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Master's Theses, Dissertations, Graduate Research and Major Papers Overview
Muscle paralysis; postoperative residual muscle paralysis; anesthesia; cholinesterase inhibitors; sugammadex;
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A Systematic Review Comparing Neostigmine Versus Sugammadex, Brittany Williams
A Systematic Review Comparing Neostigmine Versus Sugammadex, Brittany Williams
Master's Theses, Dissertations, Graduate Research and Major Papers Overview
Postoperative residual muscle paralysis can lead to very serious complications, such as hypoxia, airway obstruction, and generalized muscle weakness after surgical procedures. Traditional anesthesia practice has utilized a class of medications called cholinesterase inhibitors to mitigate these complications. Cholinesterase inhibiting agents have the potential to create adverse effects of their own, such as bradycardia, due to the drug class’s indirect mechanism of action. An ideal reversal agent would reverse quickly, and reliably, with minimal adverse effects. Recently, sugammadex, a selective relaxant- binding agent, has been introduced as an alternative reversal agent. The purpose of this systemic review was to compare …