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Nasal Polyp Cell Populations And Fungal-Specific Peripheral Blood Lymphocyte Proliferation In Allergic Fungal Sinusitis, H Pant, D Beroukas, F Kette, W Smith, Peter-John Wormald, P Macardle
Nasal Polyp Cell Populations And Fungal-Specific Peripheral Blood Lymphocyte Proliferation In Allergic Fungal Sinusitis, H Pant, D Beroukas, F Kette, W Smith, Peter-John Wormald, P Macardle
Peter-John Wormald
Background: Allergic fungal sinusitis (AFS) is considered a different disease from other polypoid chronic rhinosinusitis diseases (CRS) with eosinophilic mucus (EM) termed eosinophilic mucus chronic rhinosinusitis (EMCRS). To substantiate this, studies on cellular responses to fungi and sinus mucosal inflammatory cell populations in AFS and other EMCRS diseases are required. This study was designed to examine polyp inflammatory cell populations and peripheral blood fungal-specific T cell responses in AFS, other EMCRS subgroups (defined later) and polypoid CRS without EM. Methods: A prospective study was performed. Clinical characteristics, including CRS symptoms, sinus computed tomography (CT) scans, allergy status, intraoperative endoscopy, presence …