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Full-Text Articles in Medicine and Health Sciences

Spleen As A Distinct Site For Dendritic Cell Haematopoiesis, Jonathan Tan, Helen O'Neill Jul 2015

Spleen As A Distinct Site For Dendritic Cell Haematopoiesis, Jonathan Tan, Helen O'Neill

Jonathan Tan

No abstract provided.


The Immune System In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Sonya Marshall-Gradisnik, Donald Staines Sep 2011

The Immune System In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Sonya Marshall-Gradisnik, Donald Staines

Sonya Marshall-Gradisnik

Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a heterogeneous multifactorial disease characterised by severe fatigue and a range of systemic symptoms resulting in an ability to function at optimal levels. The symptoms of CFS/ME vary from patient to patient; however, prolonged and disabling fatigue, impaired memory and concentration and widespread pain are typical symptoms report by most patients. There is no known single causal factor associated with CFS/ME although development of the condition post-infection is common. CFS/ME may affect the nervous, immune, endocrine, muscular, cardiovascular and respiratory systems. The present chapter review research pertaining to immunological function and other related areas …


Habitat As A Source Of Intrapopulational Variation Of Ornament Size In Galápagos Lava Lizards (Microlophus Albemarlensis Complex), Mark Jordan, Jennifer Hollis, Paul Stone, Howard Stone Jul 2011

Habitat As A Source Of Intrapopulational Variation Of Ornament Size In Galápagos Lava Lizards (Microlophus Albemarlensis Complex), Mark Jordan, Jennifer Hollis, Paul Stone, Howard Stone

Mark A. Jordan

Gradients in habitat structure are expected to influence the outcome of selection on traits that contribute to communicative display. Galápagos lava lizards (Microlophus albemarlensis complex) on Isla Plaza Sur in the Galápagos Islands occur across a gradient of vegetative cover. Previous work in this population has shown that traits associated with predator avoidance are magnified in habitats with low vegetative cover. This pattern suggests that predation pressure differs by habitat and thus, may act to select against the elaboration of ornamentation. We measured the size of the chin patch, an ornament known to be used in intraspecific signaling, to test …


Island Fragmentation Drives Evolutionary Diversification Of Galápagos Lava Lizards (Microlophus Spp.), Mark Jordan, H. Snell Jul 2011

Island Fragmentation Drives Evolutionary Diversification Of Galápagos Lava Lizards (Microlophus Spp.), Mark Jordan, H. Snell

Mark A. Jordan

No abstract provided.


Phenotypic Divergence Despite High Levels Of Gene Flow In Galapagos Lava Lizards (Microlophus Albemarlensis), Mark Jordan, H. Snell, H. Snell, W. Jordan Jul 2011

Phenotypic Divergence Despite High Levels Of Gene Flow In Galapagos Lava Lizards (Microlophus Albemarlensis), Mark Jordan, H. Snell, H. Snell, W. Jordan

Mark A. Jordan

The extent of evolutionary divergence of phenotypes between habitats is predominantly the result of the balance of differential natural selection and gene flow. Lava lizards (Microlophus albemarlensis) on the small island of Plaza Sur in the Galápagos archipelago inhabit contrasting habitats: dense vegetation on the western end of the island thins rapidly in a transitional area, before becoming absent on the eastern half. Associated with these habitats are phenotypic differences in traits linked to predator avoidance (increased wariness, sprint speed, and endurance in lizards from the sparsely vegetated habitat). This population provides an opportunity to test the hypothesis that reduced …


Historical Fragmentation And Genetic Drift In Populations Of Galápagos Lava Lizards (Microlophus Albemarlensis Complex), Mark Jordan, H. Snell Jul 2011

Historical Fragmentation And Genetic Drift In Populations Of Galápagos Lava Lizards (Microlophus Albemarlensis Complex), Mark Jordan, H. Snell

Mark A. Jordan

No abstract provided.


Myelopoiesis Related To Perinatal Spleen, Rebecca Hinton, Sawang Petvises, Helen O'Neill Dec 2010

Myelopoiesis Related To Perinatal Spleen, Rebecca Hinton, Sawang Petvises, Helen O'Neill

Helen O'Neill

Adult murine spleen is known to have a major role in the development of dendritic cell (DC) subsets, including conventional DC and plasmacytoid DC. In this lab, long-term cultures (LTCs) established from murine spleen support continuous production of novel dendritic-like cells, termed LTC-DC. An in vivo equivalent subset also exists in spleen, namely L-DC. As co-cultures using LTC-derived splenic stroma support the outgrowth of L-DC from spleen and bone marrow sources, it is likely that spleen represents an important niche for DC development. To investigate the appearance of L-DC during ontogeny, spleen was isolated from embryonic and neonatal mice of …


Spleen As A Distinct Site For Dendritic Cell Haematopoiesis, Jonathan Tan, Helen O'Neill Dec 2010

Spleen As A Distinct Site For Dendritic Cell Haematopoiesis, Jonathan Tan, Helen O'Neill

Helen O'Neill

No abstract provided.