Medicine and Health Sciences Commons^™

Marcks Phosphorylation Is Modulated By A Peptide Mimetic Of Marcks Effector Domain Leading To Increased Radiation Sensitivity In Lung Cancer Cell Lines, Timothy Rohrbach, Robert B. Jones, Patricia H. Hicks, Alice N. Weaver, Tiffany S. Cooper, Nicholas J. Eustace, Eddy S. Yang, John S. Jarboe, Joshua C. Anderson, Christopher D. Willey

Richard Bland Faculty Works

Lung cancer is the leading cause of cancer-associated mortality in the United States. Kinase hyperactivation is a known mechanism of tumorigenesis. The phosphorylation status of the plasma membrane-associated protein myristoylated alanine rich C-kinase substrate (MARCKS) effector domain (ED) was previously established as being important in the sensitivity of lung cancer to radiation. Specifically, when MARCKS ED was in a non-phosphorylated state, lung cancer cells were more susceptible to ionizing radiation and experienced prolonged double-strand DNA breaks. Additional studies demonstrated that the phosphorylation status of MARCKS ED is important for gene expression and in vivo tumor growth. The present study used …

Partner Influence In Diet And Exercise Behaviors: Testing Behavior Modeling, Social Control, And Normative Body Size, Brea Perry, Gabriele Ciciurkaite, Christy Freadreacea Brady, Justin Garcia

Sociology Faculty Publications

Previous research has documented social contagion in obesity and related health behaviors, but less is known about the social processes underlying these patterns. Focusing on married or cohabitating couples, we simultaneously explore three potential social mechanisms influencing obesity: normative body size, social control, and behavior modeling. We analyze the association between partner characteristics and the obesity-related health behaviors of focal respondents, comparing the effects of partners’ body type, partners’ attempts to manage respondents’ eating behaviors, and partners’ own health behaviors on respondents’ health behaviors (physical activity, fruit and vegetable consumption, and fast food consumption). Data on 215 partners are extracted …

Antitumor Activity Of 2,9-Di-Sec-Butyl-1,10-Phenanthroline, Dongsheng Wang, Shifang Peng, Arm R. Amin, Mohammad Aminur Rahman, Sreenivas Nannapaneni, Yuan Liu, Dong M. Shin, Nabil F. Saba, Jack F. Eichler, Zhuo G. Chen

Pharmaceutical Science and Research

The anti-tumor effect of a chelating phen-based ligand 2,9-di-sec-butyl-1,10-phenanthroline (dsBPT) and its combination with cisplatin were examined in both lung and head and neck cancer cell lines and xenograft animal models in this study. The effects of this agent on cell cycle and apoptosis were investigated. Protein markers relevant to these mechanisms were also assessed. We found that the inhibitory effect of dsBPT on lung and head and neck cancer cell growth (IC50 ranged between 0.1–0.2 μM) was 10 times greater than that on normal epithelial cells. dsBPT alone induced autophagy, G1 cell cycle arrest, and apoptosis. Our in vivo …

The Perceptions Of Stereotypes Of People Who Stutter In Hispanic University Students, Ruth Crutchfield, Xiaohui Wang

Communication Sciences & Disorders Faculty Publications and Presentations

The purpose of this study was to obtain data regarding how stutterers are perceived in Hispanic populations in order to identify whether stereotypes exist across cultures. This investigation was completed in order to repeat and amplify previously completed research projects that have used the Bipolar Semantic Scale and have revealed correlations between the presence of stuttering and negative feelings and reactions. University students were surveyed utilizing the Bipolar Semantic Scale which provides information regarding how stutterers are perceived. When comparing the findings of this project that deals primarily with Hispanic population to the previous studies that were completed on non-Hispanic …

Language Assessment In A Snap: Monitoring Progress Up To 36 Months, Jill Gilkerson, Jeffrey A. Richards, Charles R. Greenwood, Judy K. Montgomery

Communication Sciences and Disorders Faculty Articles and Research

This article describes the development and validation of the Developmental Snapshot, a 52-item parent questionnaire on child language and vocal communication development that can be administered monthly and scored automatically. The Snapshot was created to provide an easily administered monthly progress monitoring tool that enables parents to better recognize language milestones and offers professionals prompt information to fine-tune intervention strategies. Initial items were piloted by 15 families; refinement and further development of the instrument was conducted with parents of 308 typically developing children. Reliability and criterion validity metrics were examined on subsets of approximately 60 children who completed the Snapshot …

Exploring Knowledge, Beliefs And Practices Of Radon Gas Exposure Among Public Health Workers, Paschal Nwako

Seton Hall University Dissertations and Theses (ETDs)

Radon gas exposure is the highest cause of lung cancer among people that never smoked in the United States. People exposed to elevated levels of radon had a higher risk of developing lung cancer. Achieving the long term goal of the Indoor Radon Abatement Act (IRAA) of 1988 require a combined efforts of government agencies. Public health workers are change agents and their role in protecting and improving the health of their communities are well documented. This study created and utilized a multi question survey, the Public Health Workers Radon Assessment Instrument (PHWRAI) to explore knowledge, beliefs, personal and professional …

The Clinical Utility Of Concomitant Pten And Fas Deletion As An Early Indicator For Prostate Adenocarcinoma Subtypes That Lead To Extracapsular Metastasis, Brendan J. Coulter, Phillip Harries

Electronic Theses & Dissertations

The utility of genes PTEN and FAS as prognostic markers for the identification of early and/or aggressive prostatic adenocarcinomas is seemingly validated in the study results we obtained using fluorescence in-situ hybridization (FISH) of archived paraffin embedded surgical prostate core biopsy samples obtained from two CLIA and CAP licensed anatomical pathology labs (Bostwick Laboratories, Uniondale, NV and GoPath Laboratories, Buffalo Grove, IL). From early benign subsets of sample cases to aggressive extracapsular invasive tumors, the presence of random deletions evolves into clonal populations of co-deletion of both genes at question. We identify independent research that demonstrates the ability of these …

The Effect Of A Culturally Tailored Web-Based Physical Activity Promotion Program On Asian American Midlife Women’S Depressive Symptoms, Wonshik Chee, Sangmi Kim, Xiaopeng Ji, Sooyoung Park, Eunice Chee, Hsiu-Min Tsai, Eun-Ok Im

Asian/Pacific Island Nursing Journal

The benefits of physical activities on depressive symptoms have increasingly been reported in the literature, but the effect through which a Web-based physical activity promotion program alleviates depressive symptoms is not clearly known, especially among ethnic minority midlife women. The purpose of this pilot randomized control study is to examine the preliminary efficacy of the Web-based physical activity promotion program in enhancing the depressive symptoms of Asian American midlife women through increasing physical activity. This study adopted a randomized repeated measures pretest/posttest control group design. This study consisted of two groups of research participants: 18 in an intervention group and …

Asian/White Differences In The Relationship Of Maternal Age To Low Birth Weight: Analysis Of The Prams Survey, 2004–2011, Sangmi Kim

Asian/Pacific Island Nursing Journal

This study aimed to examine (a) maternal age patterns of low birth weight (LBW; birth weight < 2,500 g) for non-Hispanic (N-H) Asian and N-H White women, and (b) Asian–White gaps in LBW risk by maternal age and their mechanisms. Logistic regression analyses were performed on the Pregnancy Risk Assessment Monitoring System data of N-H Asian and N-H White women who delivered their first singleton birth without birth defects in 13 states between 2004 and 2011. Age- and race/ethnicity-specific LBW risk was estimated, unadjusted and adjusted for maternal risk factors (e.g., marital status, maternal education, pregnancy intention, stress, maternal morbidities, smoking, and prenatal care) and their interactions with maternal age or race/ethnicity. The interaction between maternal age and race/ethnicity was statistically significant (p < .0001) with covariates and interactions held constant. N-H Asian women showed a reverse W-shaped maternal-age pattern of LBW with the highest risk in their late 30s (OR = 1.56, 95% CI [1.26, 1.94]) whereas N-H White women experienced a maternal age-related increase in LBW. N-H Asian women were more likely to deliver LBW infant than their N-H White counterparts between their late 20s and late 30s, with the greatest racial/ethnic gap in their late 20s (OR = 4.19, 95% CI [3.33, 5.29]). Preventive strategies should be developed targeting N-H Asian women aged 25 to 39 years to reduce the Asian–White disparities in LBW. Considering the known maternal risk …

Connecting Culturally And Spiritually To Healthy Eating: A Community Assessment With Native Hawaiians, Mary Frances Oneha, Joan Dodgson, Mabel Ho`Oipo Decambra, Carol Titcomb, Rachelle Enos, Sandie Morimoto-Ching

Asian/Pacific Island Nursing Journal

Many of the chronic illnesses disproportionately experienced by Native Hawaiians are directly related to poor diets and long-standing obesity beginning in childhood. We report on the findings of in-depth key informant interviews (N = 14) that took place in two Native Hawaiian communities as part of a larger, community-based participatory research study that included a community assessment through individual interviews and focused group discussions, and a pilot intervention targeting pregnant women, their infants, and families. Four categories emerged from the qualitative analysis of interview transcripts that described an understanding of “healthy eating”: family roles and responsibilities, aspects of community …

A Study Of The Relationship Between Job Related Stress And Temporomandibular Disorders In Accountants Working In Jakarta, Cindy Maura Saputra, Laura Susanti Himawan, Ira Tanti

Journal of Dentistry Indonesia

Stress is a known risk factor for Temporomandibular Disorders (TMD), however there are few studies of TMD in people who work in high stress jobs. Accounting is a profession known for its high levels of stress and expectation. Objective: The aim of this study is to investigate the relationship between the intensity and frequency of job related stress and the occurrence of TMD in accountants in Jakarta. Methods: A cross-sectional study, with ethics approval from the Ethical Committee of the Faculty of Dentistry, University Indonesia, was performed on 116 accountants aged 21 to 50, living in Jakarta. Subjects were asked …

Asian American Women's Resilience: An Integrative Review, Andrew Thomas Reyes, Rose E. Constantino

Asian/Pacific Island Nursing Journal

Asian American women face unique stressors that threaten their overall health and well-being. However, resilience is a phenomenon that allows individuals to develop positive adaptation despite adversities and challenges. This integrative review is conducted in order to explore the current state of knowledge regarding the resilience of Asian American women. Twelve databases were used to identify related articles: Academic Search Premier, CINAHL, ERIC, Ethnic NewsWatch, GenderWatch, ProQuest Dissertations and Theses Global, ProQuest Sociological Abstracts, PsycINFO, PubMed, SAGE (Psychology and Sociology collections), Scopus, and Web of Science. Twenty-one research studies met the inclusion criteria of the integrative review. Five common themes …

A Risk Stratification Model For Antihypertensive Medication Non-Adherence Among Chinese Immigrants, Wen-Wen Li, Chih-Ling Huang

Asian/Pacific Island Nursing Journal

The purpose of this study was to establish a risk stratification model for identifying Chinese immigrants at risk for non-adherence to antihypertensive medications. Questionnaires were self-administered to 200 Chinese immigrants in San Francisco, USA. Questionnaires included demographics, culture factors (e.g., Perceived Susceptibility in General, Perceived Benefits of Western Medication, Perceived Benefits of Chinese Herbs, and Health-Related Social Support), and medications adherence. Participants' mean age was 70.6 (±10.3) years. Three stratification factors were identified for non-adherence: Lower Perceived Susceptibility in General, lower Perceived Benefit of Western Medications, and longer Length of Stay in the United States. The probability of non-adherence was …

Hematological Disorders And Pulmonary Hypertension, Rajamma Mathew, Jing Huang, Joseph M. Wu, John T. Fallon, Michael H. Gewitz

NYMC Faculty Publications

Pulmonary hypertension (PH), a serious disorder with a high morbidity and mortality rate, is known to occur in a number of unrelated systemic diseases. Several hematological disorders such as sickle cell disease, thalassemia and myeloproliferative diseases develop PH which worsens the prognosis. Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction. Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity, activation of proliferative and antiapoptotic pathways leading to vascular remodeling, elevated pulmonary artery pressure, right ventricular hypertrophy and premature death. Hemolysis observed in hematological disorders leads to free hemoglobin which …

Factors Related To Diagnosis Of Community-Acquired Pneumonia In The Elderly, Elza Febria Sari, C. Martin Rumende, Kuntjoro Harimurti

Jurnal Penyakit Dalam Indonesia

Introduction. Diagnosing community-acquired pneumonia (CAP) in the elderly remains a clinical challenge for various reasons. The clinical manifestation in the elderly is not frank and atypical manifestations, e.g. falls, decrease of functional status and food intake or urinary incontinence, may be present. These reasons may be associated with under or over diagnosis, which consequently contribute to the higher observed mortality rate in the elderly population with CAP. Study about factors related to diagnosis of CAP in the elderly was ra rely performed.

Methods. From January to October 2010, 158 elderly patients suspected of having pneumonia at RSCM were registered. Relationship …

Correlation Of Forced Expiratory Volume In 1 Second Prediction With Mean Pulmonary Arterial Pressure Using Echocardiography In Stable Chronic Obstructive Pulmonary Disease, Munadi Munadi, M. Yamin, Anna Ujainah, Cleopas Martin Rumende

Jurnal Penyakit Dalam Indonesia

No abstract provided.

Estimated Glomerular Filtration Rate (Egfr) As An In-Hospital Mortality Predictor In Acute Coronary Syndrome Patients In Iccu, Esthika Dewiasty, Idrus Alwi, Dharmeizar Dharmeizar, Kuntjoro Harimurti

Jurnal Penyakit Dalam Indonesia

No abstract provided.

Bone Mass Density In Hiv/Aids Patients, Nadia Ayu Mulansari, Nanang Sukmana, Bambang Setyohadi, Siti Setiati

Jurnal Penyakit Dalam Indonesia

No abstract provided.

Auto Immune Hemolytic Anemia (Aiha) Patients Profile And Treatment Response To Corticosteroids In Cipto Mangunkusumo Hospital, Wulyo Rajabto, Djumhana Atmakusuma, Siti Setiati

Jurnal Penyakit Dalam Indonesia

No abstract provided.

Correlation Of Frailty Status With Influenza Vaccine Seroconversion And Seroprotection Among Elderly Population, Sukamto Koesnoe, Ummu Habibah, Edy Rizal Wahyudi, Murdani Abdullah

Jurnal Penyakit Dalam Indonesia

No abstract provided.

Diagnosis And Treatment Of Acquired Hemophilia A (Aha) With Bullous Pemphigoid, Rasco Sandy Sihombing, Henry Ratno Diono Silalahi, Hamzah Shatri, Lugyanti Sukrisman, Ikhwan Rinaldi, Findy Prasetyawati, Endy Novianto, Em Yunir

Jurnal Penyakit Dalam Indonesia

No abstract provided.

Prevention Of Hepatitis B Vertical Transmission: Focus On Antenatal Antiviral Administration, Anandhara Indriani Khumaedi, Rino Alvani Gani, Irsan Hasan

Jurnal Penyakit Dalam Indonesia

No abstract provided.

Physical Therapy Management Of A Patient With Chronic Knee Pain: A Case Report, Mohamed Elsaid

Case Report Papers

Background and Purpose: Knee pain affects a large number of adults, and as a result limits their functional mobility and may induce participation restrictions. A number of risk factors may contribute to knee pain, with osteoarthritis (OA) being the most prevalent cause. The rate of knee replacement surgery among individuals 65 and older has increased significantly over the years. Physical therapy (PT) is a non-surgical option that offers individuals relief of their knee pain. Case Description: The patient was a 48-year-old Caucasian female referred to physical therapy with chronic right knee pain. She received PT twice a week for eight …

High Levels Of Iron Supplementation Prevents Neural Tube Defects In The Fpn1(Ffe) Mouse Model., Bethany A Stokes, Julia A Sabatino, Irene E. Zohn

Pediatrics Faculty Publications

BACKGROUND: Periconception maternal nutrition and folate in particular are important factors influencing the incidence of neural tube defects (NTDs). Many but not all NTDs are prevented by folic acid supplementation and there is a pressing need for additional strategies to prevent these birth defects. Other micronutrients such as iron are potential candidates, yet a clear role for iron deficiency in contributing to NTDs is lacking. Our previous studies with the flatiron (ffe) mouse model of Ferroportin1 (Fpn1) deficiency suggest that iron is required for neural tube closure and forebrain development raising the possibility that iron supplementation could prevent NTDs.

METHODS: …

Rna Sequencing Reveals A Role Of Tonebp Transcription Factor In Regulation Of Pro-Inflammatory Genes In Response To Hyperosmolarity In Healthy Nucleus Pulposus Cells: A Homeostatic Response?, Zariel I. Johnson, Irving M. Shapiro, Makarand V. Risbud

Department of Orthopaedic Surgery Faculty Papers

Transcription factor tonicity-responsive enhancer-binding protein (TonEBP/NFAT5) is critical for osmo-adaptation and extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue niche. Recent studies implicate TonEBP signaling in inflammatory disease and rheumatoid arthritis pathogenesis. However, broader functions of TonEBP in the disc remain unknown. RNA sequencing was performed on NP cells with TonEBP knockdown under hypertonic conditions. 1140 TonEBP-dependent genes were identified and categorized using Ingenuity Pathway Analysis. Bioinformatic analysis showed enrichment of matrix homeostasis and cytokine/chemokine signaling pathways. C-C motif chemokine ligand 2 (CCL2), interleukin 6 (IL6), tumor necrosis factor (TNF), and nitric oxide synthase 2 (NOS2) …

Selecting Optimal Combinations Of Transcription Factors To Promote Axon Regeneration: Why Mechanisms Matter, Ishwariya Venkatesh, Murray G. Blackmore

Biomedical Sciences Faculty Research and Publications

Recovery from injuries to the central nervous system, including spinal cord injury, is constrained in part by the intrinsically low ability of many CNS neurons to mount an effective regenerative growth response. To improve outcomes, it is essential to understand and ultimately reverse these neuron-intrinsic constraints. Genetic manipulation of key transcription factors (TFs), which act to orchestrate production of multiple regeneration-associated genes, has emerged as a promising strategy. It is likely that no single TF will be sufficient to fully restore neuron-intrinsic growth potential, and that multiple, functionally interacting factors will be needed. An extensive literature, mostly from non-neural cell …

Deficiency Of Mkrn2 Causes Abnormal Spermiogenesis And Spermiation, And Impairs Male Fertility., Xu Qian, Lin Wang, Bo Zheng, Zhu-Mei Shi, Xin Ge, Cheng-Fei Jiang, Ying-Chen Qian, Dong-Mei Li, Wei Li, Xue Liu, Yu Yin, Ji-Tai Zheng, Hua Shen, Min Wang, Xue-Jiang Guo, Jun He, Marie Lin, Ling-Zhi Liu, Jia-Hao Sha, Bing-Hua Jiang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Although recent studies have shed insights on some of the potential causes of male infertility, new underlining molecular mechanisms still remain to be elucidated. Makorin-2 (Mkrn2) is an evolutionarily conserved gene whose biological functions are not fully known. We developed an Mrkn2 knockout mouse model to study the role of this gene, and found that deletion of Mkrn2 in mice led to male infertility. Mkrn2 knockout mice produced abnormal sperms characterized by low number, poor motility, and aberrant morphology. Disruption of Mkrn2 also caused failure of sperm release (spermiation failure) and misarrangement of ectoplasmic specialization (ES) in testes, thus impairing …

Suicide Risk Assessment In A Psychiatric Medical Unit, Olga D'Argenio

Master's Projects

Suicide is a major health concern in the United States. In a scholarly article, Hutton (2015) found that annually, 2.2 million adults plan suicide, 8.3 million have thoughts of suicide, and 1 million adults attempt suicide. A 2013 Center for Disease Control (CDC) analysis found that suicide rates among persons age 35 to 64 years have increased during the years of 1999-2010 by 28.4%. Bolton, Gunnell, and Turecki (2015) found that suicide is a major international public health problem claiming one life every 40 seconds. The study also states suicide is a second leading cause of death in people age …

Minority College Women’S Views On Condom Negotiation, Tywanda Mclaurin-Jones, Maudry-Beverly Lashley, Vanessa Marshall

Publications and Research

This study utilized quantitative and qualitative methods to (1) investigate the relationship between frequency of condom use and negotiation strategies and (2) evaluate experiences with condom negotiations among sexually active, heterosexual, African American college women. One hundred female students from a Historically Black Colleges and Universities (HBCU) completed a questionnaire that included the Condom Influence Strategies Scale (CIS) and participated in a focus group. An ANOVA was conducted to compare differences between never, inconsistent, and consistent condom users. Consistent condom users scored higher than never users on the “withholding sex” subscale of the CIS (4.88 vs. 3.55; p < 0.001) as well as endorsed items more strongly on the “direct request” subscale of the CIS (4.63 vs. 3.82, p < 0.05) than never users. A thematic analysis of open discussions identified overarching themes. Similarly, refusing sex and/or having direct communications with partner emerged as primary strategies. Threats to negotiation included deciding the “right timing” of discussion and having a previous history of sexual intercourse without a condom with their partner. Other key concepts that contribute to condom negotiation are the views that condoms are a male’s responsibility and stigma of women who carry condoms.

Safety Culture And Fall Prevention: A Collaborative Effort, Cecilia Cortina

Seton Hall University DNP Final Projects

Patient falls in the United States (US) range from 700,000 to one million annually and one third of those falls can be prevented (Du Pree, Fritz-Campiz & Musbeno, 2014). Twenty to 30% of falls are moderate to severe (Schimke & Schimke, 2014). As of 2009, The Joint Commission’s (TJC) (2015) Sentinel Event databank held 465 reports of hospital falls with injury; deaths that resulted in those injuries were reported as 63 percent. Common denominators resulting in patient falls with injury are poor assessment, lack of communication, failure to follow protocols, insufficient training and supervision, staffing levels, unsafe environments and lack …