Medicine and Health Sciences Commons^™

Use Of Organ Dysfunction As A Primary Outcome Variable Following Cecal Ligation And Puncture: Recommendations For Future Studies, M. N. Abraham, A. P. Kelly, A. B. Brandwein, T. D. Fernandes, D. E. Leisman, M. D. Taylor, M. R. Brewer, C. A. Capone, C. S. Deutschman

Journal Articles

Outcomes variables for research on sepsis have centered on mortality and changes in the host immune response. However, a recent task force (Sepsis-3) revised the definition of sepsis to "life-threatening organ dysfunction caused by a dysregulated host response to infection." This new definition suggests that human studies should focus on organ dysfunction. The appropriate criteria for organ dysfunction in either human sepsis or animal models are, however, poorly delineated, limiting the potential for translation. Further, in many systems, the difference between "dysfunction" and "injury" may not be clear. In this review, we identify criteria for organ dysfunction and/or injury in …

Highly Sensitive Blocker Displacement Amplification And Droplet Digital Pcr Reveal Low-Level Parental Foxf1 Somatic Mosaicism In Families With Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins., J. A. Karolak, Q. Liu, N. G. Xie, L. R. Wu, G. Rocha, E. K. Fiorino, M. Edelman, J. Fox, D. A. Hayes, P. Stankiewicz, +9 Additional Authors

Journal Articles

Detection of low-level somatic mosaicism [alternate allele fraction (AAF) ≤ 10%] in parents of affected individuals with the apparent de novo pathogenic variants enables more accurate estimate of recurrence risk. To date, only a few systematic analyses of low-level parental somatic mosaicism have been performed. Herein, highly sensitive blocker displacement amplification, droplet digital PCR, quantitative PCR, long-range PCR, and array comparative genomic hybridization were applied in families with alveolar capillary dysplasia with misalignment of pulmonary veins. We screened 18 unrelated families with the FOXF1 variant previously determined to be apparent de novo (n = 14), of unknown parental origin (n …

Clinical Practices For Measles-Mumps-Rubella Vaccination Among Us Pediatric International Travelers., E. P. Hyle, S. R. Rao, A. C. Bangs, P. Gastañaduy, A. P. Fiebelkorn, S. H. F. Hagmann, A. T. Walker, R. P. Walensky, E. T. Ryan, R. C. Larocque

Journal Articles

Importance: The US population is experiencing a resurgence of measles, with more than 1000 cases during the first 6 months of 2019. Imported measles cases among returning international travelers are the source of most US measles outbreaks, and these importations can be reduced with pretravel measles-mumps-rubella (MMR) vaccination of pediatric travelers. Although it is estimated that children account for less than 10% of US international travelers, pediatric travelers account for 47% of all known measles importations.

Objective: To examine clinical practice regarding MMR vaccination of pediatric international travelers and to identify reasons for nonvaccination of pediatric travelers identified as MMR …

Reporting Of Child Maltreatment During The Sars-Cov-2 Pandemic In New York City From March To May 2020, E. Rapoport, H. Reisert, E. Schoeman, A. Adesman

Journal Articles

© 2020 Elsevier Ltd Background: School closures and other public health responses have decreased the extent that children interact with mandated reporters and other professionals trained to detect child maltreatment. Objective: To assess associations between the pandemic public health response and the number of allegations of child abuse or neglect. Methods: This study analyzed monthly data from New York City of the number of child maltreatment allegations, stratified by reporter type (e.g., mandated reporter, education personnel, healthcare personnel), as well as the number of Child Protective Services (CPS) investigations warranting child welfare preventative services. SARIMA models were trained using data …

Brucella Exposure Risk Events In 10 Clinical Laboratories, New York City, Usa, 2015 To 2017, J. Ackelsberg, A. Liddicoat, T. Burke, W. A. Szymczak, M. H. Levi, B. Ostrowsky, E. A. Mitchell, W. Lowe, R. Khare, M. Layton, +34 Additional Authors

Journal Articles

Copyright © 2020 American Society for Microbiology. All Rights Reserved. From 2015 to 2017, 11 confirmed brucellosis cases were reported in New York City, leading to 10 Brucella exposure risk events (Brucella events) in 7 clinical laboratories (CLs). Most patients had traveled to countries where brucellosis is endemic and presented with histories and findings consistent with brucellosis. CLs were not notified that specimens might yield a hazardous organism, as the clinicians did not consider brucellosis until they were notified that bacteremia with Brucella was suspected. In 3 Brucella events, the CLs did not suspect that slow-growing, small Gram-negative bacteria might …

Cd4 T Follicular Helper Cells Prevent Depletion Of Follicular B Cells In Response To Cecal Ligation And Puncture, M. D. Taylor, M. R. Brewer, A. Nedeljkovic-Kurepa, Y. Yang, K. S. Reddy, M. N. Abraham, B. J. Barnes, C. S. Deutschman

Journal Articles

No abstract provided.

Early Oral Colostrum Administration In Preterm Infants, D. Maffei, M. Brewer, C. Codipilly, B. Weinberger, R. J. Schanler

Journal Articles

No abstract provided.