Medicine and Health Sciences Commons^™

Imaging Of Transplanted Pancreatic Islets In Vivo, P. Joo Ho Tai, C. Foster, C. Hasil, C.W.J. Melling, D. White

Jamie Melling

No abstract provided.

Structural And Dynamic Basis Of Phospholamban And Sarcolipin Inhibition Of Ca2+-Atpase, Nathaniel J. Traaseth, Kim N. Ha, Raffaello Verardi, Lei Shi, Jarrod J. Buffy, Larry R. Masterson, Gianluigi Veglia

Larry Masterson

Cellular Effects Of Antiepileptic Drugs, Robert L. Macdonald, Michael A. Rogawski

Michael A. Rogawski

Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets, which include various ion channels, a neurotransmitter transporter, a neurotransmitter metabolic enzyme, and a synaptic vesicle protein. AED actions on these targets can be categorized into four broad groups: 1. Modulation of voltage-dependent ion channels (mainly sodium [Na] but also calcium [Ca] channels) 2. Effects on γ-aminobutyric acid (GABA) systems, including alterations in the cellular disposition of GABA and enhancement of synaptic inhibition mediated by GABA-A receptors 3. Inhibition of synaptic excitation mediated by ionotropic glutamate receptors 4. Modulation of neurotransmitter release, particularly of glutamate, through …

Correlation Network Analysis For Data Integration And Biomarker Selection, Aram Adourian, Ezra Jennings, Raji Balasubramanian, Wade M. Hines, Doris Damian, Tom N. Plasterer, Clary B. Clish, Paul Stroobant, Robert N. Mcburney, Elwin R. Verheij, Ivana I. Bobeldijk, J Van Der Greef, J Lindberg, K Kenne, U Andersson, H Hellmold, K Nilsson, H Salter, I Schuppe-Koistinen

Raji Balasubramanian

This work demonstrates the application of correlation networks to a systems-based investigation of drug-induced hepatotoxicity and the identification of specific and relevant biomarkers in this context.

Effect Of Two Milling Techniques And Flours Particle Size On Some, Theodore N'Dede Djeni

Theodore N'Dede Djeni

Two techniques of milling (milling with wooden mortar and milling with hammer grinder) for the production of millet flours were compared in term of physical, biochemical and nutritional aspects and digestibility of the produced flours. A batch of millet grains with candle (Pennisetum glaucum L. R.BR) was purchased from a local market for flour production, while the flour digestibility tests were achieved with an enzymatic crude extract get from gastric juice of and snails (Archachatina marginata). The different rough flours obtained from both milling techniques showed significant differences (p<0.05) in their granulometric profiles and their biochemical composition. The mortar …

Common Pathophysiologic Mechanisms In Migraine And Epilepsy, Michael A. Rogawski

Michael A. Rogawski

Migraine and epilepsy are comorbid episodic disorders that have common pathophysiologic mechanisms. Migraine attacks, like epileptic seizures, may be triggered by excessive neocortical cellular excitability; in migraine, however, the hyperexcitability is believed to transition to cortical spreading depression rather than to the hypersynchronous activity that characterizes seizures. Some forms of epilepsy and migraine are known to be channelopathies. Mutations in the same genes can cause either migraine or epilepsy or, in some cases, both. Given the likely commonalities in the underlying cellular and molecular mechanisms, it is not surprising that some antiepileptic drugs, including valproate, topiramate, and gabapentin, are effective …

Discordance In The Paraoxonase (Pon1)-192qr Polymorphism, Rozaida @ Poh Yuen Ying

Rozaida @ Poh Yuen Ying

Paraoxonase (PON1) has been implicated to have a cardioprotective role, due to its physical attachment with high-density lipoprotein. PON1192QR is a variation of the PON1 gene, the R allele being a risk factor for cardiovascular disease. Kinetic studies resulting in a plot of paraoxon versus diazoxon hydrolysis rates may be used to accurately predict PON1192 geno-type. In this study, paraoxonase and diazoxonase activities in plasma were measured spec-trophotometrically using plasma while PCR-based PON1192 genotyping was performed us-ing polymerase chain reaction followed by restriction digestion. The two-substrate assay-derived genotypes were cross-referred with those determined by PCR-based genotyping. When results did not …

Functional Generalized Linear Models With Applications To Neuroimaging, Philip T. Reiss, R. Todd Ogden

Philip T. Reiss

No abstract provided.