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Effect Of Direct-Acting Antiviral Agents On Hepatitis C Virus-Associated Thrombocytopenia, Alaa E. Abdelhamid, Aly M. El-Kholy, Essam A. Abdelmohsen, Hasan A. Zagla, Mohamed A. Abdelhafez, Sabry A. Shoeib, Zeinab A. A. Kasemy
Effect Of Direct-Acting Antiviral Agents On Hepatitis C Virus-Associated Thrombocytopenia, Alaa E. Abdelhamid, Aly M. El-Kholy, Essam A. Abdelmohsen, Hasan A. Zagla, Mohamed A. Abdelhafez, Sabry A. Shoeib, Zeinab A. A. Kasemy
Menoufia Medical Journal
Objectives To evaluate the effect of direct-acting antiviral agents (DAAs) on hepatitis C virus (HCV)-associated thrombocytopenia. Background The prevalence of thrombocytopenia in HCV infection ranged from 0.16 to 45.4%. The pathophysiology of HCV-associated thrombocytopenia is poorly understood and multifactorial. Cellular immunity has an important role. Antiplatelet antibodies are common. Production of thrombopoietin may be reduced. Infection of megakaryocytes with HCV may impair platelet production. Clearance of HCV with DAA is expected to restore innate functions of the hepatocytes and immune system reconstitution. Patients and methods This was a prospective study on 104 patients with HCV-associated thrombocytopenia receiving DAA (sofosbuvir and …