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Regulatory Function Of The Anticoagulant Protein S In Patients With Chuvashpolycythemia, Devin M. Melancon, Verima Pereira, Rinku Majumder
Regulatory Function Of The Anticoagulant Protein S In Patients With Chuvashpolycythemia, Devin M. Melancon, Verima Pereira, Rinku Majumder
Medical Student Research Poster Symposium
Background: Chuvash polycythemia is a hematological disorder that is present worldwide but endemic to the Chuvash population, a Turkish ethnic group, in Russia. The disorder is caused by a homozygous germline mutation (R200W) in the von Hippel Lindau gene. This mutation impairs binding of pVHL to hypoxia-inducible factor 1-alpha (HIF-1α); lack of this interaction prevents degradation of HIF-1α. The resultant upregulation of HIF-1α, even in a normal oxygen state, increases the activity of erythropoietin, thereby causing polycythemia. Affected individuals experience increased rates of arterial and venous thrombosis unrelated to the increased concentration of hemoglobin. Aims: To determine whether upregulation of …
Novel Biomarkers For Early And Accurate Detection Of A Fatal Gut Inflammatory Diseasein Preemie Babies, Lana Thaljeh, Rebecca Buckley, Anne Tufton, Maya Heath, Brian Barkemeyer, Zhide Fang, Lee Mcdaniel, Andrew Chapple, Kelly Laborde, Beverly Ogden, Misty Good, Duna Penn, Steven Spedale, Sunyoung Kim
Novel Biomarkers For Early And Accurate Detection Of A Fatal Gut Inflammatory Diseasein Preemie Babies, Lana Thaljeh, Rebecca Buckley, Anne Tufton, Maya Heath, Brian Barkemeyer, Zhide Fang, Lee Mcdaniel, Andrew Chapple, Kelly Laborde, Beverly Ogden, Misty Good, Duna Penn, Steven Spedale, Sunyoung Kim
Medical Student Research Poster Symposium
Necrotizing enterocolitis (NEC) is an inflammatory disease that primarily affects the intestinal tract of premature and low birthweight infants. It is one of the most common complications that occur with prematurity, which also results in high morbidity and mortality due to unchecked pathogenic bacterial growth. The median time between death and x-ray diagnosis is 1 day and, currently, there are no reliable molecular methods to predict the onset of NEC in infants. Association of intestinal alkaline phosphatase (iAP) with moderate and severe forms of the disease suggested that iAP can be a diagnostic tool that is accurate and specific for …