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Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
The Efficacy Of Topical Antibiofilm Agents In A Sheep Model Of Rhinosinusitis, Peter-John Wormald
The Efficacy Of Topical Antibiofilm Agents In A Sheep Model Of Rhinosinusitis, Peter-John Wormald
Peter-John Wormald
Background: Biofilms have been shown to be resistant to conventional antibiotic treatment. This study uses a sheep biofilm model developed by our department to investigate several novel topical anti-biofilm treatments. Methods: Staphylococcal biofilms were grown in 54 sheep frontal sinuses over 8 days: Each sinus was randomized to (1) no intervention, (2) single mupirocin flush, (3) regular 12-hourly mupirocin flushes for 5 days, (4) Citric Acid Zwitterionic Surfactant (CAZS) via hydrodebrider, (5) gallium nitrate, (6) CAZS with gallium nitrate, (7) CAZS with mupirocin, and (8) saline regular flushes. Sheep were sacrificed and the sinus mucosa harvested 1 or 8 days …
The Role Of Itraconazole In Recalcitrant Fungal Sinusitis, K Seiberling, Peter-John Wormald
The Role Of Itraconazole In Recalcitrant Fungal Sinusitis, K Seiberling, Peter-John Wormald
Peter-John Wormald
Background: Oral itraconazole is an antifungal that has been shown to be of benefit to patients with allergic bronchopulmonary aspergillus (ABPA). It is hypothesized that itraconazole may similarly benefit patients with allergic fungal sinusitis (AFS), a disease similar to ABPA. This study was designed to evaluate the therapeutic response of itraconazole in patients with refractory chronic fungal sinusitis who have failed maximal medical and surgical therapy. Methods: A retrospective chart review was performed of 23 patients with AFS and nonallergic eosinophilic fungal sinusitis treated with oral itraconazole. Charts were reviewed for patient demographics, comorbidities, allergies, fungal cultures, type of surgery …
Efficacy Of Different Techniques Of Sinonasal Irrigation After Modified Lothrop Procedure., A Beule, T Athanasiadis, E Athanasiadis, J Field, Peter-John Wormald
Efficacy Of Different Techniques Of Sinonasal Irrigation After Modified Lothrop Procedure., A Beule, T Athanasiadis, E Athanasiadis, J Field, Peter-John Wormald
Peter-John Wormald
Background: Post-operative irrigation after endoscopic sinus surgery and endoscopic Lothrop procedure is used to remove nasal crusts and to improve wound healing. To evaluate the optimal application protocol for irrigation of the frontal sinus, a prospective cadaver study was performed. Methods: An endoscopic modified Lothrop procedure and complete sphenoethmoidectomy were performed in 19 heads. Each was irrigated with a 1.5% solution of water and different colours using nasal spray and a squeeze bottle filles with 50, 100 and 200 mL. Intensity of local staining and percentage of area were documented using standardized videoendoscopy after irrigation in 'bending over the sink' …
Endoscopic Management Of Frontal Sinus Osteomas Revisited, K Seiberling, S Floreani, S Robinson, Peter-John Wormald
Endoscopic Management Of Frontal Sinus Osteomas Revisited, K Seiberling, S Floreani, S Robinson, Peter-John Wormald
Peter-John Wormald
Background: recent articles have published guidelines regarding the role of endoscopic surgery in the removal of frontal sinus osteomas. These guidelines recommend the endoscopic approach for small ostoemas but recommend an osteoplastic flap for larger tumors. This study presents a series of endoscopically resected tumors both large and small. Methods: retrospective chart reviews were performed. Charts were reviewed of all patients who underwent surgical resection of a frontal sinus osteoma from 1998 to 2008. Sinus CT scans were reviewed and each tumor was staged according to Kennedy's grading system proposed in 2005. Results: Twenty-three patients, 8 with a grade IV …
Immunomodulatory Effect Of Cytosine-Phosphate-Guanosine (Cpg)-Oligonucleotides In Nonasthmatic Chronic Rhinosinusitis: An Explant Model, L Tan, T Rogers, N Hatzirodos, L Baker, E Ooi, Peter-John Wormald
Immunomodulatory Effect Of Cytosine-Phosphate-Guanosine (Cpg)-Oligonucleotides In Nonasthmatic Chronic Rhinosinusitis: An Explant Model, L Tan, T Rogers, N Hatzirodos, L Baker, E Ooi, Peter-John Wormald
Peter-John Wormald
Background: The use of cytosine-phosphate-guanosine-oligodeoxynucleotides (CpG-ODNs) or immunostimulatory sequences (ISSs) in the treatment of airway diseases is gaining interest. Binding of the CpG-ODN ligand to Toll-like receptor 9 (TLR9) triggers a shift from a Th2- to a Th1-type response in the target tissue. In this study, we explored the potential use of CpG-ODN to dampen the predominantly Th2-driven chronic inflammatory state in our cohort of patients. Methods: An in vitro explant model comprising of sinonasal tissue from patients with asthma (n=12) and without asthma (n=11) were stimulated with CpG-ODN or Staphylococcus aureus enterotoxin B (SEB) or CpG-ODN in combination with …
Nasal Polyp Cell Populations And Fungal-Specific Peripheral Blood Lymphocyte Proliferation In Allergic Fungal Sinusitis, H Pant, D Beroukas, F Kette, W Smith, Peter-John Wormald, P Macardle
Nasal Polyp Cell Populations And Fungal-Specific Peripheral Blood Lymphocyte Proliferation In Allergic Fungal Sinusitis, H Pant, D Beroukas, F Kette, W Smith, Peter-John Wormald, P Macardle
Peter-John Wormald
Background: Allergic fungal sinusitis (AFS) is considered a different disease from other polypoid chronic rhinosinusitis diseases (CRS) with eosinophilic mucus (EM) termed eosinophilic mucus chronic rhinosinusitis (EMCRS). To substantiate this, studies on cellular responses to fungi and sinus mucosal inflammatory cell populations in AFS and other EMCRS diseases are required. This study was designed to examine polyp inflammatory cell populations and peripheral blood fungal-specific T cell responses in AFS, other EMCRS subgroups (defined later) and polypoid CRS without EM. Methods: A prospective study was performed. Clinical characteristics, including CRS symptoms, sinus computed tomography (CT) scans, allergy status, intraoperative endoscopy, presence …
Minitrephination Of The Frontal Sinus: Indications And Uses In Today's Era Of Sinus Surgery, K Seiberling, C Jardeleza, Peter-John Wormald
Minitrephination Of The Frontal Sinus: Indications And Uses In Today's Era Of Sinus Surgery, K Seiberling, C Jardeleza, Peter-John Wormald
Peter-John Wormald
Background: This study reviews the role of frontal sinus minitrephination in today's era of endoscopic sinus surgery. Retrospective chart review was performed of 163 patients undergoing a total of 149 bilateral and 39 unilateral frontal sinus minitrephinations. Methods: Charts were reviewed for patient demographics and outcomes. Details obtained from the chart included type of surgery performed, reason for minitrephination placement, pathology, Lund score, complications and endoscopic patency. Results: One hundred eighty-eight minitrephines were placed during 80 modified Lothrop and 108 frontal sinusotomies. Trephines were placed where there was dificulty finding the frontal recess, severe edema/ polyps, obstructing frontal cells (type3/ …