Medicine and Health Sciences Commons^™

Diagnostic Accuracy Of Various Immunochromatographic Tests For Ns1 Antigen And Igm Antibodies Detection In Acute Dengue Virus Infection, Mughees Haider, Saira Yousaf, Asifa Zaib, Azza Sarfraz, Zouina Sarfraz, Ivan Cherrez-Ojeda

Department of Paediatrics and Child Health

Introduction: Rapid diagnostic tests (RDTs) were evaluated, in this paper, for their utility as a reliable test, using resource-constrained studies. In most studies, NS1 antigen and immunoglobulin M (IgM)-based immunochromatographic tests (ICTs) were considered for acute phase detection. We aimed to evaluate the diagnostic accuracy of NS1, IgM, and NS1/IgM-based ICTs to detect acute dengue virus (DENV) infection in dengue-endemic regions.
Methods: Studies were electronically identified using the following databases: MEDLINE, Embase, Cochrane Library, Web of Science, and CINAHL Plus. Keywords including dengue, rapid diagnostic test, immunochromatography, sensitivity, specificity, and diagnosis were applied across databases. In total, 15 studies were …

Dengue With Signs Of Alarm And Leptospirosis In A Pediatric Patient With Covid-19, Mayron Nakandakari Gomez, Hamilton Marín-Macedo, Raúl Seminario-Vilca

Revista de la Facultad de Medicina Humana

Dengue and Leptospirosis are endemic metaxenic diseases that affect tropical and subtropical areas, mostly in underdeveloped countries. In addition to this, the COVID-19 pandemic is causing a great deal of damage to both the population and the health level. This is the case of a 13-year-old patient who had fever, gingival and intermenstrual bleeding, abdominal pain and shortness of breath. She had SARS-CoV-2 IgM and IgG positive rapid test, and positive serology NS1 for Dengue and IgM for Leptospira. In addition, non-contrast pulmonary tomography showed areas of consolidated and frosted glass at the base level, as well as cysturitis. Diagnoses …

Lying In Wait: The Resurgence Of Dengue Virus After The Zika Epidemic In Brazil, Anderson Fernandes Brito, Lais Ceschini Machado, Rachel J. Oidtman, Márcio Junio Lima Siconelli, Quan Minh Tran, Joseph R. Fauver, Rodrigo Dias De Oliveira Carvalho, Filipe Zimmer Dezordi, Mylena Ribeiro Pereira, Luiza Antunes De Castro-Jorge, Elaine Cristina Manini Minto, Luzia Márcia Romanholi Passos, Chaney C. Kalinich, Mary E. Petrone, Emma Allen, Guido Camargo España, Angkana T. Huang, Derek A. T. Cummings, Guy Baele, Rafael Freitas Oliveira Franca, Benedito Antônio Lopes Da Fonseca, T. Alex Perkins, Gabriel Luz Wallau, Nathan D. Grubaugh

Journal Articles: Epidemiology

After the Zika virus (ZIKV) epidemic in the Americas in 2016, both Zika and dengue incidence declined to record lows in many countries in 2017-2018, but in 2019 dengue resurged in Brazil, causing ~2.1 million cases. In this study we use epidemiological, climatological and genomic data to investigate dengue dynamics in recent years in Brazil. First, we estimate dengue virus force of infection (FOI) and model mosquito-borne transmission suitability since the early 2000s. Our estimates reveal that DENV transmission was low in 2017-2018, despite conditions being suitable for viral spread. Our study also shows a marked decline in dengue susceptibility …

The Association Between Dengue Virus Infection And Liver And Kidney Function Among Cambodian Children, Ashley Moineau

Masters Theses

Severe liver and kidney dysfunction are prevalent in 10%-30% of the Southeast Asian population. Dengue virus infection has been reported as a modifiable risk factor for liver and kidney dysfunction, especially among children in Southeast Asia. Epidemiologic studies assessing this relationship are sparse, often failed to include children, and did not adjust for important covariates. Therefore, we evaluated the relationship between dengue virus infection and liver and kidney dysfunction among hospitalized children in Cambodia (n=551). Participants with a serologically confirmed dengue virus infection were categorized according to increasing severity of infection (i.e. dengue fever, dengue hemorrhagic fever, or dengue shock …

"Urban" Dengue? An Examination Of Perceived Dengue Risk And Notions Of The Urban In Esmeraldas Province, Ecuador, Charlotte Robbins

Senior Theses and Projects

Is dengue fever an urban disease as public health literature suggests? And what does this literature mean by urban? To answer these questions, I compare perceptions of the urban and dengue risk from residents who I interviewed across different sites in Esmeraldas Province, Ecuador. I ground my analysis in four urban frameworks: the bounded city theory, postcolonial theory, assemblage urbanism, and urban political ecology. I find that residents in Esmeraldas Province think about urban spaces very differently from how the Ecuadorian government defines what is urban. In particular, residents discuss government investment in infrastructure and services as an important dimension …

Demographic, Environmental, And Clinical Variables Associated With Dengue In Saint Lucia, Brendan Lee

Walden Dissertations and Doctoral Studies

Dengue is the most important arboviral disease of public health concern on the world stage. In Saint Lucia, the disease has been endemic for years. Little research has been published on the specific epidemiology of dengue in Saint Lucia, and this study sought to identify the risk factors associated with the disease specific to the island. This study was underpinned by ecological theory, which is used to explain the possible relationships between risk factors and the occurrence of dengue. This three-manuscript study was used to evaluate the relationship between demographic, environmental, and clinical variables and the occurrence of dengue as …

The Knockdown Of Rab8 And Rab11 Proteins On The Trafficking Of Dengue Virus And The Philosophical Implications On Public Health, Maddie Labor

Regis University Student Publications (comprehensive collection)

Honors thesis

A Case-Study Approach To Investigate Transmission, Co-Infection, And Clinical Sequelae During Epidemics Of Dengue And Ebola Virus Disease, Jennifer Elizabeth Giovanni

LSU Doctoral Dissertations

From within their ecologic niches, zoonotic viruses emerge from animal reservoirs into the edges and centers of human habitation to exploit opportunities for unabated transmission within immunologically–naïve populations. Our understanding of where, in whom, and how these viruses emerge is under direct challenge, driving the evolution of modern infectious disease epidemiology within a rapidly-connected global community. The studies presented herein are based on analyses of both aggregate and case-level data, which, we argue, provide unique insight into the complexities of transmission, co-infection, and clinical sequelae occurring within, and arising from, epidemics of emerging zoonotic viruses. In Chapter II, we investigate …

Dengue, Edward Ramos

Global Issues in Public Health

The dengue virus puts one third of the world’s population at risk. Humans carry the virus and mosquitoes pick it up and are able to spread to more people. As long as there are mosquitoes near you there is the possibility that you could become infected with the dengue virus. However, people living in tropical areas that are poverty stricken are much more likely to bit by these mosquitoes and developed dengue fever. Things like mosquito netting and proper plumbing help lower the amount of these mosquitoes from biting people. There are very few treatments for when a person gets …

Evaluation Of A Microsphere-Based Immunoassay (Mia) In Measuring Diagnostic And Prognostic Markers Of Dengue Virus Infection, Jason H. Ambrose

USF Tampa Graduate Theses and Dissertations

Infections with dengue viruses (DENV) constitute both a global problem as well as locally in Florida. DENV comprise four distinct serotypes of single-stranded RNA viruses and belong to the family Flaviviridae. DENV are among the most medically important arboviruses in the world and cases may currently exceed 400 million per annum. Additionally, dengue established its first recorded endemic transmission cycle in the state of Florida in over a half century, first within the Florida Keys during 2009-10 followed by an unrelated outbreak in Martin County in 2013. The clinical profile of DENV infections ranges from a mild febrile illness …

Aedes Aegypti And Dengue In The Philippines: Centering History And Critiquing Ecological And Public Health Approaches To Mosquito-Borne Disease In The Greater Asian Pacific, Maria R. Pettis

Pomona Senior Theses

The global incidence of dengue has increase 30-fold over the past 50 years in the western or Asian Pacific, this region is also a contemporary epicenter for resource extraction and ecological destabilization. Dengue is addition to yellow fever, chikungunya and most recently zika virus, are transmitted by the mosquito vector Aedes aegypti- a domesticated mosquito adept at breeding in artificial household containers and within homes. The history of the domestication and global distribution of Aedes aegypti is intrinsically linked to European expansion into and among tropical worlds. Contemporary population genetics research suggest the westward expansion of the mosquito vector …

Dengue: Defining Protective Versus Pathologic Immunity, Alan Rothman

Alan Rothman

Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.

Clinical And Laboratory Features That Distinguish Dengue From Other Febrile Illnesses In Endemic Populations, James Potts, Alan Rothman

Alan Rothman

OBJECTIVE: Clinicians in resource-poor countries need to identify patients with dengue using readily-available data. The objective of this systematic review was to identify clinical and laboratory features that differentiate dengue fever (DF) and/or dengue haemorrhagic fever (DHF) from other febrile illnesses (OFI) in dengue-endemic populations. METHOD: Systematic review of the literature from 1990 to 30 October 2007 including English publications comparing dengue and OFI. RESULTS: Among 49 studies reviewed, 34 did not meet our criteria for inclusion. Of the 15 studies included, 10 were prospective cohort studies and five were case-control studies. Seven studies assessed all ages, four assessed children …

Prediction Of Dengue Disease Severity Among Pediatric Thai Patients Using Early Clinical Laboratory Indicators, James A. Potts, Robert V. Gibbons, Alan L. Rothman, Anon Srikiatkhachorn, Stephen J. Thomas, Pra-On Supradish, Stephenie C. Lemon, Daniel H. Libraty, Sharone Green, Siripen Kalayanarooj

Sharone Green

BACKGROUND: Dengue virus is endemic in tropical and sub-tropical resource-poor countries. Dengue illness can range from a nonspecific febrile illness to a severe disease, Dengue Shock Syndrome (DSS), in which patients develop circulatory failure. Earlier diagnosis of severe dengue illnesses would have a substantial impact on the allocation of health resources in endemic countries. METHODS AND FINDINGS: We compared clinical laboratory findings collected within 72 hours of fever onset from a prospective cohort children presenting to one of two hospitals (one urban and one rural) in Thailand. Classification and regression tree analysis was used to develop diagnostic algorithms using different …

The Basic Reproduction Number ℛ0 And Effectiveness Of Reactive Interventions During Dengue Epidemics: The 2002 Dengue Outbreak In Easter Island, Chile, Gerardo Chowell, Rodrigo Fuentes, A Olea, X. Aguilera, Hans Nesse, J. M. Hyman

Public Health Faculty Publications

We use a stochastic simulation model to explore the effect of reactive intervention strategies during the 2002 dengue outbreak in the small population of Easter Island, Chile. We quantified the effect of interventions on the transmission dynamics and epidemic size as a function of the simulated control intensity levels and the timing of initiation of control interventions. Because no dengue outbreaks had been reported prior to 2002 in Easter Island, the 2002 epidemic provided a unique opportunity to estimate the basic reproduction number ℛ0 during the initial epidemic phase, prior to the start of control interventions. We estimated ℛ0 at …

Interactions Between Serotypes Of Dengue Highlight Epidemiological Impact Of Cross-Immunity, Nicholas Reich, Sourya Shrestha, Aaron King, Pejman Rohani, Justin Lessler, Siripen Kalayanarooj, In-Kyu Yoon, Robert Gibbons, Donald Burke, Derek Cummings

Nicholas G Reich

Dengue, a mosquito-borne virus of humans, infects over 50 million people annually. Infection with any of the four dengue serotypes induces protective immunity to that serotype, but does not confer long-term protection against infection by other serotypes. The immunological interactions between sero- types are of central importance in understanding epidemiological dynamics and anticipating the impact of dengue vaccines. We analysed a 38-year time series with 12 197 serotyped dengue infections from a hospital in Bangkok, Thailand. Using novel mechanistic models to represent different hypothesized immune interactions between serotypes, we found strong evidence that infec- tion with dengue provides substantial short-term …

Refining The Global Spatial Limits Of Dengue Virus Transmission By Evidence-Based Consensus, Oliver J. Brady, Peter W. Gething, Samir Bhatt, Jane P. Messina, John S. Brownstein, Anne G. Hoen

Dartmouth Scholarship

Background: Dengue is a growing problem both in its geographical spread and in its intensity, and yet current global distribution remains highly uncertain. Challenges in diagnosis and diagnostic methods as well as highly variable national health systems mean no single data source can reliably estimate the distribution of this disease. As such, there is a lack of agreement on national dengue status among international health organisations. Here we bring together all available information on dengue occurrence using a novel approach to produce an evidence consensus map of the disease range that highlights nations with an uncertain dengue status.

Methods/Principle Findings: …

A Mathematical Model For Dengue Fever In A Virgin Environment, Jason K. Bowman

Senior Honors Projects

Dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. The disease was named in 1779 and the first recorded epidemic of it occurred simultaneously on three continents within the following decade. Dengue is characterized by flu-like symptoms and, while its symptoms are generally reported as quite unpleasant, is rarely fatal. However, in some cases patients can contract a more serious form of the disease, known as Dengue Hemorrhagic Fever, which is far more dangerous. The World Health Organization estimates that today over 2.5 billion people are at risk for Dengue (over 40% of the …

Masyarakat Depok Memilih Fogging Yang Tidak Dimengerti, Tri Krianto

Kesmas

Sampai kini, demam berdarah dengue masih menjadi masalah kesehatan yang utama di Kota Depok. Hal tersebut terlihat pada jumlah kasus yang terus meningkat dan semua kelurahan sudah berkembang menjadi daerah endemis demam berdarah dengue yang dapat dicegah dengan mengendalikan vektor. Upaya pembersihan sarang nyamuk PSN 3M Plus adalah teknologi yang disarankan untuk mengendalikan kejadian demam berdarah dengue, tetapi belum mendapat dukungan pelaksanaan dari masyarakat. Studi ini bertujuan untuk menggali informasi tentang pengetahuan, sikap dan praktek masyarakat dalam pengendalian vektor demam berdarah dengue di Kota Depok. Hasil studi menunjukkan bahwa pengetahuan dan partisipasi masyarakat dalam pengendalian vektor DBD masih rendah, dan …

Hubungan Perilaku Pemberantasan Sarang Nyamuk Dan Kejadian Demam Berdarah Dengue Di Kota Bandar Lampung, Amrul Hasan

Kesmas

Kasus demam berdarah dengue di Kota Bandar Lampung terus mengalami peningkatan. Pada tahun 2001 incidence rate sebesar 13,56 per 100.000 penduduk, meningkat menjadi 109,8/100.000 penduduk pada tahun 2006 dan akhir Februari 2007 Kota Bandar Lampung dinyatakan Kejadian Luar Biasa (KLB) Demam berdarah dengue lokal. Penelitian ini bertujuan mengetahui hubungan kebiasaan melakukan pemberantasan sarang nyamuk (PSN) dengan kejadian demam berdarah dengue di Kota Bandar Lampung. Penelitian ini menggunakan desain kasus kontrol dengan jumlah sampel sebanyak 406 individu terdiri dari 203 kasus dan 203 kontrol. Kasus adalah individu yang menderita DBD yang pernah dirawat di rumah sakit dan dilaporkan ke Dinas Kesehatan …

Dengue, Aedes Aegypti, And Hurricane Reconstruction In The Caribbean And Central America: Prevention And Control Following A Natural Disaster, Frank Cortez Flores

Frank Cortez Flores

Abstract: Dengue is currently the most important vector-borne viral disease affecting people, in terms of both morbidity and mortality. Repeated epidemics of dengue and dengue hemorrhagic fever afflicting millions of individuals occur annually in tropical and subtropical areas of the world, including The Caribbean and Central America, inhabited by the Aedes aegypti mosquito.

Accordingly, the main purpose of this study was to identify and address the dominating factors influencing the resurgence of dengue fever following a natural disaster such as a hurricane.

This study also depicted an arguable approach to dengue surveillance as well as described existing efforts to prevent, …

Dengue And Aedes Aegypti: A Public Health Problem Along The United States-Mexico Border (Lecture Number 1 - A Series Of Dengue Lectures), Frank Cortez Flores

Frank Cortez Flores

My primary public health interest is the reemerging arboviral infections (e.g., dengue) that are increasing in incidence, expanding into new geographic areas, affecting new populations, and are threatening to increase in the near future, especially following a natural disaster (e.g., hurricanes). The goal of the dengue lecture series is to promote the recognition of dengue and dengue hemorrhagic fever and improve the understanding of factors involved in prevention, surveillance and control of the Aedes aegypti mosquito, the principal mosquito vector of dengue virus. The purpose of these lectures is to accelerate learning and development of an effective dengue prevention and …