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Articles 1 - 16 of 16
Full-Text Articles in Medicine and Health Sciences
Getting Off On The Right Foot: Addressing Severe Lymphedema Through A Novel Shoe Design, Carl R. Russell Iii, Anjollie M. Ramakrishna, Christopher H. Johns Iii, Alana V. Van Wijnen
Getting Off On The Right Foot: Addressing Severe Lymphedema Through A Novel Shoe Design, Carl R. Russell Iii, Anjollie M. Ramakrishna, Christopher H. Johns Iii, Alana V. Van Wijnen
Purdue Journal of Service-Learning and International Engagement
Engineering Projects in Community Service (EPICS) is a service-learning design program run by the College of Engineering at Purdue University. EPICS teaches students design skills by providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. Biomedical Engineering is a team within EPICS that strives to serve community partners through biomedical applications. HR is a patient who suffers from severe lymphedema. This condition results in her foot swelling three times its original size and requires her to utilize weekly leg compression therapy. Prescription shoes are slightly adequate. However, they lead to sores and pain …
Effects Of Noise Electrical Stimulation On Proprioception, Force Control, And Corticomuscular Functional Connectivity, Li-Wei Chou, Shiang-Lin Hou, Hui-Min Lee, Felipe Fregni, Alice Yen, Vincent Chiun-Fan Chen, Shun-Hwa Wei, Chung-Lan Kao
Effects Of Noise Electrical Stimulation On Proprioception, Force Control, And Corticomuscular Functional Connectivity, Li-Wei Chou, Shiang-Lin Hou, Hui-Min Lee, Felipe Fregni, Alice Yen, Vincent Chiun-Fan Chen, Shun-Hwa Wei, Chung-Lan Kao
Engineering Science Faculty Publications
Sensory afferent inputs play an important role in neuromuscular functions. Subsensory level noise electrical stimulation enhances the sensitivity of peripheral sensory system and improves lower extremity motor function. The current study aimed to investigate the immediate effects of noise electrical stimulation on proprioceptive senses and grip force control, and whether there are associated neural activities in the central nervous system. Fourteen healthy adults participated in 2 experiments on 2 different days. In day 1, participants performed grip force and joint proprioceptive tasks with and without (sham) noise electrical stimulation. In day 2, participants performed grip force steady hold task before …
Working Out The Kinks: Creating Solutions To Assist Health Care Workers To Take Vital Signs Through Effective Cable Management, Carl R. Russell Iii, Emily J. Linder, Maya A. Godbole
Working Out The Kinks: Creating Solutions To Assist Health Care Workers To Take Vital Signs Through Effective Cable Management, Carl R. Russell Iii, Emily J. Linder, Maya A. Godbole
Purdue Journal of Service-Learning and International Engagement
EPICS (Engineering Projects in Community Service) is a service-learning design program run through Purdue University. It strives to teach students design skills through providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. BME (Bio-medical Engineering) is a team within EPICS that strives to serve community partners through biomedical applications. Members of a health care team often spend valuable time organizing cables associated with machines used to take patients’ vital signs. Due to time constraints and the fast-paced work environment, these cables may be mismanaged and damaged. The BME team is working on a …
Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi
Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi
Purdue Journal of Service-Learning and International Engagement
Because of its extreme rarity, the genetic disease arthrogryposis multiplex congenita (AMC) and the needs of individuals with the diagnosis are often overlooked. AMC refers to the development of nonprogressive contractures in disparate areas of the body and is characterized by decreased flexibility in joints, muscle atrophy, and developmental delays. Colton Darst, a seven-year-old boy from Indianapolis, Indiana, was born with the disorder, and since then, he has undergone numerous surgical interventions and continues to receive orthopedic therapy to reduce his physical limitations. His parents, Michael and Amber Darst, have hopes for him to regain his limbic motion and are …
Axonal Blockage With Microscopic Magnetic Stimulation, Hui Ye
Axonal Blockage With Microscopic Magnetic Stimulation, Hui Ye
Biology: Faculty Publications and Other Works
Numerous neurological dysfunctions are characterized by undesirable nerve activity. By providing reversible nerve blockage, electric stimulation with an implanted electrode holds promise in the treatment of these conditions. However, there are several limitations to its application, including poor bio-compatibility and decreased efficacy during chronic implantation. A magnetic coil of miniature size can mitigate some of these problems, by coating it with biocompatible material for chronic implantation. However, it is unknown if miniature coils could be effective in axonal blockage and, if so, what the underlying mechanisms are. Here we demonstrate that a submillimeter magnetic coil can reversibly block action potentials …
Effect Of Bout Length On Gait Measures In People With And Without Parkinson’S Disease During Daily Life, Vrutangkumar Shah, James Mcnames, Graham Harker, Martina Mancini, Patricia Carlson-Kuhta, John G. Nutt, Mahmoud El-Gohary, Carolin Curtze, Fay Horak
Effect Of Bout Length On Gait Measures In People With And Without Parkinson’S Disease During Daily Life, Vrutangkumar Shah, James Mcnames, Graham Harker, Martina Mancini, Patricia Carlson-Kuhta, John G. Nutt, Mahmoud El-Gohary, Carolin Curtze, Fay Horak
Electrical and Computer Engineering Faculty Publications and Presentations
Although the use of wearable technology to characterize gait disorders in daily life is increasing, there is no consensus on which specific gait bout length should be used to characterize gait. Clinical trialists using daily life gait quality as study outcomes need to understand how gait bout length affects the sensitivity and specificity of measures to discriminate pathological gait as well as the reliability of gait measures across gait bout lengths. We investigated whether Parkinson’s disease (PD) affects how gait characteristics change as bout length changes, and how gait bout length affects the reliability and discriminative ability of gait measures …
Modified Stent Design For A Coronary Bifurcation Lesion, Abigail Nowell
Modified Stent Design For A Coronary Bifurcation Lesion, Abigail Nowell
Biological Sciences Undergraduate Honors Theses
Currently, 18.2 million adults aged 20 and older are diagnosed with Coronary Artery Disease (CAD) (Benjamin et al., 2019). Stenosis is the most common intervention. However, when a patient has a bifurcated artery, treatment becomes more difficult and is often unsuccessful. This project created a new stent and balloon complex that was tested in vitro using a gel phantom artery model. Two separate prototypes have been created and tested so far, with improvements made upon each. Testing is still underway with Prototype 2.
Enhancement Of The Syncardia Total Artificial Heart For Pediatric Use, Margaret Clark, Madison Marks
Enhancement Of The Syncardia Total Artificial Heart For Pediatric Use, Margaret Clark, Madison Marks
Williams Honors College, Honors Research Projects
Pediatric patients with disorders and diseases of the heart have limited options with regards to implantable devices. Many of these implants are ventricular assist devices, which is not always suitable for a patient. Total artificial hearts (TAHs) have supported many adult patients until transplantation, and we believe that they could do the same for pediatric patients. SynCardia has the only Food and Drug Administration (FDA) approved TAH devices. Since SynCardia is the only company with FDA approved TAHs, we decided to modify the design of the SynCardia TAH for use in pediatric patients without compromising the function of the current …
Improving 3d Printed Prosthetics With Sensors And Motors, Rachel Zarin
Improving 3d Printed Prosthetics With Sensors And Motors, Rachel Zarin
Honors Projects
A 3D printed hand and arm prosthetic was created from the idea of adding bionic elements while keeping the cost low. It was designed based on existing models, desired functions, and materials available. A tilt sensor keeps the hand level, two motors move the wrist in two different directions, a limit switch signals the fingers to open and close, and another motor helps open and close the fingers. All sensors and motors were built on a circuit board, programmed using an Arduino, and powered by a battery. Other supporting materials include metal brackets, screws, guitar strings, elastic bands, small clamps, …
Seeing Eye To Eye: A Machine Learning Approach To Automated Saccade Analysis, Maigh Attre
Seeing Eye To Eye: A Machine Learning Approach To Automated Saccade Analysis, Maigh Attre
Honors Scholar Theses
Abnormal ocular motility is a common manifestation of many underlying pathologies particularly those that are neurological. Dynamics of saccades, when the eye rapidly changes its point of fixation, have been characterized for many neurological disorders including concussions, traumatic brain injuries (TBI), and Parkinson’s disease. However, widespread saccade analysis for diagnostic and research purposes requires the recognition of certain eye movement parameters. Key information such as velocity and duration must be determined from data based on a wide set of patients’ characteristics that may range in eye shapes and iris, hair and skin pigmentation [36]. Previous work on saccade analysis has …
Three-Dimensional Microfluidic Tumor Vascular Model For Investigating Breast Cancer Metastasis, Anastasiia Vasiukhina, Brian H. Jun, Luis Solorio, Pavlos P. Vlachos
Three-Dimensional Microfluidic Tumor Vascular Model For Investigating Breast Cancer Metastasis, Anastasiia Vasiukhina, Brian H. Jun, Luis Solorio, Pavlos P. Vlachos
The Summer Undergraduate Research Fellowship (SURF) Symposium
Metastasis is one of the primary reasons for the high mortality rates in female patients diagnosed with breast cancer. It involves the migration of cancer cells into the circulatory system allowing for the dissemination of cancer cells in distal tissues. Understanding the major processes that occur in cells and tissues during metastasis can help improve currently existing therapeutic methods. In order to understand such mechanisms, developing physiologically relevant tissue models is crucial. Advancements in microfluidics have led to the fabrication of 3D culture models with shear stress gradients and flow control that can recapitulate aspects of the tumor microenvironment in …
Compressive Sensing Framework For Mass Spectrometry Data Analysis, Khalfalla Ahmad Kh. Awedat
Compressive Sensing Framework For Mass Spectrometry Data Analysis, Khalfalla Ahmad Kh. Awedat
Dissertations
Mass Spectrometry (MS) data is ideal for identifying unique bio-signatures of diseases. However, the high dimensionality of MS data hinders any promising MS-based proteomics development. The goal of this dissertation is to develop an accurate classification tool by employing compressive sensing (CS). Not only can CS significantly reduce MS data dimensionality, but it also will allow for full reconstruction of original data. The framework developed in this work is based on using L2 and a mixed L2-L1 norms, allowing an overdetermined system to be resolved. The results show that the L2- based algorithm with regularization terms has a better performance …
Finite Element Analysis (Fea) Of The Taper-Trunnion Interface In A Metal On Metal Hip Implant, Kyle M. Bradley, Timothy L. Norman, Thomas K. Fehring
Finite Element Analysis (Fea) Of The Taper-Trunnion Interface In A Metal On Metal Hip Implant, Kyle M. Bradley, Timothy L. Norman, Thomas K. Fehring
The Research and Scholarship Symposium (2013-2019)
Metal on metal total hip replacements are a common procedure in which the hip joint is replaced with a metal stem, a metal femoral head and a metal socket, usually made of titanium or cobalt chromium. The stem has a tapered region (trunnion) where the femoral head is impacted onto. This creates what is known as the taper-trunnion interface within a hip implant. However, these hip implants seem to be very susceptible to fretting corrosion, where the corrosive fluid environment of the body accelerates the process of wear between two contact surfaces. Previous research has suggested that the design parameters …
A Novel Signal Processing Method For Intraoperative Neurophysiological Monitoring In Spinal Surgeries, Krishnatej Vedala
A Novel Signal Processing Method For Intraoperative Neurophysiological Monitoring In Spinal Surgeries, Krishnatej Vedala
FIU Electronic Theses and Dissertations
Intraoperative neurophysiologic monitoring is an integral part of spinal surgeries and involves the recording of somatosensory evoked potentials (SSEP). However, clinical application of IONM still requires anywhere between 200 to 2000 trials to obtain an SSEP signal, which is excessive and introduces a significant delay during surgery to detect a possible neurological damage. The aim of this study is to develop a means to obtain the SSEP using a much less, twelve number of recordings. The preliminary step involved was to distinguish the SSEP with the ongoing brain activity. We first establish that the brain activity is indeed quasi-stationary whereas …
Improving Health Care Quality And Safety: The Development And Assessment Of Laparoscopic Surgery Instrumentation, Practices And Procedures, Bernadette Mccrory
Improving Health Care Quality And Safety: The Development And Assessment Of Laparoscopic Surgery Instrumentation, Practices And Procedures, Bernadette Mccrory
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Adverse events due to medical errors are a leading cause of death in the United States exceeding the mortality rates of motor vehicle accidents, breast cancer and AIDS. Improvements can and should be made to reduce the rates of preventable surgical errors since they account for nearly half of all adverse events within hospitals. Although minimally invasive surgery has proven patient benefits such as reduced postoperative pain and hospital stay, its operative environment imposes substantial physical and cognitive strain on the surgeon increasing the risk of error. In order to mitigate errors and protect patients, a multidisciplinary approach was taken …
Spectral Analysis Of Pathological Acoustic Speech Waveforms, Priyanka Medida
Spectral Analysis Of Pathological Acoustic Speech Waveforms, Priyanka Medida
UNLV Theses, Dissertations, Professional Papers, and Capstones
Biomedical engineering is the application of engineering principles and techniques to the medical field. The design and problem solving skills of engineering are combined with medical and biological science, which improves medical disorder diagnosis and treatment. The purpose of this study is to develop an automated procedure for detecting excessive jitter in speech signals, which is useful for differentiating normal from pathologic speech. The fundamental motivation for this research is that tools are needed by speech pathologists and laryngologists for use in the early detection and treatment of laryngeal disorders. Acoustical analysis of speech was performed to analyze various features …