved. Numerous factors are highlighted as influential to descision-making in adolescence; however, no complete understanding has been offered despite the endeavour. Understanding is suggested to be key to decision-making, and analogical reasoning is key to understanding. In addition, figurative-language comprehension skills are reported to be practically identical in their neurological mapping as analogical reasoning skills. Furthermore, lyrical music can be heavily represented by figurative language; and adolescents are exposed to lyrical musical for up to a quarter of their waking days. The existing ...


Tackling Ability In Rugby League Players: A Strength And Conditioning Perspective, Michael Speranza Jul 2018

Tackling Ability In Rugby League Players: A Strength And Conditioning Perspective, Michael Speranza

Theses

Rugby league is a collision sport that is intermittent in nature, characterised by bouts of high intensity running, collisions and tackling, separated by periods of lower intensity activity. Success in the sport requires a multifaceted skillset with players requiring good ball handling ability, quick and accurate decision making, and the ability to perform effective tackles.

A large part of success in a collision sport such as rugby league is based on player’s ability to execute proficient and effective tackles, the ability to dominate the tackle contest, and the capacity to tolerate physical impacts. While the tackle contest is a ...


Improving Screening And Physiotherapy Management Of Vestibular Disorders In The Hospital Setting, Vicky Stewart Jun 2018

Improving Screening And Physiotherapy Management Of Vestibular Disorders In The Hospital Setting, Vicky Stewart

Theses

Vestibular disorders significantly impact a person’s quality of life and daily function with symptoms such as dizziness, vertigo, visual disturbances and balance impairment. Vestibular disorders commonly cause hospital presentations and are often under diagnosed and therefore mis-managed in the emergency department (ED) and acute medical environment (AME). There is a lack of research assisting clinicians in identifying and managing vestibular disorders in these settings. There is also limited evidence concerning the effectiveness of a physiotherapy vestibular service in the acute hospital setting for managing non-emergent vestibular disorders (non-life threatening).

The primary aim of this thesis was to improve the ...


The Contribution Of The Neighbourhood Environment To The Relationship Between Neighbourhood Disadvantage And Physical Function Among Middle-Aged To Older Adults, Hui Yee Loh Jun 2018

The Contribution Of The Neighbourhood Environment To The Relationship Between Neighbourhood Disadvantage And Physical Function Among Middle-Aged To Older Adults, Hui Yee Loh

Theses

Background

With the continuing increases in life expectancies in developed countries, an important public health goal is to ensure successful ageing—morbidity compression, maintenance of physical functioning and active engagement in life. It is well established that the onset of physical function decline begins in mid-life, and functional capacity is critical to maintaining mobility, independence and quality of life. A growing body of literature has found that residents of more disadvantaged neighbourhoods have significantly poorer physical function, independent of individual-level factors. However, the mechanisms through which neighbourhood environments are associated with this relationship remain largely unknown.

The overarching aim of ...


Changes In Waist Circumference Independent Of Weight: Implications For Population Level Monitoring Of Obesity [Accepted Manuscript], Emma Gearon, Stephanie K. Tanamas, Christopher Stevenson, Venurs Hui Yee Loh, Anna Peters Jun 2018

Changes In Waist Circumference Independent Of Weight: Implications For Population Level Monitoring Of Obesity [Accepted Manuscript], Emma Gearon, Stephanie K. Tanamas, Christopher Stevenson, Venurs Hui Yee Loh, Anna Peters

Faculty of Health Sciences Publications

ing of obesity is most commonly conducted using body mass index (BMI). We test the hypothesis that because of increases in waist circumference (WC) independent of increases in weight, BMI alone detects an increasingly smaller proportion of the population with obesity. Methods: Australian adults with measured height, weight, and WC were selected from three nationally representative cross-sectional surveys (1989, 1999–2000, 2011–12; n = 8313, 5903 & 3904). Participants were defined as having obesity using classifications for an obese BMI (≥ 30 kg·m− 2) and substantially-increased-risk WC (≥ 88 cm [women], ≥ 102 cm [men]). Age-standardised prevalence of obesity according to BMI and ...


High Dietary Fat Intake Increases Fat Oxidation And Reduces Skeletal Muscle Mitochondrial Respiration In Trained Humans [Accepted Manuscript], Jill J. Leckey, Nolan J. Hoffman, Evelyn B. Parr, Brooke L. Devlin, Adam J. Trewin, Nigel K. Stepto, James P. Morton, Louise M. Burke, John A. Hawley Jun 2018

High Dietary Fat Intake Increases Fat Oxidation And Reduces Skeletal Muscle Mitochondrial Respiration In Trained Humans [Accepted Manuscript], Jill J. Leckey, Nolan J. Hoffman, Evelyn B. Parr, Brooke L. Devlin, Adam J. Trewin, Nigel K. Stepto, James P. Morton, Louise M. Burke, John A. Hawley

Faculty of Health Sciences Publications

High-fat, low-carbohydrate (CHO) diets increase whole-body rates of fat oxidation and down-regulate CHO metabolism. We measured substrate utilization and skeletal muscle mitochondrial respiration to determine whether these adaptations are driven by high fat or low CHO availability. In a randomized crossover design, 8male cyclists consumed5dof a high-CHO diet [>70%energy intake (EI)], followed by 5dof either an isoenergetic high-fat (HFAT; >65% EI) or high-protein diet (HPRO; >65% EI) with CHO intake clamped at


Clinical Oncology Society Of Australia Position Statement On Exercise In Cancer Care [Accepted Manuscript], Prue Cormie, Morgan Atkinson, Lucy Bucci, Anne Cust, Elizabeth Eakin, Sandra Hayes, Alexandra Mccarthy, Andrew Murnane, Sharni Patchell, Diana Adams May 2018

Clinical Oncology Society Of Australia Position Statement On Exercise In Cancer Care [Accepted Manuscript], Prue Cormie, Morgan Atkinson, Lucy Bucci, Anne Cust, Elizabeth Eakin, Sandra Hayes, Alexandra Mccarthy, Andrew Murnane, Sharni Patchell, Diana Adams

Faculty of Health Sciences Publications

Introduction: Clinical research has established exercise as a safe and effective intervention to counteract the adverse physical and psychological effects of cancer and its treatment. This article summarises the position of the Clinical Oncology Society of Australia (COSA) on the role of exercise in cancer care, taking into account the strengths and limitations of the evidence base. It provides guidance for all health professionals involved in the care of people with cancer about integrating exercise into routine cancer care.

Main recommendations: COSA calls for:

  • exercise to be embedded as part of standard practice in cancer care and to be viewed ...


Outdoor Play Decision-Making By Families, Schools, And Local Government For Children With Disabilities, Julia Sterman Apr 2018

Outdoor Play Decision-Making By Families, Schools, And Local Government For Children With Disabilities, Julia Sterman

Theses

Introduction: Play is a right for all children and an essential childhood occupation. Yet, children with disabilities experience exclusion from outdoor play participation. How children’ skills interact with the environment in which they live, notably their family, school, and community, shapes their play choice.

Aim: The aim of this study was to understand outdoor play decision-making at family, school, and local government levels for primary school-age children with disabilities. Method: A multiple-perspective case study allowed for comprehensive understanding of the phenomenon of outdoor play decision-making. Data collection included: interviews with five parents of children with disabilities, four teaching assistants, three ...


Decision-Making Impairment In Long Term Opiate Users, Kathryn Biernacki Mar 2018

Decision-Making Impairment In Long Term Opiate Users, Kathryn Biernacki

Theses

The overall aim of this PhD thesis was to conduct a comprehensive investigation of decision-making impairment in long term opiate users, using three studies. The first study aimed to determine the extent of the decision-making impairment and to establish whether other co-morbid factors impacted on the severity of this deficit. Using meta-analysis, the results indicated that opiate use is associated with relatively severe decision-making impairment, and that co-morbid factors, such as head injury and poly-substance dependence did not significantly change the magnitude of the impairment. Furthermore, the decision-making impairment in opiate users was not mitigated by abstinence, and the duration ...


Using A Randomised Controlled Trial To Test The Effectiveness Of A Family-Oriented, Theoretically Based, Diabetes Self-Management Education Program To Improve Glycaemia, Self-Management And Self-Efficacy Of Individuals With Type 2 Diabetes Mellitus Living In Rural Thailand, Nutchanath Wichit Mar 2018

Using A Randomised Controlled Trial To Test The Effectiveness Of A Family-Oriented, Theoretically Based, Diabetes Self-Management Education Program To Improve Glycaemia, Self-Management And Self-Efficacy Of Individuals With Type 2 Diabetes Mellitus Living In Rural Thailand, Nutchanath Wichit

Theses

Introduction

Diabetes is increasing in prevalence throughout the world. This increase is also of concern to upper-middle-income countries such as Thailand. Diabetes mellitus develops gradually and is often undetected in the early stages, leading to long-term damage of several organs in the body with related complications. Diabetes self-management education (DSME) has been found to improve knowledge, self-care behaviours, glycaemic control, and quality of life for Thai individuals with type 2 diabetes mellitus (T2DM). Thailand is a country in which family members have a fundamental role in assisting other family members in sickness and in health. Family-oriented interventions, therefore, have the ...


Hamstring Strain Injury: Objective Assessment Tools And Exercise-Specific Progression Criteria During Pain-Threshold Rehabilitation, Jack Thomas Hickey Mar 2018

Hamstring Strain Injury: Objective Assessment Tools And Exercise-Specific Progression Criteria During Pain-Threshold Rehabilitation, Jack Thomas Hickey

Theses

Hamstring strain injury (HSI) is a persistent cause of time lost in sports that involve high speed running. Clinicians working with sports injuries are therefore often faced with the task of HSI rehabilitation, with the simultaneous aims of minimising time to return to play (RTP) and risk of re-injury. Following rehabilitation and RTP clearance, previously injured hamstrings display elevated risk of re-injury likely, in part, due to persistent deficits in eccentric knee flexor strength and biceps femoris long head (BFlh) fascicle length. Elevated re-injury risk and persistent deficits in hamstring muscle structure and function suggest inadequacies in current rehabilitation practices ...


The Prevalence And Impact Of Low Back Pain In Pre-Professional And Professional Dancers: A Prospective Study [Accepted Manuscript], Christopher T. V. Swain, Elizabeth J. Bradshaw, Douglas G. Whyte, Christina L. Ekegren Mar 2018

The Prevalence And Impact Of Low Back Pain In Pre-Professional And Professional Dancers: A Prospective Study [Accepted Manuscript], Christopher T. V. Swain, Elizabeth J. Bradshaw, Douglas G. Whyte, Christina L. Ekegren

Faculty of Health Sciences Publications

Objectives To determine the prevalence of low back pain (LBP) in pre-professional and professional dancers and its impact on dance participation, care-seeking and medication use. Design Prospective cohort study. Setting One pre-professional ballet school, two pre-professional university dance programs, and a professional ballet company. Participants Male and female classical ballet and contemporary dancers. Main outcome measures An initial questionnaire collected demographic and LBP history data. The monthly prevalence of LBP (all episodes, activity limiting episodes and chronic LBP) and impact (activity limitation, care-seeking, and medication use) was collected over a nine-month period. Results 119 dancers participated, which represented 54% of ...


The Epidemiology Of Hip Fractures Across Western Victoria, Australia [Accepted Manuscript], Kara L. Holloway, Muhammad A. Sajjad, Mohammadreza Mohebbi, Mark A. Kotowicz, Patricia M. Livingston, Mustafa Khasraw, Sharon Hakkennes, Trisha L. Dunning, Susan Brumby, Richard S. Page, Daryl Pedler, Alasdair Sutherland, Svetha Venkatesh, Sharon L. Brennan Mar 2018

The Epidemiology Of Hip Fractures Across Western Victoria, Australia [Accepted Manuscript], Kara L. Holloway, Muhammad A. Sajjad, Mohammadreza Mohebbi, Mark A. Kotowicz, Patricia M. Livingston, Mustafa Khasraw, Sharon Hakkennes, Trisha L. Dunning, Susan Brumby, Richard S. Page, Daryl Pedler, Alasdair Sutherland, Svetha Venkatesh, Sharon L. Brennan

Faculty of Health Sciences Publications

Background Hip fractures are associated with considerable morbidity and mortality. Hip fracture incidence varies across different levels of accessibility/remoteness and socioeconomic status (SES). As part of the Ageing, Chronic Disease and Injury Study, we aimed to map the pattern of hip fractures across the western region of the Australian state of Victoria, which contains a range of remoteness levels and SES. Methods Data on hip fractures resulting in hospital admission were extracted from the Victorian Admitted Episodes Dataset (VAED) for men and women aged 40 + years during 2010–2013 inclusive. An age-adjusted incidence rate (per 10,000 population/year ...


Evaluation Of The Impact Of A Personalised Post-Donation Sms On The Retention Of Whole Blood Donors [Accepted Manuscript], Carley N. Gemelli, Alison Carver, Alana Garn, Stephen T. Wright, Tanya E. Davison Mar 2018

Evaluation Of The Impact Of A Personalised Post-Donation Sms On The Retention Of Whole Blood Donors [Accepted Manuscript], Carley N. Gemelli, Alison Carver, Alana Garn, Stephen T. Wright, Tanya E. Davison

Faculty of Health Sciences Publications

BACKGROUND: Short messaging service (SMS) is routinely used by blood collection agencies to remind donors about appointments but has been applied less frequently in interventions to increase return behavior. This study aimed to investigate whether receipt of a personalized postdonation SMS promoted donor retention. STUDY DESIGN AND METHODS: A postdonation SMS was sent to 2605 whole blood donors who had donated at one of six donor centers in Australia from April to July 2015 and left without making a forward appointment. Once their donation was dispatched to ahospital or facility an SMS was sent informing the donor of the hospital ...


Adherence Of Allied Health Clinicians To The Stroke Foundation Clinical Guidelines For Management Of Stroke (2010): A Retrospective Clinical Record Audit Of Both Acute And Rehabilitation Services., Philip Thomas Abery Feb 2018

Adherence Of Allied Health Clinicians To The Stroke Foundation Clinical Guidelines For Management Of Stroke (2010): A Retrospective Clinical Record Audit Of Both Acute And Rehabilitation Services., Philip Thomas Abery

Theses

In 2012, stroke affected over 420 000 people within Australia and the number of stroke survivors is anticipated to increase. Many stroke survivors live with a disability which affects their ability to carry out activities of daily living. In Australia stroke survivors are cared for by both publicly and privately funded hospitals. Available to both systems are the Stroke Foundation Clinical Guidelines for the Management of Stroke Survivors (SF 2010a). The Stroke Foundation carries out biannual national audits in Australia, one focusing on acute services and the other on rehabilitation services, to determine hospitals’ quality of care in accordance with ...


Self-Compassion Moderates The Link Between Perfectionism And Depression Link In Both Adolescence And Adulthood, Madeleine Ferrari, Keong Yap, Nicole Scott, Danielle A. Einstein, Joseph Ciarrochi Feb 2018

Self-Compassion Moderates The Link Between Perfectionism And Depression Link In Both Adolescence And Adulthood, Madeleine Ferrari, Keong Yap, Nicole Scott, Danielle A. Einstein, Joseph Ciarrochi

Faculty of Health Sciences Publications

Background

Psychological practitioners often seek to directly change the form or frequency of clients' maladaptive perfectionist thoughts, because such thoughts predict future depression. Indirect strategies, such as self-compassion interventions, that seek to change clients' relationships to difficult thoughts, rather than trying to change the thoughts directly could be just as effective. This study aimed to investigate whether self-compassion moderated, or weakened, the relationship between high perfectionism and high depression symptoms in both adolescence and adulthood.

Methods

The present study utilised anonymous self-report questionnaires to assess maladaptive perfectionism, depression, and self-compassion across two samples covering much of the lifespan. Questionnaires were ...


An Exploration Of Three New South Wales Nurse Practitioner Services In 2008, S Jane Allnutt Feb 2018

An Exploration Of Three New South Wales Nurse Practitioner Services In 2008, S Jane Allnutt

Theses

Background

To control increasing health costs, the Australian government initiated a range of health care reforms in the late 1990s. In 2000, the development of the Nurse Practitioner (NP) Service in New South Wales (NSW) was one strategy implemented to improve health care delivery. Supported by legislation, NPs extended their role beyond other nursing roles. The number of NPs in NSW doubled between 2004 and 2007, and NP Services flourished. With little published evidence, research was vital to justify the contribution of this new and rapidly evolving service model to existing health services and the acceptability of the new service ...


More A Marathon Than A Hurdle: Towards Children’S Informed Consent In A Study On Safety [Accepted Manuscript], Tim Moore, Morag Mcarthur, Debbie Noble-Carr Feb 2018

More A Marathon Than A Hurdle: Towards Children’S Informed Consent In A Study On Safety [Accepted Manuscript], Tim Moore, Morag Mcarthur, Debbie Noble-Carr

Faculty of Health Sciences Publications

Informed consent is critical in research with children. Although much has been written about the need to see consent as an ongoing process, less has considered how to do it in practice. This article reflects on the authors’ experiences of conducting a piece of research focusing on children’s experiences of safety from abuse within institutional contexts. It draws on feedback provided by participants and the guidance of three Children’s Reference Groups. The importance of presenting information in accessible and appropriate ways, of providing opportunities for participants to negotiate their participation and for in-the-moment challenges be dealt with collaboratively ...


Higher Low-Density Lipoprotein Cholesterol Levels Are Associated With Decreased Mortality In Patients With Intracerebral Hemorrhage [Accepted Manuscript], Jason J. Chang, Aristeidis Katsanos, Yasser Khorchid, Kira Dillard, Ali Kerro, Lucia Goodwin Burgess, Nitin Goyal, Anne W. Alexandrov, Andrei V. Alexandrov, Georgios Tsivgoulis Feb 2018

Higher Low-Density Lipoprotein Cholesterol Levels Are Associated With Decreased Mortality In Patients With Intracerebral Hemorrhage [Accepted Manuscript], Jason J. Chang, Aristeidis Katsanos, Yasser Khorchid, Kira Dillard, Ali Kerro, Lucia Goodwin Burgess, Nitin Goyal, Anne W. Alexandrov, Andrei V. Alexandrov, Georgios Tsivgoulis

Faculty of Health Sciences Publications

Background and aims: The relationship between lipoprotein levels, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and clinical outcome after intracerebral hemorrhage (ICH) remains controversial. We sought to evaluate the association of lipoprotein cholesterol levels and statin dosage with clinical and neuroimaging outcomes in patients with ICH. Methods: Data on consecutive patients hospitalized with spontaneous acute ICH was prospectively collected over a 5-year period and retrospectively analyzed. Demographic characteristics, clinical severity documented by NIHSS-score and ICH-score, neuroimaging parameters, pre-hospital statin use and doses, and LDL-C and HDL-C levels were recorded. Outcome events characterized were hematoma volume, hematoma expansion, in-hospital functional ...


Perceptual-Motor Regulation In Locomotor Pointing While Approaching A Curb [Accepted Manuscript], Steven Van Andel, Michael H. Cole, Gert-Jan Pepping Feb 2018

Perceptual-Motor Regulation In Locomotor Pointing While Approaching A Curb [Accepted Manuscript], Steven Van Andel, Michael H. Cole, Gert-Jan Pepping

Faculty of Health Sciences Publications

Locomotor pointing is a task that has been the focus of research in the context of sport (e.g. long jumping and cricket) as well as normal walking. Collectively, these studies have produced abroad understanding of locomotor pointing, but generalizability has been limited to laboratory type tasks and/or tasks with high spatial demands. The current study aimed to generalize previous findings in locomotor pointing to the common daily task of approaching and stepping on to a curb. Sixteen people completed 33 repetitions of a task that required them to walk up to and step onto a curb. Information about ...


Demands Of The Kettlebell Snatch, James Alexander Ross Jan 2018

Demands Of The Kettlebell Snatch, James Alexander Ross

Theses

Kettlebell exercise has grown in popularity in the last decade. One of the exercises commonly performed is the kettlebell snatch, which is a key exercise within kettlebell sport. The kettlebell snatch involves swinging the kettlebell from between the legs to overhead in a continuous motion and is generally performed for multiple repetitions. In kettlebell sport the snatch is performed for up to ten minutes with only one hand change. A judge determines if the repetitions are performed correctly and allocates a point accordingly. Little research on the kettlebell snatch currently exists. When this thesis was started there was a single ...


The Combined Effect Of Training And Match Loads On Injury Risk In Professional Australian Footballers, Nicholas B. Murray Jan 2018

The Combined Effect Of Training And Match Loads On Injury Risk In Professional Australian Footballers, Nicholas B. Murray

Theses

Australian football is a dynamic team sport, which requires players to perform a large number of high-intensity efforts, combined with low-intensity activities throughout a match. Due to the complex and unique demands of the sport, players require an adequate training stimulus to develop and enhance the physical qualities required to succeed at the highest level. The ability to develop physically challenging but appropriate training at an individual level to 1) enhance the technical and physical qualities required, and 2) minimise the negative response to training (i.e. injury, illness, etc.) is a crucial task for practitioners involved in the preparation ...


Physical Qualities And Match Demands Of Female Australian Football, Georgia Black Jan 2018

Physical Qualities And Match Demands Of Female Australian Football, Georgia Black

Theses

Australian football (AF) is arguably the most popular sport in Australia, with over one million people participating in domestic AF annually. As participation rates have continued to rise, it is the growth of female AF that has drawn further attention to the sport in the last two years. Despite the introduction of the national women’s Australian football competition (AFLW) in 2017 and the 400,000 females who participate in recreational AF Australia-wide, there is currently no research to inform training practices. Although the physical match demands of elite male AF have been well established, the differences in physical qualities ...


Rationale And Protocol Of The Study Of Diabetic Nepropathy With Atrasentan (Sonar) Trial: A Clinical Trial Design Novel To Diabetic Nepropathy, Hiddo J. L. Heerspink, Dennis L. Andress, G. Bakris, John J. Brennan, Ricardo Correa-Rotter, Jyotirmoy Dey, Fan Fan Hou, Dalane W. Kitzman, Donald Kohan, Hirofumi Makino, John Mcmurray, Vlado Perkovic, Sheldon Tobe, Melissa Wigderson, Hans Henrik Parving, Dick De Zeeuw Jan 2018

Rationale And Protocol Of The Study Of Diabetic Nepropathy With Atrasentan (Sonar) Trial: A Clinical Trial Design Novel To Diabetic Nepropathy, Hiddo J. L. Heerspink, Dennis L. Andress, G. Bakris, John J. Brennan, Ricardo Correa-Rotter, Jyotirmoy Dey, Fan Fan Hou, Dalane W. Kitzman, Donald Kohan, Hirofumi Makino, John Mcmurray, Vlado Perkovic, Sheldon Tobe, Melissa Wigderson, Hans Henrik Parving, Dick De Zeeuw

Faculty of Health Sciences Publications

Aims
Individuals with diabetes and chronic kidney disease (CKD) are at high risk for renal events. Recent trials of novel treatments have been negative, possibly because of variability in response to treatment of the target risk factor. Atrasentan is a selective endothelin A receptor antagonist that reduces urinary albumin‐to‐creatinine ratio (UACR), with a large variability between patients. We are assessing its effect on renal outcomes in the Study Of diabetic Nephropathy with AtRasentan (SONAR; NCT01858532) with an enrichment design (>30% lowering of albuminuria) to select patients most likely to benefit.
Materials and Methods
SONAR is a randomized, double ...


Impact Of First Meal Size During Prolonged Sitting On Postprandial Glycaemia In Individuals With Prediabetes: A Randomised, Crossover Study, Evelyn Parr, Brooke Devlin, Samuel Pinto, David Dunstan, John Hawley Jan 2018

Impact Of First Meal Size During Prolonged Sitting On Postprandial Glycaemia In Individuals With Prediabetes: A Randomised, Crossover Study, Evelyn Parr, Brooke Devlin, Samuel Pinto, David Dunstan, John Hawley

Faculty of Health Sciences Publications

We compared the impact of a high versus low energy intake first meal on glucose and insulin responses during prolonged sitting in individuals with prediabetes. Thirteen adults with overweight/obesity and prediabetes (mean ± SD age: 60 ± 6 years, BMI: 33 ± 4 kg/m2; 2 h OGTT: 8.9 ± 1.1 mmol/L) completed two randomised trials: 10 h uninterrupted sitting, incorporating three meals with matching macronutrient compositions but different energy distributions: High-Energy Breakfast (HE-BF; breakfast: 50%, lunch: 30%, dinner: 20% energy intake), Low-Energy Breakfast (LE-BF: 20%/30%/50% energy intake). Venous blood was sampled from 08:00–18:00 h ...


Associations Of Total Amount And Patterns Of Objectively Measured Sedentary Behavior With Performance-Based Physical Function, Yung Liao, Hsiu-Hua Hsu, Ai Shibata, Kaori Ishii, Mohammad Javad Koohsari, Koichiro Oka Jan 2018

Associations Of Total Amount And Patterns Of Objectively Measured Sedentary Behavior With Performance-Based Physical Function, Yung Liao, Hsiu-Hua Hsu, Ai Shibata, Kaori Ishii, Mohammad Javad Koohsari, Koichiro Oka

Faculty of Health Sciences Publications

Although greater sedentary time has been found to be associated with negative health impacts, little is known whether the specific pattern of sedentary behavior (i.e. sedentary bouts, breaks and durations) are associated with physical function among older adults. The present study examined the associations between objectively measured sedentary behavior and physical function among older Japanese adults. A total of 174 male and 107 female community-dwelling older Japanese adults aged 65–84 years (mean age: 74.5 ± 5.2 years) were recruited. Sedentary behavior and physical activity were assessed using a triaxial accelerometer. Physical function was measured through hand grip ...


Baseline Characteristics And Enrichment Results From The Sonar Trial, Hiddo J. L. Heerspink, Dennis L. Andress, George Bakris, John J. Brennan, Ricardo Correa-Rotter, Fan Fan Hou, Dalane W. Kitzman, Donald Kohan, Hirofumi Makino, John Mcmurray, Vlado Perkovic, Sheldon Tobe, Melissa Wigderson, Tingting Yi, Hans-Henrik Parving, Dick De Zeeuw Jan 2018

Baseline Characteristics And Enrichment Results From The Sonar Trial, Hiddo J. L. Heerspink, Dennis L. Andress, George Bakris, John J. Brennan, Ricardo Correa-Rotter, Fan Fan Hou, Dalane W. Kitzman, Donald Kohan, Hirofumi Makino, John Mcmurray, Vlado Perkovic, Sheldon Tobe, Melissa Wigderson, Tingting Yi, Hans-Henrik Parving, Dick De Zeeuw

Faculty of Health Sciences Publications

Aim: The SONAR trial uses an enrichment design based on the individual response to the selective endothelin receptor antagonist atrasentan on efficacy (the degree of the individual response in the urinary albumin‐to‐creatinine ratio [UACR]) and safety/tolerability (signs of sodium retention and acute increases in serum creatinine) to assess the effects of this agent on major renal outcomes. The patient population and enrichment results are described here. Methods: Patients with type 2 diabetes with an estimated glomerular filtration rate (eGFR) within 25 to 75 mL/min/1.73 m2 and UACR between 300 and 5000 mg/g were ...