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Articles 1 - 30 of 46
Full-Text Articles in Medicine and Health Sciences
The Best Christmas Gift Of All, Kenneth P. Serbin
The Best Christmas Gift Of All, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Mission Of A Lifetime, Kenneth P. Serbin
The Mission Of A Lifetime, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Conjugated Quantum Dots Inhibit The Amyloid Β (1–42) Fibrillation Process, Garima Thakur, Miodrag Micic, Yuehai Yang, Wenzhi Li, Dania Movia, Silvia Giordani, Hongzhou Zhou, Roger M. Levlanc
Conjugated Quantum Dots Inhibit The Amyloid Β (1–42) Fibrillation Process, Garima Thakur, Miodrag Micic, Yuehai Yang, Wenzhi Li, Dania Movia, Silvia Giordani, Hongzhou Zhou, Roger M. Levlanc
Department of Physics
Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstrated that the amyloid beta mixed with and conjugated to dihydrolipoic acid- (DHLA) capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloid β (1–42) (Aβ (1–42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease …
A Simple Method To Reduce Infection Of Ventriculoperitoneal Shunts Clinical Article, Atiq-Ur Rehman, Tausif-Ur Rehman, Hassaan H. Bashir, Vikas Gupta
A Simple Method To Reduce Infection Of Ventriculoperitoneal Shunts Clinical Article, Atiq-Ur Rehman, Tausif-Ur Rehman, Hassaan H. Bashir, Vikas Gupta
Department of Medicine
Object: Postoperative shunt infection is the most common and feared complication of ventriculoperitoneal (VP) shunt placement for treatment of hydrocephalus. The rate of shunt infection is highest in the 1st postoperative month. The most common organisms responsible for shunt infection include coagulase-negative Staphylococcus and Staphylococcus aureus. This suggests a transfer of Patient's skin flora via the surgeons' glove as a possible means of infection. The authors conducted a study to determine if the rate of postoperative shunt infections could be reduced simply by changing gloves before handling the shunt catheter. Methods: A total of 111 neonates born with congenital hydrocephalus …
Vertex And The New Wave Of Huntington’S Research, Kenneth P. Serbin
Vertex And The New Wave Of Huntington’S Research, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Globalizing The Fight Against Huntington's, Kenneth P. Serbin
Globalizing The Fight Against Huntington's, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Donepezil And Galanin Interactions In An Animal Model Of Alzheimer’S Disease, Jonathan J. Sabbagh
Donepezil And Galanin Interactions In An Animal Model Of Alzheimer’S Disease, Jonathan J. Sabbagh
UNLV Theses, Dissertations, Professional Papers, and Capstones
Alzheimer's disease (AD) is a neurodegenerative disorder marked by a progressive loss of cognitive function. One of the neurobiological hallmarks of AD is a progressive loss of cholinergic neurons and a decrease in the amount of acetylcholine in the brain. Pharmacological therapies have targeted the cholinergic system, specifically first-line, palliative treatment using acetylcholinesterase (AChE) inhibitors, such as donepezil. Donepezil has been shown to increase cholinergic tone and ameliorate some of the cognitive deficits in AD patients. Galanin, a neuropeptide that inhibits the evoked release of several neurotransmitters including acetylcholine as well as modulates seveal intracellular cascades, is overexpressed in AD …
The Mglur2/3 Agonist Ly397268 Improves Morphometric And Behavioral Outcomes In R6/2 Huntington's Disease Mice, Dennis Craig Lafferty
The Mglur2/3 Agonist Ly397268 Improves Morphometric And Behavioral Outcomes In R6/2 Huntington's Disease Mice, Dennis Craig Lafferty
Theses and Dissertations (ETD)
A prominent theory for the pathology of Huntington's Disease (HD) is the excitotoxic injury to the striatum. Continual exposure of ionotropic NMDA receptors to glutamate from the cortex can be excitotoxic in HD and leave striatal neurons vulnerable to damage. Activation of presynaptic mGluR2/3 by an agonist dampens glutamate release from corticostriatal terminals. Treatments that target excitoxicity and oxidative stress thus may improve some of the symptoms in HD patients and it is therefore logical to pursue therapies aimed in this direction. LY379268 is an inviting mGluR2/3 agonist that has been shown to be neuroprotective in hypoxic and ischemic injuries …
Enjoying The Life We Have Left, Kenneth P. Serbin
Enjoying The Life We Have Left, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
An Expedition To The Brain, Kenneth P. Serbin
An Expedition To The Brain, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Losing Control, Seeking Connections, Kenneth P. Serbin
Losing Control, Seeking Connections, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Out Of The Closet And On To The Cure, Kenneth P. Serbin
Out Of The Closet And On To The Cure, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
More To Lose Than Ever', Kenneth P. Serbin
More To Lose Than Ever', Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Living In Limbo, Kenneth P. Serbin
Living In Limbo, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Perfil Dos Acidentes De Trabalho No Brasil, 2004-2007 / Analysis Of Labor Accidents In Brazil, 2004 - 2007, Everton Fernando Alves
Perfil Dos Acidentes De Trabalho No Brasil, 2004-2007 / Analysis Of Labor Accidents In Brazil, 2004 - 2007, Everton Fernando Alves
Everton Fernando Alves
Neste estudo sintetizam-se achados epidemiológicos de morbi- mortalidade decorrentes de acidentes de trabalho napopulação brasileira. O objetivo do estudo é descrever o perfil dos acidentes de trabalho no Brasil entre 2004 e 2007. Trata-se de um estudo descritivoexploratório utilizando como fonte de dados a estatística anual de acidentes do trabalho da Previdên- cia Social. Foram notificados 465.700 mil acidentesem 2004 e 653.090 em 2007, mostrando uma tendência ascendente nos acidentes com trabalhado- res formais no Brasil. Evidenciou-se que o estado de residência com maior acidentabilidade foi Santa Catarina com uma média de 577,3 acidentes para cada 100.000 trabalhadores. O aumento …
My Friend, The Fast Lane, Kenneth P. Serbin
My Friend, The Fast Lane, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Traveling Across America, Togetherness And Memories, Kenneth P. Serbin
Traveling Across America, Togetherness And Memories, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Hyperprolactinaemia Induced By Proton Pump Inhibitor, Abdul Jabbar, Rabbia Khan, Syed Nadir Farrukh
Hyperprolactinaemia Induced By Proton Pump Inhibitor, Abdul Jabbar, Rabbia Khan, Syed Nadir Farrukh
Section of Internal Medicine
A case of a 13 year old girl who manifested hyperprolactinaemia and galactorrhea induced by Omeprazole, a commonly used proton pump inhibitor is presented.
Charting New Territory: Going Public About Hd, Kenneth P. Serbin
Charting New Territory: Going Public About Hd, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
God, Huntington's Disease And The Meaning Of Life, Kenneth P. Serbin
God, Huntington's Disease And The Meaning Of Life, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Dad, Could You Get Hd?', Kenneth P. Serbin
Dad, Could You Get Hd?', Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
A Perfect Day: The Sunset Of A Meaningful Life, Kenneth P. Serbin
A Perfect Day: The Sunset Of A Meaningful Life, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Care Versus Cure: We Can Progress In Both, Kenneth P. Serbin
Care Versus Cure: We Can Progress In Both, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Eye Movement Measures Of Cognitive Control In Children With Tourette Syndrome, Cameron B. Jeter
Eye Movement Measures Of Cognitive Control In Children With Tourette Syndrome, Cameron B. Jeter
Dissertations & Theses (Open Access)
Tourette Syndrome begins in childhood and is characterized by uncontrollable repetitive actions like neck craning or hopping and noises such as sniffing or chirping. Worst in early adolescence, these tics wax and wane in severity and occur in bouts unpredictably, often drawing unwanted attention from bystanders. Making matters worse, over half of children with Tourette Syndrome also suffer from comorbid, or concurrent, disorders such as attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). These disorders introduce anxious thoughts, impulsivity, inattention, and mood variability that further disrupt children with Tourette Syndrome from focusing and performing well at school and home. …
Tetrahydroisoquinoline Neurotoxins In Parkinson Disease, Michael G. Decuypere
Tetrahydroisoquinoline Neurotoxins In Parkinson Disease, Michael G. Decuypere
Theses and Dissertations (ETD)
The goal of this dissertation work was to (1) determine the distribution of several tetrahydroisoquinoline (TIQ) derivatives in rodent, normal human and Parkinson disease (PD) brain, (2) quantify the levels of these TIQ derivatives in common food sources in an effort to link specific food intake patterns with the development of PD and (3) examine the neurotoxicity of select TIQ derivatives in human dopaminergic cell culture. The TIQs are a family of monoamine alkaloids that share structural homology with 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP), can be formed from dopamine or its oxidized metabolites and may be involved in the pathogenesis of monoaminergic cell …
Pain Management In Nursing Home Residents With Cancer And Dementia With And Without Hospice Services, Todd Bryant Monroe
Pain Management In Nursing Home Residents With Cancer And Dementia With And Without Hospice Services, Todd Bryant Monroe
Theses and Dissertations (ETD)
Aims: We sought to identify differences in pain management between two groups; nursing home residents with malignant cancer and dementia with and without hospice services.
Methods: Decedent records from 2003-2009 were assessed for diagnosis of dementia and cause of death as cancer. Ten malignant cancer diagnoses were determined a priori from the CDC 2004 data on the top 10 malignant cancers for all races and genders. Fifty-five decedents from 10 nursing homes were included in the final sample. Four instruments were used: Minimum Data Set (MDS) a standardized assessment tool required of most U.S. nursing homes. A large …
Ten Reasons To Cure Hd, Kenneth P. Serbin
Ten Reasons To Cure Hd, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Point Of No Return, Kenneth P. Serbin
The Point Of No Return, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Impact Of Insurance Status On Migraine Care In The United States, Andrew Wilper, Steffie Woolhandler, David U. Himmelstein, Rachel Nardin
Impact Of Insurance Status On Migraine Care In The United States, Andrew Wilper, Steffie Woolhandler, David U. Himmelstein, Rachel Nardin
Publications and Research
Objective
To determine whether insurance status is associated with differential outpatient treatment of migraine in the United States.
Methods
We analyzed 11 years of data from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey (1997–2007), which survey patient visits to doctors’ offices, hospital outpatient departments, and emergency departments (EDs) in the United States. We used logistic regression to determine whether insurance status was associated with the prescription of standard migraine therapy, defined as 1) a triptan or dihydroergotamine and 2) a prophylactic agent.
Results
We identified 6,814 individual patient visits for migraine, representing 68.6 million …
Band Heterotopia, M. S. Alam, N Naila
Band Heterotopia, M. S. Alam, N Naila
Section of Internal Medicine
Band heterotopias are one of the rarest groups of congenital disorder that result in variable degree of structural abnormality of brain parenchyma. Band of heterotopic neurons result from a congenital or acquired deficiency of the neuronal migration. MRI is the examination of choice for demonstrating these abnormalities because of the superb gray vs. white matter differentiation, detail of cortical anatomy and ease of multiplanar imaging. We report a case of band heterotopia that showed a bilateral band of gray matter in deep white matter best demonstrated on T2 Wt. and FLAIR images.