Medicine and Health Sciences Commons^™

Autonomic Nervous System Response To Interpersonal Exclusion In Borderline Personality Disorder, Ilona Ponomariova, Brock Bodenbender, Khadeja Najjar, Elizabeth Golias

Undergraduate Research Posters 2015

Intense emotional reactions to interpersonal rejection reflect the core of Borderline Personality Disorder (BPD). These reactions supported by the autonomic nervous system (ANS), which has been linked to neural regions that undergird emotional experience and regulation that are affected among individuals with BPD. Despite such links, relatively few studies have examined ANS functioning among BPD populations. The few studies that have primarily focused on the independent activity of the two sympathetic (SNS) and parasympathetic (PNS) ANS branches during resting states or in response to emotion evocative films, rather than to interpersonal rejection. The present study overcomes the above noted gaps …

Developing Affordable Wet-Sample Electron Microscopy Integrated With A Temperature Controlled Sample Holder, Dan Terrano

Undergraduate Research Posters 2015

Scanning electron microscopy (SEM) is widely used to analyze the size, shape and composition of material systems. However, using this tool for analyzing systems such as particles suspended in solution, requires drastic sample alterations, such as precipitation and fixation. Besides altering their environment, this exposes the particles to the harsh conditions within an electron microscope, such as high vacuum and electron beam exposure. To this end, the first goal of this study was to develop methodologies for imaging wet samples using electron microscopy. This is realized by creating a sandwich structure containing the solution of interest between a partially electron …

Ciliary Mechanosensation In Mdck Cells, Muhammad Tayeh

Undergraduate Research Posters 2015

Cilia are microscopic structures that extend from the surface of mammalian cells. Cilia can be categorized into two groups, primary cilia (non-motile) and motile cilia. Cilia are composed of tubulin subunits (microtubules) and covered by a plasma membrane. The physiological role of motile cilia has been very well documented, but the function of primary cilia remains largely unknown. It has been shown that primary cilia allow cells to sense and respond to mechanical stimuli. The ability for a cell to respond to mechanical stimuli is crucial for maintaining processes such as homeostasis. It has also been shown that defects in …

Lead Optimization Of Tubulin Inhibitor For Cancer Treatment, Morgan Ashcraft

Undergraduate Research Posters 2015

Tubulin-containing structures are important for many important cellular functions, including chromosome segregation during cell division, development and maintenance of cell shape, cell motility, and distribution of molecules on cell membranes. The rapid growth of cancer cells makes them very sensitive to the disruption of tubulin polymerization/depolymerization. Taxol (paclitaxel), a tubulin inhibitor approved by the FDA in 1992 for cancer treatment, is one of the most powerful chemotherapeutic agents. However, the low water solubility and drug resistance limits its clinical application. Various effort in drug discovery field focuses on more water soluble smaller molecular tubulin inhibitors. Our previous study led to …

Mechanism Of Action By Which 5-Nidr Acts As A Therapeutic Agent Against Brain Cancer, Seol Kim, Jung-Suk Choi

Undergraduate Research Posters 2015

Approximately 10,000 people in the United States are diagnosed annually with a brain tumor. In addition, the prognosis for brain cancer patients is poor as these cancers have low survival rates of less than 10%. One important chemotherapeutic agent used to treat brain cancer is temozolomide, an alkylating agent that causes cell death by damaging DNA. In this project, we tested the ability of a specific non-natural nucleoside developed in our lab, designated 5-NIdR, to increase the efficacy of temozolomide against brain cancer. Animal studies using xenograft mice were performed to evaluate the in vivo efficacy of this drug combination …

Effect Of Accelerometer Based Feedback On Paretic Upper Extremity Amount Of Use And Quality Of Movement: A Case Study, Mishgan Abdullah, Nathan Pohl, Amber Kuehn

Undergraduate Research Posters 2015

Purpose/Hypothesis: To determine the effects of accelerometer based feedback on clinical measures of paretic upper extremity (UE) recovery in people post-stroke and examine the relationship between these changes and paretic UE amount of use (AOU) measured by an accelerometer. Subjects: 7 people chronic post-stroke (5 males, 2 females; aged 62.03 ± 11.33 years) with an Upper Extremity Fugl-Meyer score range of 10-63 were included for this poster. Materials/Methods: Subjects wore wrist accelerometers for 3 weeks in the home. Clinical measures (Motor Activity Log, Stroke Impact Scale, Chedoke Arm and Hand Activity Inventory, and the ABILHAND) were assessed weekly. Data analysis …

Characterization Of The Detailed Interaction Interface Between T. Brucei Telomere Proteins Trf And Tif2, Jennifer Kungle, John Sabljic, Tia Nikova

Undergraduate Research Posters 2015

The protozoan parasite Trypanosoma brucei causes fatal African trypanosomiasis in humans and nagana in cattle. T. brucei switches its variant surface glycoproteins (VSGs) inside the mammalian host, evading the host immune response. VSGs are expressed monoallelically from subtelomeric expression sites, and telomere proteins regulate VSGs. We previously found that telomere protein TbTIF2 interacts with TbTRF (TTAGGG-repeat binding factor) and plays important roles in VSG switching regulation. TbTRF maintains the telomere terminal structure. TbTIF2 is essential for subtelomeric integrity and suppresses VSG switching by inhibiting subtelomeric gene conversion. Depletion of TbTIF2 decreases TbTRF protein level. We hypothesize that TbTRF-TbTIF2 interaction is …

Stormwater Management And Residents Perceptions, Mark Gatesman

Undergraduate Research Posters 2015

Stormwater runoff is a major problem in many residential municipalities. Rain water washes pollutants and chemicals off of streets, driveways and lawns. Stormwater management practices help filter out harmful particles before they enter into our water ways. The goal of this project was to assess green infrastructure stormwater practices throughout Cuyahoga County. We assessed 165 sites in over 10 cities in Cuyahoga County. We examined bioswales, bioretention basins, and rain gardens. Sites were visited in late May through early June and revisited in mid-July to early August. We compared spring condition of plants and gardens and recorded resident’s perceptions whether …

Feasibility And Effects Of Accelerometer Based Feedback On Paretic Upper Extremity Amount Of Use In The Home Setting In Subjects Chronic Post-Stroke, Nathan Pohl, Amber Kuehn, Mishgan Abdullah

Undergraduate Research Posters 2015

Purpose : to (1) evaluate the feasibility of using accelerometers in the home to quantify how much subjects chronic post-stroke (PS) use their upper extremities (UE), (2) measure differences between amount of UE movement in subjects PS and a healthy control group (HC), (3) determine the effects of accelerometer based feedback on paretic UE use in subjects PS, and (4) determine if those effects are retained over time. Methods : Six subjects PS wore accelerometers for 3 weeks with two feedback sessions given during week two. Seven HC subjects wore accelerometers for one week. Accelerometer based outcome measures included relative …

Safe Movement Practices By Stnas For Residents In Nursing Homes, Christine Fortuna

Undergraduate Research Posters 2015

Previous research reports that with compliance, safe movement programs and policies play a large roll in reducing worker injury and safe patient handling. The purpose for our research is to better understand the daily safe movement practices of State Tested Nursing Assistants as it relates to the safe handling and transferring of patients. We used Qualtric software to electronically survey 14 STNAs from Jenning’s Center for Older Adults Upper Level Neighborhood. The survey consisted of 7 forced choice questions and 19 open ended or follow up questions. The scope of our research covers the complexities of the daily tasks of …

Dynamics Of An Optically Trapped Particle, Flaherty Justin

Undergraduate Research Posters 2015

Particles trapped in a laser experience a linear restoring force that keeps them centered in the trap and will undergo restricted Brownian motion. The Brownian motion causes a change in the scattered laser light. The scattered light is projected onto a Quadrant Photodiode and can be used to obtain the Mean Squared Displacement of the particle, as well as the linear spring constant of the laser trap. The spring constant can be used to obtain the force applied by the laser trap, which is in the realm of piconewtons.

Development Of A Gc-Ms Method For Investigation Mouse Plasma Amino Acid Levels And Their Significance To The Circadian Clock, Kylin Emhoff

Undergraduate Research Posters 2015

An extraction procedure and gas chromatography mass spectrometry (GC-MS) method was developed for quantitation of plasma amino acids. The experimental workflow included extraction of amino acids from plasma, followed by derivatization protocol for GC-MS compatibility. Automated Mass spectral Deconvolution and Identification System (AMDIS) and laboratory developed library was used for compound identification. Levels of plasma amino acids were calculated based on one point calibration with non-physiological amino acid L-norvaline as internal standard. The assay was applied to obtain and monitor levels of plasma amino acids to study the effect of feeding restriction on the circadian clock in mice. The circadian …

Synthesis Of Optimal Polymeric Microgels And Their Characterization With Light Scattering, Christan Gunder, Daria Kulyk

Undergraduate Research Posters 2015

Polymeric microgels were synthesized in by chemically crosslinking hydroxypropylcellulose (HPC) chains with each other in aqueous solutions of sodium hydroxide at temperatures above the low solution critical temperature (LCST) of HPC. In order to create a narrower size distribution of HPC microgels, surfactant (dodecyltrimethylammonium bromide, DTAB) was added. It was found that, LCST of the solution moved from ~40C up to 80C with an increase in DTAB concentration from 0 to 12 g/l. Formed microgels were be characterized by dynamic light scattering (DLS). Microgel solutions synthesized so far resulted in reasonably monodispersed nanoparticles between the sizes of 150-90 nm below …

Nitrosylation Of S100a8/ A9 Protein Complex By Inducible Nitric Oxide Synthase, Kia Smith

Undergraduate Research Posters 2015

How does the body fight infection? What causes inflammation? These are only a few questions that have been asked by many doctors across the globe. One thing that is known for certain about infection is that there is a particular sub-group of enzymes called NOS’s (eNOS, nNOS and iNOS) that produce Nitric Oxide (NO), a molecule radical capable of oxidizing proteins and alter their function. In our study we focus on inducible Nitric Oxide Synthase (iNOS). NOS’s are comprised of oxidase and reductase domains liked by Camodulin (CAM), a polypeptide linker. According to prior studies and SEM photographs, inducible Nitric …

Enhancement Of Solar Energy Conversion In Bio-Derived Cells Via Side Selective Modification Of Photosystem I, Uchechukwu Obiako, Evan Gizzie

Undergraduate Research Posters 2015

Deleterious effects of some methods used to harness energy from the environment today have garnered the exploration of safer and more reliable options, specifically solar energy conversion. Current solar cell technology has yielded quantum efficiencies commonly in the range of 10-20% but is limited by extensive processing methods, high cost, and need for rare materials. However, bio-derived solar cells containing Photosystem I (PSI) address these problems as PSI is highly abundant, very efficient, and low-cost. PSI acts as a biomolecular photodiode through rapid photoexcited charge separation, making it very promising for use as an integral element in solar cells. To …

Control Of Meiotic Cell Divisions In Presence Of Unrepaired Chromosome Breaks, Francisco Monge, Jesus Monge, Andrew Reville, Rima Sandhu

Undergraduate Research Posters 2015

Chromosome miss-segregation during meiosis is a major factor contributing to birth defects as well as many genetic anomalies through the formation of aneuploid gametes, i.e. gametes with a deficit or surplus of one or several chromosomes. The synaptonemal complex (SC) is a major protein structure assembled with the synapsis of homologous chromosomes and is conserved from unicellular yeast to humans. One of its major roles during prophase I in meiosis is providing a structural framework for the maintenance of synapsis to facilitate the completion of reciprocal crossover events. Failure to form an effective SC or to experience crossover events leads …

The Gamut: A Journal Of Ideas And Information, No. 27, Summer 1989, Cleveland State University

The Gamut Archives

CONTENTS OF ISSUE NO. 27, SUMMER, 1989

Louis T. Milic: Editorial, 2

The New Library of the Past

Diana Orendi Hinze: Expiation and Repression, 4

German literature and the Nazi past

J. Heywood Alexander: "Our Redeemed, Beloved Land", 16

Bands, songs, Lincoln! and the Civil War.

Sylvia Whitman: Mountain Nurses, 25

Kentucky's Frontier Nursing Service for mother and child.

Ron Haybron: Fraud in Science, 33

Can we place our trust in the heirs of Galileo and Pasteur?

Pat Martaus: Feminist Literary Criticism, 45

Social reform or academic language game?

J. E. Vacha: Constance and …

The Gamut: A Journal Of Ideas And Information, No. 28, Winter 1989, Cleveland State University

The Gamut Archives

CONTENTS OF ISSUE NO. 28, WINTER, 1989

Louis T. Milic: Editorial, 2

Solution for difficult Problems

Victor M. Victoroff: Right, Wrong, and the insane Killer, 4

Frustrations of the insanity defense in criminal law

Harvey Pekar: Russian Literature’s Reawakening, 18

Avant-garde Soviet fiction writers emerge

Karen Kovacik: The Computer Muse, 29

Digitized images stimulate imagination

Barbara B. Green: Moscow and Tallinn under Gorbachev, 36

A diary of recent visits with families in Russia and Estonia

J. D. Brown: Two Churches in China, 65

Christian worship since the Cultural Revolution

Sally B. Palmer: Sing …

The Gamut: A Journal Of Ideas And Information, No. 18, Spring/Summer 1986, Cleveland State University

The Gamut Archives

CONTENTS OF ISSUE NO. 18, SPRING/SUMMER, 1986

Louis T. Milic: From the Editor, 3

Robert J. White: The Artificial Extension of Life and a New Definition of Death, 4

Neurosurgeon reveals difficulty in drawing the line between life and death.

Edward T. Bartlett III: Brain Death-A Philosopher's Perspective, 8

A commentary on Dr. White's article from an ethical viewpoint.

Keith M. Kendig: Mathematics, Truth and Beauty, 11

A great mathematician will often choose beauty over correctness.

Elizabeth Kirk: Severance Hall, Cleveland's Temple of Music, 27

The Cleveland Orchestra's sumptuous home began as John Severance's memorial …

The Gamut: A Journal Of Ideas And Information, No. 02, Winter 1981, Cleveland State University

The Gamut Archives

CONTENTS OF ISSUE NO.2, WINTER, 1981

Stuart M. Klein: The Business of City Management, 3

Anthony Addison: The Un-Person Without Whom Opera Would Not Exist, 13

Walter T. Olson: Visiting the Planets, 22

Cyril A. Dostal: Two Poems, 36

Mother and the White Slavers

Starting the Model T

Patrick de Winter: Art, Devotion and Satire -the Book of Hours of Charles the Noble, King of Navarre, 42

Helen A. Weinberg: The Novel in America Today, 60

Abe Frajndlich: Homage to Yukio Mishima -A Portfolio of Photographs, 67

Grace Butcher: Remembering Stella Walsh, 76

Earl R. Anderson: Athletic Mysticism in the …