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Full-Text Articles in Medicine and Health Sciences
Significant Association Between Scgb1d4 Gene Polymorphisms And Susceptibility To Adenoid Hypertrophy In A Pediatric Population, Tali̇h Özdaş, Si̇bel Özdaş, Mehmet Ali̇ Babademez, Sami̇ Engi̇n Muz, Mahmut Huntürk Ati̇lla, Si̇bel Başti̇mur, Afi̇fe İzbirak, Kenan Kurt, Işilay Öz
Significant Association Between Scgb1d4 Gene Polymorphisms And Susceptibility To Adenoid Hypertrophy In A Pediatric Population, Tali̇h Özdaş, Si̇bel Özdaş, Mehmet Ali̇ Babademez, Sami̇ Engi̇n Muz, Mahmut Huntürk Ati̇lla, Si̇bel Başti̇mur, Afi̇fe İzbirak, Kenan Kurt, Işilay Öz
Turkish Journal of Medical Sciences
Background/aim: Adenoid hypertrophy (AH) is chronic enlargement of the adenoid tissue. The pathophysiology of the disease is unclear. We analyzed SCGB1D4 gene polymorphisms in order to determine the effect of the variants or their genetic combinations on AH. Materials and methods: We genotyped the SCGB1D4 (IIS) gene in 167 participants (95 children with AH and 72 controls) by performing DNA sequencing in blood samples. Results: We genotyped three single nucleotide polymorphisms (SNPs). In the analysis, we found that in the presence of those SNPs and the minor alleles of individual SNPs four haplotypes were associated with an increased risk of …
Allergic And Autoimmune Disorders In Families With Selective Iga Deficiency, Mustafa Erkoçoğlu, Ayşe Meti̇n, Ayşenur Kaya, Celal Özcan, Ayşegül Akan, Ersoy Ci̇velek, Murat Çapanoğlu, Tayfur Gi̇ni̇ş, Can Naci̇ Kocabaş
Allergic And Autoimmune Disorders In Families With Selective Iga Deficiency, Mustafa Erkoçoğlu, Ayşe Meti̇n, Ayşenur Kaya, Celal Özcan, Ayşegül Akan, Ersoy Ci̇velek, Murat Çapanoğlu, Tayfur Gi̇ni̇ş, Can Naci̇ Kocabaş
Turkish Journal of Medical Sciences
Background/aim: IgA deficiency is the most common human primary immunodeficiency. The prevalence of allergic disorders and autoimmunity is thought to be increased in selective IgA deficiency (sIgAD). However, it is currently unclear if these disorders coincide within these families. We aimed to evaluate the frequency of allergic and autoimmune disorders in children with sIgAD and their firstdegree relatives (FDRs). Materials and methods: The study included 81 children diagnosed with sIgAD and 274 of their FDRs. The presence of allergic and autoimmune disorders was evaluated and serum antithyroglobulin and antithyroid peroxidase levels were measured in both patients and their first-degree relatives. …
Role Of Hygienic Factors In The Etiology Of Allergic Disorders In Children, Şule Yeşi̇l, Ahmet Kan, Olkar Abdulmajed, Arzu Bakirtaş, Mahmut Nedi̇m Sultan, Mehmet Sadik Demi̇rsoy
Role Of Hygienic Factors In The Etiology Of Allergic Disorders In Children, Şule Yeşi̇l, Ahmet Kan, Olkar Abdulmajed, Arzu Bakirtaş, Mahmut Nedi̇m Sultan, Mehmet Sadik Demi̇rsoy
Turkish Journal of Medical Sciences
Background/aim: We investigated the role of body flora and chronic inflammatory infections in the etiology of allergic disorders in Turkish children. Materials and methods: Forty pediatric asthma patients with positive skin prick tests and 40 age-matched healthy subjects with negative skin prick tests were enrolled in this cross-sectional study. Serum H. pylori IgG, viral hepatitis serology, IL-10, and TGF-beta levels were measured. Stool and throat cultures were taken and tested for occurrence of microorganisms. Results: A significantly higher percentage of nonatopic subjects tested positive for anti-H. pylori antibodies compared to atopic subjects (60% vs. 20%). Serum IL-10 levels were also …