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A Randomized Controlled Pilot Study Of Epsilon-Aminocaproic Acid As A Topical Hemostatic Agent For Postoperative Bleeding In The Sheep Model Of Chronic Sinusitis, Devika C. Thomas, Peter-John Wormald
A Randomized Controlled Pilot Study Of Epsilon-Aminocaproic Acid As A Topical Hemostatic Agent For Postoperative Bleeding In The Sheep Model Of Chronic Sinusitis, Devika C. Thomas, Peter-John Wormald
Peter-John Wormald
Background: Significant bleeding with blood clot formation in the postoperative period may predispose to the formation of postoperative adhesions. A topical hemostatic agent would potentially improve postoperative comfort and lessen adhesion formation. This pilot study was performed to evaluate the effects of a novel topical agent AMICAR (ε-aminocaproic acid; Xanodyne Pharmacal, Inc., Florence, KY) on postoperative bleeding after endoscopic sinus surgery (ESS). Methods: In a prospective randomized controlled pilot study full thickness mucosal injuries were created on the lateral nasal wall, ethmoturbinal and the maxillary ostium on both sides of 10 sheep. Eosinophilic chronic sinusitis was confirmed both by endoscopy …