Medicine and Health Sciences Commons^™

Food Quality Induces A Miscible Disease With Relevance To Alzheimer’S Disease And Neurological Diseases, Ian J. Martins

Research outputs 2014 to 2021

Food and nutrition guidelines for the handling and processing of fresh fruit, bread, and vegetables are essential and fresh produce may require cold preservation procedures to prevent minimal bacterial and fungi contamination of food. Bacterial lipopolysaccharides (LPS) corrupt lipoprotein and amyloid beta (Aβ) metabolism in diabetes, Alzheimer’s disease (AD) and various neurological diseases. In the developing world the increased plasma LPS levels induce non-alcoholic fatty liver diseases and interfere with albumin and Aβ interactions with spontaneous Aβ oligomer formation in the cerebrospinal fluid and brain that leads to neuronapoptosis by inactivation of Starling’s equation that is responsible for the maintenance …

A Meta-Analytic Review Of The Efficacy Of Physical Exercise Interventions On Cognition In Individuals With Autism Spectrum Disorder And Adhd, Wei Z. Tan, Julie Ann Pooley, Craig P. Speelman

Research outputs 2014 to 2021

This review evaluates the efficacy of using physical exercise interventions on improving cognitive functions in individuals with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD). This review includes a meta-analysis based on a random-effects model of data reported in 22 studies with 579 participants aged 3–25 year old. The results revealed an overall small to medium effect of exercise on cognition, supporting the efficacy of exercise interventions in enhancing certain aspects of cognitive performance in individuals with ASD and/or ADHD. Specifically, similar to the general population literature, the cognitive benefits of exercise are not consistent across all aspects …

A Randomised Control Trial Of Salvage Radiotherapy And Androgen Deprivation Therapy Following Prostatectomy: Commentary On Five Year Follow-Up Findings, Scott Williams, John W. Yaxley, Geoffrey D. Coughlin, Robert A. Gardiner

Research outputs 2014 to 2021

No abstract provided.

Profiling Igg N-Glycans As Potential Biomarker Of Chronological And Biological Ages: A Community-Based Study In A Han Chinese Population, Xinwei Yu, Youix Wang, Jasminka Krištić, Jing Dong, Xi Chu, Siqi Ge, Hao Wang, Honghong Fang, Qing Gao, Di Lui, Zhongya Zhao, Hongli Peng, Maja P. Baković, Lijuan Wu, Manshu Song, Igor Rudan, Harry Campbell, Gordan Lauc, Wei Wang

Research outputs 2014 to 2021

As an important post-translation modifying process, glycosylation significantly affects the structure and function of immunoglobulin G (IgG) molecules and is essential in many steps of the inflammatory cascade. Studies have demonstrated the potential of using glycosylation features of IgG as a component of predictive biomarkers for chronological age in several European populations, whereas no study has been reported in Chinese. Herein, we report various patterns of changes in IgG glycosylation associated with age by analyzing IgG glycosylation in 701 community-based Han Chinese (244 males, 457 females; 23-68 years old). Eleven IgG glycans, including FA2B, A2G1, FA2[6]G1, FA2[3]G1, FA2[6]BG1, FA2[3]BG1, A2G2, …

Resilience As Resistance To The New Managerialism: Portraits That Reframe Nursing Through Quotes From The Field, Vicki Cope, Bronwyn Jones, Joyce Hendricks

Research outputs 2014 to 2021

Aim:

This paper acknowledges the relationship between resilience and the new managerialism of contemporary nursing.

Methods:

Qualitative portraiture methodology.

Discussion:

The new managerialism in hospital settings results in a rapidly increasing turnover of acutely ill or comorbid patients, which directly relates to retention and quality service. In education settings, the management imperative to recruit more students into the profession combined with financial cutbacks leads to similar tensions. In aged care the trend equates care directly with funding, with the same effect. Yet despite this, many registered nurses remain working. Portraiture explored 'why' nurses remain in workplaces often described as awful. …

Musculoskeletal Asymmetry In Football Athletes: A Product Of Limb Function Over Time, Nicolas H. Hart, Sophia Nimphius, Jason Weber, Tania Spiteri, Timo Rantalainen, Michael Dobbin, Robert Newton

Research outputs 2014 to 2021

Purpose

Asymmetrical loading patterns are commonplace in football sports. Our aim was to examine the influence of training age and limb function on lower-body musculoskeletal morphology.

Methods

Fifty-five elite football athletes were stratified into less experienced ( ≤ 3 yr; n = 27) and more experienced ( > 3 yr; n = 28) groups by training age. All athletes underwent whole-body dual-energy x-ray absorptiometry scans and lower-body peripheral quantitative computed tomography tibial scans on the kicking and support limbs.

Results

Significant interactions between training age and limb function were evident across all skeletal parameters (F16, 91 = 0.182, P = 0.031, …

Furthering The Quality Agenda In Aboriginal Community Controlled Health Services: Understanding The Relationship Between Accreditation, Continuous Quality Improvement And National Key Performance Indicator Reporting, Beverly Sibthorpe, Karen Gardner, Daniel Mcaullay

Research outputs 2014 to 2021

A rapidly expanding interest in quality in the Aboriginal-community-controlled health sector has led to widespread uptake of accreditation using more than one set of standards, a proliferation of continuous quality improvement programs and the introduction of key performance indicators. As yet, there has been no overarching logic that shows how they relate to each other, with consequent confusion within and outside the sector. We map the three approaches to the Framework for Performance Assessment in Primary Health Care, demonstrating their key differences and complementarity. There needs to be greater attention in both policy and practice to the purposes and alignment …

The Association Between Glycosylation Of Immunoglobulin G And Hypertension: A Multiple Ethnic Cross-Sectional Study, Youxin Wang, Lucija Klarić, Xinwei Yu, Kujtim Thaqi, Jing Dong, Mislav Novokmet, Jim Wilson, Ozren Polasek, Youqin Liu, Jasminka Krištić, Siqi Ge, Maja Pučić-Baković, Lijuan Wu, Yong Zhou, Ivo Ugrina, Manshu Song, Jie Zhang, Xiuhua Guo, Qiang Zeng, Igor Rudan, Harry Campbell, Yurii Aulchenko, Gordan Lauc, Wei Wang

Research outputs 2014 to 2021

More than half of all known proteins, and almost all membrane and extra-cellular proteins have oligosaccharide structures or glycans attached to them. Defects in glycosylation pathways are directly involved in at least 30 severe human diseases. A multiple center cross-sectional study (China, Croatia, and Scotland) was carried out to investigate the possible association between hypertension and IgG glycosylation. A hydrophilic interaction chromatography of fluorescently labeled glycans was used to analyze N-glycans attached to IgG in plasma samples from a total of 4757 individuals of Chinese Han, Croatian, and Scottish ethnicity. Five glycans (IgG with digalactosylated glycans) significantly differed in participants …

Exploratory Psychomteric Properties Of The Farsi And English Version Of Spiritual Needs Questionnaire (Spnq), Nejat Nazi, Lisa Whitehead, Marie Crowe

Research outputs 2014 to 2021

The aim of this study was to translate and test the psychometric properties of a Farsi and an English version of the spiritual needs questionnaire (SpNQ) a measure originally developed in German. The World Health Organization guideline for translating and validating questionnaires was used. Participants were recruited from hospitals in Iran and New Zealand during an outpatient follow-up appointment after cancer treatment. People diagnosed with cancer in Iran (68) and New Zealand (54) completed and returned the SpNQ (at time 1) and within the two week time period (time 2). Cronbach’s alpha ranged from 0.79 to 0.92, except for the …

Investigation Of The Relationship Between Chronic Stress And Insulin Resistance In A Chinese Population, Yuxiang Yan, Huanbo Xiao, Sisi Wang, Jing Zhao, Yan He, Wei Wang, Jing Dong

Research outputs 2014 to 2021

Background:

Chronic stress may facilitate the development of metabolic diseases. Insulin resistance is present long before the clinical manifestations of individual metabolic abnormalities. To explore whether chronic stress is an independent risk factor of insulin resistance, we investigated the relationship between the stress system, selected parameters of energy homeostasis, and insulin resistance in a Chinese population.

Methods:

We recruited 766 workers employed at four companies in Beijing. The degree of insulin resistance was determined using the homeostasis model assessment of insulin resistance (HOMA-IR). The highest quartile of HOMA-IR among all study subjects was further defined as insulin resistance in our …

Accuracy In Measurement Of Elevation Gain In Road Cycling, Paolo Mensaspa, Eric Haakonssen, Avish Sharma, Brad Clark

Research outputs 2014 to 2021

Purpose

Accurate measures of elevation gain are important for monitoring energy expenditure and physical load. The aim of this study was to determine the accuracy of barometric devices used for measuring elevation gain.

Methods

Observational validation study. Twenty-eight barometric altimeter devices (SRM and Garmin) were used to measure total elevation gain during cycling over three different climbs (length range: 3.2-18.4 km), giving a total of 216 climbs. An online mapping tool (http://www.freemaptools.com/elevation-finder.htm) was used to calculate the criterion measure of total elevation gain. Data were categorised into two weather conditions: dry and wet.

Results

The standard errors of the estimate …

Appetite Control With Relevance To Mitochondrial Biogenesis And Activation Of Post-Prandial Lipid Metabolism In Obesity Linked Diabetes, Ian J. Martins

Research outputs 2014 to 2021

In various communities in the developing and developed world the understanding of the ingestion of a healthy diet [1] and hepatic fat metabolism has become of critical importance to the treatment of obesity linked Type 2 diabetes that is now linked to various organ diseases [2]. In the developing world transition to healthy diets has become urgent to prevent insulin resistance [3,4] and the obesity pandemic [5-8]. The liver is the major organ for the metabolism of dietary fat and after consumption of a meal in healthy individuals the fat is rapidly metabolized by the liver. In obesity linked Type …

Using Technology, Bioinformatics And Health Informatics Approaches To Improve Learning Experiences In Optometry Education, Research And Practice, Vivek K. Gupta, Veer B. Gupta

Research outputs 2014 to 2021

Rapid advances in ocular diagnostic approaches and emerging links of pathological changes in the eye with systemic disorders have widened the scope of optometry as the front line of eye health care. Expanding professional requirements stipulate that optometry students get a meticulous training in relevant information and communication technologies (ICT) and various bioinformatics and health informatics software to meet current and future challenges. Greater incorporation of ICT approaches in optometry education can facilitate increased student engagement in shared learning experiences and improve collaborative learning. This, in turn, will enable students to participate in and prepare for the complex real-world situations. …

Socioeconomic, Bio-Demographic And Health/Behavioral Determinants Of Neonatal Mortality In Nigeria: A Multilevel Analysis Of 2013 Demographic And Health Survey, Emmanuel O. Adewuyi, Yun Zhao, Reeta Lamichhane

Research outputs 2014 to 2021

Background:

Nigeria ranks as one of the countries in the world with considerable burden of neonatal mortality. This study aims to investigate the association of socioeconomic, bio-demographic and health/behavioural factors with neonatal mortality in the country using the most current available evidence.

Methods:

The 2013 Nigeria demographic and health survey (NDHS) dataset was analyzed. Multiple logistic regression analysis was applied to identify determinants associated with neonatal mortality. The role of breastfeeding was examined by conducting analyses with and without adjustment for ‘breastfeeding status’. Complex sample analysis was used to control for the complex sampling design used in NDHS.

Results:

Neonatal …

Breastfeeding In Nigeria: A Systematic Review, Emmanuel O. Adewuyi, Kazeem Adefemi

Research outputs 2014 to 2021

Breastfeeding confers numerous benefits on babies and mothers. Early initiation, ‘exclusive breastfeeding’ and breastfeeding for at least two years post-delivery are the recommended practices. This study aims to examine the trends of breastfeeding practice in Nigeria by reviewing available published studies. The online databases of PubMed, Science Direct and the Web of Knowledge were searched using relevant terms. Studies identified were screened for eligibility and those that met the inclusion criteria were included in this review. Graphs and regression equations were generated using Microsoft Excel® to illustrate the duration of and trends in, breastfeeding practices in Nigeria. This review adopts …

Climate Change And Malaria Control: The Importance Of Mitigation And A Call To Action, Emmanuel O. Adewuyi, Kazeem Adefemi

Research outputs 2014 to 2021

Malaria has remained an important target for global disease control efforts for decades. The streams of funds and, consequently, availability of effective interventions for the disease have resulted in considerable reduction in its burden, globally. Despite the relative success of such global efforts, malaria remains a significant threat in over a hundred countries, worldwide, leading to about one million deaths and hundreds of millions of hospital visits, annually. Many researchers and health commentators have argued that global warming, a consequence of climate change, could be linked – directly or indirectly – to the persistence as well as the re-emergence of …

Heat Shock Gene Sirtuin 1 Regulates Post-Prandial Lipid Metabolism With Relevance To Nutrition And Appetite Regulation In Diabetes, Ian J. Martins

Research outputs 2014 to 2021

New discoveries in medicine are required to understand the importance of appetite regulation that is associated with the overconsumption of foodin Type 2 and Type 3 diabetes. Food restriction in diabetes is essential to maintain the hepatic metabolism of dietary fat with relevance to defective post-prandial lipid metabolism and to the global non alcoholic fatty liver disease (NAFLD) epidemic [1,2]. Premature brain aging has become important with the development of Type 3 diabetesand Alzheimer’s disease [3] that is associated with repression of the anti-aging gene Sirtuin 1 (Sirt 1) relevant topost-prandial lipid metabolism, amyloid beta metabolism (peptide involved in amyloid …

Spatiotemporal Pattern Analysis Of Scarlet Fever Incidence In Beijing, China, 2005–2014, Gehendra Mahara, Chao Wang, Da Huo, Qin Xu, Fangfang Huang, Lixin Tao, Jin Guo, Kai Cao, Liu Long, Jagadish K. Chhetri, Qi Gao, Wei Wang, Quanyi Wang, Xiuhua Guo

Research outputs 2014 to 2021

Objective:

To probe the spatiotemporal patterns of the incidence of scarlet fever in Beijing, China, from 2005 to 2014.

Methods:

A spatiotemporal analysis was conducted at the district/county level in the Beijing region based on the reported cases of scarlet fever during the study period. Moran’s autocorrelation coefficient was used to examine the spatial autocorrelation of scarlet fever, whereas the Getis-Ord Gi* statistic was used to determine the hotspot incidence of scarlet fever. Likewise, the space-time scan statistic was used to detect the space-time clusters, including the relative risk of scarlet fever incidence across all settings.

Results:

A total of …

Changes In The Plasma Proteome At Asymptomatic And Symptomatic Stages Of Autosomal Dominant Alzheimer's Disease, Julia Muenchhoff, Anne Poljak, Anbupalam Thalamuthu, Veer Gupta, Pratishtha Chatterjee, Mark Raftery, Colin Masters, John Morris, Randall Bateman, Anne Fagan, Ralph Martins, Perminder Sachdev

Research outputs 2014 to 2021

The autosomal dominant form of Alzheimer's disease (ADAD) is far less prevalent than late onset Alzheimer's disease (LOAD), but enables well-informed prospective studies, since symptom onset is near certain and age of onset is predictable. Our aim was to discover plasma proteins associated with early AD pathology by investigating plasma protein changes at the asymptomatic and symptomatic stages of ADAD. Eighty-one proteins were compared across asymptomatic mutation carriers (aMC, n = 15), symptomatic mutation carriers (sMC, n = 8) and related noncarriers (NC, n = 12). Proteins were also tested for associations with cognitive measures, brain amyloid deposition and glucose …

Exercise Improves Physical Function And Mental Health Of Brain Cancer Survivors: Two Exploratory Case Studies, Gregory T. Levin, Kenneth M. Greenwood, Favil Singh, Daphne Tsoi, Robert U. Newton

Research outputs 2014 to 2021

Background

Malignant brain tumors are unpredictable and incurable, with 5-year survival rates less than 30%. The poor prognosis combined with intensive treatment necessitates the inclusion of complementary and supportive therapies that optimize quality of life and reduce treatment-related declines in health. Exercise therapy has been shown to be beneficial in other cancer populations, but no evidence is available for brain cancer survivors. Therefore, we report results from 2 preliminary cases.

Methods

Two female patients diagnosed with glioblastoma multiforme and oligodendroglioma participated in a structured and supervised 12-week exercise program. The program consisted of two 1-hour resistance and aerobic exercise sessions …

Cardiovascular, Metabolic Effects And Dietary Composition Of Ad-Libitum Paleolithic Vs. Australian Guide To Healthy Eating Diets: A 4-Week Randomised Trial, Angela Genoni, Philippa Lyons-Wall, Johnny Lo, Amanda Devine

Research outputs 2014 to 2021

Background:

The Paleolithic diet is popular in Australia, however, limited literature surrounds the dietary pattern. Our primary aim was to compare the Paleolithic diet with the Australian Guide to Healthy Eating (AGHE) in terms of anthropometric, metabolic and cardiovascular risk factors, with a secondary aim to examine the macro and micronutrient composition of both dietary patterns

Methods:

39 healthy women (mean ± SD age 47 ± 13 years, BMI 27 ± 4 kg/m2) were randomised to either the Paleolithic (n = 22) or AGHE diet (n = 17) for four weeks. Three-day weighed food records, body composition and biochemistry data …

Greater Strength Gains After Training With Accentuated Eccentric Than Traditional Isoinertial Loads In Already Strength-Trained Men, Simon Walker, Anthony J. Blazevich, Greg Haff, James J. Tufano, Robert Newton, Keijo Häkkinen

Research outputs 2014 to 2021

As training experience increases it becomes more challenging to induce further neuromuscular adaptation. Consequently, strength trainers seek alternative training methods in order to further increase strength and muscle mass. One method is to utilize accentuated eccentric loading, which applies a greater external load during the eccentric phase of the lift as compared to the concentric phase. Based upon this practice, the purpose of this study was to determine the effects of 10 weeks of accentuated eccentric loading vs. traditional isoinertial resistance training in strength-trained men. Young (22 ± 3 years, 177 ± 6 cm, 76 ± 10 kg, n = …

Protocol For Care After Lymphoma (Caly) Trial: A Phase Ii Pilot Randomised Controlled Trial Of A Lymphoma Nurse-Led Model Of Survivorship Care, Karen Taylor, David Joske, Max Bulsara, Caroline Bulsara, Leanne Monterosso

Research outputs 2014 to 2021

Introduction:

Lymphoma is the sixth most common cancer diagnosed in Australia and internationally. Owing to the aggressive nature of the disease and intensity of treatment, survivors face long-term effects that impact on quality of life. Current models of follow-up post-treatment fail to address these complex issues. Given that 74% of patients with lymphoma cancer now survive 5 years beyond diagnosis and treatment, it is important to address this gap in care.

Aim:

To determine self-reported informational and practical needs, anxiety, depression, stress, coping and empowerment at baseline, 3 and 6 months.

Methods and analysis:

A pilot randomised controlled trial will …

A Randomized Controlled Trial Of Very Early Rehabilitation In Speech After Stroke, Erin Godecke, Elizabeth Armstrong, Tapan Rai, Sandy Middleton, Natalie Ciccone, Anne Whitworth, Miranda Rose, Audrey Holland, Fiona Ellery, Graeme Hankey, Dominique Cadilhac, Julie Bernhardt

Research outputs 2014 to 2021

Rationale:

The efficacy of rehabilitation therapy for aphasia caused by stroke is uncertain.

Aims and hypothesis:

The Very Early Rehabilitation of Speech (VERSE) trial aims to determine if intensive prescribed aphasia therapy (VERSE) is more effective and cost saving than non-prescribed, intensive (usual care-plus) and non-intensive usual care (UC) therapy when started within 15 days of stroke onset and continued daily over four weeks. We hypothesize that aphasia therapy when started very early after stroke and delivered daily could enhance recovery of communication compared with UC.

Sample size estimates:

A total of 246 participants (82 per arm) will provide 80% …

Engaging Australian Aboriginal Narratives To Challenge Attitudes And Create Empathy In Health Care: A Methodological Perspective, Toni D. Wain, Moira Sim, Dawn Bessarab, Donna Mak, Colleen Hayward, Cobie Rudd

Research outputs 2014 to 2021

Background:

Unconscious bias and negative attitudes towards minority groups have detrimental effects on the way health care is, or is not, provided to these groups. Recognition of racist attitudes and behaviours as well as understanding clients' experiences of health and health care are pivotal to developing better health care strategies to positively impact on the quality and safety of care provided to Indigenous people. Indigenous research demands inclusive research processes and the use of culturally appropriate methodologies. This paper presents a methodological account of collecting narratives which accurately and respectfully reflect Aboriginal Australians' experiences with health care in Western Australia. …

Sources, Incidence And Effects Of Non-Physical Workplace Violence Against Nurses In Ghana, Issac Boafo, Peter Hancock, Eyal Gringart

Research outputs 2014 to 2021

Aim

To document the incidence, sources and effects of workplace verbal abuse and sexual harassment against Ghanaian nurses.

Methods

A cross-sectional study was conducted in Ghana from 2013–2014 which surveyed 592 professional nurses and midwives working in public hospitals in Ghana using the health sector violence questionnaire.

Results

The majority of participants were females (80%). The average age of participants was 31·76 years and the average number of years practising as nurse was 7·38. Twelve per cent of the participants experienced at least one incident of sexual harassment and 52·2% were exposed to verbal abuse. The majority of perpetrators of …

1h-Nmr Urinary Metabolomic Profiling For Diagnosis Of Gastric Cancer, Angela W. Chan, Pascal Mercier, Daniel Schiller, Robert Bailey, Sarah Robbins, Dean T. Eurich, Michael B. Sawyer, David Broadhurst

Research outputs 2014 to 2021

Background:

Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients.

Methods:

Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using ¹H nuclear magnetic resonance (¹H-NMR) spectroscopy, generating 77 reproducible metabolites (QC-RSD < 25%). Univariate and multivariate (MVA) statistics were employed. A parsimonious biomarker profile of GC vs HE was investigated using LASSO regularised logistic regression (LASSO-LR). Model performance was assessed using Receiver Operating Characteristic (ROC) curves.

Results:

GC displayed a clear discriminatory biomarker profile; the BN profile overlapped with GC and HE. LASSO-LR identified …

Protocol Of The Australasian Malignant Pleural Effusion-2 (Ample-2) Trial: A Multicentre Randomised Study Of Aggressive Versus Symptom-Guided Drainage Via Indwelling Pleural Catheters, Maree Azzopardi, Rajesh Thomas, Sanjeevan Muruganandan, David C.L Lam, Luke Garske, Benjamin Kwan, Muhammad Redzwan S Rashid Ali, Phan Nguyen, Elaine Yap, Fiona Horwood, Alexander Ritchie, Michael Bint, Claire Tobin, Ranjan Shrestha, Francesco Piccolo, Christian De Chaneet, Jenette Creaney, Robert Newton, Delia Hendrie, Kevin Murray, Catherine Read, David Feller-Kopman, Nick Maskell, Y C Gary Lee

Research outputs 2014 to 2021

Introduction

Malignant pleural effusions (MPEs) can complicate most cancers, causing dyspnoea and impairing quality of life (QoL). Indwelling pleural catheters (IPCs) are a novel management approach allowing ambulatory fluid drainage and are increasingly used as an alternative to pleurodesis. IPC drainage approaches vary greatly between centres. Some advocate aggressive (usually daily) removal of fluid to provide best symptom control and chance of spontaneous pleurodesis. Daily drainages however demand considerably more resources and may increase risks of complications. Others believe that MPE care is palliative and drainage should be performed only when patients become symptomatic (often weekly to monthly). Identifying the …

Abcb5-Targeted Chemoresistance Reversal Inhibits Merkel Cell Carcinoma Growth, Sonja Kleffel, Nayoung Lee, Cecilia Lezcano, Brian Wilson, Kristine Sobolewski, Karim Saab, Hansgeorg Mueller, Qian Zhan, Christian Posch, Christopher Elco, Andrew Dorosario, Sarah Garcia, Manisha Thakuria, Yaoyu Wang, Linda Wang, George Murphy, Markus Frank, Tobias Schatton

Research outputs 2014 to 2021

Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer with profound but poorly understood resistance to chemotherapy, which poses a significant barrier to clinical MCC treatment. Here we show that ATP-binding cassette member B5 (ABCB5) confers resistance to standard-of-care MCC chemotherapeutic agents and provide proof-of-principle that ABCB5 blockade can inhibit human MCC tumor growth through sensitization to drug-induced cell cytotoxicity. ABCB5 expression was detected in both established MCC lines and clinical MCC specimens at levels significantly higher than those in normal skin. Carboplatin- and etoposide-resistant MCC cell lines exhibited increased expression of ABCB5, along with enhanced ABCB1 and …

The Effectiveness Of Self-Management Mobile Phone And Tablet Apps In Long-Term Condition Management: A Systematic Review, Lisa Whitehead, Philippa Seaton

Research outputs 2014 to 2021

Background:

Long-term conditions and their concomitant management place considerable pressure on patients, communities, and health care systems worldwide. International clinical guidelines on the majority of long-term conditions recommend the inclusion of self-management programs in routine management. Self-management programs have been associated with improved health outcomes; however, the successful and sustainable transfer of research programs into clinical practice has been inconsistent. Recent developments in mobile technology, such as mobile phone and tablet computer apps, could help in developing a platform for the delivery of self-management interventions that are adaptable, of low cost, and easily accessible.

Objective:

We conducted a systematic review …