Medicine and Health Sciences Commons^™

Correlación Entre La Sintomatología Ocular Asociada Al Síndrome Visual Informático E Insuficiencia De Convergencia, César Luis Ruiz Sanabria, Erika Yuliana Niño Vega, Sandra Patricia Jurado

Ciencia y Tecnología para la Salud Visual y Ocular

El incremento en la demanda de uso de dispositivos electrónicos y pantallas digitales ha provocado la aparición de trastornos músculo esqueléticos, psicosociales y visuales; dentro de estos últimos se encuentra el trastorno denominado síndrome visual informático (svi), que se ha reportado desde hace más de veinte años; su tasa en la población oscila entre el 37 % y el 70 % (1). La alta recurrencia de alteraciones visuales dentro del svi permite relacionarlo con disfunciones de la visión binocular como la insuficiencia de convergencia (ic). Objetivo general: identificar la correlación existente entre la sintomatología ocular asociada al síndrome visual informático …

Automatic Cardiac Mri Image Segmentation And Mesh Generation, Ziyuan Li

McKelvey School of Engineering Theses & Dissertations

Segmenting and reconstructing cardiac anatomical structures from magnetic resonance (MR) images is essential for the quantitative measurement and automatic diagnosis of cardiovascular diseases [1]. However, manual evaluation of the time-series cardiac MRI (CMRI) obtained during routine clinical care are laborious, inefficient, and tends to produce biased and non-reproducible results [2]. This thesis proposes an end-to-end pipeline for automatically segmenting short-axis (SAX) CMRI images and generating high-quality 2D and 3D meshes suitable for finite element analysis. The main advantage of our approach is that it can not only work as a stand-alone pipeline for the automatic CMR image segmentation and mesh …

Reducing Brain Kynurenic Acid Synthesis Precludes Kynurenine-Induced Sleep Disturbances, Katherine M. Rentschler, Snezana Milosavljevic, Annalisa M. Baratta, Courtney J. Wright, Maria V. Piroli, Zachary Tentor, Homayoun Valafar, Christian O'Reilly, Ana Pocivavsek

Publications

Patients with neurocognitive disorders often battle sleep disturbances. Kynurenic acid is a tryptophan metabolite of the kynurenine pathway implicated in the pathology of these illnesses. Modest increases in kynurenic acid, an antagonist at glutamatergic and cholinergic receptors, result in cognitive impairments and sleep dysfunction. We explored the hypothesis that inhibition of the kynurenic acid synthesising enzyme, kynurenine aminotransferase II, may alleviate sleep disturbances. At the start of the light phase, adult male and female Wistar rats received systemic injections of either: (i) vehicle; (ii) kynurenine (100 mg kg−1; i.p.); (iii) the kynurenine aminotransferase II inhibitor, PF-04859989 (30 mg kg−1; s.c.); …

Use Of Mobile Technology To Identify Behavioral Mechanisms Linked To Mental Health Outcomes In Kenya: Protocol For Development And Validation Of A Predictive Model, Willie Njoroge, Rachel Maina, Frank Elena, Lukoye Atwoli, Anthony Ngugi, Srijan Sen, Stephen Wong, Linda Khakali, Andrew Aballa, James Orwa, Moses Nyongesa, Jasmit Shah, Amina Abubakar, Zul Merali

Brain and Mind Institute

Objective:This study proposes to identify and validate weighted sensor stream signatures that predict near-term risk of a major depressive episode and future mood among healthcare workers in Kenya.

Approach: The study will deploy a mobile application (app) platform and use novel data science analytic approaches (Artificial Intelligence and Machine Learning) to identifying predictors of mental health disorders among 500 randomly sampled healthcare workers from five healthcare facilities in Nairobi, Kenya.

Expectation: This study will lay the basis for creating agile and scalable systems for rapid diagnostics that could inform precise interventions for mitigating depression and ensure a healthy, resilient …

Calidad De Vida Y Productividad En Trabajadores Présbitas No Corregidos: Revisión Sistemática, Laura Natalia León Maldonado, Natalia Andrea Carrasco Romero, Karoll Lindhey Núñez Carranza, Nancy Piedad Molina-Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

La presbicia es un proceso degenerativo normal asociado a la edad, que afecta al sistema visual dificultando enfocar con nitidez las imágenes en visión próxima, aspecto que puede generar la disminución de la productividad de los trabajadores que precisan realizar tareas de cerca y consecuentemente afectar su calidad de vida. La presente investigación tiene por objetivo sintetizar la evidencia científica sobre cómo la presbicia no corregida disminuye la productividad y la calidad de vida del trabajador mayor de 40 años. La metodología utilizada se basó en una búsqueda bibliográfica y el reporte se realizó cumpliendo los criterios de la declaración …

Caracterización Socioeconómica, Demográfica, Laboral Y Académica De Los Graduados De Optometría De La Universidad El Bosque En Bogotá, Colombia, Diana García-Lozada, José Rudas-Valero, Reinaldo Acosta-Martínez, Jenny Maritza Sánchez-Espinosa, Alejandra Mendivelso-Suárez, Lady Johana Morales-Solano

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo: conocer las características socioeconómicas, demográficas, laborales y académicas de los graduados del Programa de Optometría de la Universidad El Bosque, entre el 2013 y el 2022. Métodos: estudio observacional de corte transversal analítico, en el que se envió una encuesta electrónica a 365 graduados del Programa de Optometría. El instrumento incluyó 54 preguntas sobre variables demográficas, socioeconómicas, laborales y de formación académica posgradual. Resultados: de 190 graduados que respondieron la encuesta el 79,7 % eran de sexo femenino y el 90,6 % tenían entre 21 y 30 años. El 76,3 % permanecían solteros, el 76,8 % no tenían personas …

Scale Model Experiments Of Toxic Gas Production From The Combustion Of Polymers When Applied With Different Droplet Sizes Of Water Mist, Nicharee Thinnakornsutubutr, Masayuki Mizuno, Kazunori Kuwana

Progress in Scale Modeling, an International Journal

This research experimentally investigated the combustion of polymeric materials with water mist application in an enclosure, with an emphasis on the production of toxic gases. Two different diameters, ~100 and ~260 μm, were tested. The experimental conditions were determined based on Froude similarity laws for low drop Reynolds number conditions. Droplets and polymers’ physical and chemical properties influence the burning/extinguishing behavior and toxic-gas evolution. In general, larger droplets can extinguish a fire in a shorter time, and toxic gas concentrations in a test chamber decreased more rapidly. However, the large droplets tended to cause the flame expansion phenomenon for thermoplastics …

Nanocellulose Based Foams For Low-Cost Disposable Medical Applications, Dominic Kugell

Electronic Theses and Dissertations

Polyurethane foams have been a staple material for their use in medical positioners, such as post-surgery elevation pillows as well as specific tailored positioners for their use during surgery. Polyurethane foams are preferred because of their lower cost compared to other petroleum derived foams, their versatility, and suitable mechanical properties. However, the environmental impact, including both cost and perception, of these foams is immense. Therefore, alternatives are being explored with biopolymers emerging as a promising class of materials. Cellulose is one such polymer that has recently demonstrated desirable properties. In this study, cellulose nanofibrils (CNF), a household foaming agent, and …

Yoga Ocular, Una Práctica Que Podría Reducir La Sintomatología Y Mejorar Algunos Aspectos De La Función Binocular En Pacientes Jóvenes, Nancy Piedad Molina-Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

No abstract provided.

Discromatopsias Y Su Relación Con El Desempeño Biopsicosocial Cotidiano, Myrna Miriam Valera-Mota, Mitzi Rubi Valencia-Estrada, Javier Alonso-Trujillo, Abraham Alonso-Ricardez, Luz Elena Maya-López, Ma. Consepcion Rodríguez-Salgado, Paola Guadalupe García-Guízar, Marco Antonio Reynoso-Castro

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo. Conocer cómo influye la visión de los pacientes discrómatas, particularmente de tipo congénito (deuteranómalos, protanómalos, deuteranopes y protanopes), en su vida cotidiana escolar, laboral o profesional y las principales dificultades enfrentadas, de acuerdo con el modelo biopsicosocial. Método. Se diseñó un instrumento de calidad de vida del paciente discrómata en el que se incluyeron diferentes categorías de la vida cotidiana, con un total de veintitrés reactivos que fueron aplicados a todos los pacientes diagnosticados con alguna discromatopsia en el gabinete de color de la Clínica de Optometría de la Facultad de Estudios Superiores Iztacala, de la Universidad Nacional Autónoma …

Percepción De Los Deportistas Sobre La Importancia Del Sistema Visual En El Rugby Paralímpico, Ana María Parra Arroyo, Sandra Patricia Jurado Medina, Sandra Milena Medrano, Nancy Piedad Molina-Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

En las últimas décadas, se ha incrementado la atención sobre la relación de las habilidades visuales y el deporte. No obstante, son pocas las investigaciones realizadas sobre este tema en deportes paralímpicos y, en particular, aquellas que indaguen sobre la percepción de la influencia del sistema visual en el desempeño deportivo de los atletas. El objetivo de este estudio fue determinar la percepción de los jugadores de rugby en silla de ruedas sobre la influencia del sistema visual en el deporte. Se incluyeron quince deportistas pertenecientes a la selección paralímpica de rugby de Bogotá y Cundinamarca, a quienes se les …

A Comparison Of Ground Reaction Forces And Muscle Activity Of The Tsunami Bar® Against A Rigid Barbell During Back Squat Phases, John Carver Middleton

Theses and Dissertations

An Institutional Review Board (IRB)-approved study was conducted to investigate the effects of the Tsunami Bar® (TB), a flexible barbell, on ground reaction force (GRF) production and muscle activity in the quadricep, hamstring, and gluteal muscle groups during phases of the squat exercise and compare the effects to the effects to using a rigid barbell (RB). A two-by-two repeated measures Analysis of Variance (ANOVA) test was used to compare the results. Descriptive statistics showed significantly higher GRFs for the TB during the unweighting phase, significant differences in GRFs between speeds for each phase, significantly higher forces on average with the …

Vertical Federated Learning Using Autoencoders With Applications In Electrocardiograms, Wesley William Chorney

Theses and Dissertations

Federated learning is a framework in machine learning that allows for training a model while maintaining data privacy. Moreover, it allows clients with their own data to collaborate in order to build a stronger, shared model. Federated learning is of particular interest to healthcare data, since it is of the utmost importance to respect patient privacy while still building useful diagnostic tools. However, healthcare data can be complicated — data format might differ across providers, leading to unexpected inputs and incompatibility between different providers. For example, electrocardiograms might differ in sampling rate or number of leads used, meaning that a …

Analyzing Pseudomonas Aeruginosa With Bacteriophage Tags Using Photoacoustic Flow Cytometry, Jennifer C. Schinke

Electronic Theses and Dissertations

The number of daily bacterial infections is climbing and the CDC explains that this is due to the antibiotic-resistant threat in the United States. Finding a faster way of bacterial identification is necessary as it currently takes 1-4 days for a medical lab to culture and identify bacteria. Photoacoustic flow cytometry (PAFC) can be used as an alternative method resulting in swift identification within an hour (Edgar, 2019). Pseudomonas aeruginosa, cell line PA01, will be coated in up to a few hundred red dyed phages making it detectible by the photoacoustic flow cytometry system. Bacteriophages (phages) are viruses that …

Proceedings Of The 2023 Berry Summer Thesis Institute, University Of Dayton. University Honors Program

Proceedings of the Berry Summer Thesis Institute

Thanks to a gift from the Berry Family Foundation and the Berry family, the University Honors Program launched the Berry Summer Thesis Institute in 2012. The institute introduces students in the University Honors Program to intensive research, scholarship opportunities and professional development. Each student pursues a 12-week summer thesis research project under the guidance of a UD faculty mentor. This contains the product of the students' research.

Contents:

• “How Porous Materials Affect the Boundary-Layer Transition of Hypersonic Flight Vehicles” (Megan C. Sieve)
• “Ultra-Stretchable, Self-Healing, DLP 3D-Printed Elastomers for Damage-Resistant Soft Robots: A Review” (Robert M. A. Drexler)
• “Extrapolation of Scalar …

In Vitro And In Vivo Diabetic Models For Assessment Of Tissue Engineered Vascular Grafts, Juan Carlos Carrillo Garcia

All Dissertations

Diabetes has become one of the leading causes of lower-limb loss worldwide. Every 30 seconds, a person loses a limb due to diabetic-related vascular complications. About one-third of patients needing lower-limb bypass surgery have debilitated autologous vessels unsuitable for use, and no other good long-term options are available. These detrimental effects on the vasculature are caused mainly by the hyperglycemic and hyperlipidemic conditions derived from diabetes. Under these conditions, an increase in advanced glycation end products (AGEs) and reactive oxygen species leads to irreversible crosslinks of extracellular matrix proteins, accelerating vascular pathology through vascular stiffening, endothelial dysfunction, inflammation, atherosclerosis, fibrosis, …

Injectable Immunomodulatory Strategies To Enhance Muscle Recovery Following Injury, Tai Huu Huynh

Graduate Theses and Dissertations

Although skeletal muscle displays an astonishing regenerative capacity, injuries or diseases that resulted in bedridden or chronic muscle wasting can overwhelm this intrinsic feature of skeletal muscle and lead to functional deficit (range of motion and/or strength) and overall reduction in quality of life. Microenvironmental cues within injured skeletal muscle dictate regenerative and repair process which are tightly coordinated interplay among resident cells, cells recruitment and immune response following an assault in the muscle extracellular matrix (ECM). The successful regeneration of functional tissues requires both appropriate modulation of the inflammatory response, and activation of a variety of cell populations. Biomaterials …

Investigation Of Possible Inflammatory Response After Ultrasound And Microbubble Procedure In The Spinal Cord., Jenna Wilkerson

Electronic Theses and Dissertations

The purpose of this experiment is to explore the inflammatory effects of focused ultrasound paired with intravenously delivered microbubbles when used in the lumbar spinal cord. There are currently very few pharmaceuticals that can successfully enter the blood spinal cord barrier (BSCB). This technique used at the lumbar enlargement might allow targeted treatment of pathologies involving the spinal cord.

To test the possible inflammatory response of this technique, an animal experiment was performed. 15 animals were given a T12 laminectomy and allowed to fully recover. Once recovered, all animals received FUS+MB at L2 and were euthanized in groups of five …

Assessment Of Knee Flexion In Young Children With Prosthetic Knee Components Using Dynamic Time Warping, Mark Daniel Geil, Zahra Safaeepour

Faculty and Research Publications

Introduction: Analysis of human locomotion is challenged by limitations in traditional numerical and statistical methods as applied to continuous timeseries data. This challenge particularly affects understanding of how close limb prostheses are to mimicking anatomical motion. This study was the first to apply a technique called Dynamic Time Warping to measure the biomimesis of prosthetic knee motion in young children and addressed the following research questions: Is a combined dynamic time warping/root mean square analysis feasible for analyzing pediatric lower limb kinematics? When provided at an earlier age than traditional protocols dictate, can children with limb loss utilize an articulating …

Survey Of How Irregularities In The Electrical System Of The Human Heart Link To Different Heart Arrhythmias, Jazmine Boloor

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis explores the circuital pathway that a signal takes within the heart throughout a full heartbeat and provides a timing analysis. It then surveys the different pathways that could arise in the electrical system of the heart, and the associated heart diseases linked to the location of each pathway. Common heart arrhythmias such as atrioventricular nodal reentrant tachycardia, atrioventricular reentrant tachycardia, atrial flutter, and atrial fibrillation are surveyed, and their pathways are analyzed. Electrocardiograms are presented to aid in understanding of the timing analysis associated with irregularity in heart function. Finally, this thesis explores an avenue of the heartbeat …

Photodynamic Therapy To Treat Triple Negative Breast Cancer In Vitro, Hunter S. Warren

All Theses

Triple negative breast cancer (TNBC) is the most resilient form of breast cancer, being one of the leading causes of death for women and making up 7% of all cancer deaths. Photodynamic therapy (PDT) offers a minimally invasive solution to TNBC as a passive-targeting treatment that reduces the need for other well established yet harsh treatments that can be taxing on the patient. PDT involves the use of a high-energy red light on the area of a tumor injected with photosensitizers (PS) that generate reactive oxygen species (ROS) in the tumor, triggering cell death. The PS tetra(hydroxyphenyl)chlorin (m-THPC) was used …

Serum Metabolomic Profiling For Colorectal Cancer Using Machine Learning, Ria Nur Puspa Sari, Diah Balqis Ikfi Hidayati, Arleni Bustami

Indonesian Journal of Medical Chemistry and Bioinformatics

Background: Colorectal cancer is one of the deadliest diseases with a high prevalence worldwide and is characterized by the appearance of adenomatous polyps in the colon mucosa which are at high risk of developing into colorectal cancer. This study aims to use serum metabolites as promising non-invasive biomarkers for colorectal cancer detection and prognostication. Differences in serum metabolites in patients with adenomatous polyps, colorectal cancer, and healthy controls are considered to be able to support the prognosis of colorectal cancer. Methods: Metabolite dataset is taken from the Metabolomic Workbench. Analysis and validation are carried out in silico using machine learning …

Editorial: Intervertebral Disc Degeneration And Osteoarthritis: Mechanisms Of Disease And Functional Repair., Graciosa Q Teixeira, Jana Riegger, Raquel M Gonçalves, Makarand V. Risbud

Department of Orthopaedic Surgery Faculty Papers

No abstract provided.

Using Machine Learning To Assist Auditory Processing Evaluation, Hasitha Wimalarathna, Sangamanatha Veeranna, Minh Vu Duong, Chris Allan Prof, Sumit K. Agrawal, Prudence Allen, Jagath Samarabandu, Hanif M. Ladak

Electrical and Computer Engineering Publications

Introduction: Approximately 0.2–5% of school-age children complain of listening difficulties in the absence of hearing loss. These children are often referred to an audiologist for an auditory processing disorder (APD) assessment. Adequate experience and training is necessary to arrive at an accurate diagnosis due to the heterogeneity of the disorder.

Objectives: The main goal of the study was to determine if machine learning (ML) can be used to analyze data from the APD clinical test battery to accurately categorize children with suspected APD into clinical sub-groups, similar to expert labels.

Methods: The study retrospectively collected data from 134 children referred …

A Molten Salt Test Loop For Component And Instrumentation Testing, T L. Head, Allison M. Berry, Keaton J. Brewster, Robert L. Brown, Hailey N. Burden, Reuben Byrd, Timothy Doty, Jess Dowdy, Kameron A. Hill, R. A. Jinkerson, Timothy J. Kennedy, Ronald C. Laehn, Dakotah Martinez, Samuel L. Mulder, Charles Onstead, Kim L. Pamplin, Dylan C. Pfeifer, Michael B. Ranger, Aaron D. Robison, Nathaniel T. Rowlands, Raymond E. Smith, Matthew T. Steele, R. S. Towell, Travis Towell, Olive Tuyishimire, T. S. Watson

Chemistry and Biochemistry

Molten salt is an effective coolant for a wide range of applications, including nuclear reactors, concentrated solar power, and other high temperature industrial heat transfer processes. The technical readiness level of components and instrumentation for high-temperature molten salt applications needs improvement for molten salt to be more widely adopted. A molten salt test loop was designed, built, and commissioned as a test bed to address these issues. The molten salt test loop at Abilene Christian University was built out of 316 stainless steel with a forced flow centrifugal-type pump, and was instrumented for remote operation. A low-temperature molten nitrate salt …

Local Chlorhexidine Delivery For Periodontal Infection Therapy: A Short Review, Muhammad Guruh Najmudin, Azizah Intan Pangesty, Rini Riastuti, Sunarso Sunarso, Abdul Halim Abdullah

Journal of Materials Exploration and Findings

Oral diseases affected more than half of the world’s population. Periodontitis is the second biggest threat to oral health after dental caries. Periodontitis is an inflammation inside periodontal pockets caused by pathogenic microbial colonies which lead to destruction of bone tissue and soft tissue. Chlorhexidine gluconate is an antimicrobial agent that effective to destroy pathogenic microbial and cure periodontitis. Chlorhexidine gluconate is given locally using a carrier material to the infected area. There are several materials that can be used to deliver Chlorhexidine gluconate to the infected periodontal tissue such as gel, liquid (mouthwash), and chip. This short review aims …

The Effect Of Heat Treatment And Chemical Treatment On Natural Fibre To The Durability Of Wood Plastic Composites – A Review, Nuratiqah Asyiqin Mohd Nasharudin, Nur Fatihah Sulaiman, Nurul Aziemah Mohammad, Wan Nor Raihan Wan Jaafar, Falah Abu Dr., Siti Norasmah Surip

Journal of Materials Exploration and Findings

The application of WPC is not only limited to indoor applications but has been extended to exterior applications where properties of WPC could compromise during service life. WPC was derived from wood fiber of various sizes to reinforce polymers. Wood fiber has the advantage of a cheaper price, being abundantly available, and ease of processing, however, the critical factor is its hydrophilic nature, where moisture absorption is likely to occur. Thus, treatments for reducing the hydrophilicity of wood fibers are applied. By treatment of wood fiber, the surface impurities were removed, leaving the roughened surface of fibers, thus providing a …

Development Of A Covid-19 Vulnerability Index (Cvi) For The Counties And Residents Of New Jersey, Usa., Remo Disalvatore, Sarah K Bauer, Jeong Eun Ahn, Kauser Jahan

Henry M. Rowan College of Engineering Faculty Scholarship

The coronavirus disease 2019, or COVID-19, has impacted countless aspects of everyday life since it was declared a global pandemic by the World Health Organization in March of 2020. From societal to economic impacts, COVID-19 and its variants will leave a lasting impact on our society and the world. During the height of the pandemic, it became increasingly evident that indices, such as the Center for Disease Control's (CDC) Social Vulnerability Index (SVI), were instrumental in predicting vulnerabilities within a community. The CDC's SVI provides important estimates on which communities will be more susceptible to 'hazard events' by compiling a …

Evaluating An Mhealth Application For Cancer Survivors With Disabilities Through Usability Testing, Kevin Baez

University Honors Program Senior Projects

The effect of cancer treatment can cause difficulties in a cancer survivor's life due to the risk of attaining a long-term disability which has potential negative cognitive, psychological, physical, and social consequences. Furthermore, post-treatment support has been shown to be severely limited, leaving many to deal with new obstacles and struggles on their own. With no real support system in place, cancer survivors with disabilities can be lost during post-cancer transition. However, mHealth interventions have been proven to effectively aid users in dealing with various health issues. We aim to support and empower cancer survivors through an application called, WeCanManage. …

Mechanisms Of Theta Burst Transcranial Ultrasound Induced Plasticity In The Human Motor Cortex, Yazan Shamli Oghli, Talyta Grippe, Tarun Arora, Tasnuva Hoque, Ghazaleh Darmani, Robert Chen

Department of Medicine Faculty Papers

BACKGROUND: Transcranial ultrasound stimulation (TUS) is a novel non-invasive brain stimulation technique with high depth penetrance and spatial resolution. Theta-burst TUS (tbTUS) is a plasticity-inducing protocol which increases motor cortical excitability for up to 30 min following 80s of sonication. While this protocol may have therapeutic potential for the treatment of psychiatric and neurological disorders, the mechanisms of action of TUS remain unclear.

OBJECTIVE: We conducted the first pharmacological study to examine the mechanisms of TUS in human primary motor cortex. By administering brain-active drugs with known mechanisms of action, we aimed to elucidate the mechanisms of tbTUS.

METHODS: Fourteen …