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Articles 1 - 21 of 21
Full-Text Articles in Medicine and Health Sciences
What Should Oncology Nurses Know When Caring For Veterans?, Elizabeth A. Delaney
What Should Oncology Nurses Know When Caring For Veterans?, Elizabeth A. Delaney
Nursing Faculty Publications
No abstract provided.
Sirt2 Maintains Genome Integrity And Suppresses Tumorigenesis Through Regulating Apc/C Activity, Hyun-Seok Kim, Athanassios Vassilopoulos, Rui-Hong Wang, Tyler Lahusen, Zhen Xiao, Xiaoling Xu, Cuiling Li, Timothy D. Veenstra, Bing Li, Hongtao Yu, Junfang Ji, Xin Wei Wang, Seong-Hoon Park, Yong I Cha, David Gius, Chu-Xia Deng
Sirt2 Maintains Genome Integrity And Suppresses Tumorigenesis Through Regulating Apc/C Activity, Hyun-Seok Kim, Athanassios Vassilopoulos, Rui-Hong Wang, Tyler Lahusen, Zhen Xiao, Xiaoling Xu, Cuiling Li, Timothy D. Veenstra, Bing Li, Hongtao Yu, Junfang Ji, Xin Wei Wang, Seong-Hoon Park, Yong I Cha, David Gius, Chu-Xia Deng
Pharmaceutical Sciences Faculty Publications
Members of sirtuin family regulate multiple critical biological processes, yet their role in carcinogenesis remains controversial. To investigate the physiological functions of SIRT2 in development and tumorigenesis, we disrupted Sirt2 in mice. We demonstrated that SIRT2 regulates the anaphase-promoting complex/cyclosome activity through deacetylation of its coactivators, APC(CDH1) and CDC20. SIRT2 deficiency caused increased levels of mitotic regulators, including Aurora-A and -B that direct centrosome amplification, aneuploidy, and mitotic cell death. Sirt2-deficient mice develop gender-specific tumorigenesis, with females primarily developing mammary tumors, and males developing more hepatocellular carcinoma (HCC). Human breast cancers and HCC samples exhibited reduced SIRT2 levels compared with …
Novel Membrane-Associated Androgen Receptor Splice Variant Potentiates Proliferative And Survival Responses In Prostate Cancer Cells, Xi Yang, Zhiyong Guo, Feng Sun, Wei Li, Alan Alfano, Hermela Shimelis, Mingyuan Chen, Angela M H Brodie, Hegang Chen, Zhen Xiao, Timothy D. Veenstra, Yun Qiu
Novel Membrane-Associated Androgen Receptor Splice Variant Potentiates Proliferative And Survival Responses In Prostate Cancer Cells, Xi Yang, Zhiyong Guo, Feng Sun, Wei Li, Alan Alfano, Hermela Shimelis, Mingyuan Chen, Angela M H Brodie, Hegang Chen, Zhen Xiao, Timothy D. Veenstra, Yun Qiu
Pharmaceutical Sciences Faculty Publications
Progression from the androgen-sensitive to androgen-insensitive (or castration-resistant) stage is the major obstacle for sustained effectiveness of hormonal therapy for prostate cancer. The androgen receptor (AR) and its splice variants play important roles in regulating the transcription program essential for castration resistance. Here, we report the identification of a novel AR splice variant, designated as AR8, which is up-regulated in castration-resistant prostate cancer cells. AR8 is structurally different from other known AR splice variants because it lacks a DNA binding domain and therefore, unlikely functions as a transcription factor on its own. Immunofluorescence staining revealed that AR8 was primarily localized …
Let Them Be Heroes, Christina J. Kinch
Presence Of Porphyromonas Gingivalis In Gingival Squamous Cell Carcinoma, J. Katz, M. Onate, Kaleb M. Pauley, I Bhattacharyya, S. Cha
Presence Of Porphyromonas Gingivalis In Gingival Squamous Cell Carcinoma, J. Katz, M. Onate, Kaleb M. Pauley, I Bhattacharyya, S. Cha
Science and Mathematics Faculty Publications
Periodontal disease has been recently linked to a variety of systemic conditions such as diabetes, cardiovascular disease, preterm delivery, and oral cancer. The most common bacteria associated with periodontal disease, Porphyromonas gingivalis (P. gingivalis) has not yet been studied in the malignant gingival tissues. The objective of this study was to investigate the presence of P. gingivalis in specimens from squamous cell carcinoma patients. We have performed immunohistochemical staining to investigate the presence of P. gingivalis and Streptococcus gordonii (S. gordonii), a non invasive oral bacteria, in paraffin embedded samples of gingival squamous cell carcinoma (n=10) and …
The Tao And The Art Of Feminine Beauty, Tia Zirkle
The Tao And The Art Of Feminine Beauty, Tia Zirkle
CedarEthics Online
No abstract provided.
The Effect Of Tamoxifen And Raloxifene On Estrogen Metabolism And Endometrial Cancer Risk, Marian Y. Williams-Brown, Sana M. Salih, Xia Xu, Timothy D. Veenstra, Muhammad Saeed, Shaleen K. Theiler, Concepcion R. Diaz-Arrastia, Salama A. Salama
The Effect Of Tamoxifen And Raloxifene On Estrogen Metabolism And Endometrial Cancer Risk, Marian Y. Williams-Brown, Sana M. Salih, Xia Xu, Timothy D. Veenstra, Muhammad Saeed, Shaleen K. Theiler, Concepcion R. Diaz-Arrastia, Salama A. Salama
Pharmaceutical Sciences Faculty Publications
Selective estrogen receptor modulators (SERMs) demonstrate differential endometrial cancer (EC) risk. While tamoxifen (TAM) use increases the risk of endometrial hyperplasia and malignancy, raloxifene (RAL) has neutral effects on the uterus. How TAM increases the risk of EC and why TAM and RAL differentially modulate the risk for EC, however, remain elusive. Here, we tested the hypothesis that TAM increases the risk for EC, at least in part, by enhancing the local estrogen biosynthesis and directing estrogen metabolism towards the formation of genotoxic and hormonally active estrogen metabolites. In addition, the differential effects of TAM and RAL in EC risk …
Regulation Of Microtubule-Based Microtubule Nucleation By Mammalian Polo-Like Kinase 1, Yoshikazu Johmura, Nak-Kyun Soung, Jung-Eun Park, Li-Rong Yu, Ming Zhou, Jeong K. Bang, Bo-Yeon Kim, Timothy D. Veenstra, Raymond L. Erikson, Kyung S. Lee
Regulation Of Microtubule-Based Microtubule Nucleation By Mammalian Polo-Like Kinase 1, Yoshikazu Johmura, Nak-Kyun Soung, Jung-Eun Park, Li-Rong Yu, Ming Zhou, Jeong K. Bang, Bo-Yeon Kim, Timothy D. Veenstra, Raymond L. Erikson, Kyung S. Lee
Pharmaceutical Sciences Faculty Publications
Bipolar spindle formation is pivotal for accurate segregation of mitotic chromosomes during cell division. A growing body of evidence suggests that, in addition to centrosome- and chromatin-based microtubule (MT) nucleation, MT-based MT nucleation plays an important role for proper bipolar spindle formation in various eukaryotic organisms. Although a recently discovered Augmin complex appears to play a central role in this event, how Augmin is regulated remains unknown. Here we provide evidence that a mammalian polo-like kinase 1 (Plk1) localizes to mitotic spindles and promotes MT-based MT nucleation by directly regulating Augmin. Mechanistically, we demonstrated that Cdc2-dependent phosphorylation on a γ-tubulin …
2011 Baseball All-Americans Announced, Cedarville University
2011 Baseball All-Americans Announced, Cedarville University
Baseball News Releases
No abstract provided.
Department Of Nursing Class Of 2011 Convocation Program, Cedarville University
Department Of Nursing Class Of 2011 Convocation Program, Cedarville University
B.S.N. and M.S.N. Academic Celebrations
No abstract provided.
The Rag1 V(D)J Recombinase/Ubiquitin Ligase Promotes Ubiquitylation Of Acetylated, Phosphorylated Histone 3.3, Jessica M. Jones, Anamika Bhattacharyya, Carrie Simkus, Brice Vallieres, Timothy D. Veenstra, Ming Zhou
The Rag1 V(D)J Recombinase/Ubiquitin Ligase Promotes Ubiquitylation Of Acetylated, Phosphorylated Histone 3.3, Jessica M. Jones, Anamika Bhattacharyya, Carrie Simkus, Brice Vallieres, Timothy D. Veenstra, Ming Zhou
Pharmaceutical Sciences Faculty Publications
Histone variant H3.3 is associated with transcriptionally active chromatin and accumulates at loci undergoing preparation for V(D)J recombination, a DNA rearrangement required for the assembly of antigen receptors and development of B and T lymphocytes. Here we demonstrate that the RAG1 V(D)J recombinase protein promotes ubiquitylation of H3.3 that has been heavily acetylated and phosphorylated on serine 31 (acetyl-H3.3 S31p). A fragment of RAG1 promoted formation of a mono-ubiquitylated H3 product that was identified using mass spectrometry as ubiquitylated acetyl-H3.3 S31p. H3 was ubiquitylated at multiple lysine residues, and correspondingly, di-, tri- and higher-order ubiquitylated products were detected at low …
2011 American Mideast Conference Championship, Cedarville University
2011 American Mideast Conference Championship, Cedarville University
Men's and Women's Track & Field Programs
No abstract provided.
The Nazi Research Data: Should We Use It?, Sarah Wilson
The Nazi Research Data: Should We Use It?, Sarah Wilson
CedarEthics Online
No abstract provided.
2011 Naia Women's Outdoor Track & Field All-America Team Announced, Cedarville University
2011 Naia Women's Outdoor Track & Field All-America Team Announced, Cedarville University
Men's and Women's Track & Field News Releases
No abstract provided.
Healthy In Mind, Body, And Spirit, Milton E. Becknell
Healthy In Mind, Body, And Spirit, Milton E. Becknell
Psychology Faculty Publications
The stress of modern life can manifest itself in our physical, mental, and spiritual health. Rest is crucial for optimal health across all dimensions.
2011 Cedarville Collegiate Open, Cedarville University
2011 Cedarville Collegiate Open, Cedarville University
Men's and Women's Track & Field Programs
No abstract provided.
2011 Richey High School Tune-Up Track & Field Meet, Cedarville University
2011 Richey High School Tune-Up Track & Field Meet, Cedarville University
Men's and Women's Track & Field Programs
No abstract provided.
2011 Cedarville Collegiate Invitational, Cedarville University
2011 Cedarville Collegiate Invitational, Cedarville University
Men's and Women's Track & Field Programs
No abstract provided.
Genome Medicine: Past, Present And Future, Charles Auffray, Timothy Caulfield, Muin J. Khoury, James R. Lupski, Matthias Schwab, Timothy D. Veenstra
Genome Medicine: Past, Present And Future, Charles Auffray, Timothy Caulfield, Muin J. Khoury, James R. Lupski, Matthias Schwab, Timothy D. Veenstra
Pharmaceutical Sciences Faculty Publications
No abstract provided.
Pharmacy And Faith Can Intersect, Marc A. Sweeney
Pharmacy And Faith Can Intersect, Marc A. Sweeney
Faculty Integration Papers
No abstract provided.
Epilepsy In The Older Adult, Timothy E. Welty, Marty L. Eng
Epilepsy In The Older Adult, Timothy E. Welty, Marty L. Eng
Pharmacy Faculty Publications
No abstract provided.