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Full-Text Articles in Medicine and Health Sciences
Exposure To Environmentally Relevant Doses Of The Xenoestrogen Bisphenol-A Alters Development Of The Fetal Mouse Mammary Gland, Laura Vandenberg, Maricel V. Maffini, Perinaaz R. Wadia, Carlos Sonnenschein, Beverly S. Rubin, Ana M. Soto
Exposure To Environmentally Relevant Doses Of The Xenoestrogen Bisphenol-A Alters Development Of The Fetal Mouse Mammary Gland, Laura Vandenberg, Maricel V. Maffini, Perinaaz R. Wadia, Carlos Sonnenschein, Beverly S. Rubin, Ana M. Soto
Laura Vandenberg
Humans are routinely exposed to bisphenol-A (BPA), an estrogenic compound that leaches from dental materials, food and beverage containers, and other plastic consumer products. Effects of perinatal BPA exposure on the mouse mammary gland have been observed in puberty and adulthood, long after the period of exposure has ended. The aim of this study was to examine fetal mammary gland development at embryonic day (E)18 and assess changes in the tissue organization and histoarchitecture after exposure to an environmentally relevant dose of BPA. In unexposed fetuses, the relative position of the fetus with respect to its female and male siblings …
Evidence Of Altered Brain Sexual Differentiation In Mice Exposed Perinatally To Low, Environmentally Relevant Levels Of Bisphenol A, Beverly S. Rubin, Jenny R. Lenkowski, Cheryl M. Schaeberle, Laura Vandenberg, Paul M. Ronsheim, Ana M. Soto
Evidence Of Altered Brain Sexual Differentiation In Mice Exposed Perinatally To Low, Environmentally Relevant Levels Of Bisphenol A, Beverly S. Rubin, Jenny R. Lenkowski, Cheryl M. Schaeberle, Laura Vandenberg, Paul M. Ronsheim, Ana M. Soto
Laura Vandenberg
Humans are routinely exposed to bisphenol A (BPA), an estrogenic chemical present in food and beverage containers, dental composites, and many products in the home and workplace. BPA binds both classical nuclear estrogen receptors and facilitates membrane-initiated estrogenic effects. Here we explore the ability of environmentally relevant exposure to BPA to affect anatomical and functional measures of brain development and sexual differentiation. Anatomical evidence of alterations in brain sexual differentiation were examined in male and female offspring born to mouse dams exposed to 0, 25, or 250 ng BPA/kg body weight per day from the evening of d 8 of …