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Full-Text Articles in Medicine and Health Sciences
Prolonged Administration Of Kappa Opioid Agonist Difelikefalin Retains Its Efficacyon The Diuretic Response, Ashlyn Y. Anderson, Luke E. Beckendorf, Daniel R. Kapusta
Prolonged Administration Of Kappa Opioid Agonist Difelikefalin Retains Its Efficacyon The Diuretic Response, Ashlyn Y. Anderson, Luke E. Beckendorf, Daniel R. Kapusta
Medical Student Research Poster Symposium
RATIONALE: Disease states exhibiting high amounts of edema, including congestive heart failure, hepatic cirrhosis, and hypertension, are often treated with a combination of diuretics to reduce water retention in the body. Patients treated with the loop diuretic furosemide face an increased risk for developing adverse conditions, such as hyponatremia and hypokalemia and with time loss of diuretic efficacy (diuretic resistance). In contrast, the kappa opioid agonist difelikefalin produces a sodium sparing diuresis by inhibiting hypothalamic neurons responsible for the secretion/release of antidiuretic hormone (ADH) located in the paraventricular nucleus (PVN). Consequently, inhibition of ADH release increases urine output by increasing …
Effect Of Mitochondrial Ros In Binge Etoh Bone Toxicity, Bretton Urban, Kyler Pisciotta, Alexandra Denys, Kim Pedersen, Martin J. Ronis
Effect Of Mitochondrial Ros In Binge Etoh Bone Toxicity, Bretton Urban, Kyler Pisciotta, Alexandra Denys, Kim Pedersen, Martin J. Ronis
Medical Student Research Poster Symposium
The molecular basis of ethanol (EtOH) toxicity on bone turnover has yet to be fully understood. It is known that chronic consumption increases bone resorption by osteoclast activation while at the same time decreasing bone formation by downregulating osteoblast functions. Our previous work indicated oxidative stress and reactive oxygen species (ROS) generation having a role, as dietary antioxidants such as N-acetyl cysteine partially blocked EtOH-induced bone loss in female mice. Mitochondria are a source of ROS such as superoxide and hydrogen peroxide. MitoTEMPO is a superoxide dismutase mimic that accumulates in mitochondria and scavenges superoxide radicals. Our aim was to …
The Effects Of Mitochondrial Catalase Overexpression On Alcohol-Induced Skeletal Toxicity, Kyler Pisciotta, Bretton Urban, Alexandra Denys, Kim Pedersen, Martin J. Ronis
The Effects Of Mitochondrial Catalase Overexpression On Alcohol-Induced Skeletal Toxicity, Kyler Pisciotta, Bretton Urban, Alexandra Denys, Kim Pedersen, Martin J. Ronis
Medical Student Research Poster Symposium
Alcohol induces deleterious effects on the quantity and quality of bone in the skeleton. The mechanism of these effects is believed to be through increased concentrations of reactive oxygen species (ROS) within bone cells. Hydrogen peroxide (H2O2) is a form of ROS that is converted to water (H2O) and oxygen (O2) by the enzyme catalase. Our previous studies have demonstrated that nicotinamide adenine dinucleotide phosphate oxidase (NOX) enzymes 2 and 4 are contributors of ROS within the cellular environment of bone; however, selective knockout of these enzymes did not lead to complete protection against alcohol’s inhibition of osteoblastogenesis and upregulation …
Alcohol Metabolism Negatively Affects Early Atdc5 Chondrocyte Differentiationindependent Of Nox4 Expression, Hardy Hang, Alexandra Denys, Martin J. J. Ronis
Alcohol Metabolism Negatively Affects Early Atdc5 Chondrocyte Differentiationindependent Of Nox4 Expression, Hardy Hang, Alexandra Denys, Martin J. J. Ronis
Medical Student Research Poster Symposium
Alcohol (ethanol) abuse is a widely recognized risk factor in the development of several diseases. Previous studies in our lab have shown that ethanol induces reactive oxygen species (ROS) production in osteogenic cells, which results in oxidative damage, skeletal dysfunction, and osteoporosis. Moreover, ethanol inhibits epiphyseal plate proliferation in longitudinal bones and affects chondrocyte function, which results in shorter bones. In osteogenic cells, a major source of ethanol-mediated ROS is derived from NADPH oxidases (NOXs). However, it remains uncertain if ROS produced by NOXs during alcohol metabolism result in impaired chondrocyte function and differentiation. In this study, we investigated if …
Effects Of Delta-9-Tetrahydrocannabinol (Thc) On Thermal Nociception Andconditioned Behavior In Sprague Dawley Rats, Taylor Marks, Peter Winsauer, Tamara Morris, Madison Priestley, Kayla Prevost
Effects Of Delta-9-Tetrahydrocannabinol (Thc) On Thermal Nociception Andconditioned Behavior In Sprague Dawley Rats, Taylor Marks, Peter Winsauer, Tamara Morris, Madison Priestley, Kayla Prevost
Medical Student Research Poster Symposium
Cannabinoids have been suggested as a possible alternative to opioids for pain management and as an adjunct to opioid administration to reduce the many adverse effects associated with their administration (i.e., administered to produce opioid-sparing effects). Although cannabinoids such as delta-9-tetrahydrocannabinol (THC) have been shown to produce antinociceptive effects, these effects have not typically been compared directly with its adverse effects – some of which include the disruption of cognitive and conditioned behaviors. These types of studies are necessary if cannabinoids such as THC can be considered a valid option for pain management. The present experiment was conducted to directly …