Medicine and Health Sciences Commons^™

Covid-19 Convalescent Plasma Therapy Decreases Inflammatory Cytokines: A Randomized Controlled Trial, Feben Habtehyimer, Xianming Zhu, Andrew D Redd, Kelly A Gebo, Alison G Abraham, Eshan U Patel, Oliver Laeyendecker, Thomas J Gniadek, Reinaldo E Fernandez, Owen R Baker, Malathi Ram, Edward R Cachay, Judith S Currier, Yuriko Fukuta, Jonathan M Gerber, Sonya L Heath, Barry Meisenberg, Moises A Huaman, Adam C Levine, Aarthi Shenoy, Shweta Anjan, Janis E Blair, Daniel Cruser, Donald N Forthal, Laura L Hammitt, Seble Kassaye, Giselle S Mosnaim, Bela Patel, James H Paxton, Jay S Raval, Catherine G Sutcliffe, Matthew Abinante, Kevin S Oei, Valerie Cluzet, Marie Elena Cordisco, Benjamin Greenblatt, William Rausch, David Shade, Amy L Gawad, Sabra L Klein, Andrew Pekosz, Shmuel Shoham, Arturo Casadevall, Evan M Bloch, Daniel Hanley, Aaron A R Tobian, David J Sullivan

Journal Articles

This study examined the role that cytokines may have played in the beneficial outcomes found when outpatient individuals infected with SARS-CoV-2 were transfused with COVID-19 convalescent plasma (CCP) early in their infection. We found that the pro-inflammatory cytokine IL-6 decreased significantly faster in patients treated early with CCP. Participants with COVID-19 treated with CCP later in the infection did not have the same effect. This decrease in IL-6 levels after early CCP treatment suggests a possible role of inflammation in COVID-19 progression. The evidence of IL-6 involvement brings insight into the possible mechanisms involved in CCP treatment mitigating SARS-CoV-2 severity.

The Passive Approach: How Academically Motivated Students Approach Their Mental Health., Megan E. Mccoy

Anthós

The research utilizes qualitative interviews and focus groups to understand how academically motivated students approach their mental health. Mental health is defined as “emotional, psychological, and social well-being,” by the Center for Disease Control and Prevention and is becoming a more significant concern in collegiate student populations. At Portland State University, the effects of mental health concerns on students are nearly double that of students around the U.S (Community Commons, n.d.). Academically motivated students are a group who seemingly strive for success and likely experience high levels of stress daily. The study found that students often take a passive approach …

Efficacy And Safety Of Covid-19 Convalescent Plasma In Hospitalized Patients: A Randomized Clinical Trial, Mila B Ortigoza, Hyunah Yoon, Keith S Goldfeld, Andrea B Troxel, Johanna P Daily, Yinxiang Wu, Yi Li, Danni Wu, Gia F Cobb, Gillian Baptiste, Mary O'Keeffe, Marilou O Corpuz, Luis Ostrosky-Zeichner, Amee Amin, Ioannis M Zacharioudakis, Dushyantha T Jayaweera, Yanyun Wu, Julie V Philley, Megan S Devine, Mahalia S Desruisseaux, Alessandro D Santin, Shweta Anjan, Reeba Mathew, Bela Patel, Masayuki Nigo, Rabi Upadhyay, Tania Kupferman, Andrew N Dentino, Rahul Nanchal, Christian A Merlo, David N Hager, Kartik Chandran, Jonathan R Lai, Johanna Rivera, Chowdhury R Bikash, Gorka Lasso, Timothy P Hilbert, Monika Paroder, Andrea A Asencio, Mengling Liu, Eva Petkova, Alexander Bragat, Reza Shaker, David D Mcpherson, Ralph L Sacco, Marla J Keller, Corita R Grudzen, Judith S Hochman, Liise-Anne Pirofski, Lalitha Parameswaran, Anthony T Corcoran, Abhinav Rohatgi, Marta W Wronska, Xinyuan Wu, Ranjini Srinivasan, Fang-Ming Deng, Thomas D Filardo, Jay Pendse, Simone B Blaser, Olga Whyte, Jacqueline M Gallagher, Ololade E Thomas, Danibel Ramos, Caroline L Sturm-Reganato, Charlotte C Fong, Ivy M Daus, Arianne Gisselle Payoen, Joseph T Chiofolo, Mark T Friedman, Ding Wen Wu, Jessica L Jacobson, Jeffrey G Schneider, Uzma N Sarwar, Henry E Wang, Ryan M Huebinger, Goutham Dronavalli, Yu Bai, Carolyn Z Grimes, Karen W Eldin, Virginia E Umana, Jessica G Martin, Timothy R Heath, Fatimah O Bello, Daru Lane Ransford, Maudry Laurent-Rolle, Sheela V Shenoi, Oscar Bate Akide-Ndunge, Bipin Thapa, Jennifer L Peterson, Kelly Knauf, Shivani U Patel, Laura L Cheney, Christopher A Tormey, Jeanne E Hendrickson

Journal Articles

IMPORTANCE: There is clinical equipoise for COVID-19 convalescent plasma (CCP) use in patients hospitalized with COVID-19.

OBJECTIVE: To determine the safety and efficacy of CCP compared with placebo in hospitalized patients with COVID-19 receiving noninvasive supplemental oxygen.

DESIGN, SETTING, AND PARTICIPANTS: CONTAIN COVID-19, a randomized, double-blind, placebo-controlled trial of CCP in hospitalized adults with COVID-19, was conducted at 21 US hospitals from April 17, 2020, to March 15, 2021. The trial enrolled 941 participants who were hospitalized for 3 or less days or presented 7 or less days after symptom onset and required noninvasive oxygen supplementation.

INTERVENTIONS: A unit of …

Friction Testing Of Contemporary Self-Ligating Appliance Systems, Michael Greene

Electronic Thesis and Dissertation Repository

Background: Resistance to tooth movement is multifactorial, with friction (FR) one of many important components. There is limited data comparing contemporary Passive and Active self-ligating bracket (SLB) systems in terms of FR created by archwire engagement. Aim: To compare classical FR in contemporary SLB systems and traditional twin brackets in vitro, and to identify the point of initiation of bracket-archwire engagement. Materials & Methods: Nine bracket systems of .022-in slot size were FR tested: Victory Series (3M Unitek) with elastic ligature (control); Passive SLB systems Damon Q (Ormco), Carriere SLX (Henry Schein), H4 (Ortho Classic), Altitude …

Heart Rate Recovery And Blood Pressure Recovery Influenced By A Slow-Breathing Protocol After Exercise In Moderately Trained Females, Emily Layne Zumbro

Electronic Theses and Dissertations

Heart rate (HR) and blood pressure (BP) increases in order to meet metabolic demands as a result of exercise primarily through way of the sympathetic nervous system (SNS) and parasympathetic nervous system (PNS). This study aimed to build on previous research in finding the best method to rapidly decrease HR and BP after exercise during the recovery period. PURPOSE: The purpose of this study was to determine the effectiveness of a breathing technique on HRR and BPR within a healthy female population during an exercise recovery period compared to active recovery and upright passive recovery. METHODS: Nine moderately trained female …

An Examination Of Spasticity Of The Lower Extremity Among Young People With Cerebral Palsy, Jordan Nourse

Honors College Theses

Background: Spasticity is the most common symptom among individuals with Cerebral Palsy (CP). Spasticity is often presented as stiff limbs often resulting in pain. Currently, clinicians are limited in diagnosing spasticity using observational tools. The purpose of this study was compare spasticity at various functional levels using dynamometry. Methods: Participants included nine adolescents (12-19) with CP and nine adolescents (age-matched) without CP. The participants participated in passive stretches delivered by the Biodex System 4 Pro Dynamometer at four different speeds (90, 120, 150, and 180 deg/s), Measurements of the quadriceps will be collected before and during passive knee extension stretches …

A Study Of Engagement In Active And Passive Roles In Casual Leisure Occupations, Anne M. Fenech

The Open Journal of Occupational Therapy

Background: This article explores whether engagement with listening occupations varies depending on the occupational role or the level of sensory stimulation presented to participants with neuropalliative conditions.

Method: The study used a multiple case quasi-experimental study involving marginal-participant time-sampled observations of engagement of individuals with neuropalliative conditions, with casual leisure occupations using the Individual Child Engagement Record. Data was collected using the Individual Child Engagement Record with 14 participants (who had Barthel scores averaging 7/100). The participants represented a particular sub-group of individuals with profound levels of neurological disability.

Results: The time-sampled observations of engagement showed a significant difference between …

An Evaluation Of The Emerging Interventions Against Respiratory Syncytial Virus (Rsv)-Associated Acute Lower Respiratory Infections In Children, Harish Nair, Vasundhara R. Verma, Evropi Theodoratou, Lina Zgaga, Tanvir Huda, Eric Af Simoes, Peter F. Wright, Igor Rudan, Harry Campbell

Dartmouth Scholarship

Background: Respiratory Syncytial Virus (RSV) is the leading cause of acute lower respiratory infections (ALRI) in children. It is estimated to cause approximately 33.8 million new episodes of ALRI in children annually, 96% of these occurring in developing countries. It is also estimated to result in about 53,000 to 199,000 deaths annually in young children. Currently there are several vaccine and immunoprophylaxis candidates against RSV in the developmental phase targeting active and passive immunization.

Methods: We used a modified CHNRI methodology for setting priorities in health research investments. This was done in two stages. In Stage I, we systematically reviewed …

An Investigation Of Forearm Vasomotor And Sudomotor Thresholds During Passive Heating, Following Whole-Body Cooling, Joanne N. Caldwell, Asa Nykvist, Nicholas Powers, Sean R. Notley, Daniel S. Lee, Gregory E. Peoples, Nigel A.S Taylor

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

High Plantar-Flexor Passive Stiffness Increases Achilles Tendon Loading During Landings, John Whitting, Julie R. Steele, Deirdre Mcghee, Bridget J. Munro

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.