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Full-Text Articles in Medicine and Health Sciences
The Effect Of Silica Inhibition Of Macrophage On Renal Allograft Rejection, Carman A. Giacomantonio
The Effect Of Silica Inhibition Of Macrophage On Renal Allograft Rejection, Carman A. Giacomantonio
Vivian C. McAlister
Kidney failure, one of the most serious complications of diabetes is routinely managed by kidney allograft transplantation. Research into the etiology of diabetes has revealed that macrophages are primarily responsible for the β-islet cell destruction in diabetes and that depletion of macrophages using intraperitoneal (i.p.) silica, which is selectively toxic to macrophages, prevents this. Macrophages accounts for approximately 50% of the graft infiltrating cells (GIC) observed in an acutely rejecting kidney, a process phenotypically very similar to a delayed type hypersensitivity (DTH) reaction. Macrophages are known to be essential for DTH reactions. Their exact role has never been elucidated in …
The Role Of Rejection In Aortic Valve Allograft Failure, Ahmad Moustapha
The Role Of Rejection In Aortic Valve Allograft Failure, Ahmad Moustapha
Vivian C. McAlister
At present the main question is whether homograft failure is due to rejection or mechanical degeneration. The use of cardiac valve transplants between syngeneic and allogeneic strains of rats permits investigations into the role of immune mediated rejection of these grafts. We expanded an already developed microsurgical rat model for aortic interposition allografts to include the aortic valve. Aortic valves were harvested from donor rats and then heterotopically transplanted into the abdominal aorta of a recipient rat using inbred strains. All recipient rats were Lewis and donor rats were either Lewis (syngeneic) or Brown Norway (allogeneic). Grafts were transplanted either …