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Evaluation Of Rough Brucella Strains As Vaccines For Brucellosis And Pseudorabies In Swine, Lorraine Harrow Molin
Evaluation Of Rough Brucella Strains As Vaccines For Brucellosis And Pseudorabies In Swine, Lorraine Harrow Molin
LSU Master's Theses
Brucellosis and pseudorabies lead to abortion in pregnant sows and are perpetuated by feral swine reservoirs. A multivalent oral vaccine for these diseases would improve vaccination and eradication programs worldwide. Previous studies have shown that the rough attenuated Brucella strains RB51 and VTRS1, when administered subcutaneously to swine, stimulate host immune responses, transiently colonize tissues, and provide partial protection against virulent B. suis infection in pregnant sows. A plasmid encoding for the pseudorabies virus glycoprotein D (PRV gD) has also been added to these strains as part of this project. This study evaluates the use of these strains as oral …