Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Humans (2)
- 25-Hydroxyvitamin D 2/blood (1)
- Actins/metabolism (1)
- Adolescent (1)
- Adult (1)
-
- Animals (1)
- Anti-microbial peptide (1)
- Asthma/physiopathology (1)
- Biological Availability (1)
- Calcifediol/blood (1)
- Cell Differentiation/drug effects (1)
- Cell Line (1)
- Cell Proliferation (1)
- Cells (1)
- Child (1)
- Chronic Disease (1)
- Cultured (1)
- Cystic Fibrosis/physiopathology (1)
- Cystic fibrosis (1)
- Dietary Supplements (1)
- Ethanol (1)
- Female (1)
- Fibroblasts/cytology/drug effects/metabolism (1)
- Gene Expression Regulation (1)
- Influenza A virus (1)
- Interstitial/physiopathology (1)
- Intestinal Absorption (1)
- Lung Diseases (1)
- Lung/cytology/drug effects/growth & development (1)
- Lung/physiopathology (1)
Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Pilot Study Of Vitamin D Supplementation In Adults With Cystic Fibrosis Pulmonary Exacerbation, Ruth Grossmann, Susu Zughaier, Meena Kumari, Shabnam Seydafkan, Robert Lyles, Shuling Liu, Viranuj Sueblinvong, Michael Schechter, Arlene Stecenko, Thomas Ziegler, Vin Tangpricha
Pilot Study Of Vitamin D Supplementation In Adults With Cystic Fibrosis Pulmonary Exacerbation, Ruth Grossmann, Susu Zughaier, Meena Kumari, Shabnam Seydafkan, Robert Lyles, Shuling Liu, Viranuj Sueblinvong, Michael Schechter, Arlene Stecenko, Thomas Ziegler, Vin Tangpricha
Ruth E. Grossmann
Background: Vitamin D insufficiency is common in cystic fibrosis (CF) and vitamin D repletion may have an important role in improving clinical outcomes in CF. This randomized, placebo-controlled, pilot study examined the feasibility and impact of a single, large dose of cholecalciferol on vitamin D status and clinical outcomes in subjects with CF. Methods: Thirty adults with were randomized in a double-blinded, pilot study to receive 250,000 IU cholecalciferol or placebo within 48 h of hospital admission for a pulmonary exacerbation. Concentrations of 25-hydroxyvitamin D (25(OH)D), clinical outcomes and potential adverse events were assessed up to one year after randomization. …
Impact Of Vitamin D Supplementation On Markers Of Inflammation In Adults With Cystic Fibrosis Hospitalized For A Pulmonary Exacerbation, Ruth Grossmann, S. Zughaier, S. Liu, R. Lyles, V. Tangpricha
Impact Of Vitamin D Supplementation On Markers Of Inflammation In Adults With Cystic Fibrosis Hospitalized For A Pulmonary Exacerbation, Ruth Grossmann, S. Zughaier, S. Liu, R. Lyles, V. Tangpricha
Ruth E. Grossmann
Patients with cystic fibrosis (CF) suffer from chronic lung infection and inflammation leading to respiratory failure. Vitamin D deficiency is common in patients with CF, and correction of vitamin D deficiency may improve innate immunity and reduce inflammation in patients with CF. We conducted a double-blinded, placebo-controlled, randomized clinical trial of high-dose vitamin D to assess the impact of vitamin D therapy on antimicrobial peptide concentrations and markers of inflammation. We randomized 30 adults with CF hospitalized with a pulmonary exacerbation to 250 000 IU of cholecalciferol or placebo, and evaluated changes in plasma concentrations of inflammatory markers and the …
Risk Factors For Vitamin D Deficiency And Relationship With Cardiac Biomarkers, Inflammation And Immune Restoration In Hiv-Infected Youth, A. Eckard, S. Judd, T. Ziegler, A. Camacho-Gonzalez, A. Fitzpatrick, G. Hadley, Ruth Grossmann, L. Seaton, S. Seydafkan, M. Mulligan, N. Rimann, V. Tangpricha, G. Mccomsey
Risk Factors For Vitamin D Deficiency And Relationship With Cardiac Biomarkers, Inflammation And Immune Restoration In Hiv-Infected Youth, A. Eckard, S. Judd, T. Ziegler, A. Camacho-Gonzalez, A. Fitzpatrick, G. Hadley, Ruth Grossmann, L. Seaton, S. Seydafkan, M. Mulligan, N. Rimann, V. Tangpricha, G. Mccomsey
Ruth E. Grossmann
BACKGROUND: Vitamin D deficiency is common in HIV-infected individuals. In adults, traditional and HIV-related factors play a role in vitamin D status, and deficiency appears to impair immune restoration and exacerbate HIV complications, like cardiovascular disease (CVD). This study sought to determine factors contributing to vitamin D status in HIV-infected youth and investigate the relationship with CVD risk, inflammation and immune restoration. METHODS: HIV-infected subjects (1-25 years old) were enrolled prospectively along with healthy controls that were group-matched by age, sex and race. HIV data were collected for the HIV-infected group, while traditional risk factors, including vitamin D intake, sun …
Vitamin D And Chronic Lung Disease: A Review Of Molecular Mechanisms And Clinical Studies, J. Finklea, Ruth Grossmann, V. Tangpricha
Vitamin D And Chronic Lung Disease: A Review Of Molecular Mechanisms And Clinical Studies, J. Finklea, Ruth Grossmann, V. Tangpricha
Ruth E. Grossmann
Vitamin D is classically recognized for its role in calcium homeostasis and skeletal metabolism. Over the last few decades, vitamin D deficiency has increased in prevalence in adults and children. Potential extraskeletal effects of vitamin D have been under investigation for several diseases. Several cross-sectional studies have associated lower vitamin D status with decreased lung function. This finding has prompted investigators to examine the association of vitamin D deficiency with several chronic lung diseases. One major focus has been the link between maternal vitamin D status and childhood asthma. Vitamin D deficiency has also been associated with increased risk of …
Pdgf-Ralpha Gene Expression Predicts Proliferation, But Pdgf-A Suppresses Transdifferentiation Of Neonatal Mouse Lung Myofibroblasts, P. Kimani, A. Holmes, Ruth Grossmann, S. Mcgowan
Pdgf-Ralpha Gene Expression Predicts Proliferation, But Pdgf-A Suppresses Transdifferentiation Of Neonatal Mouse Lung Myofibroblasts, P. Kimani, A. Holmes, Ruth Grossmann, S. Mcgowan
Ruth E. Grossmann
BACKGROUND: Platelet-derived growth factor A (PDGF-A) signals solely through PDGF-Ralpha, and is required for fibroblast proliferation and transdifferentiation (fibroblast to myofibroblast conversion) during alveolar development, because pdgfa-null mice lack both myofibroblasts and alveoli. However, these PDGF-A-mediated mechanisms remain incompletely defined. At postnatal days 4 and 12 (P4 and P12), using mouse lung fibroblasts, we examined (a) how PDGF-Ralpha correlates with ki67 (proliferation marker) or alpha-smooth muscle actin (alphaSMA, myofibroblast marker) expression, and (b) whether PDGF-A directly affects alphaSMA or modifies stimulation by transforming growth factor beta (TGFbeta). METHODS: Using flow cytometry we examined PDGF-Ralpha, alphaSMA and Ki67 in mice which …
Evaluation Of Vehicle Substances On Vitamin D Bioavailability: A Systematic Review, Ruth Grossmann, V. Tangpricha
Evaluation Of Vehicle Substances On Vitamin D Bioavailability: A Systematic Review, Ruth Grossmann, V. Tangpricha
Ruth E. Grossmann
Vitamin D insufficiency is a common medical condition. Vitamin supplements can be ingested to improve vitamin D status. It is not known if the vehicle substance that is combined with the vitamin D tablet influences the bioavailability of vitamin D. The purpose of this review is to examine the impact of different vehicles on vitamin D bioavailability. A comprehensive literature search identified studies that directly compared the absorption of vitamin D from two or more vehicles. The change in mean serum 25(OH)D per average daily dose of vitamin D supplemented was calculated and compared among the studies. We identified four …