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Full-Text Articles in Medicine and Health Sciences
Stage Ii Endometrial Carcinoma With False Positive Para-Aortic Lymphadenopathy: The Importance Of Pretest Probability., John Cooper, Agustin A. Garcia
Stage Ii Endometrial Carcinoma With False Positive Para-Aortic Lymphadenopathy: The Importance Of Pretest Probability., John Cooper, Agustin A. Garcia
Medical Student Research Poster Symposium
Purpose: Case report to increase awareness of pretest probability in the presence of abnormal imaging findings Methods: Review of Electronic Health Records and literature review Results: This patient is a 61-year-old female with a history of intermittent vaginal spotting since her early 50’s. On physical exam, normal vaginal atrophy was observed, and bi-manual recto-vaginal exam showed normal-sized uterus without adnexal masses or nodularity. A Pap-smear with dilation and curettage revealed endometrial carcinoma, endometrioid type with squamous differentiation. Hysterectomy with bilateral salpingo-oophorectomy, bilateral pelvic sentinel biopsy, and bilateral pelvic lymphadenectomy was performed. Pathology showed a grade 1 endometrioid carcinoma with greater …
Disparities In Treatment Of Hepatocellular Carcinoma In Hepatitis C Positive Patients, José Decastro-Vázquez, Stacey Rhodes, John Hutchings, Evrim Oral, Lisa Moreno- Walton
Disparities In Treatment Of Hepatocellular Carcinoma In Hepatitis C Positive Patients, José Decastro-Vázquez, Stacey Rhodes, John Hutchings, Evrim Oral, Lisa Moreno- Walton
Medical Student Research Poster Symposium
BACKGROUND: Primary liver cancer is the sixth most diagnosed cancer and the third leading cause of cancer death worldwide in 2020, with approximately 906,000 new cases and 830,000 deaths.1 Hepatocellular Carcinoma (HCC) comprises 85-90% of primary liver cancers. Risk factors for HCC vary by region. According to recent data, Hepatitis C Virus (HCV) accounts for approximately one-third of HCC cases in the United States (US). Studies have shown HCC and HCV disproportionally impact racial/ethnic minorities in the US. This population is encouraged to perform screening in 6-months intervals to avoid delays in diagnosis and progression of the disease.2 Moreover, socioeconomic …
Notch Dependency In Triple Negative Breast Cancer Mitochondrial Metabolism, Christine Edomwande, Deniz Ucar, Giulia Monticone, Samarpan Majumder, Lucio Miele, Fokhrul Hossain
Notch Dependency In Triple Negative Breast Cancer Mitochondrial Metabolism, Christine Edomwande, Deniz Ucar, Giulia Monticone, Samarpan Majumder, Lucio Miele, Fokhrul Hossain
Medical Student Research Poster Symposium
Introduction: Triple Negative Breast Cancer (TNBC) makes up 15 – 20% of breast cancers. It has the worst prognosis amongst the breast cancer carcinomas. TNBC lacks expression of human epidermal growth factor receptor 2 (HER2) and the endocrine receptors for estrogen and progesterone. Because it is negative for all three therapeutic targets, TNBC is difficult to treat. Chemotherapy is the standard for treatment of TNBC, however, about 80% of TNBC patients do not completely respond to chemotherapy. Resistance to therapy and the recurrence of breast cancer is thought to be caused by breast cancer stem cells. Notch signaling (canonical) is …
Joint Pain: Keeping All Differentials In Mind, Hira Hasan, Sara Javadi, Erin Hauck, Lauren Raney, Emily Klepper
Joint Pain: Keeping All Differentials In Mind, Hira Hasan, Sara Javadi, Erin Hauck, Lauren Raney, Emily Klepper
Medical Student Research Poster Symposium
Introduction: Acute lymphoblastic leukemia (ALL) results from the clonal proliferation of lymphoblasts. ALL is the most common pediatric cancer, accounting for one more than 25% of all pediatric malignancies. It primarily affects children between the ages of 1 and 5, with males being slightly more affected than females. A definitive diagnosis of ALL is made by the presence of ≥20% blasts on bone marrow biopsy. The prodromal stage of ALL may last from weeks to months and presents with nonspecific symptoms such as fever and fatigue. Infiltration of the bone marrow leads to decreased production of other cell lines, leading …
Investigating The Epigenetic Role Of Spdef In Prostate Cancer Through Identification Ofproteins Involved In Spdef Function, Margaret E. Larsen, Virginia Ronchi, Mousa Vatanmakanian, Jennifer Klein, Hari K. Koul
Investigating The Epigenetic Role Of Spdef In Prostate Cancer Through Identification Ofproteins Involved In Spdef Function, Margaret E. Larsen, Virginia Ronchi, Mousa Vatanmakanian, Jennifer Klein, Hari K. Koul
Medical Student Research Poster Symposium
Prostate cancer (PCa) is the most non-cutaneous cancer diagnosed in men, and results in approximately 30,000 deaths each year in the United States. Therapy resistant PCa, known as castration-resistant prostate cancer (CRPC), does not fully respond to common therapeutics. Most of the deaths from prostate cancer are due to metastatic CRPC indicating the importance of studying PCa to formulate more effective treatments. Previous studies have shown that the SAM pointed domain containing ETS transcription factor (SPDEF) protein plays a key role in the inhibition of prostate cancer metastasis; however, the mechanism for how SPDEF regulates metastasis is still poorly understood. …
Obese Microenvironment Contributes To Mdsc Phenotype Throughepigenetic Mechanisms, Rose Luder, Ramesh Thyur Puttalingaiah, Augusto Ochoa, Maria D. Sanchez Pino
Obese Microenvironment Contributes To Mdsc Phenotype Throughepigenetic Mechanisms, Rose Luder, Ramesh Thyur Puttalingaiah, Augusto Ochoa, Maria D. Sanchez Pino
Medical Student Research Poster Symposium
Obese patients are more susceptible to developing several different types of cancer. Myeloid derived suppressor cells (MDSC) promote tumor growth by blocking anti-tumor T cell responses. The expanded number and heightened function of MDSC have been found in mouse models of obesity. Our preliminary data show that patients with morbid obesity (body mass index [BMI] > 40 kg/m2) also have increased numbers of MDSC in peripheral blood, which could contribute to the cancer risk. Here, we investigate in vitro whether the cholesterol, as a factor of obese microenvironment, regulates the immunosuppressive phenotype of MDSC via epigenetic mechanisms. MDSC exert their immunosuppressive …
Oligometastatic (Ogm) Disease: An Emerging Concept In Oncology, Humza Malik, Tanner Dawson, James Ellia, Agustin Garcia
Oligometastatic (Ogm) Disease: An Emerging Concept In Oncology, Humza Malik, Tanner Dawson, James Ellia, Agustin Garcia
Medical Student Research Poster Symposium
A 46-year old presented with pain in her right axilla. Medical history was significant for stage II triple negative breast cancer (TNBC) diagnosed in 2008 treated with surgery (SRG), radiation (XRT) and chemotherapy (CTX). In 2014 she had a recurrence in the axilla treated with SRG and CTX. In 2016 she was found to have a chest wall recurrence treated with CTX and XRT. In 2018 she had a new unresectable chest wall recurrence and due to prior XRT she was considered to be at high risk for tissue necrosis with additional treatment. She was then treated with chest wall …
How The Level Of Subspecialty Of Faculty Involved In An Emergency Departmentencounter Affects The Time Until Diagnosis And Time Until Initiation Of Treatment Ingynecologic Oncology, Whitney Sternfels, Taylor Lambert, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
How The Level Of Subspecialty Of Faculty Involved In An Emergency Departmentencounter Affects The Time Until Diagnosis And Time Until Initiation Of Treatment Ingynecologic Oncology, Whitney Sternfels, Taylor Lambert, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Medical Student Research Poster Symposium
Background: An emergency room visit is an opportunity to intervene and provide the needed care in a timely fashion. However, there is great variability in the level of subspecialty of the medical professionals involved in emergency visits. We aimed to determine if different levels of subspecialty involvement during an emergency visit had an affect on the time until first interaction with a gynecologic oncologist, time until cancer diagnosis, and time until the initiation of treatment. Methods: A retrospective chart review was conducted that included women who were referred from the emergency department (ED) to gynecologic oncology at Touro Infirmary, University …
Evaluation Of Oridonin Derivatives With Protacs Against Triple-Negative Breast Cancer, Gabrielle Vontz, Doerte Raphi Fricke, Ruixia Ma, Junhai Xu, Qiang Shen
Evaluation Of Oridonin Derivatives With Protacs Against Triple-Negative Breast Cancer, Gabrielle Vontz, Doerte Raphi Fricke, Ruixia Ma, Junhai Xu, Qiang Shen
Medical Student Research Poster Symposium
Oridonin, a natural kaurene-type diterpenoid enriched in the traditional Chinese medicinal herb Rabdosia rubescens, is a promising anticancer agent that has been shown to improve survival rates of cancer patients. Although oridonin exhibits antiproliferative capabilities including induction of apoptosis and cell cycle arrest, its low potency against aggressive cancers including triple-negative breast cancer (TNBC) and poor bioavailability limit its incorporation into standard chemotherapeutic regimens. To improve oridonin’s chemotherapeutic efficacy, several derivatives containing a thiazole ring were previously synthesized and assessed. Oridonin derivative compound CYD0618 was identified as a potent anticancer agent inhibiting cancer growth both in vitro and in vivo. …
Identification Of Copy Number Variants In Hereditary Lung Cancer Families, John Waldron, Kirsten W. Termine, Anthony M. Musolf, Mariza De Andrade, Colette Gaba, Ramaswamy Govindan, Ping Yang, Ming You, Marshall W. Anderson, Ann G. Schwartz, Susan M. Pinney, Christopher I. Amos, Joan E. Bailey-Wilson, Diptasri Mandal
Identification Of Copy Number Variants In Hereditary Lung Cancer Families, John Waldron, Kirsten W. Termine, Anthony M. Musolf, Mariza De Andrade, Colette Gaba, Ramaswamy Govindan, Ping Yang, Ming You, Marshall W. Anderson, Ann G. Schwartz, Susan M. Pinney, Christopher I. Amos, Joan E. Bailey-Wilson, Diptasri Mandal
Medical Student Research Poster Symposium
Lung cancer is the most common cause of cancer mortality and the third most common cancer by incidence in the United States. While environmental factors (e.g. tobacco smoke) play an important role in its development, lung cancer risk also exhibits a high degree of heritability. Linkage analyses and genome-wide association studies have identified multiple loci associated with increased lung cancer risk; however, much of the heritability has yet to be explained by these loci. Structural mutations, including a gain or loss of DNA (copy number variants or CNVs), contribute to phenotypic diversity through dosage and/or cis-regulatory effects. CNVs are important …
Reported Lvsi And Survival Outcomes For Stage I-Ii Endometrial Cancers In A Region With Limited Access To Formal Gynecologic Pathology Review., Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Reported Lvsi And Survival Outcomes For Stage I-Ii Endometrial Cancers In A Region With Limited Access To Formal Gynecologic Pathology Review., Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Medical Student Research Poster Symposium
Approximately 1 in 5 women with early-stage endometrial cancer (EC) will have lymphovascular space invasion (LVI). LVI reporting requires skilled evaluation and has prognostic implications that impact adjuvant treatment. Access to gynecologic pathologists (GPath) may contribute to disparate healthcare outcomes. From the practice setting of a deep south institution with no employed GPath, we aim to describe reporting rate and survival outcomes of LVI in stage I-II EC. A multicenter, IRB-approved retrospective chart review was performed at 3 hospitals with no employed GPath. Women with stage I-II EC treated with hysterectomy from 2013-2019 were included. Women were excluded if they …