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The Role Of Itraconazole In Recalcitrant Fungal Sinusitis, K Seiberling, Peter-John Wormald
The Role Of Itraconazole In Recalcitrant Fungal Sinusitis, K Seiberling, Peter-John Wormald
Peter-John Wormald
Background: Oral itraconazole is an antifungal that has been shown to be of benefit to patients with allergic bronchopulmonary aspergillus (ABPA). It is hypothesized that itraconazole may similarly benefit patients with allergic fungal sinusitis (AFS), a disease similar to ABPA. This study was designed to evaluate the therapeutic response of itraconazole in patients with refractory chronic fungal sinusitis who have failed maximal medical and surgical therapy. Methods: A retrospective chart review was performed of 23 patients with AFS and nonallergic eosinophilic fungal sinusitis treated with oral itraconazole. Charts were reviewed for patient demographics, comorbidities, allergies, fungal cultures, type of surgery …
A Randomized Controlled Pilot Study Of Epsilon-Aminocaproic Acid As A Topical Hemostatic Agent For Postoperative Bleeding In The Sheep Model Of Chronic Sinusitis, Devika C. Thomas, Peter-John Wormald
A Randomized Controlled Pilot Study Of Epsilon-Aminocaproic Acid As A Topical Hemostatic Agent For Postoperative Bleeding In The Sheep Model Of Chronic Sinusitis, Devika C. Thomas, Peter-John Wormald
Peter-John Wormald
Background: Significant bleeding with blood clot formation in the postoperative period may predispose to the formation of postoperative adhesions. A topical hemostatic agent would potentially improve postoperative comfort and lessen adhesion formation. This pilot study was performed to evaluate the effects of a novel topical agent AMICAR (ε-aminocaproic acid; Xanodyne Pharmacal, Inc., Florence, KY) on postoperative bleeding after endoscopic sinus surgery (ESS). Methods: In a prospective randomized controlled pilot study full thickness mucosal injuries were created on the lateral nasal wall, ethmoturbinal and the maxillary ostium on both sides of 10 sheep. Eosinophilic chronic sinusitis was confirmed both by endoscopy …