Medicine and Health Sciences Commons^™

Exposure To Environmentally Relevant Doses Of The Xenoestrogen Bisphenol-A Alters Development Of The Fetal Mouse Mammary Gland, Laura Vandenberg, Maricel V. Maffini, Perinaaz R. Wadia, Carlos Sonnenschein, Beverly S. Rubin, Ana M. Soto

Laura Vandenberg

Humans are routinely exposed to bisphenol-A (BPA), an estrogenic compound that leaches from dental materials, food and beverage containers, and other plastic consumer products. Effects of perinatal BPA exposure on the mouse mammary gland have been observed in puberty and adulthood, long after the period of exposure has ended. The aim of this study was to examine fetal mammary gland development at embryonic day (E)18 and assess changes in the tissue organization and histoarchitecture after exposure to an environmentally relevant dose of BPA. In unexposed fetuses, the relative position of the fetus with respect to its female and male siblings …

Evidence Of Altered Brain Sexual Differentiation In Mice Exposed Perinatally To Low, Environmentally Relevant Levels Of Bisphenol A, Beverly S. Rubin, Jenny R. Lenkowski, Cheryl M. Schaeberle, Laura Vandenberg, Paul M. Ronsheim, Ana M. Soto

Laura Vandenberg

Humans are routinely exposed to bisphenol A (BPA), an estrogenic chemical present in food and beverage containers, dental composites, and many products in the home and workplace. BPA binds both classical nuclear estrogen receptors and facilitates membrane-initiated estrogenic effects. Here we explore the ability of environmentally relevant exposure to BPA to affect anatomical and functional measures of brain development and sexual differentiation. Anatomical evidence of alterations in brain sexual differentiation were examined in male and female offspring born to mouse dams exposed to 0, 25, or 250 ng BPA/kg body weight per day from the evening of d 8 of …

Non-Extraction Orthodontic Treatment In Management Of Moderately Crowded Class Ii Division 2 Malocclusion: A Case Report, Othman S. A.

Siti Adibah Othman

A case report of a 13-year old male presented in his mixed dentition stage with a Class II division 2 incisor relationship on a mild Class II skeletal base, complicated by an increased overbite, retroclined upper and lower incisors (bimaxillary retroclination) and moderate crowding in the upper and lower labial segments. Treatment was undertaken without extraction employing an upper removable appliance with a flat anterior bite plane to correct the overbite, and an anterior screw to proclined the upper incisors while waiting for the eruption of the permanent teeth. Pre-adjusted edgewise fixed appliances were placed in the lower arch, then …

An Ethnographic Study Of The Social Context Of Migrant Health In The United States, Seth M. Holmes Phd, Md

Seth M. Holmes PhD, MD

Background

Migrant workers in the United States have extremely poor health. This paper aims to identify ways in which the social context of migrant farm workers affects their health and health care.

Methods and Findings

This qualitative study employs participant observation and interviews on farms and in clinics throughout 15 months of migration with a group of indigenous Triqui Mexicans in the western US and Mexico. Study participants include more than 130 farm workers and 30 clinicians. Data are analyzed utilizing grounded theory, accompanied by theories of structural violence, symbolic violence, and the clinical gaze. The study reveals that farm …

Auditory Inhibitory Gating In Medial Prefrontal Cortex: Single Unit And Local Field Potential Analysis, Howard C. Cromwell

Howard Casey Cromwell

Medial prefrontal cortex is a crucial region involved in inhibitory processes. Damage to the medial prefrontal cortex can lead to loss of normal inhibitory control over motor, sensory, emotional and cognitive functions. The goal of the present study was to examine the basic properties of inhibitory gating in this brain region in rats. Inhibitory gating has recently been proposed as a neurophysiological assay for sensory filters in higher brain regions that potentially enable or disable information throughput. This perspective has important clinical relevance due to the findings that gating is dramatically impaired in individuals with emotional and cognitive impairments (i.e. …