Medicine and Health Sciences Commons^™

What Is The Minimal Dose For Resistance Exercise Effectiveness In Prostate Cancer Patients? Systematic Review And Meta-Analysis On Patient-Reported Outcomes, Pedro Lopez, Dennis R. Taaffe, Robert U. Newton, Laurien M. Buffart, Daniel A. Galvão

Research outputs 2014 to 2021

© 2020, The Author(s). Background: Active treatments for prostate cancer are well known to result in several adverse effects such as fatigue, depression and anxiety symptoms, impacting the overall quality of life (QoL) and wellbeing of a considerable proportion of patients. Resistance-based exercise interventions have shown positive effects to reduce or mitigate these treatment-related side effects. However, the minimal dosage required to derive these benefits is unknown. We systematically reviewed the resistance training effects in prostate cancer patients to determine the minimal dosage regarding the exercise components (mode, duration, volume and intensity) on fatigue, QoL, depression and anxiety. Methods: Using …

Bridging The Research To Practice Gap: A Systematic Scoping Review Of Implementation Of Interventions For Cancer-Related Fatigue Management, Oluwaseyifunmi Andi Agbejule, Nicolas H. Hart, Stuart Ekberg, Koczwara Bogda, Rahul Ladwa, Camilla Simonsen, Elizabeth P. Pinkham, Raymond Javan Chan

Research outputs 2014 to 2021

Background: Cancer-related fatigue (CRF) is one of the most common and distressing symptoms in people with cancer. Although efficacy of interventions for CRF have been extensively investigated, less has been done to ensure successful translation into routine clinical practice. The aim of this systematic scoping review was to synthesise knowledge surrounding the implementation of CRF interventions, summarise the processes and outcomes of implementation strategies used, and identify opportunities for further research. Methods: PubMed, Cochrane CENTRAL, EMBASE and CINAHL databases were searched (up to December 2020). The Cochrane Effective Practice and Organisation of Care (EPOC) Group taxonomy and the RE-AIM Framework …

Change In Mental Health, Physical Health, And Social Relationships During Highly Restrictive Lockdown In The Covid-19 Pandemic: Evidence From Australia, Shane Rogers, Travis Miles Cruickshank

Research outputs 2014 to 2021

Background

A novel coronavirus first reported in Wuhan City in China in 2019 (COVID-19) developed into a global pandemic throughout 2020. Many countries around the world implemented strict social distancing policies to curb the spread of the virus. In this study we aimed to examine potential change in mental/physical health and social relationships during a highly restrictive COVID-19 lockdown period in Australia during April 2020.

Methods

Our survey (n = 1, 599) included questions about concerns, social behaviour, perceived change in relationship quality, social media use, frequency of exercise, physical health, and mental health during COVID-19 lockdown (April, 2020). …

Evaluating A Web- And Telephone-Based Personalised Exercise Intervention For Individuals Living With Metastatic Prostate Cancer (Exerciseguide): Protocol For A Pilot Randomised Controlled Trial, Holly E. L. Evans, Cynthia C. Forbes, Daniel A. Galvão, Corneel Vandelanotte, Robert U. Newton, Gary Wittert, Suzanne Chambers, Andrew D. Vincent, Ganessan Kichenadasse, Nicholas Brook, Danielle Girard, Camille E. Short

Research outputs 2014 to 2021

© 2021, The Author(s). Introduction: Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. Despite this, many individuals do not engage in sufficient exercise to gain the benefits. There are many barriers, which limit the uptake of face-to-face exercise in this population including lack of suitable facilities, remoteness, and access to experts, significant fatigue, urinary incontinence and motivation. Technology-enabled interventions offer a distance-based alternative. This protocol describes a pilot two-armed randomised controlled study that will investigate the feasibility and preliminary efficacy of an online exercise and behavioural change tool (ExerciseGuide) amongst …

Using Exercise And Nutrition To Alter Fat And Lean Mass In Men With Prostate Cancer Receiving Androgen Deprivation Therapy: A Narrative Review, Rebekah L. Wilson, Dennis R. Taaffe, Robert U. Newton, Nicolas H. Hart, Philippa Lyons-Wall, Daniel A. Galvao

Research outputs 2014 to 2021

Fat mass (FM) gain and lean mass (LM) loss are common side effects for patients with prostate cancer receiving androgen deprivation therapy (ADT). Excess FM has been associated with an increased risk of developing obesity-related comorbidities, exacerbating prostate cancer progression, and all-cause and cancer-specific mortality. LM is the predominant contributor to resting metabolic rate, with any loss impacting long-term weight management as well as physical function. Therefore, reducing FM and preserving LM may improve patient-reported outcomes, risk of disease progression, and ameliorate comorbidity development. In ADT-treated patients, exercise and nutrition programs can lead to improvements in quality of life and …

Fatigue-Related Feedback From Calf Muscles Impairs Knee Extensor Voluntary Activation, Harrison T. Finn, David S. Kennedy, Simon Green, Janet L. Taylor

Research outputs 2014 to 2021

INTRODUCTION:

Fatigue-related group III/IV muscle afferent firing from agonist, antagonist or distal muscles impairs the ability to drive the elbow flexors maximally, that is, reduces voluntary activation. In the lower limb, the effect of feedback from distal muscles on the proximal knee extensors is unknown. Here, we test whether maintained group III/IV afferent feedback from the plantarflexor muscles reduces voluntary activation of the knee extensors.

METHODS:

On 2 d, voluntary activation of the knee extensors during maximal voluntary contractions (MVCs) was assessed in 12 participants before and after a 3-min fatiguing task of the plantarflexors. On 1 d, an inflatable …

The Effects Of Environmental Temperature On High-Intensity Interval Training, Jason R. Boynton

Theses: Doctorates and Masters

Endurance athletes typically spend the large majority of training (> 70%) at low intensities (i.e. below lactate threshold) coupled with short and intermittent bouts of high-intensity exercise or interval training (HIIT). Despite HIIT being a relatively small part of training in terms of duration, it has a substantial effect on the adaptations to endurance training. While it is well-established endurance exercise performance is affected in both hot and cold environmental conditions, the effect ambient temperature (TA; frequently referred to as environmental temperature) has on HIIT as performed by an endurance athlete population is not well understood. Therefore, the overall purpose …

Exercise And Nutrition Induced Weight Loss For Prostate Cancer Patients, Rebekah Louise Wilson

Theses: Doctorates and Masters

This thesis encompasses six main chapters - two reviews and four experimental chapters, in addition to a general introduction and discussion.

Review 1 (Chapter 2) is a discussion of the negative impact of obesity on prostate cancer prognosis and common prostate cancer treatments.

Review 2 (Chapter 3) is an evaluation of the current literature examining prostate cancer patients receiving androgen deprivation therapy (ADT) and how exercise and nutrition interventions can be used to induce fat loss, while preserving or improving lean mass.

Study 1 (Chapter 4) is an examination of the efficacy of a weight loss program in altering body …

The Current State Of Subjective Training Load Monitoring—A Practical Perspective And Call To Action, Joseph O. C. Coyne, G. Gregory Haff, Aaron J Coutts, Robert U. Newton, Sophia Nimphius

Research outputs 2014 to 2021

This commentary delivers a practical perspective on the current state of subjective training load (TL) monitoring, and in particular sessional ratings of perceived exertion, for performance enhancement and injury prevention. Subjective measures may be able to reflect mental fatigue, effort, stress, and motivation. These factors appear to be important moderators of the relationship TL has with performance and injury, and they also seem to differ between open and closed skill sports. As such, mental factors may affect the interaction between TL, performance, and injury in different sports. Further, modeling these interactions may be limited due to the assumption that an …

Proficiency In Pole Handling During Nordic Walking Influences Exercise Effectiveness In Middle-Aged And Older Adults, Eiji Fujita, Karen Yakushi, Masaki Takeda, Mohammod Monirul Islam, Masaki Nakagaichi, Dennis Taaffe, Nobuo Takeshima

Research outputs 2014 to 2021

Nordic walking (NW) is a total body version of walking increasingly used as a health-promoting activity by middle-aged and older adults. The present study examined the relationship between force exerted through the pole and physiological response during NW. In this non-randomized exercise trial, 17 participants comprising 8 middle-aged and older recreationally trained Nordic walkers (NWrec: 63.7 ± 8.1 years) and 9 experienced NW instructors (NWinstr: 57.5 ± 7.8 years) underwent outdoor ordinary walking (OW) and NW bouts as fast as possible for 12 minutes. Walking distance, speed, heart rate (HR), energy expenditure (METs and J/kg/m) and upper and lower limb …

Time On Androgen Deprivation Therapy And Adaptations To Exercise: Secondary Analysis From A 12-Month Randomized Controlled Trial In Men With Prostate Cancer, Dennis R. Taaffe, Laurien M. Buffart, Robert U. Newton, Nigel Spry, James Denham, David Joseph, David Lamb, Suzanne K. Chambers, Daniel A. Galvao

Research outputs 2014 to 2021

Objectives

To explore if duration of previous exposure to androgen deprivation therapy (ADT) in men with prostate cancer (PCa) undertaking a year-long exercise programme moderates the exercise response with regard to body composition and muscle performance, and also to explore the moderator effects of baseline testosterone, time since ADT, and baseline value of the outcome.

Patients and Methods

In a multicentre randomized controlled trial, 100 men who had previously undergone either 6 months (short-term) or 18 months (long-term) of ADT in combination with radiotherapy, as part of the TROG 03.04 RADAR trial, were randomized to 6 months supervised exercise, followed …

The Effects Of Acute And Chronic Sprint-Interval Training On Cytokine Responses Are Independent Of Prior Caffeine Intake, Guilherme Ferreira, Leandro Felippe, Rômulo Bertuzzi, David Bishop, Emiliano Barreto, Fernando De-Oliveira, Adriano Lima-Silva

Research outputs 2014 to 2021

We examined the effect of acute and chronic sprint interval training (SIT), with or without prior caffeine intake, on levels of exercise-induced inflammatory plasma cytokines [interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α]. Twenty physically-active men ingested either a placebo (n = 10) or caffeine (n = 10) 1 h before each SIT session(13-s × 30-s sprint/15 s of rest) during six training sessions (2 weeks). The early (before, immediately after, and 45 min after the exercise) and late (24 and 48 h after the exercise) cytokine and creatine kinase (CK) responses were analyzed for the first and last …

Bridging The Gap Between Clinicians And Fitness Professionals, Rachele Pojednic, Amy Bantham, Fred Arnstein, Mary A. Kennedy, Edward Phillips

Research outputs 2014 to 2021

Objective Health clubs (HC) and personal trainers (PT) are traditional outlets for the promotion of physical activity (PA) and exercise programming. As physicians are increasingly being called on to write exercise prescriptions for their patients, this study sought to investigate the level of integration between the healthcare and fitness systems.

Design An internet study was designed with five domains to understand physicians’: (1) overall perception of HC, (2) appropriateness and recommendation of HC and PT to their patients, (3) attitude regarding specific aspects of HC, (4) support of patient participation in HC sponsored exercise and (5) elements of HC that …

Interpreting Signal Amplitudes In Surface Electromyography Studies In Sport And Rehabilitation Sciences, Andrew D. Vigotsky, Israel Halperin, Gregory J. Lehman, Gabriel S. Trajano, Taian M. Vieira

Research outputs 2014 to 2021

Surface electromyography (sEMG) is a popular research tool in sport and rehabilitation sciences. Common study designs include the comparison of sEMG amplitudes collected from different muscles as participants perform various exercises and techniques under different loads. Based on such comparisons, researchers attempt to draw conclusions concerning the neuro- and electrophysiological underpinning of force production and hypothesize about possible longitudinal adaptations, such as strength and hypertrophy. However, such conclusions are frequently unsubstantiated and unwarranted. Hence, the goal of this review is to discuss what can and cannot be inferred from comparative research designs as it pertains to both the acute and …

Effects Of Long-Term Participation In Tennis On Cognitive Function In Elderly Individuals, Scott Culpin

Theses: Doctorates and Masters

Many studies have reported the relationship between exercise and cognition with conflicting results. This may be due to differences in intervention durations, session lengths, intensities, and type of exercise. It has been suggested that exercises requiring greater cognitive demand such as football, basketball and racquet sports, are protective against cognitive decline, compared to less cognitively demanding exercises such as swimming, cycling and running, however, research concerning exercise types are currently limited. The present study tested the hypothesis that elderly individuals who had been regularly playing tennis more than 10 years, would have greater cognitive function than those who had been …

Study Protocol Of The Intense Physical Activity And Cognition Study: The Effect Of High-Intensity Exercise Training On Cognitive Function In Older Adults, Belinda M. Brown, Stephanie Rainey-Smith, Natalie Castalanelli, Nicole Gordon, Shaun Markovic, Hamid R. Sohrabi, Michael Weinborn, Simon Laws, James Doecke, Kaikai Shen, Ralph Martins, Jeremiah J. Peiffer

Research outputs 2014 to 2021

Introduction:

Inconsistent results from previous studies of exercise and cognitive function suggest that rigorously designed randomized controlled trials are urgently needed. Here, we describe the design of the Intense Physical Activity and Cognition (IPAC) study, which will assess the impact of a 6-month high-intensity exercise intervention on cognitive function and biomarkers of dementia risk, compared with a 6-month moderate-intensity exercise intervention and control group (no study-related exercise).

Methods:

One-hundred and five cognitively healthy men and women aged between 60 and 80 years are randomized into a high-intensity exercise, moderate-intensity exercise, or control group. Individuals randomized to an exercise …

Effects Of Different Exercise Modalities On Fatigue In Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Year-Long Randomised Controlled Trial, Dennis Taaffe, Robert Newton, Nigel Spry, David Joseph, Suzanne K. Chambers, Robert Gardiner, Brad Wall, Prue Cormie, Kate Bolam, Daniel A. Galvao

Research outputs 2014 to 2021

Background

Physical exercise mitigates fatigue during androgen deprivation therapy (ADT); however, the effects of different exercise prescriptions are unknown.

Objectives

To determine the long-term effects of different exercise modes on fatigue in prostate cancer patients undergoing ADT.

Design, setting, and participants

Between 2009 and 2012, 163 prostate cancer patients aged 43–90 y on ADT were randomised to exercise targeting the musculoskeletal system (impact loading + resistance training; ILRT; n = 58), the cardiovascular and muscular systems (aerobic + resistance training; ART; n = 54), or to usual care/delayed exercise (DEL; n = 51) for 12 mo across university-affiliated exercise clinics …

Exercise Preserves Physical Function In Prostate Cancer Patients With Bone Metastases, Daniel A. Galvao, Dennis R. Taaffe, Nigel Spry, Prue Cormie, David Joseph, Suzanne K. Chambers, Raphael Chee, Carolyn J. Peddle-Mcintyre, Nicolas H. Hart, Freerk T. Baumann, James Denham, Michael Baker, Robert U. Newton

Research outputs 2014 to 2021

The presence of bone metastases has excluded participation of cancer patients in exercise interventions and is a relative contraindication to supervised exercise in the community setting due to concerns of fragility fracture. We examined the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases.Between 2012 and 2015, 57 prostate cancer patients (70.0 ± 8.4 years; BMI 28.7 ± 4.0 kg/m) with bone metastases (pelvis 75.4%, femur 40.4%, rib/thoracic spine 66.7%, lumbar spine 43.9%, humerus 24.6%, other sites 70.2%) were randomised to multi-modal supervised aerobic, resistance and flexibility exercises undertaken thrice weekly (EX, n …

Evaluation Of Acceptance And Efficiency Of Exercise For Indigenous Australians To Benefit Physiological, Anthropometric And Metabolic Syndrome Outcomes, Tuguy Esgin

Theses: Doctorates and Masters

The proposed study will provide an increased understanding in a much-understudied area of how the Australian Indigenous community perceives physical activity and the beneficial effects for improving health outcomes.

The PhD will be made up of three studies:

1) To design an exercise prescription that is culturally appropriate and specifically addresses the major Indigenous health issues around metabolic syndrome.

The first will be a cross sectional study that surveys the motivators and barriers to physical activity within the Perth Noongar community. The results of this study will be used to enhance the intervention section of the PhD. It will provide …

Bone Strength, Load Tolerance And Injury Risk In Elite Australian Football, Nicolas H. Hart

Theses: Doctorates and Masters

A paucity of research exists to characterise and investigate lower-body musculoskeletal characteristics and morphological adaptations in elite Australian Footballers with the aim to improve screening, monitoring and load management practices. Given the high prevalence of lower-body skeletal injuries in Australian Football; and the ability to measure, modify and train muscle and bone strength and their derivatives; this project served to extend scientific understanding of musculoskeletal morphology and bone strength characteristics in elite level field-based team sport athletes through a series of research studies using Dual-energy X-ray Absorptiometry (DXA) and peripheral Quantitative Computed Tomography (pQCT). In particular, studies one and two …

Pgc-1Α Mediated Muscle Aerobic Adaptations To Exercise, Heat And Cold Exposure, Mohammed Ihsan, Greig Watson, Chris R. Abbiss

Research outputs 2014 to 2021

PGC-1α is regarded as a key regulator of mitochondrial biogenesis due to its central role in regulating the activity of key transcription factors associated with encoding mitochondrial components. Additionally, PGC-1α has shown to mediate adaptations that increase fat metabolism and angiogenesis, contributing to the overall oxidative phenotype of the muscle. While it is well established that exercise is a potent stimulator of PGC-1α, recent evidence indicates that heat and cold exposures may also influence mitochondrial biogenesis through the up-regulation of PGC-1α. This highlights the potential use of these modalities in conjunction with exercise to enhance training adaptations. As such, the …

Iron Status And The Acute Post-Exercise Hepcidin Response In Athletes, Peter Peeling, Marc Sim, Claire E. Badenhorst, Brian Dawson, Andrew D. Govus, Chris R. Abbiss, Dorine W. Swinkels, Debbie Trinder

Research outputs 2014 to 2021

This study explored the relationship between serum ferritin and hepcidin in athletes. Baseline serum ferritin levels of 54 athletes from the control trial of five investigations conducted in our laboratory were considered; athletes were grouped according to values 100 mg/L (SF>100). Data pooling resulted in each athlete completing one of five running sessions: (1) 8x3 min at 85% vVO2peak; (2) 5x4 min at 90% vVO2peak; (3) 90 min continuous at 75% vVO2peak; (4) 40 min continuous at 75% vVO 2peak; (5) 40 min continuous at 65% vVO2peak. Athletes from each running session were represented amongst all four groups; hence, …

Predicting Optimal Cancer Rehabilitation And Supportive Care (Polaris): Rationale And Design For Meta-Analyses Of Individual Patient Data Of Randomized Controlled Trials That Evaluate The Effect Of Physical Activity And Psychosocial Interventions On Health-Related Quality Of Life In Cancer Survivors, Laurien M. Buffart, Joeri Kalter, Mai Jm Chinapaw, Martijn W. Heymans, Neil K. Aaronson, Kerry S. Courneya, Paul B. Jacobsen, Robert Newton, Irma M. Verdonck-De Leeuw, Johannes Brug

Research outputs 2013

Effective interventions to improve quality of life of cancer survivors are essential. Numerous randomized controlled trials have evaluated the effects of physical activity or psychosocial interventions on health-related quality of life of cancer survivors, with generally small sample sizes and modest effects. Better targeted interventions may result in larger effects. To realize such targeted interventions, we must determine which interventions that are presently available work for which patients, and what the underlying mechanisms are (that is, the moderators and mediators of physical activity and psychosocial interventions). Individual patient data meta-analysis has been described as the ‘gold standard’ of systematic review …

Muscle Damage And Metabolic Profiles Of Eccentric Cycling, Luis Penailillo

Theses: Doctorates and Masters

Eccentric cycling, in which the knee extensor muscles perform eccentric contractions while trying to brake the backward rotational movements of the cranks of a cycle ergometer, has been shown to effectively increase muscle function and volume with a low metabolic cost. However, acute responses to repeated eccentric cycling bouts have not been well documented. Thus, the primary purposes of this PhD project were to investigate muscle damage and metabolic profiles of eccentric cycling in comparison to concentric cycling (Studies 1-3), and muscle-tendon behaviour (Study 4) during eccentric cycling in relation to muscle damage.

Study 1 compared muscle damage and metabolic …

Two Maximal Isometric Contractions Attenuate The Magnitude Of Eccentric Exercise-Induced Muscle Damage, Hsin-Lian Chen, Kazunori Nosaka, Alan Pearce, Trevor C Chen

Research outputs 2012

This study investigated whether maximal voluntary isometric contractions (MVC-ISO) would attenuate the magnitude of eccentric exercise-induced muscle damage. Young untrained men were placed into one of the two experimental groups or one control group (n = 13 per group). Subjects in the experimental groups performed either two or 10 MVC-ISO of the elbow flexors at a long muscle length (20° flexion) 2 days prior to 30 maximal isokinetic eccentric contractions of the elbow flexors. Subjects in the control group performed the eccentric contractions without MVC-ISO. No significant changes in maximal voluntary concentric contraction peak torque, peak torque angle, range of …

Feedback Control For Exergames, Jeff Sinclair

Theses: Doctorates and Masters

The concept of merging exercise equipment with video games, known as exergaming, has the potential to be one of the main tools used in addressing the current rising obesity epidemic. Existing research shows that exergaming can help improve fitness and additionally motivate people to become more active. The two key elements of attractiveness - how much people want to play or use the exergaming system; and effectiveness – how effective the exergaming system is in actually increasing or maintaining physical fitness, need to be maximised to obtain the best outcomes from an exergaming system; we put this forward as the …

Proprioceptive And Muscle Activation Changes In Triceps Surae Associated With Exercise Induced Muscle Damage, Carmel Nottle

Theses: Doctorates and Masters

The aim of this thesis was to examine proprioceptive and activation changes that occur in triceps surae in response to exercise induced muscle damage (EIMD). While proprioceptive changes have previously been demonstrated in association with EIMD, the present investigation examined the role of a number of potential contributing factors to these changes, following both single and repeated bouts of eccentric exercise.

The Effects Of Movement Based Interventions On Doms And Muscle Damage Following Eccentric Exercise, Zainal A. Zainuddin

Theses: Doctorates and Masters

Delayed onset muscle soreness (DOMS) is a common symptom experienced by most adults following unaccustomed exercise. It is known that DOMS is peculiar to eccentric exercise that results in muscle damage which is characterized by prolonged loss of muscle function. DOMS and subsequent impaired muscle function, reduces the ability to maximize performance of daily living tasks, and has negative effects on sports adherence and activity based healthy lifestyle. Thus, treatments to ameliorate DOMS and enhance recovery of muscle function are important.

The Effects Of A Heavy Resistance Training Intervention Of The Plantar Flexors On The Recovery Of Strength, Power, Acceleration, And Agility In Recreational Athletes, Naomi A. Forrest

Theses: Doctorates and Masters

Resistance training is a highly utilised form of exercise that is used to develop strength, power, speed and muscular endurance. Although it is associated with many positive benefits it also has some potentially unfavourable effects. These are manifested in the form of altered muscle function through the effects of muscle fatigue and exercise induced muscle damage. Various aspects muscle fatigue and damage have been well studied, however research into the effects of these on tests of strength, power, acceleration and agility is sparse. Therefore the aim of this study was to investigate the effects of a heavy resistance intervention on …

The Effect Of Prescribed And Preferred Intensity Exercise On The Relationship Between Self-Efficacy And Perceived Exertion In Older Adults, Keith R. Scotson

Theses: Doctorates and Masters

This study was concerned with acute responses to exercise in people over the age of 50 (N = 80). In particular the relationship between Self-efficacy and perceived exertion during exercise at workloads (a) based on a target heart rate (prescribed intensities) and (b) based on participant preference (preferred intensities) were observed. Perceptual (perceived exertion), Self-efficacy and heart rate responses of low active older participants engaged in either walking or cycle ergometer exercise at preferred and prescribed intensities were also reported. Significant inverse correlations were observed between pre and post exercise Self-efficacy and perceived exertion during acute exercise at prescribed intensities …