Medicine and Health Sciences Commons^™

Influence Of Apathy And Grit On Exercise Adherence For Persons With Parkinson’S Disease: A Cohort Study, Erica J. Kiernan, Evan M. Pucillo, Christopher M. Wiedman

Internet Journal of Allied Health Sciences and Practice

Purpose: Parkinson’s disease (PD) is the second most common neurodegenerative disease in the United States. A preponderance of evidence supports exercise and physical activity as an effective intervention to slow the progression of motor symptoms in persons with PD. However, less study has been given to the influence of non-motor symptoms of PD, such as apathy and grit, on adherence to therapeutic exercise programs. The primary aim of this study was to characterize levels of apathy and grit in individuals with PD and explore any relationship to adherence in a community exercise program. Due to the importance of caregiver interaction, …

Glyphosate And Dopaminergic Neurotoxicity: Herbicide Impacts On Parkinson's Disease Development, Lojy Hozyen

Undergraduate Research Posters

Nearly one million individuals in the United States are living with Parkinson’s disease (PD). In the past two decades, the death rate from PD has risen by about 63 percent in the United States. Major findings have been made in the past five years about the potential impact of glyphosate (N-(phosphonomethyl) glycine) exposure on the onset of PD symptoms. The purpose of this meta-analysis is to provide a compiled update on the chemical and biological alterations that glyphosate imposes on the human brain. A meta-analysis was conducted to create a quantitative estimate of the connection between PD and glyphosate. Findings …

A Systematic Literature Review On The Capability Of Sio₂-Np’S Exposure To Exacerbate Parkinson’S (Pd) Pathology And The Risk Factors For Biomedical Applications In Pd, Seth Abdallah

Capstone Experience

Silica Dioxide nanoparticles (SiO₂-NP) have become increasingly ubiquitous in industry, which has stimulated research into the potential toxicity of these compounds. Recent studies have explored the association between amorphous silica nanoparticle exposure and the potential for neurotoxicity. Additionally, research has been conducted in the application of SiO₂-NP’s in theranostics and as drug directing agents , which based on current literature may be contraindicated for individuals with conditions such as Parkinson's Disease (PD) which is characterized by neuroinflammation. The following literature review will discuss evidence for silica dioxide nanoparticle exposure to induce neurotoxicity which may exacerbate neurodegenerative diseases such as PD. …

Perceptions Of Caregivers Of Parkinson's Patients Regarding Using Advance Directives, Meghan Morgan

Walden Dissertations and Doctoral Studies

The increasing focus on end-of-life (EOL) care is influencing the role of advance directive (AD) documents. Difficult conversations among family caregivers and their loved ones are becoming more and more critical. Considering the value of communicating EOL wishes, family caregivers’ perceptions about ADs for their loved ones with Parkinson’s disease (PD) must be examined. Using the theory of planned behavior (TPB) as a foundation, the purpose of this generic qualitative study was to understand family caregivers of PD patients and their perceptions and experiences relating to AD documents. This study involved using purposeful sampling and semi-structured interviews with 11 family …

Plasma Proteins That May Cause Parkinson’S Disease And Multiple Sclerosis: A Mendelian Randomization Study, Brigid A. Staley

Dissertations and Theses

Multiple sclerosis (MS) and Parkinson’s disease (PD) are progressively disabling neurologic disorders that profoundly affect quality of life and shorten life expectancy. There is no cure for either disease, and current treatments only alleviate symptoms and may cause serious side effects. The causes of MS and PD are not well understood. Previous epidemiologic studies have documented numerous environmental risk factors for both diseases. However, these studies are inherently prone to bias from confounding which may generate spurious results. The lack of unbiased evidence on environmental causes of MS and PD has been a critical barrier to fully understanding their pathophysiology. …

Measuring Community Mobility In Older Adults With Parkinson’S Disease Using A Wearable Gps Sensor And Self-Report Assessment Tools, Lynn Zhu

Electronic Thesis and Dissertation Repository

Community mobility (CM) is an important instrumental activity of daily living associated with quality of life and independence. Measuring the CM of older adults, particularly those with gait disorders such as Parkinson’s disease (PD), is an important way to understand how to help people maintain mobility in the real life setting. CM is measured using self-report measures and emergent technologies, such as wearable Global Positioning System (GPS) sensors. However, the measurement properties of most available assessments have not been compared within a PD population to determine their appropriateness and identify any feasibility issues.

The primary objective of this project was …

Quantitative Tremor Analysis In Welders: Comparison With Idiopathic Parkinson's Disease And Essential Tremor, Juan Sanchez-Ramos, Dacy Reimer, Theresa A. Zesiewicz, Kelly L. Sullivan, Paul A. Nausieda

Kelly L. Sullivan

Background: Workers chronically exposed to manganese in welding fumes may develop an extra-pyramidal syndrome with postural and action tremors.
Objectives: To determine the utility of tremor analysis in distinguishing tremors among workers exposed to welding fumes, patients with Idiopathic Parkinson’s Disease (IPD) and Essential Tremor (ET).
Methods: Retrospective study of recorded tremor in subjects from academic Movement Disorders Clinics and Welders. Quantitative tremor analysis was performed and associated with clinical status.
Results: Postural tremor intensity was increased in Welders and ET and was associated with visibly greater amplitude of tremor with arms extended. Mean center frequencies (Cf) of welders and …