Medicine and Health Sciences Commons^™

Quality Of Life And Subjective Outcomes Following Maxillomandibular Advancement Surgery For The Treatment Of Obstructive Sleep Apnea, Andrew D. Emanuele

Electronic Thesis and Dissertation Repository

Objective: The aim of this study was to assess outcomes related to general quality of life, daytime sleepiness and functional sleep outcomes, functional outcomes of orthognathic surgery, and facial aesthetics in patients undergoing maxillomandibular advancement (MMA) surgery for the treatment of obstructive sleep apnea (OSA).

Materials and Methods: This was a cross-sectional self-report study. A questionnaire was constructed using questions drawn from previously validated questionnaires. The survey was distributed to 25 patients who underwent MMA surgery for the treatment of OSA at LHSC in London, Ontario by a single surgeon between 2002 and 2013.

Results: The survey results showed that …

The Role Of Bone Sialoprotein In Periodontal Tissue Development And Bone Repair, Yohannes Soenjaya

Electronic Thesis and Dissertation Repository

Bone development and repair involve complex processes that include interaction between cells and their surrounding matrix. In the body, bone sialoprotein (BSP) expression is up-regulated at the onset of mineralization. BSP is a multifunctional acidic phosphoprotein with collagen-binding, hydroxyapatite nucleating, and integrin recognition (RGD sequence, which is important for cell-attachment and signaling) regions. Mice lacking BSP expression (Bsp^-/-), exhibit a bone phenotype with reductions in bone mineral density, bone length, osteoclast activation, and impaired bone healing. This thesis examined the role of BSP in tooth development and also its potential use as a therapeutic reagent for bone …

Dexamethasone Regulates Gene Expression Induced By The Mechanosensitive P2x7 Receptor In Osteoblasts, Meena Na

Electronic Thesis and Dissertation Repository

Orthodontic tooth movement involves activation of osteoblasts and osteoclasts in response to mechanical forces. Extracellular nucleotides, released in response to mechanical stimuli, signal through P2 receptors in osteoblasts. P2X7 receptors are ATP-gated cation channels implicated in mechanotransduction in bone. Corticosteroids such as dexamethasone exhibit anti-inflammatory effects and their chronic use has been linked to serious side-effects such as osteoporosis. We investigated gene expression following P2X7 receptor activation with benzoylbenzoyl-ATP (P2X7 receptor agonist) in osteoblast precursor cells in the presence or absence of dexamethasone. We hypothesized that dexamethasone inhibits the ability of ATP to stimulate the expression of anabolic (bone forming) …

An Evaluation Of The Constructed Frankfort Mandibular Plane Angle Bisector (Cfmab) Wits' Appraisal In The Assessment Of Anteroposterior Jaw Relationships, Derek R. Tomson

Electronic Thesis and Dissertation Repository

For proper orthodontic diagnosis and treatment planning, an accurate measurement of the relationship of the maxilla to the mandible in the sagittal plane is required. The ANB measurement has long been the gold standard for explaining this association. The purpose of this longitudinal study was to evaluate three linear measurements of the maxillomandibular anteroposterior relationship and determine which one best correlates with ANB. The constructed Frankfort horizontal-mandibular plane angle bisector (cFMAB-Wits), maxillomandibular bisector (MMB-Wits), and Frankfort-mandibular plane angle bisector (FMAB-Wits) were measured using a Wits’-type analysis and compared to ANB.

Pre-treatment (TO), immediate post-treatment (T1), and two years post-retention (T2) …

Mass Spectrometric Analyses Of Surface Proteins From Candida Albicans After Treatment With Histatin 5, Shirley Fan

Electronic Thesis and Dissertation Repository

Current drug therapies have lost their effectiveness in controlling the fungal species known as C. albicans; therefore, the need for newer drugs becomes crucial. Histatin 5 (Hst 5), a naturally occurring peptide found in the oral cavity, has demonstrated strong effects on controlling candidiasis. Here, we have proposed that the adhesion of cells through surface proteins is an important process. To allow the analysis of surface proteins, the concept of on-whole cell tryptic digestions were developed. This on-target approach allows for isolation of the peptides of interest, while greatly reducing digestion times.

To study the effects of Histatin 5 …

The Application Of The Ultrafine Technology In Improving The Biocompatibility And Osteo-Inductivity Of Dental Implants, Nicholas Y. Hou

Electronic Thesis and Dissertation Repository

Dental implants are very effective medical devices. However, although stable, the conventional titanium implants are not very bioactive which in some instances could reduce their efficacy. This thesis described the research progress of using polymeric ultrafine-particles with bioactive additives to enrich the surface of titanium substrate, thereby increasing the biocompatibility and osteo-inductivity of the biomaterial. During this doctoral project, three different types of polymers were examined, initially the conventional polyester, and later the novel epoxy as well as the epoxy/polyester hybrid polymers. Physical characterizations confirmed that all of the coating powders were ultrafine particles, and homogeneous surfaces were constructed from …

Novel Protective Salivary Peptides And The Chitosan Nanoparticles Delivery System, Flavia Zaidan Cardoso Salina

Electronic Thesis and Dissertation Repository

As a result of its protein composition, saliva performs many essential functions that contribute to oral homeostasis. However, salivary proteins suffer quick degradation in the oral cavity, which decreases the protective potential of that fluid (Chapter 2). Using scanning electron microscopy (SEM), we evaluated the effect of our novel salivary peptides DR9, DR9-DR9, DR9-RR14 and RR14 on the crystallization of calcium oxalate (CaOx). All peptides containing DR9 showed significant inhibitory effect on the crystallization of CaOx, whereas RR14 showed no effect (Chapter 3). Next, we tested the adsorption behavior of our chitosan nanoparticles (CHNP) delivery system to hydroxyapatite (HA) surface …

Underlying Mechanisms Regulating Gingival Healing And Fibrosis, Shawna Soheun Kim

Electronic Thesis and Dissertation Repository

Successful wound healing involves tightly controlled regulation of extracellular matrix (ECM) deposition and remodeling, and myofibroblast-mediated wound contraction, to restore normal tissue function. However, these events involved in healing are also associated with development of tissue fibrosis, which is characterized by excessive deposition of ECM and the presence of myofibroblasts. Increasing evidence suggests that periostin is a critical player in regulating skin healing and fibrosis. In contrast to most adult tissues, gingival connective tissue is known to heal more rapidly and with less scarring, yet is still associated with fibrosis, such as drug-induced gingival enlargement. The aim of this study …

An In-Vitro Comparison Of Different Palatal Sites For Orthodontic Miniscrew Insertion: The Effect Of Bone Quality And Quantity On Primary Stability, Carine Bourassa

Electronic Thesis and Dissertation Repository

Introduction: The maxillary hard palate is a desirable location for orthodontic miniscrew (OMS) placement. The related anatomy is well known, but little data exists regarding the primary stability of palatal OMSs.

Purpose: To assess the quality and quantity of human cadaveric palatal bone at different insertion sites using microCT imaging, and to determine their effect on the primary stability of OMSs.

Materials and methods: One hundred and thirty OMSs (VectorTAS^TM, 6 mm) were inserted into ten human cadaveric maxillary hard palates and maximal insertion torques (IT) were recorded. MicroCT images were obtained before and after OMS insertion for …

Clinical Outcomes Of Maxillomandibular Advancement Surgery For The Treatment Of Obstructive Sleep Apnea, Brian L. Phee

Electronic Thesis and Dissertation Repository

Objective: To evaluate clinical and radiographic treatment outcomes after maxillomandibular advancement (MMA) surgery on subjects suffering from obstructive sleep apnea (OSA).

Materials and Methods: This was a retrospective cohort analysis. Subjects underwent pre- and post-surgical polysomnography (PSG) studies and were also asked to complete a subjective self-assessment via the Epworth Sleepiness Scale (ESS) questionnaire. Twenty-two patients (11 male, 11 female) met the inclusion criteria.

Results: The mean pre-surgical apnea-hypopnea index (AHI) score was 48.4 (+/-31.3) and mean ESS score was 11.6 (+/-4.6). After surgery, the mean AHI reduced to 14.0 (+/-15.0) and ESS reduced to 5.7 (+/-3.5). Treatment success was …

An Evaluation Of The Frankfort Mandibular Plane Angle Bisector (Fmab) Wits Appraisal In The Assessment Of Anteroposterior Jaw Relationships In Class Ii Individuals, Harbinder Sangha

Electronic Thesis and Dissertation Repository

Accurate diagnosis and treatment planning are of vital importance to practicing orthodontists. The purpose of this longitudinal study was to evaluate the reliability and validity of the Frankfort Mandibular Plane Angle Bisector (FMAB) reference plane in the assessment of anteroposterior discrepancies in a sample of Class II Division 1 individuals. Comparisons were made between the FMAB, ANB angle, and maxillo-mandibular Bisector (MMB) in both treated and control samples of Class II Division 1 patients.

The data was collected from pre-treatment (T0), immediate post-treatment (T1) and two year post-retention (T2) lateral cephalograms of 40 female and 36 male Class II Division …