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Articles 31 - 60 of 98
Full-Text Articles in Medicine and Health Sciences
Alcohol Metabolism Negatively Affects Early Atdc5 Chondrocyte Differentiationindependent Of Nox4 Expression, Hardy Hang, Alexandra Denys, Martin J. J. Ronis
Alcohol Metabolism Negatively Affects Early Atdc5 Chondrocyte Differentiationindependent Of Nox4 Expression, Hardy Hang, Alexandra Denys, Martin J. J. Ronis
Medical Student Research Poster Symposium
Alcohol (ethanol) abuse is a widely recognized risk factor in the development of several diseases. Previous studies in our lab have shown that ethanol induces reactive oxygen species (ROS) production in osteogenic cells, which results in oxidative damage, skeletal dysfunction, and osteoporosis. Moreover, ethanol inhibits epiphyseal plate proliferation in longitudinal bones and affects chondrocyte function, which results in shorter bones. In osteogenic cells, a major source of ethanol-mediated ROS is derived from NADPH oxidases (NOXs). However, it remains uncertain if ROS produced by NOXs during alcohol metabolism result in impaired chondrocyte function and differentiation. In this study, we investigated if …
Joint Pain: Keeping All Differentials In Mind, Hira Hasan, Sara Javadi, Erin Hauck, Lauren Raney, Emily Klepper
Joint Pain: Keeping All Differentials In Mind, Hira Hasan, Sara Javadi, Erin Hauck, Lauren Raney, Emily Klepper
Medical Student Research Poster Symposium
Introduction: Acute lymphoblastic leukemia (ALL) results from the clonal proliferation of lymphoblasts. ALL is the most common pediatric cancer, accounting for one more than 25% of all pediatric malignancies. It primarily affects children between the ages of 1 and 5, with males being slightly more affected than females. A definitive diagnosis of ALL is made by the presence of ≥20% blasts on bone marrow biopsy. The prodromal stage of ALL may last from weeks to months and presents with nonspecific symptoms such as fever and fatigue. Infiltration of the bone marrow leads to decreased production of other cell lines, leading …
Tropism Of Novel Aav Capsid Variants In The Inner Ear, Leigh C. Hickham, David Odenheimer, Grant Rauterkus, Sanford L. Boye, Shannon E. Boye, Jennifer J. Lentz
Tropism Of Novel Aav Capsid Variants In The Inner Ear, Leigh C. Hickham, David Odenheimer, Grant Rauterkus, Sanford L. Boye, Shannon E. Boye, Jennifer J. Lentz
Medical Student Research Poster Symposium
Background: Usher syndrome (Usher) is the leading genetic cause of combined deaf-blindness. Of the three clinical types, type 1 (USH1) is the most severe with congenital sensorineural hearing impairment and vestibular dysfunction, and adolescent onset of retinitis pigmentosa. While the genetics of Usher is well understood, the treatment options for these patients are limited. To fill this gap, we created a mouse model of Type 1C Usher (USH1C) that contains the splice site mutation (USH1C c.216G>A) responsible for USH1C in patients. USH1C mice have hearing, balance, and visual dysfunction similar to patients. Additionally, the expression of harmonin protein, encoded …
Comparison Of Regenerative Limb Salvage To Flap-Based Reconstruction Of Complexextremity Wounds: A Randomized Control Trial, Ryan D. Hoffman, Denise Danos, Ann Mckendrick, Frank Lau
Comparison Of Regenerative Limb Salvage To Flap-Based Reconstruction Of Complexextremity Wounds: A Randomized Control Trial, Ryan D. Hoffman, Denise Danos, Ann Mckendrick, Frank Lau
Medical Student Research Poster Symposium
Introduction Complex extremity wounds present unique challenges to the reconstructive surgeon. Flap- based limb salvage (fLS) is the standard of care for achieving durable coverage of exposed bone and tendon, but this approach is resource intensive. An alternative technique is regenerative limb salvage (rLS) using dehydrated human amnion/chorion membrane (dHCAM). We previously reported successful rLS case series in adults and children. The goal of this study was to compare rLS to fLS in a multi-centered, prospective, randomized controlled trial (RCT) with a crossover option upon reconstructive failure. Methods Between 2016 and 2018, 48 subjects with complex wounds of the extremities …
Sarcopenia In Lower Extremity Reconstruction, Ryan Hoffman, Suma Maddox, Patrick Palines, Denise Danos, Daniel Womac, Charles Tuggle, Mark Stalder
Sarcopenia In Lower Extremity Reconstruction, Ryan Hoffman, Suma Maddox, Patrick Palines, Denise Danos, Daniel Womac, Charles Tuggle, Mark Stalder
Medical Student Research Poster Symposium
Introduction: Sarcopenia is linked to poor outcomes throughout the surgical literature and can be assessed on preoperative imaging to potentially aid in risk stratification. This study examined the effects of sarcopenia on surgical morbidity following lower extremity (LE) reconstruction, and also compared two methods of assessment, one of which is novel (“ellipse method”). Methods: A retrospective cohort study of fifty patients receiving free flap-based reconstruction of the LE was performed. Bilateral psoas density and area were quantified at L4 through tracing (“traditional method”) and encircling (“ellipse method”) to calculate Hounsfield Unit average calculation (HUAC). Logistic regression and ROC analysis for …
Survey Says: Shingrix Saves, Claire Holmes, Taylor Phelps, Maria Bernal
Survey Says: Shingrix Saves, Claire Holmes, Taylor Phelps, Maria Bernal
Medical Student Research Poster Symposium
Shingles (herpes zoster) results from reactivation of latent varicella zoster virus in spinal and cranial neurosensory ganglia. Nearly 1 in 3 people will develop shingles in their lifetime, with possible complications including hearing loss, vision loss, bacterial superinfection, and post- herpetic neuralgia. In 2006, the Food and Drug Administration (FDA) approved the use of the live attenuated Zostavax® vaccine for prevention of herpes zoster and post-herpetic neuralgia. Due to limitations in its use in immunocompromised individuals, a new non-live recombinant zoster vaccine (Shingrix®) became approved for use in 2017. In comparison to the Zostavax® vaccine, the Shingrix® vaccine has been …
Attenuating Collagen Deposition By Synoviocytes From Osteoarthritic Patientswith Synovial Fibrosis, Peter Issa, Stefan Sarkovich, Jose Cruz-Ayala, Vinod Dasa, Luis Marrero
Attenuating Collagen Deposition By Synoviocytes From Osteoarthritic Patientswith Synovial Fibrosis, Peter Issa, Stefan Sarkovich, Jose Cruz-Ayala, Vinod Dasa, Luis Marrero
Medical Student Research Poster Symposium
Fibrosis is the deposition of stiff extracellular matrix mostly composed of type-I collagen (COL1), which can impair function of diseased musculoskeletal components. COL1 is synthesized by myofibroblasts and mostly driven by the receptor-mediated transforming growth factor (TGF)β1- ALK5-Smad2/3 cascade. Stimulation of naïve fibroblasts with TGFβ1 induces proliferation, smooth muscle actin (SMA)+ myofibroblast differentiation, and COL1 synthesis. COL1 undergoes modifications to its triple helix, such as the conversion of lysine to hydroxylysine by Plod2-encoded lysyl hydroxylase (LH) 2b to facilitate cross-links that effectively strengthen COL1 fibrils. Synovial fibrosis (SFb) is a hallmark of osteoarthritis (OA) characterized by aberrant COL1 deposition in …
The Potential Role Of Atn-161 As An Integrin Α5Β1 Inhibitor In Preventing Commonviral Infections, Peter Issa, H Wang, Ko Mcdonald, Be Ouvrier, Gj Bix
The Potential Role Of Atn-161 As An Integrin Α5Β1 Inhibitor In Preventing Commonviral Infections, Peter Issa, H Wang, Ko Mcdonald, Be Ouvrier, Gj Bix
Medical Student Research Poster Symposium
Integrins are transmembrane proteins which mediate many cellular signaling processes such as immunological function, extracellular matrix composition, apoptosis, and cell adhesion. In addition to these features, integrins have been implicated in viral infection. Integrin alpha5beta1, which has an arginine-glycine-aspartic acid (RGD) binding motif, has been shown to play a role in the pathogenesis of many viruses including porcine hemagglutinating encephalomyelitis virus (PHEV), human immunodeficiency virus (HIV-1), and severe acute respiratory syndrome- coronavirus 2 (SARS-CoV-2). However, a concise review of the role of integrin alpha5beta1 with regards to viruses and its potential as an antiviral therapeutic, especially with regards to SARS- …
Utilizing Quantitative Covid-19 Serological Testing To Assess Pathophysiologicalimportance Of Complement Activation In Disease Severity, Shivani Jain, Harrison Travis, Meredyth Berard, Alexis Scheurermann, Alison A. Smith
Utilizing Quantitative Covid-19 Serological Testing To Assess Pathophysiologicalimportance Of Complement Activation In Disease Severity, Shivani Jain, Harrison Travis, Meredyth Berard, Alexis Scheurermann, Alison A. Smith
Medical Student Research Poster Symposium
Background. COVID-19, the clinical syndrome caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to cause high disease burden in the world. Not enough is known about immunological mechanisms driving COVID-19 disease severity in patients hospitalized in the ICU compared to those who test positive but do not develop severe disease. Extreme activation of the immune system has been linked to disease course complications in COVID-19. The complement system plays a key role in the innate immune response, and it has previously been suggested that it may be driving these disease complications. Immunoglobulin G (IgG) activates the classical complement …
The Effect Of Hernia Size On Length Of Stay And Outcomes In Roboticventral Hernia Repair, Yasmeen Kawji, Leslie Son, Karl Leblanc
The Effect Of Hernia Size On Length Of Stay And Outcomes In Roboticventral Hernia Repair, Yasmeen Kawji, Leslie Son, Karl Leblanc
Medical Student Research Poster Symposium
Hernia repairs are common procedures that have been performed laparoscopically for many years. However, the Federal Drug Administration approved the Intuitive Surgical robot for use in hernia repair surgeries in 2014. Since then, Our Lady of the Lake’s Surgery Department in Baton Rouge has primarily adopted robotic surgery for elective surgical operations. It has become the standard surgical approach for the institution over the laparoscopic approach, particularly for ventral hernia repair. Using robotic surgery, rather than laparoscopic surgery, allows for better ergonomics in terms of greater surgical dexterity, precision, vision, and ability to close hernia defects. However, one factor that …
The Implementation And Feasibility Of A Patient/Family Satisfaction Surveyat A Growing Pediatric Palliative Care Program, Tabitha Kearns, Mallory Robichaux, Alexis Morvant, Annie Vaden, Judy Zeringue, Ashley Kiefer
The Implementation And Feasibility Of A Patient/Family Satisfaction Surveyat A Growing Pediatric Palliative Care Program, Tabitha Kearns, Mallory Robichaux, Alexis Morvant, Annie Vaden, Judy Zeringue, Ashley Kiefer
Medical Student Research Poster Symposium
Because of the remarkable growth of pediatric palliative care (PPC), many programs remain in their infancy. It is important to develop sustainable and efficient standardized operating procedures to assess patient and family satisfaction. An anonymous, online survey was developed using Pediatric Palliative Improvement Network’s Patient/ Family Satisfaction Survey tool and several program-specific questions. Eligibility criteria included: patient is followed by the PPC team; participants had at least one PPC interaction in the past six months, speak English or Spanish and are not in emotional distress; patient participants are at least 13 years of age and capable of completing the survey. …
The Effects Of Cognitive Impairment And Brain Atrophy On The Development Of Depressionin Patients With Multiple Sclerosis, Caitlyn Kelly, Jaeyeon Kweon, Carrie Pham, Shannin Moody, Deidre Devier
The Effects Of Cognitive Impairment And Brain Atrophy On The Development Of Depressionin Patients With Multiple Sclerosis, Caitlyn Kelly, Jaeyeon Kweon, Carrie Pham, Shannin Moody, Deidre Devier
Medical Student Research Poster Symposium
Background: Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease characterized by the demyelination of axons within the central nervous system leading to the development of motor, sensory, and cognitive deficits. The cognitive impairment present in people with MS typically presents as deficits in complex attention, memory, and planning. 25- 50% of patients with MS will develop depressive symptoms during the course of their disease. Depression can also affect aspects of cognition, particularly executive functioning, which can mimic the cognitive deficits seen in patients with MS. Previous studies have found that depressive symptoms appear more often in patients in the later …
Combination Therapy With Sodium Nitrite And Hydralazine Attenuates Oxidative Stress In Heart Failure With Preserved Ejection Fraction, Kashyap Koul, Kyle Lapenna, Zhen Li, Jake Doiron, John Wang, Thomas E. Sharp Iii, David J. Lefer
Combination Therapy With Sodium Nitrite And Hydralazine Attenuates Oxidative Stress In Heart Failure With Preserved Ejection Fraction, Kashyap Koul, Kyle Lapenna, Zhen Li, Jake Doiron, John Wang, Thomas E. Sharp Iii, David J. Lefer
Medical Student Research Poster Symposium
Introduction: Nitric oxide (NO) based therapeutics are powerful cardioprotective agents in the treatment of heart failure with reduced ejection fraction (HFrEF). However, NO therapy has failed to exert beneficial effects clinical studies of heart failure with preserved ejection fraction (HFpEF), We investigated (1) the effects of the NO donor, sodium nitrite, as a monotherapy, (2) hydralazine monotherapy, a known vasodilator and antioxidant, and (3) combination therapy with both drugs in a murine model of HFpEF assessed of left ventricular (LV) function, exercise tolerance, vascular function and oxidative stress. Methods: Male, C57/BL6N (n=15 per group) were placed on a Western high …
Has Enhanced Recovery After Surgery (Eras) Changed Opioid Prescribing Patterns Ingynecologic Surgery, Taylor Lambert, Whitney C. Sternfels, M. Brown, Andrew Chapple, Amelia Jernigan, Tara Castellano, Navya Nair
Has Enhanced Recovery After Surgery (Eras) Changed Opioid Prescribing Patterns Ingynecologic Surgery, Taylor Lambert, Whitney C. Sternfels, M. Brown, Andrew Chapple, Amelia Jernigan, Tara Castellano, Navya Nair
Medical Student Research Poster Symposium
Introduction: Opioid prescribing for pain management has significantly increased in the United States in the last three decades. Enhanced recovery after surgery (ERAS) is a multimodal approach to perioperative care that has been shown to improve patient outcomes. A component of ERAS is using a multimodal analgesia approach to pain management which emphasizes the use of opioid-sparing analgesics to achieve post-operative pain control. Though ERAS implementation has shown success in reducing inpatient opioid use, evidence in the reduction of post-discharge opioid prescribing patterns is lacking. In this study, we evaluate the effect of implementing an ERAS program on post-operative opioid …
Longitudinal Shotgun Metagenomic Analysis Of The Vaginal Microbiome During The Onsetof Bacterial Vaginosis, John W. Lammons, Jacob H. Elnagger, Evelyn Toh, Amy Dong, Kristal J. Aaron, Meng Luo, Ashutosh Tamhane, Elliot J. Lefkowitz, David E. Nelson, Christina A. Muzny, Christopher M. Taylor
Longitudinal Shotgun Metagenomic Analysis Of The Vaginal Microbiome During The Onsetof Bacterial Vaginosis, John W. Lammons, Jacob H. Elnagger, Evelyn Toh, Amy Dong, Kristal J. Aaron, Meng Luo, Ashutosh Tamhane, Elliot J. Lefkowitz, David E. Nelson, Christina A. Muzny, Christopher M. Taylor
Medical Student Research Poster Symposium
Introduction: Bacterial Vaginosis (BV) is a common disorder associated with the vaginal microbiome characterized by the displacement of lactobacillus with an overgrowth of anaerobes. Symptomatic cases can be associated with Pelvic Inflammatory Disease (PID), complications with pregnancy, and greater susceptibility to sexually transmitted infections. In cases where antibiotics are needed to treat BV, recurrence commonly occurs within 3 months to a year. Despite the prevalence of BV, the specific mechanism associated with the onset is unclear. In this pilot study we utilized shotgun metagenomics to identify the discrete changes occurring in the vaginal microbiome leading up to the onset of …
Switching To Intranasal Esketamine Maintains The Antidepressant Response Tointravenous Racemic Ketamine Administration: A Case Series Of 10 Patients, Michael D. Banov, Rachel E. Landrum, Michelle B. Moore, Steven T. Szabo
Switching To Intranasal Esketamine Maintains The Antidepressant Response Tointravenous Racemic Ketamine Administration: A Case Series Of 10 Patients, Michael D. Banov, Rachel E. Landrum, Michelle B. Moore, Steven T. Szabo
Medical Student Research Poster Symposium
Purpose This retrospective case series aims to assess the efficacy and safety of intranasal esketamine as maintenance antidepressant therapy in patients who have demonstrated clinical improvement with off-label intravenous racemic ketamine for treatment-resistant depression. Methods Included in this study are ten consecutive outpatients with treatment-resistant depression who all had a clinically meaningful response when treated with intravenous racemic ketamine and were then switched to intranasal esketamine for maintenance therapy. Patient outcomes were assessed with the Montgomery-Asberg Depression Rating Scale, Patient-Health Questionnaire- 9, and Clinical Global Impression of Improvement scale at each visit. Adverse effects were assessed at each treatment. Findings …
Investigating The Epigenetic Role Of Spdef In Prostate Cancer Through Identification Ofproteins Involved In Spdef Function, Margaret E. Larsen, Virginia Ronchi, Mousa Vatanmakanian, Jennifer Klein, Hari K. Koul
Investigating The Epigenetic Role Of Spdef In Prostate Cancer Through Identification Ofproteins Involved In Spdef Function, Margaret E. Larsen, Virginia Ronchi, Mousa Vatanmakanian, Jennifer Klein, Hari K. Koul
Medical Student Research Poster Symposium
Prostate cancer (PCa) is the most non-cutaneous cancer diagnosed in men, and results in approximately 30,000 deaths each year in the United States. Therapy resistant PCa, known as castration-resistant prostate cancer (CRPC), does not fully respond to common therapeutics. Most of the deaths from prostate cancer are due to metastatic CRPC indicating the importance of studying PCa to formulate more effective treatments. Previous studies have shown that the SAM pointed domain containing ETS transcription factor (SPDEF) protein plays a key role in the inhibition of prostate cancer metastasis; however, the mechanism for how SPDEF regulates metastasis is still poorly understood. …
Predictors Of Frailty Transitions Among People Living With Hiv, Viet Le, Hui-Yi Lin, Robert Siggins, Tekeda Ferguson, David Welsh
Predictors Of Frailty Transitions Among People Living With Hiv, Viet Le, Hui-Yi Lin, Robert Siggins, Tekeda Ferguson, David Welsh
Medical Student Research Poster Symposium
Background: Frailty is a geriatric syndrome typically marked by increased vulnerability to environmental stressors generally attributed to a diminished physiological reserve. People living with HIV (PLH) experience a precocious onset of frailty. Several biological and sociobehavioral factors have been associated with frailty in PLH. For example, we have recently reported that lifetime alcohol use increases the prevalence of frailty in PLH. The objective of this analysis was to identify potential predictors of frailty progression in PLH using a preliminary cross-sectional analysis. Methods: The New Orleans Alcohol Use in HIV (NOAH) Study collects a rich dataset that includes extensive survey-based and …
Rare Case Of Diffuse Skeletal Fluorosis Due To Inhalant Abuse Of Difluoroethane, Olivia G. Leonovicz, Patrik Suwak, J Chandler Van Dyke, Kaleb J. Robin, Matthew G. Cable
Rare Case Of Diffuse Skeletal Fluorosis Due To Inhalant Abuse Of Difluoroethane, Olivia G. Leonovicz, Patrik Suwak, J Chandler Van Dyke, Kaleb J. Robin, Matthew G. Cable
Medical Student Research Poster Symposium
Case: We present a rare case of diffuse skeletal fluorosis in a 56-year-old man with a history of inhalation and topical abuse of aerosolized dust cleaner containing difluoroethane as well as prior industrial exposure to chlorofluorocarbon-rich organic solvent cleaners. This patient had diffuse osteosclerotic bone disease on radiographs that elicited concern for a potentially aggressive physiologic or pathologic process, until increased fluoremia was identified as the cause. Management was conservative with removal of the causative agent. Conclusion: Skeletal fluorosis is an osteosclerotic bone disease caused by excessive ingestion of fluoride. Although this pathology is endemic in some parts of the …
The Development Of A Novel Gene Therapy, Flexion’S Fx201, For Thetreatment Of Osteoarthritis, Andrew Longanecker, Jessica Rivera, Luis Marrero, Vinod Dasa, Becca Senter, Jennifer Simkin
The Development Of A Novel Gene Therapy, Flexion’S Fx201, For Thetreatment Of Osteoarthritis, Andrew Longanecker, Jessica Rivera, Luis Marrero, Vinod Dasa, Becca Senter, Jennifer Simkin
Medical Student Research Poster Symposium
Background: Osteoarthritis is a complex multifactorial disorder that is the most frequent cause of pain, loss of function, and disability in adults1. Many modalities of treatment involve symptom alleviation but typically lead to joint replacement in end-stage disease. Consequently, there has been a shift towards the prevention of disease progression of early osteoarthritis. Due to advances in biochemical marker development, pro-inflammatory interleukins, specifically interleukin 1β (IL1β), has come into focus2. IL1β is implicated in many of the pathological advancement of osteoarthritis such as degradation of cartilage, bony malformation, and thickening of synovial tissue3-5. Previously, IL1 receptor antagonist (IL1ra) proved to …
Obese Microenvironment Contributes To Mdsc Phenotype Throughepigenetic Mechanisms, Rose Luder, Ramesh Thyur Puttalingaiah, Augusto Ochoa, Maria D. Sanchez Pino
Obese Microenvironment Contributes To Mdsc Phenotype Throughepigenetic Mechanisms, Rose Luder, Ramesh Thyur Puttalingaiah, Augusto Ochoa, Maria D. Sanchez Pino
Medical Student Research Poster Symposium
Obese patients are more susceptible to developing several different types of cancer. Myeloid derived suppressor cells (MDSC) promote tumor growth by blocking anti-tumor T cell responses. The expanded number and heightened function of MDSC have been found in mouse models of obesity. Our preliminary data show that patients with morbid obesity (body mass index [BMI] > 40 kg/m2) also have increased numbers of MDSC in peripheral blood, which could contribute to the cancer risk. Here, we investigate in vitro whether the cholesterol, as a factor of obese microenvironment, regulates the immunosuppressive phenotype of MDSC via epigenetic mechanisms. MDSC exert their immunosuppressive …
A Prospective, Double-Blinded, Randomized Controlled Trial Of Dehydrated Humanamniotic-Chorionic Membrane For Incisional Hernia Prophylaxis, Mark A. Maier, Tanja Milosavljevic, Frank Lau
A Prospective, Double-Blinded, Randomized Controlled Trial Of Dehydrated Humanamniotic-Chorionic Membrane For Incisional Hernia Prophylaxis, Mark A. Maier, Tanja Milosavljevic, Frank Lau
Medical Student Research Poster Symposium
Background: Patients undergoing open abdominal surgery face a 3.8 – 15% risk for developing an incisional hernia (IH). In IH, intra-abdominal contents protrude through the abdominal wall, placing patients at risk for bowel obstruction or necrosis, sepsis, and death. Herniorrhaphy is the mainstay of treatment but has a 50% failure rate at 1 year. Prevention of IH formation would reduce patient risk and healthcare cost. However, there exists no standard of care for IH prophylaxis. In a xenograft small animal model and subsequent pilot study of high- risk IH patients, dehydrated human amniotic-chorionic membrane (dHACM) significantly reduced IH formation by …
Local Control Of Pyoderma Gangrenosum, Mark A. Maier, Frank Lau, Alison Smith
Local Control Of Pyoderma Gangrenosum, Mark A. Maier, Frank Lau, Alison Smith
Medical Student Research Poster Symposium
Background: Pyoderma gangrenosum (PG) is a rare, chronic, ulcerative disease characterized by nonhealing wounds that worsen with debridement (i.e. pathergy). Its histopathology is classically marked by neutrophil infiltration, there is often no evidence of underlying infection. No consensus exists regarding pathogenesis, diagnosis, or treatment. In a small case series, we previously showed that applying dehydrated human amniotic-chorionic membrane (dHACM) after excisional debridement allows for normal wound healing and successfully closure through skin grafting. We present a case study outlining the treatment used for PG in this trial and methodology for gene analysis. We hypothesize that biomarker identification will predict which …
Oligometastatic (Ogm) Disease: An Emerging Concept In Oncology, Humza Malik, Tanner Dawson, James Ellia, Agustin Garcia
Oligometastatic (Ogm) Disease: An Emerging Concept In Oncology, Humza Malik, Tanner Dawson, James Ellia, Agustin Garcia
Medical Student Research Poster Symposium
A 46-year old presented with pain in her right axilla. Medical history was significant for stage II triple negative breast cancer (TNBC) diagnosed in 2008 treated with surgery (SRG), radiation (XRT) and chemotherapy (CTX). In 2014 she had a recurrence in the axilla treated with SRG and CTX. In 2016 she was found to have a chest wall recurrence treated with CTX and XRT. In 2018 she had a new unresectable chest wall recurrence and due to prior XRT she was considered to be at high risk for tissue necrosis with additional treatment. She was then treated with chest wall …
Effects Of Delta-9-Tetrahydrocannabinol (Thc) On Thermal Nociception Andconditioned Behavior In Sprague Dawley Rats, Taylor Marks, Peter Winsauer, Tamara Morris, Madison Priestley, Kayla Prevost
Effects Of Delta-9-Tetrahydrocannabinol (Thc) On Thermal Nociception Andconditioned Behavior In Sprague Dawley Rats, Taylor Marks, Peter Winsauer, Tamara Morris, Madison Priestley, Kayla Prevost
Medical Student Research Poster Symposium
Cannabinoids have been suggested as a possible alternative to opioids for pain management and as an adjunct to opioid administration to reduce the many adverse effects associated with their administration (i.e., administered to produce opioid-sparing effects). Although cannabinoids such as delta-9-tetrahydrocannabinol (THC) have been shown to produce antinociceptive effects, these effects have not typically been compared directly with its adverse effects – some of which include the disruption of cognitive and conditioned behaviors. These types of studies are necessary if cannabinoids such as THC can be considered a valid option for pain management. The present experiment was conducted to directly …
The Relevance Of More Training Data On Accuracy Of Model Prediction On Chest X-Ray, Ardenne S. Martin, Carl F. Sabottke, Bradley M. Spieler
The Relevance Of More Training Data On Accuracy Of Model Prediction On Chest X-Ray, Ardenne S. Martin, Carl F. Sabottke, Bradley M. Spieler
Medical Student Research Poster Symposium
Background: Artificial Intelligence (AI) has the potential to augment radiologist workflow and decrease strain on radiologists. Development of deep neural networks, artificial neural networks with neurons, synapses, weights, and functions, can be used to train AI models, serving as a response to this need. Publicly available databases like MIMIC-CXR and ChestX-ray8 offer hundreds of thousands of chest x-rays (CXR) used to train neural network models to detect and localize devices or disease. These publicly available databases make training AI models on large datasets possible. Once models are aptly trained, however, challenges include implementation into hospital Picture Archiving and Communication Systems …
Evaluation Of Rashes Among Patients Testing Positive For Covid-19 In An Urbanemergency Department, Kyla Maupin, Norris Akpan, Stacey Rhodes, Heather Murphy-Lavoie, Evrim Oral, Lisa Moreno-Walton
Evaluation Of Rashes Among Patients Testing Positive For Covid-19 In An Urbanemergency Department, Kyla Maupin, Norris Akpan, Stacey Rhodes, Heather Murphy-Lavoie, Evrim Oral, Lisa Moreno-Walton
Medical Student Research Poster Symposium
SARS-CoV-2 virus emerged in the United States in early 2020 causing a pandemic of respiratory illness. While respiratory and flu-like symptoms are well-known, other cutaneous findings such as maculopapular lesions, purpura, pruritic lesions, urticaria, acral lesions and chilblain are not. As a novel virus, it is important to document any COVID-related associations, as they may serve as a diagnostic, epidemiological, or prognostic markers of disease, and fill in gaps in our current understanding of COVID. We aim to identify the types of cutaneous manifestations among patients who tested positive for COVID in the ED, and to identify which groups are …
Regulatory Function Of The Anticoagulant Protein S In Patients With Chuvashpolycythemia, Devin M. Melancon, Verima Pereira, Rinku Majumder
Regulatory Function Of The Anticoagulant Protein S In Patients With Chuvashpolycythemia, Devin M. Melancon, Verima Pereira, Rinku Majumder
Medical Student Research Poster Symposium
Background: Chuvash polycythemia is a hematological disorder that is present worldwide but endemic to the Chuvash population, a Turkish ethnic group, in Russia. The disorder is caused by a homozygous germline mutation (R200W) in the von Hippel Lindau gene. This mutation impairs binding of pVHL to hypoxia-inducible factor 1-alpha (HIF-1α); lack of this interaction prevents degradation of HIF-1α. The resultant upregulation of HIF-1α, even in a normal oxygen state, increases the activity of erythropoietin, thereby causing polycythemia. Affected individuals experience increased rates of arterial and venous thrombosis unrelated to the increased concentration of hemoglobin. Aims: To determine whether upregulation of …
Evaluation And Optimization Of Autologous Asymmetric Bilateral Breastreconstruction Techniques, Margaret Mena, Cayley Leblanc, Harel Schwartzberg, Patrick Palines, Mark Stalder
Evaluation And Optimization Of Autologous Asymmetric Bilateral Breastreconstruction Techniques, Margaret Mena, Cayley Leblanc, Harel Schwartzberg, Patrick Palines, Mark Stalder
Medical Student Research Poster Symposium
Introduction: Breast reconstruction is an important part of breast cancer management and care. In autologous asymmetric bilateral breast reconstruction, the surgeon’s goal is to achieve a symmetric result despite working on two breasts with asymmetric needs. In addition, the surgeons often use different types of flaps, where a pedicle of the patient’s skin, fat, and blood supply is transferred to the breast. For example, the deep inferior epigastric perforator (DIEP) flap is a common choice for surgeons and uses the blood supply from the deep inferior epigastric artery. This use of the patient’s own tissue allows for a more natural, …
Vertiflex Improves Quality Of Life In Military Veterans Suffering Fromlow Back And Leg Pain, Andrew Mercante, Casey A. Murphy, Randolph L. Roig, E. Thomas Fincke
Vertiflex Improves Quality Of Life In Military Veterans Suffering Fromlow Back And Leg Pain, Andrew Mercante, Casey A. Murphy, Randolph L. Roig, E. Thomas Fincke
Medical Student Research Poster Symposium
Objectives: Lumbar interspinous process decompression (IPD) has been in use to treat patients with lumbar spinal stenosis (LSS) since the 1980’s. Vertiflex, a minimally invasive IPD procedure which inserts a small spacer between the vertebrae, is a FDA approved treatment that has been used to treat United States military veterans suffering from LSS. Our study aims to confirm that the Vertiflex procedure has successfully improved the quality of life through comparing pre-operative and post-operative surveys provided to the patients. Methods: Patients were given the SF-12v2 health survey at consistent time points: Pre- operation, 1 week post-op, 1 month post-op, 3 …