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Engaging Hmong Americans Long-Term Use Of Healthcare Technology Using Culturally Revised Social Cognitive Theory Model, Peggy Xiong Dec 2019

Engaging Hmong Americans Long-Term Use Of Healthcare Technology Using Culturally Revised Social Cognitive Theory Model, Peggy Xiong

Theses and Dissertations

Purpose: Information technology benefits the world, and it’s required for health care system, such as electronic medical records (EMR). User acceptance model is to systematically study how users come to accept and use a technology. For example, the cultural values of a society restrict use of technology in which an individual can be less incline to accept it. There is a significant amount of Hmong population in great Milwaukee area. Spirits are a central part of Hmong religious beliefs where the spirit is tied to health. Chronic disease is believed to be caused by bad actions done by the individual’s …


Engaging Hmong Americans Long-Term Use Of Healthcare Technology Using Culturally Revised Social Cognitive Theory Model, Peggy Xiong Dec 2019

Engaging Hmong Americans Long-Term Use Of Healthcare Technology Using Culturally Revised Social Cognitive Theory Model, Peggy Xiong

Theses and Dissertations

Purpose: Information technology benefits the world, and it’s required for health care system, such as electronic medical records (EMR). User acceptance model is to systematically study how users come to accept and use a technology. For example, the cultural values of a society restrict use of technology in which an individual can be less incline to accept it. There is a significant amount of Hmong population in great Milwaukee area. Spirits are a central part of Hmong religious beliefs where the spirit is tied to health. Chronic disease is believed to be caused by bad actions done by the individual’s …


Medication Self-Management Behaviors Of Community-Dwelling Adults With Chronic Disease, Michelle Yvonne Williams Aug 2019

Medication Self-Management Behaviors Of Community-Dwelling Adults With Chronic Disease, Michelle Yvonne Williams

Theses and Dissertations

MEDICATION SELF-MANAGEMENT BEHAVIORS OF COMMUNITY- DWELLING

ADULTS WITH CHRONIC DISEASE

by

Michelle Y. Williams, PhD, MSN, RN

The University of Wisconsin-Milwaukee, 2019

Under the Supervision of Professor Rachel Schiffman, PhD, RN, FAAN

Chronic conditions threaten public health, individuals, and families and affect all areas of a person’s life and require significant self-management from the individual with the disease, care from the healthcare provider and team, and support from the individual’s family. The relationship of selected risk and protective factors and communication with healthcare providers to medication self-management behaviors and quality of life was examined in 616 adults with chronic disease …


Information Overload: Auditing The Clinical Utility Of Smart Pump Reporting Tools, Elizabeth Rodman May 2019

Information Overload: Auditing The Clinical Utility Of Smart Pump Reporting Tools, Elizabeth Rodman

Theses and Dissertations

Purpose: Smart pump technology provides detailed information about each infused drug and fluid that can be used to examine trends and assist in data set optimization. When smart pumps interface with the electronic health record through interoperability, additional data are available.

Methods: The primary outcomes of this study were to identify the top 10 drugs implicated in smart pump near miss events and to reduce the number of near miss events related to smart pump programming. Interoperability data from April 2017 to October 2017 were assessed for near miss trends. Potential interventions for the top 10 drugs were compared using …


Stability Analysis For The Equilibria Of A Monkeypox Model, Rachel Elizabeth Tewinkel May 2019

Stability Analysis For The Equilibria Of A Monkeypox Model, Rachel Elizabeth Tewinkel

Theses and Dissertations

Monkeypox virus was first identified in 1958 and has since been an ongoing problem in Central and Western Africa. Although the smallpox vaccine provides partial immunity against monkeypox, the number of cases has greatly increased since the eradication of smallpox made its vaccination unnecessary. Although studied by epidemiologists, monkeypox has not been thoroughly studied by mathematicians to the extent of other serious diseases. Currently, to our knowledge, only three mathematical models of monkeypox have been proposed and studied. We present the first of these models, which is related to the second, and discuss the global and local asymptotic stability of …


Critical Illness Survivors’ Perceptions Of Their Recovery: An Interpretive Phenomenological Inquiry, Kelly Calkins Dec 2018

Critical Illness Survivors’ Perceptions Of Their Recovery: An Interpretive Phenomenological Inquiry, Kelly Calkins

Theses and Dissertations

Surviving critical illness with its physical, cognitive, and psychosocial morbidities is a growing clinical and research challenge and an important public health concern. Currently, there are few interventions for survivors of critical illness after hospital discharge. Potential interventions include rehabilitation services, Intensive Care Unit (ICU) diaries and ICU follow-up clinics, however, most survivors do not have access to these post-hospital interventions.

The purpose of this study is to gain a better understanding of how critical illness survivors experience their recovery, interventions they use, and what they perceive as facilitators and barriers to their recovery. A better understanding of these factors, …


The Impact Of Maternal Diabetes On Fetal And Infant Outcomes: A Secondary Analysis Of Peridata.Net® From 2013 To 2017, Christina Lynn Dzioba Dec 2018

The Impact Of Maternal Diabetes On Fetal And Infant Outcomes: A Secondary Analysis Of Peridata.Net® From 2013 To 2017, Christina Lynn Dzioba

Theses and Dissertations

ABSTRACT

THE IMPACT OF MATERNAL DIABETES ON FETAL AND INFANT OUTCOMES:

A SECONDARY ANALYSIS OF PERIDATA.NET® FROM 2013 TO 2017

Christina Dzioba, MS, ARNP, WHNP-BC, C-EFM

Background: Diabetes is a leading cause of morbidity and mortality for most of the developed world and is known to contribute to adverse maternal, fetal, and infant outcomes. The purpose of this study was to examine the relationship of maternal diabetes to fetal and infant outcomes for infants born in a small heterogeneous urban community with significant disparities in infant mortality using data in the PeriData.Net® database.

Methods: Women with diabetes were case matched …


Network Analysis Of Scientific Collaboration And Co-Authorship Of The Trifecta Of Malaria, Tuberculosis And Hiv/Aids In Benin., Gbedegnon Roseric Azondekon Aug 2018

Network Analysis Of Scientific Collaboration And Co-Authorship Of The Trifecta Of Malaria, Tuberculosis And Hiv/Aids In Benin., Gbedegnon Roseric Azondekon

Theses and Dissertations

Despite the international mobilization and increase in research funding, Malaria, Tuberculosis and HIV/AIDS are three infectious diseases that have claimed more lives in sub Saharan Africa than any other place in the World. Consortia, research network and research centers both in Africa and around the world team up in a multidisciplinary and transdisciplinary approach to boost efforts to curb these diseases. Despite the progress in research, very little is known about the dynamics of research collaboration in the fight of these Infectious Diseases in Africa resulting in a lack of information on the relationship between African research collaborators. This dissertation …


Understanding Public Health Professional Socialization And Professional Identity Formation Experiences, Jennifer M. Freiheit Dec 2017

Understanding Public Health Professional Socialization And Professional Identity Formation Experiences, Jennifer M. Freiheit

Theses and Dissertations

Public health is in unstable times with funding decreasing, an exodus of retirees, and a paradigm shift with emergency preparedness and response critically changing the identity of the profession. Public health is at a grave trigger point where if something is not done, the entire field may be in jeopardy of caving in to consolidations, poor succession planning, and a field that cannot work toward the health of the public if they themselves are not operating well. It is commonly accepted that orientation practices exist in public health agencies, but the orientations that currently exist lack transfer to full socialization …


Association Of Childhood Blood Lead Levels With Firearm Violence Perpetration And Victimization, Lindsay Rae Emer Dec 2017

Association Of Childhood Blood Lead Levels With Firearm Violence Perpetration And Victimization, Lindsay Rae Emer

Theses and Dissertations

Over 10,000 Americans are killed in firearm homicides each year, and an additional 40,000 are injured in nonfatal shootings. There is a significant public health need to identify risk factors that can be modified to prevent firearm violence. Environmental lead exposure is a demonstrated neurotoxicant which causes behavior changes that are known to be criminogenic. More recent research has demonstrated that homicides and nonfatal shootings differ by the circumstances that lead to the shootings (i.e. gang, domestic violence, arguments) and aggregating them could lead to biased results. Although studies have found a relationship between childhood lead exposure and criminal behaviors, …


Social Engagement And Health: A Structural Equation Modelling Analysis Of Downstream Links To Health Outcomes Among White-Collar Professionals, Ahmad Iqmer Nashriq Bin Mohd Nazan Dec 2017

Social Engagement And Health: A Structural Equation Modelling Analysis Of Downstream Links To Health Outcomes Among White-Collar Professionals, Ahmad Iqmer Nashriq Bin Mohd Nazan

Theses and Dissertations

ABSTRACT

SOCIAL ENGAGEMENT AND HEALTH: A STRUCTURAL EQUATION MODELLING ANALYSIS OF DOWNSTREAM LINKS TO HEALTH OUTCOMES AMONG WHITE-COLLAR PROFESSIONALS

by

Ahmad Iqmer Nashriq bin Mohd Nazan

The University of Wisconsin – Milwaukee, 2017

Under the Supervision of Associate Professor Amy E. Harley

High level of social engagement has been associated with improved health outcomes. Its capacity to influence one’s health has led to the conception of Berkman’s social relationship model which hypothesizes that health is impacted by social relationship through a series of causal processes that begin at the macro-social level (upstream factors) to micro-psychobiological processes (downstream factors). Social engagement …


Unveiling Recovery: A Discourse Analysis Of Mental Illness Recovery Narratives, Elizabeth Albert Dec 2017

Unveiling Recovery: A Discourse Analysis Of Mental Illness Recovery Narratives, Elizabeth Albert

Theses and Dissertations

The discussion of mental illness recovery, both academically and socially, has been framed mainly as a morally necessary medical pursuit and has left shadowed the deeper social and cultural implications of recovery ideologies and practices. Previous research has embraced the growing demand for recovery-based practices in mental health organizations, especially those led by persons labeled mentally ill (or “peers”); however, they have yet to more deeply uncover and understand the subjective meanings of recovery. More specifically, how cultural and social interactions of daily life, while both experiencing and being labeled mentally ill, direct the course and meaning of an individual’s …


Cultural Correlates Of Ptsd In Latinos Residing In The U.S., Gabriela A. Nagy Aug 2017

Cultural Correlates Of Ptsd In Latinos Residing In The U.S., Gabriela A. Nagy

Theses and Dissertations

The present study examined the associations between cultural variables (i.e., acculturative stress, discrimination, social support, migration planning, and reasons for migrating) and exposure to trauma and PTSD in a sample of Latinos (N=2,554) residing in the United States, who participated in the National Latino and Asian America Study (NLAAS). Results showed that there were significant positive associations between trauma exposure and migrating because of political reasons, migrating in search of medical attention, migrating due to

marital or family problems, and forced migration, suggesting they may be risk factors for being exposed to trauma. There was a negative association between trauma …


The Impact Of Stand-Biased Desks On After-School Physical Activity Behaviors In Children, Nathan Tokarek Aug 2017

The Impact Of Stand-Biased Desks On After-School Physical Activity Behaviors In Children, Nathan Tokarek

Theses and Dissertations

The purpose of this study was to assess changes in after-school time spent performing sedentary behavior (SB), light intensity physical activity (LPA), and moderate to vigorous-intensity physical activity (MVPA) among elementary school children in response to the introduction of stand-biased desks in the classroom. Thirty-one 6th grade participants randomly assigned by their teacher to a traditional (CON) or stand-biased (INT) desk provided complete accelerometer data. After-school PA and SB were measured on four consecutive weekdays at baseline and 10-weeks. Wilcoxon Rank Sum Tests were used to detect significant differences (p<0.10) in changes in the proportion of after-school wear time performing SB and PA between groups. Results suggested no significant differences in changes in after-school time performing SB (p=0.770), LPA (p=0.740), or MVPA (p=0.470). Significant differences in the change in moderate PA (INT: -1.4%; CON: -0.2%, p=0.093) were detected. Stand-biased desks were not detrimental to children’s after-school PA and SB.


Which Activities Count? Gender And Socioeconomic Differences In The Conceptualization Of Physical Activity: The Role Of Leisure, Housework And Dependent Care, And Paid Work, Rachel N. Cusatis Jun 2017

Which Activities Count? Gender And Socioeconomic Differences In The Conceptualization Of Physical Activity: The Role Of Leisure, Housework And Dependent Care, And Paid Work, Rachel N. Cusatis

Theses and Dissertations

Survey research on the overall health and physical activity of the United States has relied on self-reports from questions that ask about leisure-only activity. Leisure activity patterns are known to be plagued by social forces that inhibit access and opportunity for women, compared to men, and for lower-socioeconomic individuals, compared to higher-socioeconomic individuals, making the further unpacking of leisure and other time use patterns imperative. To address this, the objective of this dissertation is to assess the different pathways individuals take to engage in health-benefiting physical activity and investigate the reliability and validity of physical activity survey questions as they …


Exploring Factors Influencing Health Promoting Behaviors Among Latino Immigrants, Martin Joseph Mikell May 2017

Exploring Factors Influencing Health Promoting Behaviors Among Latino Immigrants, Martin Joseph Mikell

Theses and Dissertations

Latinos immigrants may experience stress during acculturation to the U. S., which can influence their ability to engage in health-promoting behaviors, such as dietary intake and physical activity. Dietary intake and physical activity influence the prevention or development of pre-diabetes/Type 2 Diabetes (T2DM). The immigrant’s ability to perform health-promoting behaviors can also be influenced by their perceptions of self-efficacy to engage in health-promoting behaviors. Limited information is available in the literature on effective strategies for decreasing stress during the acculturation process of Latino immigrants, while also increasing self-efficacy on health-promoting behaviors. The purpose of this study was to explore the …


Complementary And Integrative Health Services In A Low-Resource Community: A Retrospective Examination, Barbara M. Wesson May 2017

Complementary And Integrative Health Services In A Low-Resource Community: A Retrospective Examination, Barbara M. Wesson

Theses and Dissertations

ABSTRACT

COMPLEMENTARY AND INTEGRATIVE HEALTH SERVICES IN A LOW-RESOURCE COMMUNITY: A RETROSPECTIVE EXAMINATION

by

Barbara M. Wesson

The University of Wisconsin – Milwaukee, 2017

Under the Supervision of Professor Ron Cisler

Study Background and Significance: Complementary and Integrative Health (CIH) continues to be widely utilized despite a lack of consensus regarding its efficacy. Since 2001, CORE El Centro (CEC) has been providing acupuncture, massage, reiki, and mindful movement classes, charging sliding scale fees in a low-resource, primarily Latino community; underrepresented in the CIH literature.

Purpose: This study examined the association between CIH use (time and treatment), subjective well-being assessments, biometrics …


Layperson Perceptions And Attitudes Towards A National Electronic Health Record Introduction In Saudi Arabia, Jwaher Abdullah Almulhem May 2017

Layperson Perceptions And Attitudes Towards A National Electronic Health Record Introduction In Saudi Arabia, Jwaher Abdullah Almulhem

Theses and Dissertations

Introduction: Since patients and the general public may interact with a national electronic health record (EHR), including them during implementation of an EHR is important. Such acceptance has been documented as one of the critical areas in the development of a national EHR. However, only a few studies have considered public perceptions and attitudes regarding use of their health information in a universal EHR. This is the first study that concentrated on Saudi patients and citizens’ attitudes regarding a national EHR. . Objectives: The purpose of this quantitative study was to understand perceptions and attitudes regarding the introduction of a …


The Influences Of Family Supportive Supervisor Behaviors On The Relationships Among Work-Family Conflict, Stress, And Turnover Intention In Saudi Arabian Registered Nurses, Sitah S. Alshutwi Dec 2016

The Influences Of Family Supportive Supervisor Behaviors On The Relationships Among Work-Family Conflict, Stress, And Turnover Intention In Saudi Arabian Registered Nurses, Sitah S. Alshutwi

Theses and Dissertations

Many countries around the world are struggling to maintain adequate number of nurses. Inadequate nurse staffing could compromise the quality of patient care. Among many factors that contribute to RN turnover, the influence of work–family conflict (WFC) has gained little attention. In Saudi Arabia, the turnover rate among Saudi nurses reached 50 % of the total employed nurses. Work-family conflict was found to be a reason that influence Saudi nurses to leave their workplace. In addition, WFC was found to be significantly association with increased turnover intention (TI) among employees. Furthermore, WFC has been linked to a number of negative …


Patient-Delivered Partner Therapy: Elicitation Research Using A Mixed-Method Study Design To Support The Development Of A Behavioral Intervention For Sexually Transmitted Infection Clinic Patients, Steven Alan John Dec 2016

Patient-Delivered Partner Therapy: Elicitation Research Using A Mixed-Method Study Design To Support The Development Of A Behavioral Intervention For Sexually Transmitted Infection Clinic Patients, Steven Alan John

Theses and Dissertations

The transmission of sexually transmitted infections (i.e., STIs) remains a preventable public health problem within the United States. Repeatedly acquired STIs are highly prevalent despite efficacious treatment options, and mechanisms to increase partner notification are paramount to decreasing reinfections. One mechanism to accelerate the time to partner treatment, increase partner treatment, reduce repeat infections, and reduce community prevalence of STIs is the use of patient-delivered partner therapy (PDPT). PDPT is the practice of providing patients diagnosed with a bacterial STI medication to give directly to their partner for treatment without requiring the partner to participate in diagnostic testing, screening, or …


Point Of Use Biosand Filters Of The Rural Dominican Republic, Kurtis Quamme Aug 2016

Point Of Use Biosand Filters Of The Rural Dominican Republic, Kurtis Quamme

Theses and Dissertations

The point of use biosand filter (BSF) is used globally as a drinking water treatment solution. In this research, point of use BSFs were inoculated with active biosand from the Linnwood Drinking Water Treatment plant slow sand filter beds (Milwaukee, Wisconsin) and with sands collected from point of use filters operating in the Dominican Republic. These filters were maintained with varying source waters (surface water, groundwater, or tap water to simulate chlorination encountered in the field). The microbial community of filters with varied influents and biosand inoculum were analyzed quantitatively by sequencing and qPCR. Filter efficacy and microbial community were …


Exploring Proximal And Distal Psychosocial Stressors Influencing The Health Outcomes Of Urban American Indians In The Midwest, Alina Aloma Aug 2016

Exploring Proximal And Distal Psychosocial Stressors Influencing The Health Outcomes Of Urban American Indians In The Midwest, Alina Aloma

Theses and Dissertations

Researchers have theorized that colonization and forced assimilation of American Indians/Alaska Natives (AI/AN) in the U.S. are associated with the current health outcomes of AI/AN groups. The literature has begun to link a number of negative health outcomes such as chronic illnesses, substance abuse, grief, depression, and anxiety with distal stressors associated with historical loss, as well as with proximal stressors that are continued reminders of historical trauma such as present day discrimination. The present study utilized a quantitative methodology along with a community informed framework through collaboration with multiple urban AI/AN-serving agencies in a metropolitan area of the Midwest …


Survey Of Assessing Pain In Clinical Practice And Applicability Of A New Assessment, Michelle Rose Konz Aug 2016

Survey Of Assessing Pain In Clinical Practice And Applicability Of A New Assessment, Michelle Rose Konz

Theses and Dissertations

ABSTRACT

SURVEY OF ASSESSING PAIN IN CLINICAL PRACTICE AND APPLICABILITY OF A

NEW ASSESSMENT

by

Michelle Konz

The University of Wisconsin-Milwaukee, 2016

Under the Supervision of Professor Joyce Engel, PhD

Aims The purpose of this study is to identify pain assessments that are being used to measure an individual’s pain experience and to discover how occupational therapists are currently assessing pain in youths who have complex communication needs with a developmental disability (DD). Methods Phase 1: A literature review was conducted through the use of electronic databases to research 17 different methods of pain assessment to create descriptive charts to …


Essays On Two Implications Of The Affordable Care Act (Aca), Esmaeil Salem May 2016

Essays On Two Implications Of The Affordable Care Act (Aca), Esmaeil Salem

Theses and Dissertations

ESSAYS ON TWO IMPLICATIONS

OF THE AFFORDABLE CARE ACT (ACA)

by

Esmaeil Salem

The University of Wisconsin-Milwaukee, 2016

Under the Supervision of Professor Scott J. Adams

The main objective of my dissertation is to investigate some of the causal effects of the Affordable Care Act (ACA) on U.S. healthcare system. After an overview about some of the new provisions enacted by the ACA and their components and timelines, effects of the ACA on immunization coverage for children under age of three and its impact on retention of the insureds receiving newly established rebates would be assessed.

Chapter 2 evaluates changes …


Rn Perceptions Of Coworker Incivility And Collective Efficacy As Influential To Hospital Structures And Outcomes, Jessica Grace Smith May 2016

Rn Perceptions Of Coworker Incivility And Collective Efficacy As Influential To Hospital Structures And Outcomes, Jessica Grace Smith

Theses and Dissertations

Background: An aging population and retiring workforce might affect United States health delivery care and could threaten the quality of care in hospitals. Nurses, as the largest profession in healthcare, can buffer these effects if supported in a safe nurse work environment. The purpose of this dissertation was to understand how peer-to-peer registered nurse workplace incivility as a mediator, and collective efficacy as a moderator, influence relationships among hospital structures (i.e. nurse manager leadership and staffing) and hospital outcomes (i.e. missed nursing care and patient safety cultures).

Methods: Donabedian’s (1980) structure-process-outcomes conceptual framework was the theoretical basis for this study. …


Three Essays On Public Policy And Health, Darin F. Ullman May 2016

Three Essays On Public Policy And Health, Darin F. Ullman

Theses and Dissertations

This dissertation consists of three chapters. My first chapter examines the effect of mandatory first time offender ignition interlock laws. Specifically, I use difference in difference techniques to estimate the effect of the laws on alcohol related fatal accidents. I also discuss and link behavioral models of deterrence and incapacitation to the results, so that finding can easily be interpreted. Results of the study provide pivotal policy relevant information that are essential to maximizing public health and reducing dangerous alcohol related crashes. In particular, results show that states which adopt legislation that requires mandatory participation of first time offenders in …


From Data To Decision: An Implementation Model For The Use Of Evidence-Based Medicine, Data Analytics, And Education In Transfusion Medicine Practice, Nazanin Tabesh Dec 2015

From Data To Decision: An Implementation Model For The Use Of Evidence-Based Medicine, Data Analytics, And Education In Transfusion Medicine Practice, Nazanin Tabesh

Theses and Dissertations

Healthcare in the United States is underperforming despite record increases in spending. The causes are as myriad and complex as the suggested solutions. It is increasingly important to carefully assess the appropriateness and cost-effectiveness of treatments especially the most resource-consuming clinical interventions. Healthcare reimbursement models are evolving from fee-for-service to outcome-based payment. The Patient Protection and Affordable Care Act has added new incentives to address some of the cost, quality, and access issues related to healthcare, making the use of healthcare data and evidence-based decision-making essential strategies. However, despite the great promise of these strategies, the transition to data-driven, evidence-based …


The Lived Experiences Of An Injured Athlete And Members Of A Performance Management Team During Injury Rehabilitation: An Interpretative Phenomenological Analysis, Courtney Wynne Hess Dec 2015

The Lived Experiences Of An Injured Athlete And Members Of A Performance Management Team During Injury Rehabilitation: An Interpretative Phenomenological Analysis, Courtney Wynne Hess

Theses and Dissertations

In response to an ever growing understanding of the biopsychosocial nature of health and well-being, multidisciplinary and interdisciplinary approaches to rehabilitation have grown in acceptance over the past decade. Studies that have explored the effect of these two approaches have found them to be effective in improving rehabilitation outcomes (McAlister et al., 2001; Tur et al., 2003). Although they have been shown to be objectively effective, the impact that these approaches have on the lived experiences of the team employing them, and the athlete or patient they serve, is not well understood. As such, the purpose of the current study …


Improving Mental Health Literacy: A Single-Subject Design Experiment Examining The Effects Of Text Messaging On Adolescent Mental Health Literacy, Emma Coffman Aug 2015

Improving Mental Health Literacy: A Single-Subject Design Experiment Examining The Effects Of Text Messaging On Adolescent Mental Health Literacy, Emma Coffman

Theses and Dissertations

The purpose of the study is to determine the feasibility of delivering a text-based mental health literacy intervention for adolescent children who have family members with mental illness. The effectiveness of the text message intervention was measured using a single subject, multiple baseline study design. Each participant received three text messages per week for a total of 6 weeks, containing information regarding mental illness, managing crisis, resources, stigma, and assertiveness. The subjects were evaluated using qualitative and quantitative measures at multiple periods throughout the study. Assessments utilized include: Schizophrenia Vignette quiz developed by Jorm et. al. (1997), Perceived Stress Scale-14(PSS-14) …


Ancestral Dvelopmental Exposure To Methylmercury Induces Transgenerational Inheritance Of Visual And Neurobehavioral Deficits, Thomas Achankunju Kalluvila Aug 2015

Ancestral Dvelopmental Exposure To Methylmercury Induces Transgenerational Inheritance Of Visual And Neurobehavioral Deficits, Thomas Achankunju Kalluvila

Theses and Dissertations

Methylmercury (MeHg) is an environmental neurotoxicant of global concern. It is considered one of the top ten chemicals of public health concern by the World Health Organization. Prenatal exposure to MeHg has been associated with altered neurodevelopment, neurobehavioral and neurocognitive functions. The effects of low dose MeHg exposure are more subtle and can range from impaired motor function to sensory defects. Using quantitative neurobehavioral assays and zebrafish as a model organism, our laboratory has demonstrated that developmental MeHg exposure causes neurological dysfunction in adult zebrafish. Recently, a wide range of environmental insults (e.g., pesticides, fungicides, plasticizers and endocrine disruptors) has …