Medicine and Health Sciences Commons^™

Small Molecules Targeting Insm1 For The Treatment Of High-Risk Neuroblastoma, Michael S. Lan, Chiachen Chen

School of Medicine Faculty Publications

Human neuroblastoma (NB) is the most common childhood extracranial tumor arising from the sympathetic nervous system. It is also a clinically heterogeneous disease that ranges from spontaneous regression to high-risk stage 4 disease. The cause of this disease remains elusive. However, the amplification of NMYC oncogene occurred in roughly 30% of NB patients, which strongly correlated with the advanced stage of disease subtype and the worse prognosis status. We discovered that N-Myc oncoprotein binds and activates INSM1, a zinc-finger transcription factor of neuroendocrine tumors. We also found that INSM1 modulates N-Myc stability mediated through PI3K/AKT/GSK3β signaling pathway. Therefore, INSM1 emerges …

Effects Of Salinity On Plant Development Of In Vitro Sweet Potato (Ipomoea Batatas) Explants And Growth Of Pakchoi (Brassica Rapa Var. Chinensis) Seedlings, Tristan Paulino, Mari Marutani, Phd

Journal of Health Disparities Research and Practice

Climate change has affected the Pacific Islands with increased sea levels, and the contamination of freshwater with saltwater, which has become a serious problem for plant development. Bioassays were performed to examine the effects of salinity on root and shoot development of in-vitro sweet potato (Ipomoea batatas), and effects on the seedling growth of pakchoi (Brassica rapa var. chinensis).

Sterilized stems with one or two nodes of sweet potato cv. Liberty were placed in in-vitro Murashige & Skoog solid media with NaCl concentrations of 0%, 0.5%, 1.0% and 1.5%. Newly emerged roots and shoots were recorded …