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Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
On The Roles Of Trait Anxiety And Toll Like Receptor 4 In Amphetamine Sensitization In Adolescent Male Rats, Corey A. Calhoun
On The Roles Of Trait Anxiety And Toll Like Receptor 4 In Amphetamine Sensitization In Adolescent Male Rats, Corey A. Calhoun
Graduate Doctoral Dissertations
Mammalian adolescence can be a difficult transition from childhood to adulthood, where increases in impulsivity and novelty- and risk-seeking are combined with heightened affect and elevated sensitivity to stress. Indeed, during adolescence, first drug use patterns emerge and in the continental United States, increasing misuse of amphetamines has been observed in adolescent youth. Myriad neural mechanisms underlie this shift in adolescence, including the dynamic remodeling of the mesocorticolimbic (MCL) pathway. Repeated drug administration affects neuroimmune substrates within the MCL circuit including toll-like receptor 4 (TLR4)Advances in addiction neuroscience indicate that drugs of abuse activate neural TLR4 and implicate glial TLR4 …
Effects Of Genetics And Sex On Hippocampal Gene Expression And Adolescent Behaviors Following Neonatal Ethanol Exposure In Bxd Recombinant Inbred Mice, Jessica A. Baker
Effects Of Genetics And Sex On Hippocampal Gene Expression And Adolescent Behaviors Following Neonatal Ethanol Exposure In Bxd Recombinant Inbred Mice, Jessica A. Baker
Theses and Dissertations (ETD)
Fetal alcohol spectrum disorders (FASD) are the leading preventable neurodevelopmental disorders in the western world. A hallmark symptom of FASD is cognitive and learning deficits that present in early childhood and continue throughout adulthood. Teratogenic effects of alcohol include increased cell death in the hippocampus, a brain region critically important in learning and memory. Genetics have been shown to have a role in the severity of alcohol’s teratogenic effect on the developing brain. Previous work in our lab identified differential vulnerability to ethanol-induced call death in the hippocampus using fourteen BXD strains and the two parental strains. The goal of …
Behavior Coding Strategies: Population Coupling And The Functional Role Of Excitatory/Inhibitory Balance In Primary Motor Cortex, Patrick Aaron Kells
Behavior Coding Strategies: Population Coupling And The Functional Role Of Excitatory/Inhibitory Balance In Primary Motor Cortex, Patrick Aaron Kells
Graduate Theses and Dissertations
The complexities of an organism’s experience of- and interaction with the world are emergent phenomena produced by large populations of neurons within the cerebral cortex and other brain regions. The network dynamics of these populations have been shown to be sometimes synchronous, with many neurons firing together, and sometimes asynchronous, with neurons firing more independently, leading to a decades-old debate within the neuroscience community. This discrepancy comes from viewing the system at two different scales; at the single cell level, the spiking activity of two neurons within cortex tend to be rather independent, but when the average activity of a …
Persistent Neurobehavioral Traits In A Mouse Model Of Prenatal Ethanol Exposure, Jill M. Lawrence
Persistent Neurobehavioral Traits In A Mouse Model Of Prenatal Ethanol Exposure, Jill M. Lawrence
Neuroscience Honors Papers
Fetal Alcohol Spectrum Disorders (FASD) effect an estimated 2% of the population, causing a range of symptoms: from craniofacial defects to inhibited cortical growth (May, et al., 2009; Murawski, et al., 2015). Impaired medial forebrain function apparent in FASD is associated with lifelong cognitive behavioral deficits, but these consequences may be avoided with early diagnosis and intervention (Streissguth, et al., 2004). Our goal is to identify early neurobehavioral abnormalities that persist into adulthood that could potentially serve as early indicators for FASD. Mouse models of prenatal ethanol exposure were developed using a voluntary drinking paradigm that introduced a sweetened ethanol …
Your Brain: Unconscious Decision-Making And How It Affects Your Life And Learning, James Stellar
Your Brain: Unconscious Decision-Making And How It Affects Your Life And Learning, James Stellar
Campus Conversations in Standish
No abstract provided.
Eye-Tracking Measures Of Attentional Bias In Cocaine Dependent Subjects, Nadeeka Dias
Eye-Tracking Measures Of Attentional Bias In Cocaine Dependent Subjects, Nadeeka Dias
Dissertations & Theses (Open Access)
Cocaine-dependent (CD) subjects show evidence of attentional bias toward cocaine-related cues, and this measure of cue-reactivity is predictive of craving and relapse. In previous work, cue-reactivity and attentional bias have been assessed by models that present drug-relevant stimuli (e.g., cocaine-specific Stroop task) and measure physiological and behavioral reactivity (e.g., heart rate, reaction times). Studies have indicated competition between the higher-order cortical processes (frontal eye-fields, DLPFC) in voluntary eye control (i.e., anti-saccades) and more reflexive saccades driven by involuntary midbrain (superior colliculus) perceptual input (i.e., pro-saccades). In addition, neuroimaging studies in patients with cocaine dependence have shown activation in frontal regions …