Medicine and Health Sciences Commons^™

Squamous Cell Carcinoma Response To Cisplatin Exposure, Khanh V. Luong

Theses & Dissertations

Purpose: This thesis attempted to quantitatively analyze the individual cell fate choice in resistant head and neck UM-SCC38 cells exposed to cisplatin using the most current techniques available.

Methods: UM-SCC-38 cells were grown in Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 10% fetal bovine serum (FBS). They were treated with cisplatin and ATM/ATR inhibitors of known dosages. Using live cell imaging, one hundred cells were tracked in each experiment and their behaviors were analyzed and entered into Microsoft Excel Spreadsheet to generate cell profile graphs. HaCaT cells, non-tumorigenic keratinocyte cell line, were also analyzed using live cell imaging and their …

Quality Of Life And Subjective Outcomes Following Maxillomandibular Advancement Surgery For The Treatment Of Obstructive Sleep Apnea, Andrew D. Emanuele

Electronic Thesis and Dissertation Repository

Objective: The aim of this study was to assess outcomes related to general quality of life, daytime sleepiness and functional sleep outcomes, functional outcomes of orthognathic surgery, and facial aesthetics in patients undergoing maxillomandibular advancement (MMA) surgery for the treatment of obstructive sleep apnea (OSA).

Materials and Methods: This was a cross-sectional self-report study. A questionnaire was constructed using questions drawn from previously validated questionnaires. The survey was distributed to 25 patients who underwent MMA surgery for the treatment of OSA at LHSC in London, Ontario by a single surgeon between 2002 and 2013.

Results: The survey results showed that …

The Role Of Bone Sialoprotein In Periodontal Tissue Development And Bone Repair, Yohannes Soenjaya

Electronic Thesis and Dissertation Repository

Bone development and repair involve complex processes that include interaction between cells and their surrounding matrix. In the body, bone sialoprotein (BSP) expression is up-regulated at the onset of mineralization. BSP is a multifunctional acidic phosphoprotein with collagen-binding, hydroxyapatite nucleating, and integrin recognition (RGD sequence, which is important for cell-attachment and signaling) regions. Mice lacking BSP expression (Bsp^-/-), exhibit a bone phenotype with reductions in bone mineral density, bone length, osteoclast activation, and impaired bone healing. This thesis examined the role of BSP in tooth development and also its potential use as a therapeutic reagent for bone …

Ada News - 12/07/2015, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Dental Hygienists' Cognitive Process In Periodontal Soft Tissue Charting, Kelsey M. Schwei

Theses and Dissertations

Introduction: Dental hygienists have not had the opportunity to be involved in the design and development of the periodontal soft tissue charts and the surrounding interface features that are used while examining dental patients in daily practice. In some cases, dentists are able to give their opinions, wants, and needs into the development of the health information systems that they use on a daily basis, but too often, the dental hygienist is forgotten about and no input is ever given to the developers from the dental hygienists. This project considers the impact of well-designed interfaces on effectiveness and workflow particularly …

Strategies For Improving Patient Compliance, Diana V. Macri

Publications and Research

Patient compliance is the degree to which a person adheres to the professional advice healthcare providers offer. Aside from significantly compromising a person’s health, non-compliance also wastes resources and productivity. The monetary costs of medical noncompliance has been estimated to be around $300 billion a year. Demographic, disease severity and gender effects on compliance are small. In dental hygiene, where practitioners focus on the prevention of oral disease, motivating patients to practice healthy behaviors has long been a challenging, and often frustrating, aspect of practice. Any discussion of compliance must begin with a brief review of human development and the …

The Use Of Lasers For Direct Pulp Capping, Takashi Komabayashi, Arata Ebihara, Akira Aoki

Dental Medicine Faculty Publications

Direct pulp capping helps extend the life of a diseased tooth by maintaining tooth vitality. Nowadays, lasers are more frequently used during direct pulp capping in the clinic, but their use has not been previously reviewed. This review presents the basic properties of currently available lasers, scientific evidence on the effects of laser application on direct pulp capping, and future directions for this technology. An extensive literature search was conducted in various databases for articles published up to January 2015. Original in vitro, in vivo, and clinical studies, reviews, and book chapters published in English were included. Various laser systems …

Assessing Orthodontic-Bracket Impacts On Lip Profile At Bonding And Debonding Stages, Martin Trockel

Student Theses, Dissertations and Capstones

Introduction: One factor that contributes greatly to the lower face appearance and orthodontists have the ability to affect is lip profile. Clinical assessment of the lip profile is an important element in the decision of orthodontic treatment planning and in the evaluation of treatment progress and outcome. Three known factors influence the lip profile; the lip thickness, the underlying bone, and the tooth position. The positions and inclinations of the anterior teeth can affect the lip position, but it is unclear whether orthodontic brackets bonded to the labial surface of anterior teeth move the lip position and thereafter change the …

Effects Of Sodium Hypochlorite On Enamel Composition, Sonni Pellillo

Student Theses, Dissertations and Capstones

The purpose of this study was to evaluate the effects of sodium hypochlorite on the organic and inorganic composition of enamel. Background: With the advent of enamel bonding for orthodontic appliances in the late 1970s, it has been shown that traditional phosphoric acid etching affects the inorganic portion of the enamel.1, 2 In an attempt to enhance the acid etching pattern and, furthermore, the bond strength, additional pretreatment techniques that target the organic components of the enamel biofilm have been proposed. One such method is the non-invasive enamel pretreatment with 5.25% sodium hypochlorite (NaOCl) prior to phosphoric acid etching.3, 4 …

Evaluation Of Frictional Forces Between Brackets Of Different Types At Various Angulations And An Arch Wire: With And Without Pulsating Vibration, Benjamin M. Christman

Student Theses, Dissertations and Capstones

Objective: The objective of this study was to determine the effect of pulsating vibration on the sliding resistance between orthodontic brackets and stainless steel wires. Brackets were placed at two different angulations (0° and 5°) to simulate leveling of a tipped tooth during tooth movement. Pulsating vibration was delivered via the AcceleDent device.

Background: Friction is defined as a force that retards or resists the relative motion of two objects in contact, and its direction is tangential to the common boundary of the two surfaces in contact. This has been of interest to the orthodontist since the mid-20th century. Since …

Transdermal Delivery Of Functional Collagen Via Polyvinylpyrrolidone Microneedles, Wenchao Sun, Mohammed Inayathullah, Martin A. C. Manoukian, Andrey V. Malkovskiy, Sathish Manickam, M. Peter Marinkovich, Alfred T. Lane, Lobat Tayebi, Alexander M. Seifalian, Jayakumar Rajadas

School of Dentistry Faculty Research and Publications

Collagen makes up a large proportion of the human body, particularly the skin. As the body ages, collagen content decreases, resulting in wrinkled skin and decreased wound healing capabilities. This paper presents a method of delivering type I collagen into porcine and human skin utilizing a polyvinylpyrrolidone microneedle delivery system. The microneedle patches were made with concentrations of 1, 2, 4, and 8% type I collagen (w/w). Microneedle structures and the distribution of collagen were characterized using scanning electron microscopy and confocal microscopy. Patches were then applied on the porcine and human skin, and their effectiveness was examined using fluorescence …

Comparison Of Digital Scanning And Polyvinyl Siloxane Impression Techniques By Dmd Students : Instructional Efficiency And Attitudes Toward Technology., Alexander M. Marti

Electronic Theses and Dissertations

The aim of this research was compare the ability of dental students to learn an digital scanner (3M LAVA) and material-based (PVS) impression techniques and to determine attitudes and preferences towards each. D2 dental students (n=25) were recruited and instructed on the use of 3M LAVA and PVS techniques using three pedagogic methods: 1) video lecture (P1), 2) investigator-led demonstration (P2), and 3) independent clinical exercise (P3). The amount of time for each pedagogic method was measured, averaged (± s.d.) and compared using Wilcoxon Signed-Ranks tests. A pre- and post-test was administered assessing their attitudes towards both techniques using a …

A 3d Radiographic Evaluation Of Crestal Bone Changes Around Immediately Loaded Endosseous Implants, Keerthi Senthil

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this clinical investigation is to evaluate and compare the 3-dimensional radiographic crestal bone changes around 4 immediately placed and loaded implants supporting full arch fixed mandibular prosthesis in 2 groups of patients. The Test group comprises of patients with failing mandibular teeth needing extraction. ( due to caries, periodontal disease, fractures or prosthetic reasons).The Control group comprises of patients with a fully edentulous mandible presenting for fixed implant supported prosthesis with at least 6 months after the last extraction or bone grafting procedure. Stereolithographic bone model obtained from the patient’s DICOM files was used to fabricate the …

Synthesis And Functional Evaluation Of Peptide Modified Poly (Lactic-Co-Glycolic Acid) Nanoparticles To Inhibit Porphyromonas Gingivalis Biofilm Formation., Paridhi Kalia

Electronic Theses and Dissertations

Periodontal disease is an oral inflammatory disorder that afflicts roughly 46% of the adults in the U.S. Currently, treatment of periodontal disease involves the removal of plaque from the gingival pocket (with possible antibiotic treatment) and if necessary, gingival surgery. To our knowledge, no therapeutic approach exists that promotes host-biofilm homeostasis by limiting pathogen recolonization of the oral cavity after prophylaxis or treatment. The interaction of the pathogen Porphyromonas gingivalis with commensal streptococci is critical for initiation of periodontitis and represents a target for limiting P. gingivalis colonization of the oral cavity. Previous studies showed that a synthetic peptide …

Access To Oral Health For Children On Mainecare In The Lakes Region Towns Of Bridgton, Casco, Sebago, And Naples, Carissa L. Parent

Muskie School Capstones and Dissertations

Although we know that children covered by Medicaid often do not receive needed dental services, the extent of the problem in Maine is not fully understood. In particular, rural communities in Maine may face challenges for families to access dental services for their children given low reimbursement rates and fewer available providers. This project addresses these gaps in knowledge by examining MaineCare- funded utilization and dental care access for children with MaineCare in four rural Maine towns in the Lakes Region.

Assessment Of Orthodontic Patients' Preferences Regarding Treatment From General Dentists Or Orthodontists, Brian Robert Wilde

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study evaluated how parents of prospective orthodontic patients choose between taking their child to a general dentist or an orthodontist for orthodontic treatment. It also looked at which factors influence patients’ satisfaction with the progress of treatment and likelihood to refer other patients to the practice. This study included two phases. The first phase was a qualitative assessment of the decision making process through conducting and analyzing focus groups. The second phase was the development and administration of a nationwide online survey regarding the topics covered in the focus groups. Influential factors in the decision making process fell into …

Cbct Evaluation Of Adolescent Mandibular Morphology In Different Classifications Of Facial Type, Annie Hsu

UNLV Theses, Dissertations, Professional Papers, and Capstones

The goal of this study is to use the improved imaging capability of cone-beam computerized tomography (CBCT) to investigate the relationship between vertical facial patterns and mandibular tooth-alveolar morphology in the adolescent population. Pre-treatment orthodontic records were obtained from the UNLV School of Dental Medicine archival dental records. One hundred and seventy three patients (72 males, 101 females) between the ages of 12 and 18 years were included in this study. Among these patients, 61 displayed the vertical growth pattern, 30 displayed the horizontal growth pattern, and 82 displayed the average growth pattern. The samples were categorized into 4 age …

Scardovia Wiggsiae Prevalence In Orthodontic Patients, Brandon Joseph Streiff

UNLV Theses, Dissertations, Professional Papers, and Capstones

Dental caries has mainly been associated with Streptococcus, Lactobacillus, Actinomyces and Veillonella species. But in recent salivary studies a new cariogenic pathogen, has been identified. This new bacteria, Scardovia wiggsiae (SW), is currently being tested within the UNLV School of Dental Medicine patient population. Although these current studies are being conducted to study its prevalence in both pediatric and adult populations, it has not been evaluated among patients with an altered oral environment as seen in patients with orthodontic appliances. Fixed orthodontic appliances increase the difficulty of removing daily plaque on and in between the teeth with standard oral hygiene …

Analysis Of Stresses In Mandible And Skull Under Angular Impact, Dr. Shobha E S, Dr. Suresh Nagesh, Dr. H P. Raghuveer, Mr. Vinay K. S

Innovative Research Publications IRP India

Finite element analysis has gained a significant attention in the field of biomechanics. The versatility of finite element analysis is the major reason behind its implementation and adoption has made the study of biomechanics much easier and simpler. FEA, as a tool has helped in analyzing the various organs in human body in different loading conditions. Be it Orthopedic,Maxillofacial fractures,Orthodontics, Prosthodontics, hemodynamics, it is finding its applications in all areas of biomechanics. In this paper, one such study has been carried out to understand the behavior of skull and mandible under inclined impacts. Skull is one of the highly complicated …

Dexamethasone Regulates Gene Expression Induced By The Mechanosensitive P2x7 Receptor In Osteoblasts, Meena Na

Electronic Thesis and Dissertation Repository

Orthodontic tooth movement involves activation of osteoblasts and osteoclasts in response to mechanical forces. Extracellular nucleotides, released in response to mechanical stimuli, signal through P2 receptors in osteoblasts. P2X7 receptors are ATP-gated cation channels implicated in mechanotransduction in bone. Corticosteroids such as dexamethasone exhibit anti-inflammatory effects and their chronic use has been linked to serious side-effects such as osteoporosis. We investigated gene expression following P2X7 receptor activation with benzoylbenzoyl-ATP (P2X7 receptor agonist) in osteoblast precursor cells in the presence or absence of dexamethasone. We hypothesized that dexamethasone inhibits the ability of ATP to stimulate the expression of anabolic (bone forming) …

The State Of Oral Health On The African Continent, Megan E. Josefczyk

Senior Honors Theses

The African continent has continuously suffered from poverty, poor sanitation, and malnutrition, leaving it an open feeding ground for infectious disease and premature death. Along with poor oral hygiene and an unavailability of dental clinics, oral disease is allowed to thrive and cause great harm. In the last two decades, the World Health Organization and others have tried to implement better systems of oral health care for the African people and have advocated for more well-trained dentists, dental clinics, equipment, and affordable dental care. Progress has been made in some African countries, but the continent is still in serious need …

Ada News - 11/16/2015, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

An Evaluation Of The Constructed Frankfort Mandibular Plane Angle Bisector (Cfmab) Wits' Appraisal In The Assessment Of Anteroposterior Jaw Relationships, Derek R. Tomson

Electronic Thesis and Dissertation Repository

For proper orthodontic diagnosis and treatment planning, an accurate measurement of the relationship of the maxilla to the mandible in the sagittal plane is required. The ANB measurement has long been the gold standard for explaining this association. The purpose of this longitudinal study was to evaluate three linear measurements of the maxillomandibular anteroposterior relationship and determine which one best correlates with ANB. The constructed Frankfort horizontal-mandibular plane angle bisector (cFMAB-Wits), maxillomandibular bisector (MMB-Wits), and Frankfort-mandibular plane angle bisector (FMAB-Wits) were measured using a Wits’-type analysis and compared to ANB.

Pre-treatment (TO), immediate post-treatment (T1), and two years post-retention (T2) …

Color Of Porcelain Veneer After Final Cementation In Comparison To Try-In Paste And Permanent Cement: An In Vitro Study, Abdulelah Aldahlawi

Student Theses, Dissertations and Capstones

Objectives: To evaluate and compare the color of porcelain veneers with try-in paste in relation to porcelain veneers with permanent cement. Also, to evaluate and compare combinations of three different shades and thicknesses of porcelain veneers and three cement shades before and after final cementation. Additionally, to evaluate and compare the color of porcelain veneers with cured permanent cement before and after aging. Background: Porcelain veneers and ceramic restorations have become one of the most popular approaches in the anterior area due to their natural appearance and esthetics. However, more conservative approaches have led to thinner restorations with increased translucency. …

Ada News - 11/02/2015, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Biomaterial Properties Of Titanium In Dentistry, Soni Prasad, Mark Ehrensberger, Monica Prasad Gibson, Hyeongil Kim, Edward A. Monaco, Jr.

School of Dentistry Faculty Research and Publications

Background

Among various dental materials and their successful restorative uses, titanium provides an excellent example of integrating science and technology involving multiple disciplines of dentistry including biomaterials, prosthodontics and surgical sciences. Titanium and its alloys have emerged as a material of choice for dental implants fulfilling all requirements biologically, chemically and mechanically. Several excellent reviews have discussed the properties of titanium and its surface characteristics that render it biocompatible. However, in most patients, titanium implants are used alongside several other metals. Presence of different metals in the same oral environment can alter the properties of titanium. Other influencing factors include …

Ex Vivo Effects Of An Orthodontic-Specific Bleaching System On Tooth Color And Existing Bracket Bonding, Kirk James Bean

Student Theses, Dissertations and Capstones

Objective: The purpose of this ex vivo study was to assess the changes in tooth color and existing orthodontic bracket bonding when exposed to a bleaching agent. Methods: 120 freshly extracted human premolars were equally divided into 4 groups: a negative-control group, a positive-control bleaching group, a bracket-bonded group, and a bracket bonded-bleached group. The bleaching protocol was carried out as recommended by the manufacturer of Opalescence Go® – 30 minutes each day for 10 consecutive days. The color value of each tooth was measured daily by spectrophotometry for the negative-control group and the positive-control bleaching group in 6 different …

Adjunctive Appliance Wear And Gender Affect Patients' Oral Health-Related Quality Of Life During The Late Stage Of Orthodontic Treatment In Adolescents, Monica Dinh

Student Theses, Dissertations and Capstones

Objective: This study was conducted to determine how oral health-related quality of life (OHQoL) changes during the late stage of comprehensive fixed orthodontic treatment in adolescents and what factors may be involved. Background: Completion of orthodontic treatment has been shown to improve patients’ OHQoL due to the changes in esthetics, function and emotional well-being. The levels of OHQoL fluctuate throughout treatment where an initial decrease within the first 6 months occurs followed by an improvement towards patients’ pre-treatment levels. At 18 months of fixed orthodontic treatment, the level is unclear. The aims of this study were to clarify the changes …

Condylar Hyperplasia: An Updated Review Of The Literature, Luis Eduardo Almeida, Joseph Zacharias, Sean Pierce

School of Dentistry Faculty Research and Publications

Condylar hyperplasia (CH) is a rare disorder characterized by excessive bone growth that almost always presents unilaterally, resulting in facial asymmetry. Classification of the different types of CH can differ depending on the authors. Correct diagnosis is critical in determining the proper treatments and timing. This paper is a review of the recent literature on the epidemiology, etiology, diagnosis, classification, and surgical treatments of CH.

Effect Of Clark’S Twin-Block Appliance (Ctb) And Non-Extraction Fixed Mechano-Therapy On The Pharyngeal Dimensions Of Growing Children, Batool A. Haider, Attiya Shaikh, Mubassar Fida

Department of Surgery

Abstract

INTRODUCTION:

Narrow airway dimensions due to mandibular deficiency can predispose an individual to severe respiratory distress. Hence, treatment with mandibular advancement devices at an early age might help improving the pharyngeal passage and reduce the risk of respiratory difficulties. Therefore, the aim of the current study was to evaluate the mean changes in the pharyngeal dimensions of children with mandibular deficiency treated with Clark's twin-block appliance (CTB) followed by fixed orthodontic treatment.

METHODS:

Orthodontic records of 42 children with mandibular deficiency were selected. Records comprised three lateral cephalograms taken at the start of CTB treatment, after CTB removal and …