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Articles 31 - 39 of 39
Full-Text Articles in Medicine and Health Sciences
Tissue Factor Expression, Regulation, And Signaling In Human Airway Cells, Michael D. Davis
Tissue Factor Expression, Regulation, And Signaling In Human Airway Cells, Michael D. Davis
Theses and Dissertations
Rationale: Tissue Factor (TF) is a transmembrane glycoprotein that canonically functions as the initiator of the coagulation cascade. Increased levels of TF have been associated with inflammatory airway diseases. Since lipopolysaccharide (LPS) is known to elicit and inflammatory response in airway epithelium, we hypothesized that airway epithelial cells release TF when exposed to LPS. Since TF aids in local wound healing, we also hypothesized that inhibition of TF would decrease NHBE growth. The specific aim of this work was to evaluate the effects of LPS exposure on TF production and release from airway epithelia and determine the signaling pathways involved. …
The Role Of Nicotine, A7 Nicotinic Acetylcholine Receptors And Extracellular Matrix Remodeling In Pulmonary Fibrosis., Glenn Ward Vicary
The Role Of Nicotine, A7 Nicotinic Acetylcholine Receptors And Extracellular Matrix Remodeling In Pulmonary Fibrosis., Glenn Ward Vicary
Electronic Theses and Dissertations
The median survival for idiopathic pulmonary fibrosis (IPF) patients from diagnosis is a dismal 3 years. This condition is characterized by pulmonary fibroproliferation and excess production and disordered deposition of extracellular matrix (ECM) proteins resulting in obliteration of the original tissue architecture, loss of lung function and eventual death due to respiratory failure. The main hindrance to the development of effective treatments against pulmonary fibrosis is the late detection of its progression and is often of unknown cause. Tobacco smoke represents the most important environmental factor linked to the development of pulmonary fibrosis, with over 60% of IPF patients current …
Patient-Reported Variables Associated With The Success Of Behavioral Intervention For Patients With Chronic Cough, Bridget Loomis
Patient-Reported Variables Associated With The Success Of Behavioral Intervention For Patients With Chronic Cough, Bridget Loomis
Graduate Student Theses, Dissertations, & Professional Papers
Purpose: To determine if patient-related variables exist that can potentially discriminate patients with refractory chronic cough (RCC) that are reasonable candidates for behavioral cough therapy (BCT). This study is a small sub-set of a larger, ongoing study, which aims to create and validate a screening tool that primary care physicians can use in order to refer patients early and appropriately for medical or behavioral intervention.
Methods: In this prospective, exploratory study, 20 adult participants, aged 29-68 years of age, answered a bank of questions developed by an expert panel, and the Leicester Cough Questionnaire (LCQ), before and after BCT. Questions …
A Study Of Emergency Room Utilization Related To Poorly Controlled Asthma In Pediatrics, Leistey T. Wortman
A Study Of Emergency Room Utilization Related To Poorly Controlled Asthma In Pediatrics, Leistey T. Wortman
Nursing Theses and Capstone Projects
Asthma is a disease of the respiratory system, which causes swelling and narrowing of the airways. Asthma is commonly seen in children. It is the leading cause of hospital stays and school absences. Hospitalization accounts for the single largest portion of the direct health care costs for asthma, estimated at nearly $18 billion a year (Everage, et al, 2010). Children with asthma may be able to breathe normally most of the time but when they encounter a substance that can cause problems (a "trigger"); an asthma attack (exacerbation) can occur (PubMed Health, 2011). The purpose of this study is to …
Copd Care Coordination Program, Glenda Mccall
Copd Care Coordination Program, Glenda Mccall
Nursing Theses and Capstone Projects
COPD is the fourth leading cause of death in the United States. Several studies confirm only 50% of COPD patients receive optimal care. The disease is greatly under-recognized and generally is not diagnosed until it is clinically apparent and moderately advanced. COPD is also a major resource consuming disease. Considering these facts, Mission Hospitals realized the opportunity to improve evidence based quality care for patients diagnosed with COPD as well as the development of a Care Coordinated Program to improve outcomes for the patient as well as the organization. The goal of the program is to provide correct, comprehensive, and …
Quantitative Respirator Fit Testing: Probed Facepiece Versus Probed Cartridge, Sonya Melissa Seward
Quantitative Respirator Fit Testing: Probed Facepiece Versus Probed Cartridge, Sonya Melissa Seward
Community & Environmental Health Theses & Dissertations
This study was performed to determine if there is a quantifiable difference between quantitative fit testing using a probed facepiece and a probed cartridge. Four subjects were tested on four different respirators. The respirators used were MSA & 3M full and half face respirator. Each subject performed each method five times per respirator. The results indicated no correlation between the two fit testing methods overall. However, a moderate correlation was found between the MSA respirators and the two methods. This study found many variables which influence fit testing. These include the type of respirator used (brand and facepiece), the probe …
The Effects Of Progressive Relaxation And Myoelectric Feedback On Respiratory Resistance In Bronchial Asthmatics, Daphne Browne Shah
The Effects Of Progressive Relaxation And Myoelectric Feedback On Respiratory Resistance In Bronchial Asthmatics, Daphne Browne Shah
Loma Linda University Electronic Theses, Dissertations & Projects
For the individual with bronchial asthma, an asthmatic attack can be a life threatening experience. A theory of bronchial asthma as a conditioned response has been recently proposed by several investigators. It was suggested that this conditioned response may be modified by lowering the arousal level, and as a result, decreasing the asthmatic response.
The problem identified in this exploratory study was to measure the effects of relaxation on the smaller or peripheral airways of a convenience sample of six asthmatic subjects fourteen to seventy years of age. It was hypothesized that an increased degree of total body relaxation would …
A Comparison Of Various Teaching Methods For Patients With Chronic Obstructive Pulmonary Diseases, B. Carol Altizer, Nancy S. Bailey
A Comparison Of Various Teaching Methods For Patients With Chronic Obstructive Pulmonary Diseases, B. Carol Altizer, Nancy S. Bailey
Loma Linda University Electronic Theses, Dissertations & Projects
The purpose of this study was to find out whether patients with chronic obstructive pulmonary disease (C.O.P.D.) learn more from auditory or from visual teaching. Of the 30 patients in the sample, 10 used a programmed instruction booklet, 10 used a taped recording of the same programmed material and 10 were in a control group which received no specific teaching.
A pre-test was given to each of the patients who met the criteria for the study. One researcher gave the pre-test through an oral interview with the patient. After the pre-test, the patient received the teaching device assigned to him …
A Follow-Up Study Of Patients With Chronic Obstructive Lung Disease And Their Practice Of The Breathing Pattern, A. Theodora Djagia
A Follow-Up Study Of Patients With Chronic Obstructive Lung Disease And Their Practice Of The Breathing Pattern, A. Theodora Djagia
Loma Linda University Electronic Theses, Dissertations & Projects
The purpose of this descriptive survey was to do a follow-up study on patients with COPD to find out to what extent these patients have followed instruction to continue exercising the abdominal and diaphragmatic muscles, with the utilization of a breathing pattern. Literature was reviewed which revealed contradictory findings in regard to the physiological benefits of the use of the breathing pattern. Nine patients met the criteria and signed a consent sheet to be visited in their homes. An Observation Data Sheet and Interview Guide were the tools used to collect data. A point system was constructed and used with …