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Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Vitro Bacteriophage Treatment For A Staphylococcus Aureus And Pseudomonas Aeruginosa Co-Culture, Alexis Perry
Vitro Bacteriophage Treatment For A Staphylococcus Aureus And Pseudomonas Aeruginosa Co-Culture, Alexis Perry
Arkansas Women in STEM Conference
Recent studies show that up 27-36% of all infections are polymicrobial, involving more than one bacteria species. In all categories, polymicrobial infections are often more virulent and harmful to the patient. Since different types of bacteria can communicate with each other through quorum-sensing when in the presence of each other, they can display different genomic characteristics. Further research into polymicrobial infections needs to be done because these changing characteristics can prevent treatment from working, such as antibiotics or bacteriophage therapy. This experiment focused on the co-culture between the two bacteria, Pseudomonas aeruginosa and Staphylococcus aureus, which can be found co-existing …
Keynote Speaker Arkansas Women In Stem Conference Presentation, Maria Ines Ines Dow
Keynote Speaker Arkansas Women In Stem Conference Presentation, Maria Ines Ines Dow
Arkansas Women in STEM Conference
The Keynote Speaker of the 3rd Annual Arkansas Women in STEM Conference is Dr. Diana Escalona-Vargas, Assistant Professor of Pediatrics at UAMS and ACH, and Scientific Director of the Arkansas Children's Hospital Magnetoencephalography Laboratory.
A Brief Discussion Of Gasdermin D'S Function In Multiple Sclerosis, Amie Brint
A Brief Discussion Of Gasdermin D'S Function In Multiple Sclerosis, Amie Brint
Arkansas Women in STEM Conference
Multiple Sclerosis (MS) is a neurodegenerative disease that particularly affects the nerves of the central nervous system (CNS). MS results in the degradation of the myelin sheath surrounding the axon, which is crucial for effective transmission of nerve signals. MS can be detected using lumbar punctures to look for elevated oligoclonal levels and using magnetic resonance imaging (MRI). The MRI can screen for plaques in the CNS, indicating the severity and probability of progression of the disease. Plaques are regions of nerves where the myelin has been removed from the nerves, preventing them from conducting the electrical signals necessary for …
Combination Chemo-Pdt Ionic Nanomedicines As Enhanced Therapeutics For Cancer, Samantha Macchi
Combination Chemo-Pdt Ionic Nanomedicines As Enhanced Therapeutics For Cancer, Samantha Macchi
Arkansas Women in STEM Conference
Cancer remains as one of the leading causes of death in humans worldwide. Nanotechnology has made great strides in improving treatment for the disease. This work describes a simplistic approach to design self-assembled combination nanomedicines. A facile one-step ion exchange reaction is utilized to combine a chemotherapeutic (phosphonium) cation and photodynamic therapeutic (porphyrin) anion. An aqueous nanomedicine is prepared from the hydrophobic ionic combination drug via a single-step reprecipitation method. Upon conversion to ionic combination drug, improved photophysical properties of porphyrin were observed. These characteristics subsequently led to increased photodynamic therapeutic activity of nanomedicines—explained by greater singlet oxygen quantum yield. …
Arkansas Women In Stem Conference Presentation: Investigations Of Salvia Officinalis Secondary Metabolites, Maria Ines Ines Dow
Arkansas Women In Stem Conference Presentation: Investigations Of Salvia Officinalis Secondary Metabolites, Maria Ines Ines Dow
Arkansas Women in STEM Conference
Salvia officinalis or Sage (The “Salvation Plant”) is known to have various health benefits. Salvia officinalis has been known to treat menstrual cycle pains, gastroenteritis problems, improve liver function, as well as in applications for anticancer remedies and neurodegenerative diseases. This fragrant plant is most often found in the Mediterranean, Southeast Asia, and South America. This research aims to test the raw and vinegar-baked medicinal plant to investigate the change in its chemistry and its biological effect. The plant was purchased as dry leaves and stems. It was then grounded and extracted. The extractions were done via a Soxhlet extraction …
Carrier-Free Chemo-Ptt/Pdt Ionic Nanomaterials For Combination Cancer Therapy, Samantha Macchi
Carrier-Free Chemo-Ptt/Pdt Ionic Nanomaterials For Combination Cancer Therapy, Samantha Macchi
Arkansas Women in STEM Conference
Herein, we describe a carrier-free combination nanodrug for treatment of cancer. In this work, we combined a photothermal compound and a chemotherapeutic drug using ionic liquid chemistry. We utilized a facile, one-step metathesis approach to replace the counter cation of a near infra-red (NIR) dye (photothermal agent) with a chemotherapeutic cation to synthesize an ionic material-based combination cancer therapy drug to deliver multiple mechanisms simultaneously. The nanodrugs were developed by using a reprecipitation method. The detailed photophysical properties of this new combination therapy molecule was investigated in ethanol solution as well as in nanoparticles forms in aqueous media. The singlet …
Lowering The Cost And Raising The Efficiency Of A Cure To Chagas Disease, Madeleine Peters
Lowering The Cost And Raising The Efficiency Of A Cure To Chagas Disease, Madeleine Peters
Arkansas Women in STEM Conference
Chagas disease, classified as a neglected tropical disease (NTD), is caused by the parasite Trypanosoma cruzi and is an underfunded and under researched disease. The only FDA-approved drug in the United States is benznidazole which is expensive, harmful, and only effective in the illness’ acute phase. The goal is to create a more effective, lower costing and less harmful drug by using a condensation reaction to substitute different amines to diethyl squarate (DES) to make cycloalkylsquaramides. Both DES and the amines used are relatively low in price with a simple, efficient, and high yielding synthesis. Low synthetic cost and ability …